GBM Drug Bank

Drugs for Glioblastoma

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Compound	PubChem CID	Reported Effect	MoA	Models	PMID	Clinical PMID	Clinical Trials	Patents
Baicalein-5,6,7-trimethylether	442583	peroxisomal fatty acid beta-oxidation	ACSVL1	U87MG	18470630			PubChem Google
Vorinostat	5311	proliferation, radiosensitization, viability	Histone deacetylase, SN38	GL26, LN18, LN229, mouse model, primary human glioma cells, T98G, U251MG, U373MG, U87MG	17289901, 19622715, 20135194, 23962875, 25040548, 25275596, 26794465, 27863490, 29384188, 30878553	19307505	NCT00238303, NCT00268385, NCT00555399, NCT00641706, NCT00731731, NCT00762255, NCT01110876, NCT01189266, NCT01266031, NCT01342757, NCT01378481, NCT01738646, NCT03426891	PubChem Google
Vandetanib	3081361	proliferation, temozolomide enhancer	VEGFR, EGFR, RETtyrosine kinase	GBM6, GBM8, U251MG, U87MG	15305185, 16061883, 16299247, 19622715, 20371720, 20811710, 21095630, 23799852	20137866, 23099652	NCT00441142, NCT00613223, NCT00821080, NCT00995007	PubChem Google
Eupalmerin acetate	5459169	apoptosis	JNK	U373MG, U87MG	17237278			Google
Decursin	442126	apoptosis, cell cycle arrest	JNK, p38, BCL2, CDK4, cyclin D1	C6, U87MG	30627007			PubChem Google
?/??Thujone	91456	angiogenesis, apoptosis, proliferation, viability	VEGF, Ang-4, CD31	C6, U87MG	26900077			PubChem Google
Hypericin	3663	viability		T98G, U251MG, U87MG	24066060	21456013		PubChem Google
Toxin C3	137185910	water influx suppression	Nicotinamide adenine dinucleotide (NAD)	1321N1	19772916			Google
Ascochlorin	11258227	invasion, migration		A172, U373MG	28569433			PubChem Google
Hispidulin	5281628	apoptosis, proliferation	AMPK, mTOR	primary human glioma cells	20698539			PubChem Google
Tanshinone IIA	164676			LN229	30021339			PubChem Google
AM7	11650194	proliferation	Met, LCK, BTK	MKN45, U87MG	18055465			PubChem Google
EIPA	1795	cell swelling suppression	NHE	1321N1	19772916			PubChem Google
Sorafenib	216239	proliferation, radiosensitization, temozolomide enhancer, viability	Tyrosine protein kinase, VEGFR2, Raf, PDGFR, cKIT,	GBM12, GBM14, GBM5, GBM6, LN229, orthotopic mouse model, primary human glioma cells, U1242, U251MG, U87MG	19001435, 20371721, 20470863, 23324350, 24139873, 24911215, 24965413, 27542273, 30219696, 30338715, 30469352, 30515262	20443129, 20564147, 21954442, 23099651, 23898124, 24786603, 28988377	NCT00093613, NCT00329719, NCT00335764, NCT00445588, NCT00544817, NCT00597493, NCT00621686, NCT00734526, NCT00884416, NCT01183663, NCT01434602, NCT01441388, NCT01817751, NCT02599090	PubChem Google
Perphenazine	4748	apoptosis, proliferation, viability	Casp3	C6, U87MG	14997012, 20811727			PubChem Google
Reversan	2298706				26136652			PubChem Google
Tolbutamide	5505	proliferation	Cx43	C6	11741589, 15781061, 16718685, 19176641			PubChem Google
Fotemustine	104799		DNA alkylation			27165580	NCT01474239	PubChem Google
AG-1478	2051	proliferation	EGFR	mice xenografts, U87MG	16522318, 19828040			PubChem Google
ML299	56593054	invasion, migration	PLD1, PLD2	U87MG	23445448			Google
Mercuric Chloride	24085	cell swelling suppression	Aquaporin1	1321N1	19772916			PubChem Google
Magnolol	72300	cell cycle arrest, proliferation	CDK2/p21, Cip1	U373	19645506			PubChem Google
Phenylbutyrate	5258	radiosensitisation	HDAC	D54, SKMG3, U251MG, U87MG	17707275			PubChem Google
Diazepinomicin	9868980		RAS			22048878	NCT00730262	PubChem Google
BE-16627B	132070	apoptosis	MMP	U251MG, U373MG, U87MG	14604227			Google
Alantolactone	72724	viability		LN229, U373, U87MG	22837216			PubChem Google
Docetaxel	148124	viability	Microtubules	LN229, primary human glioma cells, U87MG	24433351, 30219696, 30318217, 30796690		NCT00049296	PubChem Google
Thymeleatoxin	5476508	proliferation	PKC, cPKC	C6	18778746			Google
Epoxomicin	11226684	apoptosis	Proteasome	U251MG, U343, U373, U87MG	18341587, 19201384, 19690139			PubChem Google
Indoximod	405012	viability	IDO	GL261	25054064	30415456	NCT02052648, NCT02502708, NCT04049669	PubChem Google
Forskolin	47936	proliferation	Adenylate cyclase, Hedgehog (Hh) signaling	A172, C62B, NB19, U87MG	18719351, 20015475, 21472212, 24649161, 6199388, 9484714			PubChem Google
4-HPR	5288209	apoptosis, differentiation	Casp8, tBid, BIRC, Calpain, Casp3	C6, T98G, U87MG	18602901, 19285047		NCT00075491	PubChem Google
Digitoxigenin	4369270	viability		U87MG	27029345, 29333657			PubChem Google
Caffeic acid phenethyl ester	5281787	apoptosis, proliferation		C6, primary human glioma cells	14637186, 15885897, 23165409, 24997497			PubChem Google
Ispinesib	6851740	proliferation	KSP, HsEg5	mouse xenograft model	19554570			PubChem Google
JTE013	10223146	invasion	S1P(2)	U373	18819934			PubChem Google
MP470	11282283	apoptosis, radiosensitization, viability	cMET	murine xenograft tumor, SF126, SF188, SF210, SF268, SF295, SF767, SSF763, U87MG	20028557			PubChem Google
NSC23766	409805	viability	RAC1	GL15, SF767, U105MG, U251MG, U343MG, U373MG	23736154			PubChem Google
STF-62247	704473	apoptosis	mTORC1	MZ54	30250198			PubChem Google
Temozolomide	5394	viability	ATRCHK1, p21, NFkappaB	C6, LN229, LN229MGMT, LN308, mouse model, SF767, U105MG, U138, U251MG, U343MG, U87MG, XO8	23736154, 24647572, 27878252, 27993939, 29354058, 29454008, 30361254, 30569180, 30705757, 30853911, 30881038	31789	NCT00003176, NCT00003464, NCT00003567, NCT00004113, NCT00004200, NCT00005637, NCT00005951, NCT00006025, NCT00006263, NCT00006353, NCT00006358, NCT00006474, NCT00014105, NCT00021307, NCT00025558, NCT00027625, NCT00028795, NCT00038493, NCT00039494, NCT00047294, NCT00049387, NCT00050986, NCT00052455, NCT00068952, NCT00083096, NCT00085254, NCT00086879, NCT00089427, NCT00099125, NCT00102648, NCT00112502, NCT00128700, NCT00187486, NCT00200161, NCT00238277, NCT00253487, NCT00262730, NCT00268385, NCT00274833, NCT00275067, NCT00302159, NCT00304031, NCT00305864, NCT00311857, NCT00316849, NCT00323115, NCT00335075, NCT00354068, NCT00365222, NCT00376103, NCT00385853, NCT00387400, NCT00390403, NCT00392171, NCT00394628, NCT00402116, NCT00431561, NCT00433381, NCT00436436, NCT00441142, NCT00458601, NCT00471653, NCT00481455, NCT00482677, NCT00486603, NCT00492687, NCT00498927, NCT00501891, NCT00504660, NCT00508456, NCT00516282, NCT00516607, NCT00521482, NCT00525525, NCT00544284, NCT00544817, NCT00548938, NCT00553150, NCT00555399, NCT00574964, NCT00575887, NCT00590681, NCT00597402, NCT00597493, NCT00610571, NCT00612339, NCT00612651, NCT00612989, NCT00613093, NCT00615186, NCT00616005, NCT00619112, NCT00626015, NCT00643097, NCT00643825, NCT00650923, NCT00657267, NCT00662506, NCT00669669, NCT00684567, NCT00686725, NCT00687765, NCT00689221, NCT00704080, NCT00704808, NCT00720564, NCT00723827, NCT00725010, NCT00731731, NCT00734526, NCT00756106, NCT00761280, NCT00768911, NCT00770471, NCT00782756, NCT00792012, NCT00805961, NCT00813943, NCT00817284, NCT00820963, NCT00841555, NCT00869401, NCT00883298, NCT00884741, NCT00904852, NCT00915694, NCT00916409, NCT00941460, NCT00943462, NCT00943826, NCT00960492, NCT00967330, NCT00977431, NCT00979017, NCT01004874, NCT01013285, NCT01019434, NCT01022918, NCT01026493, NCT01043536, NCT01044966, NCT01062399, NCT01062425, NCT01102595, NCT01110876, NCT01115491, NCT01119599, NCT01120639, NCT01149109, NCT01149850, NCT01164189, NCT01180816, NCT01181193, NCT01186406, NCT01209442, NCT01220271, NCT01222221, NCT01242566, NCT01269424, NCT01285414, NCT01294735, NCT01342757, NCT01345370, NCT01390571, NCT01402063, NCT01430351, NCT01466686, NCT01473901, NCT01478321, NCT01480050, NCT01480479, NCT01502241, NCT01514201, NCT01517776, NCT01587144, NCT01700569, NCT01702610, NCT01740258, NCT01752491, NCT01765088, NCT01777919, NCT01790503, NCT01800695, NCT01830101, NCT01837862, NCT01849146, NCT01860638, NCT01868906, NCT01907165, NCT01956734, NCT01957956, NCT01977677, NCT01985087, NCT02010606, NCT02029573, NCT02039778, NCT02046187, NCT02052648, NCT02085304, NCT02092038, NCT02137759, NCT02152982, NCT02168270, NCT02177578, NCT02179086, NCT02209948, NCT02227901, NCT02311920, NCT02315534, NCT02329795, NCT02330991, NCT02337426, NCT02340156, NCT02343406, NCT02343549, NCT02344355, NCT02364206, NCT02366728, NCT02378532, NCT02394665, NCT02395692, NCT02414165, NCT02455557, NCT02502708, NCT02510950, NCT02530502, NCT02573324, NCT02590263, NCT02599090, NCT02617589, NCT02649582, NCT02655601, NCT02661282, NCT02663440, NCT02667587, NCT02685605, NCT02715609, NCT02761070, NCT02770378, NCT02781792, NCT02799238, NCT02805179, NCT02843230, NCT02871843, NCT02880410, NCT02898012, NCT02928575, NCT02977780, NCT03008148, NCT03018288, NCT03034135, NCT03119064, NCT03137888, NCT03139916, NCT03149575, NCT03174197, NCT03197506, NCT03213002, NCT03224104, NCT03225963, NCT03232424, NCT03243461, NCT03246113, NCT03291990, NCT03310372, NCT03345095, NCT03363659, NCT03388372, NCT03405792, NCT03419403, NCT03426891, NCT03451799, NCT03463265, NCT03463733, NCT03466450, NCT03477110, NCT03480867, NCT03491683, NCT03514069, NCT03529448, NCT03535350, NCT03548571, NCT03576612, NCT03581292, NCT03587038, NCT03607643, NCT03631823, NCT03633552, NCT03643549, NCT03650257, NCT03660761, NCT03687034, NCT03688178, NCT03705351, NCT03746080, NCT03749187, NCT03776071, NCT03778294, NCT03780569, NCT03782415, NCT03914742, NCT03927222, NCT03970447, NCT04019262, NCT04047706, NCT04049669, NCT04077866, NCT04091503, NCT04105374, NCT04116411, NCT04119674, NCT04157478	PubChem Google
Cyclopamine	442972	apoptosis	Hedgehog (Hh) signaling	CD34+, U251MG	19245435, 29313231			PubChem Google
SB202190	5169	chemosensitivity	p38, MAPK	T98G, U251MG	19435873			PubChem Google
RapaLink-1	121231411	proliferation	mTOR	U87MG	28292440			PubChem Google
Tivantinib	11494412	proliferation	PI3K/Akt, mTOR	T98MG, U251	31575848			PubChem Google
Doxorubicin	31703	proliferation	DNA intercalation	A172, LN443, primary human glioma cells, SHSY5Y, U118, U373, U87MG, U87MGATCC	19101989, 19564615, 19633683, 23165409, 24433351, 27029345, 27993939, 28612256, 30368972, 30448308, 30606517, 30639216, 30836216, 30869664		NCT00002608, NCT00944801, NCT01851733, NCT02372409, NCT02758366	PubChem Google
AMG-925	60202647	proliferation	FLT3, CDK4	A172, LN18, LNZ308, T98G, U373, U87MG	26585571			PubChem Google
Fludarabine	657237	proliferation		primary human glioma cells	23165409		NCT00990496, NCT01174121, NCT01454596, NCT02844062, NCT02937844, NCT03412877, NCT04102436	PubChem Google
Ancitabine	25051	proliferation	TopoisomeRASe 2	primary human glioma cells	23165409			PubChem Google
Isolinderalactone	5318587	apoptosis, DNA damage, proliferation, viability	BCL2, survivin, XIAP, PARP, Casp3, TUNEL	glioblastoma xenograft mouse model, U87MG	30503550			PubChem Google
Terfenadine	5405	viability		U87MG	27029345			PubChem Google
JQ1	46907787	proliferation, temozolomide enhancer	BET	C6, rat xenograft model, U87MG	25056450, 27388964, 29777137			PubChem Google
Alendronate	2088	proliferation, viability	FDPS	primary human glioma cells	28646347, 30333528			PubChem Google
Amlodipine	2162	viability	YAP, TAZ	LN18, LN229, T98G	30082911			PubChem Google
Proscillaridin A	222154	proliferation	GSK3beta	GBM6, GBM9, orthotopic mouse model, U251MG, U87MG	25400117, 27029345, 30250248			PubChem Google
AC1MMYR2	3246569	proliferation		LN229, orthotopic mouse model, U87MG	23811941
DPI (Diphenyleneiodonium chloride)	2733504	migration/invasion	NADPH	U87MG	19804834			PubChem Google
TC-A 2317 hydrochloride	46911725	apoptosis, cell cycle, viability	Aurora A kinase	human glioblastoma neurosphere tumor xenografts	25106428, 29396807			Google
Pazopanib	10113978		Tyrosine kinase			20200024, 23363814	NCT00350727, NCT00459381, NCT01392352, NCT01931098, NCT02331498, NCT03275558	PubChem Google
NU7441	11327430	radiosensitivity	DNA-PK inhibitor, NHEJ	U87MG		19770758		PubChem Google
DNQX	3899541	viability	AMPA	U87MG	19997873			PubChem Google
Y27632	448042	migration, proliferation	ROCK	C6, LN18	18814230, 19331140, 19427347, 19772916			PubChem Google
Raddeanin A	174742	apoptosis, viability	JNK	U251MG	29843152			Google
Decitabine	451668	viability	iNOS, DNA, FPR	C6, HEK, T98G, U87MG	14725971, 18607344, 18793349, 18803327, 18976507, 19037090, 19047176, 19787267, 19847810, 19966297			PubChem Google
MK-2206	24964624	proliferation	Akt	LN229, U87MG	19828040, 22057914, 28320338, 29354058		NCT01295632	PubChem Google
Pegdinetanib	86278317		VEGFR2	human tumor xenograft models, orthotopic mouse model, U87MG	20190562, 22875706	25388940		PubChem Google
Demethoxycurcumin	5469424			mouse xenograft model, primary human glioma cells	27757851			PubChem Google
Phorbol 12-myristate 13-acetate	27924	proliferation	PKCalpha, PKCdelta, PKCvarepsilon	C6, U87MG	18778746, 19357285, 19804834			PubChem Google
Digitonin	6474107	proliferation		primary human glioma cells	23165409			PubChem Google
Adavosertib	24856436	viability	WEE1	GBM22, mouse xenograft model, T98G, U251MG	21992793, 25609063	29798906	NCT01849146, NCT01922076, NCT02207010	PubChem Google
Diclofenac	3033	migration, proliferation		A172, HTZ349, U87MG	26485029			PubChem Google
Proteasome inhibitor IX	11639443	apoptosis inhibition	Proteasome	LN229, U251MG	19190249			PubChem Google
Idarubicin	42890	viability		U87MG	24433351			PubChem Google
Volasertib	10461508	radiosensitization, viability	PLK1	primary human glioma cells	24204733, 29535822			PubChem Google
Osajin	95168	cytotoxicity		U87MG	30836216			PubChem Google
Fenbendazole	3334	proliferation		primary human glioma cells	23165409			PubChem Google
Altiratinib	54576299		cMET, TIE2, VEGFR2	mouse xenograft model, primary human glioma cells	26965451			PubChem Google
Adenosine dialdehyde	99920	proliferation		C6	23353701			PubChem Google
Bosutinib	5328940	viability	Src family kinase, Akt	LN229, primary human glioma cells, U87MG	30219696	25290090, 25411098	NCT00959946, NCT01331291	PubChem Google
Paclitaxel	36314	apoptosis, proliferation, viability	Microtubules	C6, G144, G166, G179, GBM2, GBM7, GliNS2, LN229, primary human glioma cells, U87MG	18599610, 18804099, 19285047, 23165409, 28962238, 30219696, 30321641, 30633585		NCT00002814, NCT00014573, NCT00019019, NCT00479765, NCT02711137	PubChem Google
Quinine	3034034	apoptosis	PARP, CHOP, GADD153	LN229, U251MG, U87MG	25727221			PubChem Google
ZSTK474	11647372	proliferation	PI3K	mouse spontanious GBM model, mouse xenograft model, U118, U87MG	24297065, 27553832			PubChem Google
Baicalein	5281605	apoptosis	ERK	C6, U87MG	16814338, 19804834			PubChem Google
SH-6	16760283	apoptosis	Akt	LNZ308, U251MG	17041888, 18802038, 19808964, 19827268			Google
Propranolol	4946	mRNA synthesis inhibition	Nonselective badrenoceptor antagonist	U373	18498711			PubChem Google
GSK J4	71729975	proliferation	JMJD3	U251MG, U87MG	28978140			PubChem Google
VER-50589	135446210	cross-resistance	Hsp90	SF268, U87MG	19244114			PubChem Google
Linsidomine	5219	viability	NO, p53	BV2, CRTMG, D54MG, LNZ308	14695179, 19748528			PubChem Google
Chaetocin	11657687	viability	Histone lysine methyltransfeRASes	C6	24905315			PubChem Google
Deoxyglucose	108223	invasion, migration, radiosensitization	glycolysis, miR75p, TFF3	A172, LN229, SF268, T98G, U373MG, U87MG	18483381, 19244119, 19826036, 20009287, 20009289, 20009297, 28756228, 29621542	20009294		PubChem Google
Tivozanib	9911830	invasion, proliferation	VEGFR	A172, T98G, U87MG	28287096		NCT01846871	PubChem Google
Veliparib	11960529	radiosensitization, temozolomide enhancer	PARP	LN18, orthotopic mouse model, primary human glioma cells, T98G, U251MG, U87MG	19174557, 23510353, 28314386		NCT00770471, NCT01026493, NCT01514201, NCT02152982, NCT03581292	PubChem Google
C75	4248455	apoptosis	FAS inhibitor	U87MG	20009104			PubChem Google
Triapine	9571836	radiosensitization, viability	RR (ribonucleotide reductase)	U251MG	16675588			PubChem Google
Epigallocathecin	72277	viability		T98G, U87MG	19894226			PubChem Google
Flavopiridol	5287969	radiosensitization	CDK	MO59K, mouse model, T98G, U87MG	14712094, 23943501, 27461656, 28111642			PubChem Google
Dioleoyl phosphatidic acid	9547172	radiosensitization	Calcium signaling	C6	17499746, 18481020			PubChem Google
Pyrvinium pamoate	54680693	proliferation	GIC	GBM (primary human glioma cells), murine xenograft tumors	26152745			PubChem Google
Amiodarone	2157	apoptosis	CHOP	U251MG	21292685			PubChem Google
Talampanel	164509					19636006, 20143438	NCT00062504, NCT00064363, NCT00267592	PubChem Google
2-Hydroxyoleic acid	9796304	viability		1321N1, SF767, U118	23133576, 23471028		NCT03867123	PubChem Google
Selenium	6326970	apoptosis, viability		DBTRG	30796690			PubChem Google
Sanguinarine	5154	viability		U118MG, U87MG	26472194			PubChem Google
NSC-87877	92577	proliferation	SHP2 PTPase	LN229.EGFRvIII, U87MG.EGFRvIII	19427850			PubChem Google
Lanatoside C	3879	viability		U87MG	21184646, 27029345			PubChem Google
Flubendazole	35802	viability		U87MG	24433351			PubChem Google
KT5720	454202	mRNA synthesis inhibition	PKA, H1R	U373, U87MG	18498711, 20015475			PubChem Google
GANT61	421610	viability	GLI	U251MG, U87MG	27894350			PubChem Google
Camptothecin	24360	proliferation, viability		GL15, primary human glioma cells, SF767, U105MG U251MG, U343MG, U373MG, U87MG	16356833, 19633536, 23165409, 23736154, 27029345			PubChem Google
Nicardipine	4474	apoptosis	ABCG2	CD133+	19340456			PubChem Google
3,5-Dihydroxyphenylglycine (DHPG)	108001	neuroprotection, proliferation, synaptic modulation	mGluR1, mGluR5	C6	19822193			PubChem Google
Fingolimod	107970	viability		A172, mouse xenograft model, SHG44, U251MG, U87MG	25070489, 25939952		NCT02490930	PubChem Google
Naltrindole hydrochloride (NTI)	24840086	proliferation inhibition	Nonpeptide ?-opioid receptor	1028S, U87MG	19208828			Google
Lopinavir	92727	ritonavir enhancer				20683757	NCT01095094	PubChem Google
Hellebrigenin	259577	apoptosis, proliferation	Cdc25C, Cyclin B1, survivin, MAPK	U87MG	30272276			PubChem Google
PD184352	6918454	radiosensitivity, viability	MEK	SNB19	30647839			PubChem Google
Vinblastine	13342	proliferation		primary human glioma cells, U118	23165409, 6690037		NCT00498979	PubChem Google
Atorvastatin	60823	proliferation, viability	HMGCoA reductase	A172, LN229, primary human glioma cells, T98G, U138, U373, U87MG	20009104, 23165409, 28181188		NCT02029573	PubChem Google
Troglitazone	5591	apoptosis	PTPN1, pY705STAT3, glyoxalase I	LN18, MG328, T98G, U87MG	11719831, 16319070, 18346464, 19158480			PubChem Google
Tetraethylammonium	5413	proliferation		C6, U87MG	25700359			PubChem Google
SSR128129E	68853159	radiosensitization	FGFR	SF763, U87MG	24953334			PubChem Google
Dinaciclib	46926350	proliferation	CDK1, CDK2, CDK5, CDK9	A172, LN18, LNZ308, T98G, U373, U87MG	26585571			PubChem Google
GSK1838705A	25182616		IGF1R	mouse xenograft model, U87MG	26238593			PubChem Google
XL765	49867926		PI3K, mTOR	mouse xenograft model	21317208	26019185	NCT00704080, NCT01240460	PubChem Google
Fluoxetine	3386	apoptosis	AMPAR	C6, SHSY5Y, U87MG, xenograft model of glioblastoma in nude mice	16055945, 20811727, 25671301			PubChem Google
Thymoquinone	10281	proliferation		T98G, U87MG	24039814, 29651429, 30197342			PubChem Google
Fluvastatin	446155	proliferation		primary human glioma cells	23165409			PubChem Google
WYE-132	25260757	apoptosis, proliferation, viability	mTOR	U87MG	20068177			PubChem Google
Lonidamine	39562	proliferation, radiosensitization, viability	glycolysis	U373MG	20009297			PubChem Google
JIB-04	6519698	viability	Histone lysine demethylase	A172, CAS1, DBTRG, U251MG, U87MG	28432280			PubChem Google
Pivaloyloxymethyl	60748	apoptosis, proliferation	Histone deacetylase	murine xenograft glioma tumor, U251MG	16373710			PubChem Google
Thalidomide	5426					25239666, 25427949	NCT00006358, NCT00014443, NCT00039468, NCT00047281, NCT00047294, NCT00049296, NCT00079092, NCT00112502, NCT00412542, NCT00521482	PubChem Google
Nilotinib	644241		Tyrosine kinase inhibitor		18677408			PubChem Google
Dehydroxymethylepoxyquinomicin	9881652		NFkappaB	mouse xenograft model, U251MG, U87MG	21968049			PubChem Google
3,3'-Diindolylmethane	3071	apoptosis		U87MG	30617655			PubChem Google
Pyrazolanthrone	8515	viability	JNK	C6, U251MG, U87MG	18561312, 18813807, 19427347, 19517066, 19788921, 20060865, 23210245, 30229380			PubChem Google
Cytarabine	6253	proliferation		primary human glioma cells	23165409		NCT01044966	PubChem Google
Clioquinol	2788	viability		U87MG	26725099			PubChem Google
NF115	10000429	proliferation	Synthetic glycolipid	C6, U373MG	23245511			Google
GDC-0941	17755052	radiosensitization, viability	PI3K	A172, mouse xenograft model, SHG44, T98G, U373, U87MG	19584227, 23427298, 24757258, 28147244, 30132519, 30920104			PubChem Google
Rapamycin	5284616	radiosensitization, viability	mTOR	A172, CSCs5, CSCs7, Gli36 cells, mouse xenograft model, primary human glioma cells, T98G, U251MG, U87MG	18519772, 19177002, 19190120, 19738049, 19808964, 19827268, 21367753, 23261661, 24043497, 25886314, 30569180		NCT00047073, NCT00509431, NCT00672243, NCT00821080, NCT01522820	PubChem Google
7-Hydroxystaurosporine	72271	proliferation	PKC	mouse xenograft model, primary human glioma cells, U87MG	15780200, 24810059			PubChem Google
Tigecycline	54686904	apoptosis, proliferation	HES1, PI3K, Akt	U87MG	26823491			PubChem Google
A-192621	5310991	proliferation	ETRB	A375, LN229, SW1088, WM35	19040731			PubChem Google
Furanodienone	6442374	apoptosis, cytokine levels, inflammatory responses, TMZ enhancer	CSPG4	A172, U118, U251MG, U87MG	31006910			PubChem Google
PX-478	11234794	radiosensitization	HIF1	C6	19372568			PubChem Google
Carnosine	439224	proliferation	LDHA	primary human glioma cells, T98G	19909581			PubChem Google
VPC32183	44392752	viability	LPA(1), LPA(3)	C6	18481020			Google
Isotretinoin	5282379					25239666	NCT00003564, NCT00112502, NCT00555399, NCT01103375	PubChem Google
HJC0152	71719978	apoptosis, chemosensitivity, motility, proliferation	STAT3	xenograft tumors	31105997			Google
PD98059	4713	migration, proliferation	MEK1, MEK2	C6, T98G, U373	17327470, 18346464, 18411719, 18636433, 18975108, 19108760, 19158403, 19362079, 19435873			PubChem Google
Valproic acid	3121	proliferation, radiosensitization, viability	HDAC	C6, G144, G166, G179, G361, GBM2, GBM7, GliNS2, LN229, SF295, SKNMC, T98G, U373MG, U87MG	16373706, 18550052, 18582478, 18611290, 18679414, 18751431, 18765532, 19030781, 19239041, 19360904, 20332466, 23253698, 24348849, 25275596, 27802437, 28108734, 28962238, 30112328, 30243186, 30591460	23523186	NCT02648633	PubChem Google
Cidofovir	60613	angiogenesis, survival	Cytomegalovirus (CMV)	MCMV+ mice	30855281			PubChem Google
Penta-acetyl geniposide	162083	apoptosis	NSMase, NGF, p75, FasL, caspase cascades, PI3K, ER	C6	16763091, 19464279			Google
OSI-420	18924996	viability	EGFR	LN229, primary human glioma cells, U87MG	30219696			PubChem Google
Prochlorperazine	4917	viability		U87MG	29441946			PubChem Google
Procarbazine	4915					20855843, 225004	NCT00003293, NCT00003564, NCT00003788, NCT00004004, NCT00005796, NCT00052455, NCT00079092, NCT01737346	PubChem Google
Finasteride	57363	proliferation	ESF1, RIF1	U87MG	29543748			PubChem Google
NHI 2	51355147	apoptosis, cell cycle arrest, proliferation	LDHA	U87MG	26494310			PubChem Google
Glutamate	33032	invasion, proliferation	AMPA	U87MG	19997873			PubChem Google
Digoxin	2724385	proliferation, viability		primary human glioma cells, U87MG	21184646, 23165409			PubChem Google
NVP-AEW541	11476171		IGF1R	KNS42_A4, mouse xenograft model, primary human glioma cells	18677408, 20378689, 20488164, 21659463			PubChem Google
AMG 232	58573469		MDM2			31359240	NCT03107780	PubChem Google
4egi-1	5717952	proliferation	eIF4E	U251MG	26220902			PubChem Google
KU55933	5278396	radiosensitization	ATM	orthotopic mouse model, primary human glioma cells, WK1	25017126, 25205037	19931733		PubChem Google
Bafetinib	11387605		Tyrosine kinase			23380277	NCT01234740	PubChem Google
KU60019	15953870	radiosensitization	ATM	orthotopic mouse model, primary human glioma cells, U87MG	23620409, 24443327, 25091220			PubChem Google
CDK2 inhibitor II	3551941	apoptosis		U87MG	19549905			PubChem Google
Abemaciclib	46220502		CDK4, CDK6	mouse xenograft model, U87MG	26149830		NCT02977780, NCT02981940, NCT04074785, NCT04118036	PubChem Google
Valproate	3549980	3-bromopyruvate enhancer, apoptosis	MRP2, BCRP	T98G	30138705		NCT02648633	PubChem Google
Linifanib	11485656	apoptosis	VEGFR2, PDGFRbeta, Receptor tyrosine kinase	murine glioma models, orthotopic rat model	16648571, 22080168			PubChem Google
RG7112	57406853		MDM2	mouse model	26482041			PubChem Google
3-BrOP	11513992	viability		primaru human glioma cells	23132831			PubChem Google
Tunicamycin	56927832	proliferation		C6, U251MG	18483264, 2706513			Google
Andrographolide	5318517	proliferation		U251MG, U87MG	22634579			PubChem Google
PD153035	11246488	proliferation	EGFR	U87MG	19642173			PubChem Google
Akt inhibitor VIII (Akti-1/2)	135398501	proliferation inhibition	Akt	1028S, U87MG	19208828			PubChem Google
LY341495	9819927	proliferation		U87MG	23724064			PubChem Google
TGX-221	9907093	proliferation	p110beta	U251MG, U87MG	29048665			PubChem Google
ARP101	11292680	apoptosis, autophagy	MT1MMP	U87MG	30291676			PubChem Google
Fucoxanthin	5281239	proliferation		mouse xenograft model, U251MG, U87MG	27394418			PubChem Google
Astemizole	2247	viability		U87MG	27029345			PubChem Google
Antroquinonol	24875259			C6, mouse model	26517117			PubChem Google
Juglone	3806	proliferation		U251MG	18697955, 28388894, 28791366			PubChem Google
UNII-2AW48LAZ4I	72941968		Telomerase	orthotopic mouse model, U87MG	26183089
JS-K	9572720			mouse xenograft model, U87MG	23370169, 28653883			PubChem Google
Tandutinib	3038522		Multiple kinases	mouse xenograft model, transgenic mouse model	22146535, 23638177		NCT00379080, NCT00667394	PubChem Google
Nocodazole	4122	apoptosis	Microtubules	T98G	30268825			PubChem Google
Quercetin	5280343	proliferation, viability		U251MG, U373MG, U87MG	18971417, 19491660, 19804834, 24379902, 24902789			PubChem Google
Celecoxib	2662	migration, proliferation, viability	COX2	A127, C6, GOGCCM, T98G, U251MG, U373, U87MG	18634847, 19664879, 20062571, 20193113, 21763744, 21847707, 23280445	25239666	NCT00047281, NCT00047294, NCT00068770, NCT00112502, NCT00504660, NCT02770378	PubChem Google
Enzastaurin	176167	apoptosis, proliferation, temozolomide enhancer	PKCbeta, PI3K, Akt	A172	16103100, 18448327, 18462865, 18662322, 19913408	19417015, 20124186, 20150385, 20156802, 22291006	NCT00295815, NCT00402116, NCT00509821, NCT00516607, NCT00586508, NCT03776071	PubChem Google
Fludarabine phosphate	30751	viability	DNA, RNA synthesis	LN229, primary human glioma cells, U87MG	30219696			PubChem Google
Zoledronic acid	68740	viability	RAS, Rho GTPAses, FDPS	LN229, primary human glioma cells, U87MG	30219696, 30333528		NCT00301873	PubChem Google
Nobiletin	72344	proliferation		C6	23546290			PubChem Google
Amentoflavone	5281600	apoptosis, viability	NFkappaB, FAS, cFLIP, MCL1	U87MG	29475910			PubChem Google
781661-94-7	11178236	apoptosis, migration, proliferation	Survivin	A172, LN18, LN229, LNZ308, LNZ428, M059J, M059K, T98G, U373, U87MG	22770110, 23325792, 25201484, 27805285			PubChem Google
Arctigenin	64981	proliferation		T98G, U87MG	28356992			PubChem Google
Chloramphenicol	5959	proliferation	ALDH	U87MG	15777731, 19500061			PubChem Google
Latrunculin B	6436219	apoptosis	?v?3, ?v?5	D293MED, D54MG, D645MG, UW2282	20124512			PubChem Google
Schizandrin B	158103	invasion, proliferation		U251MG, U87MG	27977512			PubChem Google
Withaferin A	265237	apoptosis, G2/M arrest	CDK1, ATF4-ATF3-CHOP, Bim, Bad	nude mice xenografts, U251, U87	31642559			PubChem Google
Isoflurane	3763	apoptosis, proliferation	EAAT3, PKC, PI3K	C6	14639147			PubChem Google
CBL-0137	44519124	apoptosis, proliferation	SSRP1, SOX2, OCT4, NANOG, OLIG2, CD133, FACT, p53,	A1207, orthotopic mouse model, primary human glioma cells, U87MG	26921329, 27370399, 30581774		NCT01905228	PubChem Google
Palbociclib	5330286		CDK4, CDK6	mouse xenograft model	20354191, 24098593, 26149830, 26354993, 27370397, 28903422	30151703	NCT02255461, NCT03158389	PubChem Google
Embelin	3218	viability		LN18, T98G, U87MG	19409438, 19649204, 23514760, 23545899, 29384188			PubChem Google
Phloretin	4788	cell swelling suppression	Aquaporin9	1321N1	19772916			PubChem Google
TG101209	16722832	proliferation	JAK2	primary human glioma cells	26283544			PubChem Google
Digitoxin	441207	proliferation, viability		primary human glioma cells, U87MG	21184646, 23165409			PubChem Google
Hispolon	53395354, 10082188	apoptosis, cell cycle arrest, viability	CDK, p21, p53	U87MG	28618133			PubChem Google
Isobutylmethylxanthine	3758	proliferation, viability	PDE	A172, U87MG	22227470, 9484714			PubChem Google
GSK2256098	46214930		FAK			29788497		PubChem Google
RO4929097	49867930		Gamma secretase	IGRG121, mouse xenograft model	25486598		NCT01119599, NCT01122901, NCT01131234, NCT01189240, NCT01269411	PubChem Google
Daidzein	5281708	apoptosis, proliferation	BCL2	LN229	19429088			PubChem Google
Cannabidiol	644019	MK-886 enhancer, viability	5Lipoxygenase, FAAH	murine xenograft glioma tumor, U87MG	18028339		NCT03607643	PubChem Google
SH-4-54	72188643	proliferation	STAT3	orthotopic mouse model	24900612			PubChem Google
Emetine	10219	proliferation		primary human glioma cells	23165409			PubChem Google
Sandoz 58-035	122215	invasion, proliferation	ACAT	U87MG	19502590			PubChem Google
ES936	4470790	resistance, sensitivity	NQO1	SF268, U87MG	19244114			PubChem Google
Dactolisib	11977753	cell cycle, proliferation, radiosensitization	PI3K, mTOR	orthotopic mouse mode, primary human glioma cells, SHG44, T98G, U251MG, U87MG	18606717, 19671762, 23603977, 24366691, 25431423, 26188279, 27542970, 27553832, 29685176, 30251117		NCT01508104	PubChem Google
Kaempferol	5280863	apoptosis, proliferation, viability	ERK, Akt	A172	18949556, 19001439			PubChem Google
AZD6482	44137675	apoptosis, cell cycle arrest, proliferation	PI3Kbeta	U118, U87MG	30542720			PubChem Google
Pristimerin	159516	proliferation		primary human glioma cells	23165409			PubChem Google
Mebendazole	4030	proliferation		GL261, orthotopic mouse model, primary human glioma cells	23165409, 28386621		NCT01729260, NCT01837862, NCT02644291	PubChem Google
(S)-3,5-Dihydroxyphenylglycine	443586	neuroprotection, proliferation, synaptic modulation	Selective group I mGlu agonist	C6	19822193			PubChem Google
Kainic acid	10255	viability	AMPK, NFkappaB	C6	18445478			PubChem Google
Xanthohumol	639665	apoptosis		T98G	22111577			PubChem Google
PP242	135565635	migration, proliferation	mTORC1, mTORC2	LN18	25243800, 26719046			PubChem Google
NOX-A12	86278354	angiogenesis, viability	CXCL12, SDF1alfa	C6, human G12 glioblastomas, rat brain tumor models	24335554, 27940247			Google
APCP	10442687	proliferation	ecto5\'NT, CD73	C6, U138MG	18636315			PubChem Google
Lomustine	3950		OIP5	GBM12, GBM6, orthotopic mouse model	27474153, 28672195, 30284228	20124186, 20855843, 23940216, 24958095, 30522967	NCT00003788, NCT00005796, NCT00052455, NCT00068952, NCT00295815, NCT00503204, NCT00504660, NCT00761280, NCT00777153, NCT00948389, NCT01067469, NCT01149109, NCT01290939, NCT01562197, NCT01582269, NCT01737346, NCT01860638, NCT01934361, NCT02076152, NCT02343406, NCT02414165, NCT02765165, NCT02843230, NCT02926222, NCT03022578, NCT03025893, NCT03149575, NCT03463265, NCT03678883, NCT03970447, NCT04049669	PubChem Google
Erlotinib	176870	apoptosis, proliferation	EGFR	BS153, C6, DKMG, LN229, primary human glioma cells, SF188, U87MG	17804702, 18955445, 19301967, 19737945, 20456371, 26032687, 27546621, 30219696, 30989436	19562254, 19770758, 20615922, 20716591, 22407177, 24470557, 24637230	NCT00030498, NCT00039494, NCT00045110, NCT00054496, NCT00086879, NCT00112736, NCT00124657, NCT00227032, NCT00274833, NCT00301418, NCT00335764, NCT00337883, NCT00387894, NCT00445588, NCT00509431, NCT00609999, NCT00671970, NCT00672243, NCT00720356, NCT01103375, NCT01110876, NCT01257594	PubChem Google
1-Methyl-L-tryptophan	676159	proliferation, suppression of enzyme activity	Indoleamine-2,3-dioxygenase (IDO)	LN229	19199463			PubChem Google
AZD1152-HQPA	16007391	proliferation	Aurora B kinase	mouse xenograft model, T98G, U118, U251MG, U373	22382783			PubChem Google
AZD1390	126689157	radiosensitization		GL261, mouse xenograft model	29938225		NCT03423628	PubChem Google
Rolipram	5092	proliferation	PDE4	A172, mouse xenograft model, U87MG	12432276, 17234775, 18719351, 19642024, 28202289			PubChem Google
AMD3100	65015	angiogenesis	SDF1, HIF1, CXCR4	LN229, mouse xenograft model, U251MG, U87MG	20157762, 20179352		NCT00669669, NCT01339039, NCT01977677, NCT03746080	PubChem Google
F90	68343	proliferation	EGFR, ERK1, JNK, p38, BCL2, p53	SHG44	19024103			PubChem Google
Mevalonolactone	10428	oxidative stress response	ROS, MKD, MVK	U87MG	29753116			PubChem Google
A-443654	10172943	apoptosis, proliferation inhibition	Akt	1028S, U87MG	19208828			PubChem Google
Bufalin	9547215	proliferation, viability	ATP1A1	murine xenografts, U251MG, U87MG	28787697, 29653366			PubChem Google
Fenoterol	3343	mRNA synthesis inhibition	H1R	U373	18498711			PubChem Google
PLX-4720	24180719		BRAF	DBTRG05MG, orthotopic mouse model	26023796			PubChem Google
STX-0119	4253236	proliferation	STAT3	mouse model, primary human glioma cells, U87MG	23612755, 24820265, 28716484			PubChem Google
KPT276	71496742	viability	CRM1	AGBM1, BT145, BT159, BT172, orthotopic mouse model	25366336			PubChem Google
Artesunate	65664	cell cycle arrest, proliferation, radiosensitization	CDK2, CDK4, cyclin D1, cyclin B1	A172, LN229, U251MG, U87MG	22560712, 29600654			PubChem Google
Succinyl phosphonate	46209593	viability	OGDH, Reactive oxygen species	1321N1, LN405, T98G, U87MG	27027236			Google
NBQX	3272524	proliferation	AMPA	U87MG	23724064			PubChem Google
Dobesilate	29963	apoptosis, proliferation	FGF, MAPK	C6	16551428, 16563234			PubChem Google
gamma-Tocopherol	92729	apoptosis, proliferation	PKC, ERK	C6	16843827			PubChem Google
Rucaparib	9931954		PARP	GBM12, GBM39, orthotopic mouse model	26438157		NCT02711137	PubChem Google
Temsirolimus	6918289		mTOR	T98G, U251MG	26748241	15998902, 16012795, 23099651, 23564811, 24470557	NCT00016328, NCT00022724, NCT00112736, NCT00316849, NCT00329719, NCT00335764, NCT00784914, NCT00800917, NCT01019434, NCT01051557, NCT01183663, NCT02238496, NCT03158389	PubChem Google
H-89	449241	proliferation	PKA inhibitor	U87MG	20015475			PubChem Google
Z-VAD	9845918	apoptosis, viability	Pancaspase	U138MG	18454276			PubChem Google
Eribulin	11354606	survival, tumour growth	(TERT)-RNA-dependent RNA polymerase	mouse brain tumor xenograft with U87MG	31099446			PubChem Google
Tnp-470	369976	angiogenesis		9L	27542173, 8615672			PubChem Google
Acridine orange	62344	photosensitisation, proliferation, viability		U373MG	29631084			PubChem Google
Dexamethasone	5743	invasion, migration, proliferation, temozolomide enhancer	MIF, PKC	C6, U373MG	17453149, 19759012, 30333749	19714445	NCT01169415, NCT02031965, NCT04128774	PubChem Google
Disufenton	11603334	angiogenesis, apoptosis, proliferation, temozolomide enhancer, viability	TGF-beta1, IDO1, SUMO2, PFN1	F98, human G55 GBM orthotopic xenograft model, IC3752GBM, orthotopic mouse model, rat model, U87MG	23328810, 26248280, 30468988			PubChem Google
LAQ824 (Dacinostat)	6445533	apoptosis	HDAC	Hs683, LN401, SF767, U343, U373	18483381			PubChem Google
72926-24-0	2930014	proliferation	Eg5	U251MG, U87MG	28965307			PubChem
Sevoflurane	5206	invasion, migration		U251MG	27840895			PubChem Google
Rutin	5280805	apoptosis, proliferation		GBM95, U251MG	19491660, 30868970			PubChem Google
Trabedersen	132472120					20980335	NCT00761280	Google
Masitinib	10074640	viability	FAK, cKIT, PDGFR, FGFR	LN229, primary human glioma cells, U87MG	30219696			PubChem Google
OSU03012	10027278	apoptosis, proliferation	PDK1, PI3K, Akt	D283 MED, D324 MED, D458 MED, MEBMED8A, medulloblastoma human xenograft tumors, PFSK1, UW2283	16622074, 16675657, 20028853			PubChem Google
Palomid 529	11998575		mTOR	orthotopic mouse model, U87MG	23436212			PubChem Google
Germacrone	6436348	proliferation		U251MG, U87MG	24889088			PubChem Google
Gramicidin S	73357	proliferation		GBM6, U87MG	29750582			PubChem Google
GSK-3 inhibitor IX	448949	apoptosis, proliferation	GSK-3, EGFR, NF-kB	U87MG	30984989			PubChem Google
Infigratinib	53235510		FGFR	HEK293T	30344944		NCT01975701	PubChem Google
Apatinib	11315474		Tyrosine kinase			29245310	NCT03567135, NCT03660761	PubChem Google
WP1066	11210478	proliferation	JAK, STAT3	primary human glioma cells, U87MG	17942891, 23612755		NCT01904123	PubChem Google
BDP-9066	132275018	invasion, motility	MRCK	xenograft model of GBM	30279244			PubChem
Afatinib	10184653	viability	EGFR, HER2	A7, LN229, mouse xenograft model, U87MG	19037840, 25444177, 30219696		NCT00977431, NCT02423525	PubChem Google
Neratinib	9915743	viability	HER2, EGFR	DBTRG05MG, orthotopic mouse model, SF268, SKMG3	18765999, 26023796		NCT02977780	PubChem Google
Digoxigenin	15478	proliferation, viability		primary human glioma cells, U87MG	23165409, 27029345			PubChem Google
Navitoclax	24978538	proliferation, viability	BCL2, BclxL, BCLw, BH3mimetic	KNS42, LN229, SF188, T98G, U87MG	24757258, 26474387, 29016820, 30337641			PubChem Google
4506-66-5	78260	migration, proliferation	FAK	DBTRG, orthotopic mouse model, T98G, U118MG, U87MG	23243059, 23387973, 26883759			PubChem Google
Iripallidal	14335632	viability		A172, LN229, T98G, U87MG	20576128			PubChem Google
Fluorouracil	3385	viability	Nucleic Acid Synthesis	U118MG, U87MG	24391839, 30989436, 6690037		NCT01183663, NCT03607643	PubChem Google
Rosiglitazone	77999	apoptosis, proliferation	PPARgamma, COX2	A172, C6, M059J, M059K, U251MG, U87MG	14699130, 15254749			PubChem Google
Paroxetine	43815	apoptosis	SSRIs	C6, SHSY5Y	16055945			PubChem Google
Zafirlukast	5717	invasion, migration	CysLT (cysteinyl leukotriene receptor)	A172, U373	28600709			PubChem Google
Escitalopram	25379795	proliferation		C6	146570			Google
Lipoxin A4	5280914	anti-inflammatory effects, proliferation		1321N1	19357230			PubChem Google
172889-27-9	4878	radiosensitization	Src family kinase	T98G, U251MG	26044161			PubChem Google
Apigenin	5280443	viability		T98G, U87MG	19894226			PubChem Google
Karenitecin	148202	radiosensitization	TopoisomeRASe	MO59K, T98G	28111642		NCT00014521	PubChem Google
U0126	3006531	apoptosis, migration, proliferation	MEK1, MEK2, ERK1, ERK2, MAPK, ERK	A1207, A172, C6, LN18, SKMG15, SKMG4, SKMG5, T98G, TC620, U178, U251MG, U373, U87MG	17327470, 18834856, 19336886, 20809186, 21850371, 26748241			PubChem Google
2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid	115288	apoptosis, proliferation	LAT1	A1207, C6, nude mice xenografts, U178MG, U87MG	18382329, 18520037			PubChem Google
MAZ51	9839842	proliferation		C6, U251MG	25268128			PubChem Google
6-Bromo-5-nitroquinoline	280563	apoptosis, proliferation		C6	30431695			PubChem Google
Vasculostatin	12617	angiogenesis, proliferation	CD36	U87MG	19176395			PubChem Google
Triptolide	107985	viability		A172, LN443, U118, U87MG	24433351			PubChem Google
R428	46215462	proliferation	AXL	SNB19, UP007	25980499			PubChem Google
Glasdegib	25166913		Smoothened			22223823	NCT03466450	PubChem Google
Atazanavir	148192	apoptosis	GRP78 (HSPA5), CHOP	LN229, U251MG	18006837			PubChem Google
Sulfasalazine	5359476	proliferation, radiosensitization	MAPK, NFkappaB	A172, D54MG, D65MG, GBM62, GM1, GM2, GM3, GM4, GM5, LN18, STTG1, U251MG, U87MG	15328202, 16079392, 19015640, 25798841, 25937318, 28929335	19840379		PubChem Google
KU0063794	16736978	viability	mTOR	U373MG	22125077			PubChem Google
Zalcitabine	24066	proliferation		HTB10	2542824			PubChem Google
Moroxydine	71655	proliferation, viability	CLIC1	GBM1, GBM2, GBM3, GBM4, GBM5, GBM6, GBM7	30186163			PubChem Google
Dorsomorphin	11524144	viability		A172, T98G, U87MG	19428322, 24419061			PubChem Google
Gefitinib	123631	apoptosis, elacridar enhancer, proliferation, radiosensitization, viability	EGFR, Akt	G111, G152, GL15, LN229, mouse model, primary human glioma cells, SF767, T98G, U105MG, U251MG, U343MG, U373MG, U87MG	14643025, 16550610, 18386816, 18566746, 18803287, 19033425, 19435839, 19435898, 21744078, 23724064, 23736154, 24876095, 25368255, 30219696, 30875975	23182702	NCT00014170, NCT00016991, NCT00025675, NCT00027625, NCT00042991, NCT00052208, NCT00085566, NCT00132158, NCT00238797, NCT01310855	PubChem Google
Colchicine	6167	proliferation		primary human glioma cells	23165409			PubChem Google
Dovitinib	135398510	proliferation	Multiple kinases	primary human glioma cells	28500786	27100354	NCT01753713, NCT01972750	PubChem Google
Parthenolide	7251185	cell resistance to TRAIL	IB phosphorylation	LN443	19432816			PubChem Google
Ki16425	10367662	viability	LPA(1), LPA(3)	C6	18481020			PubChem Google
Foretinib	42642645	collagen invasion, migration, proliferation, Survival	cMET, VEGFR2, ROS1, RTK, TAM, MerTK, Akt, Erk	A172, mouse model, SF188, U251MG	24658326	24218589		PubChem Google
Falcarindiol	5281148	apoptosis, differentiation		U373	30388862			PubChem Google
Gemcitabine	60750	radiosensitivity	DNA and RNA			19770758	NCT02711137, NCT03434262, NCT03607643, NCT03678883, NCT03684811	PubChem Google
Cucurbitacin I	5281321	apoptosis, cell cycle arrest, proliferation	JAK, STAT3	A172, LN18, LN229, LNZ308, mouse xenograft model, T98G, U251MG, U87MG, U87MGEGFRviii	18487947, 18829483, 24599950, 25482928			PubChem Google
Gossypol	3503	viability		U251MG, U343, U373, U87MGluc2	20587533, 25375271			PubChem Google
Calcipotriol	5288783	migration, proliferation, viability		T98G	29575677			PubChem Google
GW3965	447905	proliferation	LXR	mouse xenograft model, U87MG	22059152			PubChem Google
Propofol	4943	apoptosis	Reactive oxygen species	GBM 8401, LN299	28804952, 29928428			PubChem Google
Mitoxantrone	4212	proliferation, viability	TopoisomeRASe	primary human glioma cells, U87MG	19340456, 21184646, 23165409			PubChem Google
RG2833	56654642	Temozolomide enhancer	HDAC1, HDAC3		27632183			PubChem Google
Ticlopidine	5472	apoptosis, viability	Akt, mTOR, EGF	primary human glioma cells	26412325			PubChem Google
Mangostin	5281650	autophagy, viability	AMPK	DBTRG05MG, GBM8401	21314123			PubChem Google
Otx-008	11953346	viability	galectin1	U87MG	23978989			Google
PD0325901	9826528	, viability	MEK	LN229, mouse xenograft model, primary human glioma cells, U373	19737945, 22573716, 25431423			PubChem Google
Haloperidol	3559		PER1, CRY1	U87MG	27746588			PubChem Google
SNS-032	3025986	angiogenesis, proliferation, radiosensitization	VEGF, HIF1A	U87MG	17534442, 19287962			PubChem Google
Cabozantinib	25102847	proliferation	Multiple kinases	E98, mouse model	20127563, 21926191, 23484006	29016998, 29036345, 29687244	NCT00704288, NCT00960492, NCT01068782, NCT02885324	PubChem Google
Cimetidine	2756	proliferation	GSK3beta	primary human glioblastoma cells	28423558			PubChem Google
IC86621 (DNA-PK Inhibitor III)	9859309	apoptosis	DNA-PK	SCID mice	19425167			PubChem Google
SU1498	5941539	proliferation, viability	VEGFR2	A172, Gli06, SF126, T98G, U118MG, U251MG, U373MG, U87MG	18719373			PubChem Google
PHA-665752	10461815	apoptosis	HGF, Casp3, Casp8, Casp9	Daoy	18992144			PubChem Google
Tamoxifen	2733526	viability	ER-alpha66, ER-alpha36	U118, U251MG, U87MG	25554223, 30417588		NCT00002608, NCT00006388, NCT00492687, NCT00541138	PubChem Google
D4476	6419753	apoptosis	CK1	Daoy	19943845			PubChem Google
Cathepsin S Inhibitor	16760355	viability	CatS	U251MG, U87MG	24875536			Google
YU238259	121473004	proliferation	HDR, HRR	U251MG, U87MG	26116172, 31020489			PubChem Google
SZ-685C	12301973	apoptosis, viability	Akt, FOXO transcription factors	LN444	20128807			Google
AZ32	134814488	apoptosis, radiosensitization	ATM	A172, CF5STTG1, H4, Hs683, LN18, M059J, SW1088, SW1783, T98G, U118MG, U138MG, U87MG	29769307			Google
Clozapine	135398737	proliferation	PKA, chloride channel 4, CDK5, PI3K, Akt, GSK-3bet	SHSY5Y, U87MG	16542821, 25246152			PubChem Google
Sertraline	68617	viability		A172, LN443, U118, U87MG	24433351		NCT02770378	PubChem Google
Olanzapine	135398745	proliferation		LN229, mouse xenograft model, T98G	25338992, 25524815			PubChem Google
KNK437	46195007	radiosensitization	HSP	A172	16966184			PubChem Google
Semaxanib	5329098	angiogenesis, apoptosis, proliferation	Flk1, KDR	GS9L, rat models	11733657		NCT00004868	PubChem Google
Perampanel	9924495	proliferation	AMPA	HROG02, HROG05, HROG15, HROG24	30716120			PubChem Google
Gartanin	5281633	proliferation		T98G	27491646			PubChem Google
L-NAME	39836	migration	Nitric oxide synthases (NOS)	T98G, U87MG	19629394			PubChem Google
Oxibendazole	4622	proliferation		primary human glioma cells	23165409			PubChem Google
Vatalanib	151194	angiogenesis, temozolomide enhancer	VEGFR, PDGFR, cKIT, cFms	orthotopic mouse model, U251MG	15271251, 20090952	19248046, 19945857, 30382439	NCT00128700, NCT00387933	PubChem Google
Gamma-aminobutyric acid	119	neuroinflammation	IL6	C6	18679050			PubChem Google
Metformin	4091	invasion, proliferation	Akt	primary human glioma cells, SF268, U87MG	24965413, 30046513	30980539	NCT01430351, NCT02149459, NCT02780024, NCT03151772	PubChem Google
Anthothecol	21596360	proliferation		primary human glioma cells	23165409			PubChem Google
Pimozide	16362	apoptosis	USP1	MZ54, orthotopic mouse model, primary human glioma cells	26032834, 30250198			PubChem Google
Chloroquine	2719	radiosensitization, viability	Ced3	LN229, LN308, U118, U251MG, U87MG	20406898, 25434381, 27644442, 30878553	17350410	NCT00224978, NCT02378532, NCT02432417, NCT03243461	PubChem Google
Noscapine	275196	angiogenesis, apoptosis	HIF1	T98G, U87MG	16596228, 18525314			PubChem Google
Cabazitaxel	9854073	viability	Microtubules	T98G, U87MG	27203678, 29369439		NCT01740570, NCT01866449	PubChem Google
Cardamonin	641785	proliferation		mouse model, primary human glioma cells, U87MG	26150336			PubChem Google
O(6)-benzylguanine	4578	apoptosis	MGMT	U87MG	18812520		NCT00002971, NCT00003348, NCT00003567, NCT00004892, NCT00005081, NCT00006474, NCT00017147, NCT00046878, NCT00253487, NCT00362921, NCT00436436, NCT00612989, NCT00613093, NCT00669669, NCT01269424	PubChem Google
Tesevatinib	10458325					30030583	NCT02844439	PubChem Google
Isoprenaline	3779	papaverine enhancer, proliferation	cAMP	C6	6254438			PubChem Google
Estradiol	5757	apoptosis, proliferation	JNK, cjun	C6, T98G	22848302			PubChem Google
NKTR-102	71300727					25935109		Google
MST-312	10385095	cell cycle arrest, DNA damage, double strand breaks, viability	Telomerase inhibitor	KNS60, MO59K, ONS76	25307264			PubChem Google
OTS964	89675898	viability	TOPK	U251MG, U87MG	29423027			PubChem Google
Isoquercitrin (Quercetin 3-glucoside)	5280804	proliferation		GBM95	19491660			PubChem Google
Donepezil	3152	proliferation	Acetylcholinesterase	primary human glioma cells, T98G, U373	19679463	16549835	NCT00070161, NCT00369785	PubChem Google
Combretastatin A-4	5351344	apoptosis	Microtubules	T98G	30268825			PubChem Google
Iniparib	9796068					26285766	NCT00687765	PubChem Google
Wortmannin	312145	proliferation	PI3K	U87MG	19208828, 19738049, 19997873, 23724064			PubChem Google
Methanandamide	6321351	apoptosis	COX2	H4	16267630			PubChem Google
Lys01	70673567	viability		LN229	22566612			PubChem Google
Aminolevulinic acid	137	apoptosis, viability	NFkappaB, BIRC3, Casp3	U87MG	17335970		NCT00752323, NCT00961090, NCT01148966, NCT01208909, NCT01310868, NCT01351519, NCT01445691, NCT01575275, NCT02119338	PubChem Google
Mefloquine	40692	apoptosis	PARP, CHOP, GADD153	LN229, U251MG, U87MG	25727221		NCT01430351	PubChem Google
Momelotinib	25062766	autophagy, proliferation, temozolomide enhancer	JAK2, STAT3	U251MG	30664175			PubChem Google
Aldoxorubicin	9810709		DNA intercalation	mouse xenograft model, U87MG	25379024		NCT02014844	PubChem Google
11-deoxy-PGE1	5283055	proliferation	ERK	U87MG	20015475			PubChem Google
UniPR1331	134817215	angiogenesis	Ephrin	U87MG	29849945			Google
Xyloketal B	10980896	proliferation, viability		U251MG	25913706			Google
Bisacodyl	2391	viability	WNK1 kinase, Akt, SGK1, NBCfamily Na+, HCO3	primary human glioblastoma cells	29930759			PubChem Google
2-Amino-1,3-propanediol	68294	angiogenesis, apoptosis, proliferation	hTP	U87MG	30615449			PubChem Google
AXL1717	72435	proliferation	IGF1R	mouse xenograft model, primary human glioma cells, U563MG, U87MG	20150364, 23165409		NCT01721577	PubChem Google
SU6656	5312137	invasion	Src family kinase	U251MG	15561776			PubChem Google
Repaglinide	65981			GL261, orthotopic mouse model	28476618			PubChem Google
Doxycycline	54671203	proliferation, viability	MMP2	LNT229, T98G, U343	19828040, 28112361, 29772845			PubChem Google
Curcumin	969516	cell cycle arrest, proliferation	Wnt, beta-catenin, NFkappaB	U251MG, U373	26046466, 30585634, 30864499			PubChem Google
Losartan	3961	apoptosis, proliferation	AT1	C6	11720480, 15785746		NCT01805453, NCT03951142	PubChem Google
Salinomycin	3085092	apoptosis, proliferation		mouse xenograft model, primary human glioma cells, U251MG, U87MG	23165409, 28358414, 28498472, 29925966			PubChem Google
AMG 900	24856041	proliferation	Aurora kinase	A172, U118MG, U87MG	30221846			PubChem Google
Hydroxichloroquine	3652	apoptosis	PARP, CHOP, GADD153	LN229, U251MG, U87MG	25727221		NCT00486603, NCT01602588	PubChem Google
Itraconazole	55283	viability		A172, U118, U87MG	24433351		NCT02770378	PubChem Google
1134156-31-2	25195348	proliferation	Hsp70, Hsp90	U87MG	26185541			PubChem Google
Mibefradil	60663	viability	T type calcium channels	C6, rat model, T98G, U251MG, U87MG	23198803, 23287412	28371832	NCT01480050, NCT02202993	PubChem Google
Crenolanib	10366136	viability	PDGFRalpha	primary human glioma cells	25380967		NCT02626364	PubChem Google
Furin Inhibitor I	16760442	migration, survival	Furin	LN229, U87MG	19690139			Google
Epirubicin	41867	proliferation, viability	DNA intercalation	A172, LN443, primary human glioma cells, U118, U87MG	23165409, 24433351, 28963609			PubChem Google
SH5-07	72550504	viability	STAT3	mouse xenograft model, U251MG, U373MG, U87MG	26088127			PubChem Google
Celastrol	122724			C6, mouse xenograft model, SHG44, U251MG, U373MG	18343027, 19909582, 20007406, 21786165, 24810052			PubChem Google
GSK1904529A	25124816		IGF1R	mouse model, U87MG	26035416			PubChem Google
Lapatinib	208908	proliferation, viability	EGFR, HER2	, GBM12, GBM14, GBM5, GBM6, LN229, mouse and rat xenograft model, primary human glioma cells, U87MG	19254954, 19603143, 24911215, 30219696	19499221, 20009104, 23363814	NCT00095940, NCT00099060, NCT00107003, NCT00350727, NCT02101905	PubChem Google
Asiatic acid	119034	apoptosis, necrosis	Calcium signaling	U87MG	16897440			PubChem Google
Semustine	5198		DNA alkylation			225004, 24248532, 26852708, 7013978	NCT00335075	PubChem Google
CCG-1423	2726015	invasion	RhoA	T98GMG, U251MG	29207169			PubChem Google
PIK-108	54751698	radiosensitization, viability	PKB, Akt, PI3K	LN229, SF126, SF210, U138MG, U251MG, U87MG	18413797			Google
Manumycin	6438330	apoptosis	STAT3, Reactive oxygen species	A172, T98G, U87MG	19409983			PubChem Google
Peruvoside	12314120	proliferation		primary human glioma cells	23165409			PubChem Google
Glaucocalyxin A	10471963	proliferation		U87MG	24041957			Google
Modafinil	4236	proliferation, viability	CYP3A4	GL261, SHSY5Y	22434147			PubChem Google
Berberine	2353	apoptosis, cytotoxicity		C6	19424587			PubChem Google
Rescovitine	46881287	migration	CDK5	neural stem cells (F3), U87MG	19351187			Google
YC-1	5712	proliferation	factor1alpha	C6	18430796, 19108760			PubChem Google
AT13387	11955716		Hsp90	mouse xenograft model, primary human glioma cells, U251MGHFGFP, zebrafish xenograft model	28679777			PubChem Google
6-HYDROXYQUINOLINE-4-CARBOXYLIC ACID	71363454		Proteasome	4C8, mouse model	26645398			Google
Amlexanox	2161	proliferation	IKBKE	U251MG, U87MG	29048430			PubChem Google
Clasto-Lactacystin .beta.-lactone (?-Clastolactacystin)	91746126		20S proteasome	118MGC, U373MG	19201384			Google
5,7-dihydroxy-4'-methoxy-6,8-diprenylisoflavone	44403741	cytotoxicity		U87MG	30836216			Google
Pravastatin	54687	viability	HMGCoA reductase, MAPK, ERK1, 2, RAS, PI3K, Akt, J	LN405, U138, U87MG	21120479			PubChem Google
Dactinomycin	457193	proliferation, viability		A172, LN443, primary human glioma cells, U118, U87MG	23165409, 24433351			PubChem Google
Daunorubicin	30323	proliferation		primary human glioma cells	23165409			PubChem Google
BDBM86691	57340709	proliferation	ACAT1	U251MG	26252415
Fingolimod	107969	invasion, migration		U251MG, U87MG	25070489			PubChem Google
JNJ-10198409	9797370	viability	PLK1	primary human glioma cells	24204733			PubChem Google
Caudatin	72948694	proliferation		U251MG, U87MG	25860846			Google
Naringin	442428	invasion, migration		U251MG	26474590			PubChem Google
GK921	56682080		Transglutaminase 2	83NS, orthotopic mouse model	28754668			PubChem Google
Azacitidine	9444	apoptosis, migration, viability	CD31, PDGFRbeta	primary glioblastoma cells, U373MG, U87MG	18679414, 29427211		NCT02223052, NCT02711137, NCT03684811	PubChem Google
Clomifene	1548953	apoptosis	IDH1, D2HG	C6	15289732			PubChem Google
Doxazosin	3157	apoptosis, proliferation	RAS	C6, U138MG, U373MG	27123999, 30370863			PubChem Google
Aloe emodin	10207	apoptosis, proliferation	ERK	C6, U87MG	15747063, 30218594			PubChem Google
Entrectinib	25141092		Trk, ROS1, ALK	mouse model	28695888			PubChem Google
NCL-1	73755256	proliferation	KDM1A	LN229, orthotopic mouse model, T89G, U138, U251MG, U87MG	23248157, 27893719			Google
AEE788	10297043	apoptosis, proliferation	mTOR, EGFR/HER2	D5MG, LN18	15657358, 19033391, 19199503		NCT00107237, NCT00116376	PubChem Google
Thallium acetate	11247	apoptosis, viability	CDK2	LC6	15965099			PubChem Google
Methyl Pyruvate	11748		GDH, Akt	SF188	19826036			PubChem Google
Sunitinib	5329102	angiogenesis, invasion, proliferation	Receptor tyrosine kinases, STAT3, Akt	Daoy, F98, mouse model, T98G, U251MG, U87MG	17622648, 19101989, 19603143, 20179017, 22449730, 25458015, 30472587	20053726, 20872043, 21744079, 22832897, 24311637, 24424564	NCT00499473, NCT00535379, NCT00606008, NCT00864864, NCT00923117, NCT01100177, NCT01441388, NCT02928575, NCT03025893, NCT03275558	PubChem Google
Pexidartinib	25151352		CSF-1R			26449250, 31258629	NCT01349036, NCT01790503	PubChem Google
Nisoldipine	4499	viability		U87MG	24433351			PubChem Google
Minocycline	54675783			C6, mouse xenograft model	21079420		NCT02770378	PubChem Google
Harmol	68094	viability		U251MG	23338618			PubChem Google
AG490	5328779	invasion, migration, proliferation	JAK2, STAT3, survivin, cyclin D1, COX2, c-Myc	A172, MZ18, MZ256, MZ304, MZ54, U87MG, UW2282, UW2283	18592012, 19326989, 20589525			PubChem Google
CA074 methyl ester	6610318	apoptosis, proliferation	CatB, Clik148	BV2, U87MG	19748528, 20302512			PubChem Google
Vinorelbine	5311497	viability		U87MG	24433351			PubChem Google
Dimethyl fumarate	637568	proliferation	Rel, NFkappaB	A172, primary human glioma cells	24404403, 25482938			PubChem Google
Dynole 34-2	44157463	migration, neurosphere formation, viability	GTPase dynamin 2	GSCs, U251MG, U87MG	30907150			Google
Ritonavir	392622	proliferation		Hu197, U87MG	28319810		NCT01095094, NCT02770378	PubChem Google
Aclidinium bromide	11519741	apoptosis, invasion, migration, proliferation	Long-acting muscarinic antagonist (LAMA)	U251, U87	29940755			PubChem Google
LLnL	4332	apoptosis, cell cycle	COX2, IL-1beta, TNFalpha, IL6, iNOS, p27, TRIAL, N	BV2, primary human glioblastoma cells	10411338, 15504253, 19748528			PubChem Google
Doxepin	667477	inhibitors of cellular respiration		IPSB18	20332444			PubChem Google
Guggulsterone	53394010	viability		A172, T98G, U87MG	23548480			PubChem Google
PCI-24781	11749858	proliferation	HDAC	LN18, LN229, U87MG	25505847			PubChem Google
POCA	54217	fatty acid beta-oxidation	CPT1	U87MG	18470630			PubChem Google
LGK974	46926973	proliferation, temozolomide enhancer	porcupine, ALDH3A1	GBM1, GBM10, JHH520, LN229, SF188	26222502, 29854309			PubChem Google
Disulfiram	3117	proliferation		primary human glioma cells	23165409		NCT01777919, NCT01907165, NCT02678975, NCT02715609, NCT02770378, NCT03151772, NCT03363659	PubChem Google
Topotecan	60700	proliferation, radiosensitization, viability	TopoisomeRASe	A172, LN443, primary human glioma cells, U118, U251MG, U87MG	18819996, 19466380, 19584228, 19812371, 23165409, 24303074, 24433351, 28797568		NCT00002814, NCT00014443, NCT00541138, NCT00610571, NCT01004874, NCT01931098	PubChem Google
ML04	11640604	proliferation, radiosensitization	EGFR	U138MG, U87MG	17210462			Google
Peroxynitrite	104806	viability	NO, p53	D54MG, LNZ308	14695179			PubChem Google
L-DOPA	6047	migration, proliferation		T98G	30591448			PubChem Google
Archazolid B	16757019	cholesterol homeostasis, endosomal/lysosomal malfunction	H(+)ATPase	U87MG	25218289			Google
Imipramine	3696	apoptosis, autophagy	PI3K, Akt, mTOR	T98G, U87MG	21889492, 26412325, 28500556			PubChem Google
Cediranib	9933475	apoptosis, proliferation, viability	VEGFR	4C8, mouse xenograft model	18814988, 19332720, 19671039, 21095630, 25490024, 25676691, 26645398, 30423822	17222792, 19549889, 20458050, 23940216, 26008604	NCT00305656, NCT00458731, NCT00503204, NCT00662506, NCT00777153, NCT00979862, NCT01062425, NCT01131234, NCT01310855, NCT02974621	PubChem Google
Ciglitazone	2750	viability	PPARgamma	C6, U251MG	14699130			PubChem Google
Vismodegib	24776445	proliferation	HPI, PI3K	primary human glioma cells	19716296, 19726788, 21123452		NCT00980343, NCT03158389	PubChem Google
Dacomitinib	11511120	viability	ErbB	LN229, primary human glioma cells, U251MG, U373, U87MG	24658109, 25939761, 30247945		NCT01112527, NCT01520870	PubChem Google
Aspirin	2244	proliferation, viability		SK?N?SH (N)	31429199		NCT00790452	PubChem Google
Binimetinib	10288191	radiosensitization	MAP2K	GBM8, orthotopic mouse model, U87MG	28958992		NCT03973918	PubChem Google
beta-Peltatin	92122	proliferation		primary human glioma cells	23165409			Google
Salvianolic acid B	6451084	viability		U87MG	23842993			PubChem Google
MLN4924	16720766		NEDD8activating enzyme	orthotopic mouse model, U251MG	25904638			PubChem Google
HU-331	11393311	apoptosis	Topo2	U87MG	31020489			PubChem Google
Larotrectinib	46188928		TrkA, TrkB, TrkC.			30220707		PubChem Google
GM6001	132519	migration, survival	MMP, ADAM	LN229, U373, U87MG	19220854, 19690139			PubChem Google
Birinapant	49836020	viability	IAP	primary human glioma cells	26657652			PubChem Google
Papaverine	4680	inhibitors of cellular respiration	ADP, ATP, cyclic nucleotide phosphodiesteRASe	C6	4367754			PubChem Google
Sinomenine	5459308			mouse model, U87MG	28891980			PubChem Google
Arenobufagin	12305198	apoptosis, cell arrest, cytotoxicity, proliferation	Cdc25C, Cyclin B1, survivin, MAPK	U87MG	30272276			Google
Oroxindin	3084961	viability		A172, SHG44, U251MG, U87MG	24970553			PubChem Google
LB-100	45101433	radiosensitization	PP2A	mouse xenograft model, U251MG	25939762		NCT03027388	PubChem Google
Pitavastatin	5282452	radiosensitization, viability	NFkappaB	A172, LN443, U118, U87MG	19046042, 24433351			PubChem Google
Etomoxir	9840324	proliferation	Akt	U251MG, U373U, U87MG	30574020			PubChem Google
Ribociclib	44631912		CDK4, CDK6			28351928	NCT02345824, NCT02933736, NCT03355794, NCT03434262, NCT03834740	PubChem Google
GF109203X	2396	proliferation	PKC	C6	18778746, 19822193, 19965895			PubChem Google
Capsaicin	1548943	apoptosis	DR5	SNU444, T98G, U251MG, U251MGN, U343, U87MG	19939880			PubChem Google
Marizomib	11347535	viability	Proteasome	LN18, mouse xenograft model, SNB19, U251MG, U87MG	20165695, 21247382, 26681765, 26804704		NCT03345095	PubChem Google
PI-540	11669062	proliferation	mTOR	U87MG	19584227			PubChem Google
Aurintricarboxylic acid	2259	invasion, migration		A172, GBM44, T98G	28103571			PubChem Google
alpha-Bisabolol	442343	apoptosis	mPTP	C6, T67, U87MG	14975741, 19570051			PubChem Google
SB-415286	4210951	apoptosis	GSK3	U87MG	18582478			PubChem Google
Clomipramine	68539	inhibitors of cellular respiration		IPSB18	20332444			PubChem Google
Lovastatin	53232	proliferation	HMGCoA reductase	U343, U87MG	18566746, 25497898			PubChem Google
Anisomycin	253602	viability		primary human glioma cells, U251MG, U87MG	21184646, 22684030, 23165409			PubChem Google
Simvastatin	54454	proliferation		primary human glioma cells	23165409			PubChem Google
Penfluridol	33630	apoptosis	Akt	U87MG, xenograft model of glioblastoma in nude mice	28380428			PubChem Google
Luminespib	135539077	viability	Hsp90	mouse xenograft model, SF268, U87MG	20457619			PubChem Google
NS-398	4553	inflammatory response	Cyclooxygenase2	1321N1, C6, U87MG	19804834, 19854233			PubChem Google
LY294002	3973	proliferation, radiosensitization	PI3K, PKB, Akt	mice glioma cells, T98G, U251MG, U87MG	15735908, 18473825, 18567800, 18676851, 19101213, 19435873, 19435898, 19827268, 19828040, 19836430, 19911116, 22086271, 25425962, 29354058			PubChem Google
RITA	374536	proliferation, temozolomide enhancer	ASK1	U251MG, U87MG	30562758			PubChem Google
zVAD-fmk	5497171	cytotoxicity		T9	19247476			PubChem Google
Glycitein	5317750	angiogenesis, invasion	MMP3, MMP9	U87MG	20188714			PubChem Google
Cryptotanshinone	160254			LN229, mouse xenograft model, U87MG	28492557, 30021339			PubChem Google
RC 3095	122127	proliferation	GRPR	C6, U373MG, U87MG	18473825			PubChem Google
Rosuvastatin	446157	viability	HMGCoA reductase, MAPK, ERK1, 2, RAS, PI3K, Akt, J	LN405, U138, U87MG	21120479			PubChem Google
Memantine	4054	autophagy, proliferation	NMDAR1, LC3II, LC3I, beclin1	T98G, U251MG	28264232		NCT01260467, NCT01430351	PubChem Google
Thioridazine	5452	autophagy	AMPK	U87MG	25950483, 30289977			PubChem Google
Evodiamine	442088			mouse model, U87MG	28514905			PubChem Google
BQ788	3081333	proliferation	ETRB	A375, LN229, SW1088, WM35	19040731			PubChem Google
Cyclosporine A	5284373		mPTP	T67	19570051			PubChem Google
Paxilline	105008	apoptosis	DR5, CHOP, GADD153, cFLIPs	U251MG, U251MGN, U343, U87MG	21150246			PubChem Google
Citral	638011		PHGDH	U251MG	19089318			PubChem Google
CEP-7055	9936664	proliferation, temozolomide enhancer, viability	VEGFR	human glioblastoma xenografts	16891460			PubChem Google
UNC2025	73425588		MER, FLT3	A172, orthotopic mouse model, SF188, U251MG	27783662, 28605477			PubChem Google
Dehydroeburicoic acid	15250826	apoptosis, proliferation	Calpain, Calcium signaling	U87MG	19848398			PubChem Google
Visudyne	5362420	proliferation, viability	YAP	LN229, SNB19, U343, U87MG	28790340, 30254296, 30423822			PubChem Google
Meloxicam	4051	proliferation	15PGDH, cyclin D1, p21	T98G, U118, U373	18757412			Google
Ralimetinib	11570805		MAPK	mouse xenograft model, U87MG	24356814		NCT02364206	PubChem Google
Ruxolitinib	25126798	viability	JAK	LN229, primary human glioma cells, U87MG	29788332, 30219696		NCT02711137, NCT03514069	PubChem Google
Casticin	5315263	viability		U251MG, U373, U87MG	23816816			PubChem Google
Mepacrine	237	viability		4C8, U87MG	25490024, 25727221, 27029345			PubChem Google
Everolimus	6442177		mTOR, IKK, NF?B, RAI14	LN229, LN427, LN428, LN751, NCT00085566, NCT00107237, NCT00387400, NCT00515086, NCT00553150, NCT00805961, NCT01062399, NCT01434602, NCT01508104, NCT03355794, NCT03834740, U251MG, U87MG	18483381, 18559622, 25371289, 30554401	20864273, 23725999, 25526733		PubChem Google
Lactacystin	6610292	viability	Proteasome	C6, F98, mouse xenograft model	16609837, 18539596, 19738049, 23569132			PubChem Google
Homidium	3624	proliferation		primary human glioma cells	23165409			PubChem Google
GDC-0084	57384863		PI3K, mTOR	orthotopic mouse model, U87MG	27638506		NCT01547546, NCT03522298, NCT03696355	PubChem Google
Rottlerin	5281847	proliferation		SNB19, U251MG	18778746, 19965895, 27626499			PubChem Google
Oligomycin	78358496	viability		T98G, U251MG, U87MG	23523615			Google
Pyrvinium	5281035	proliferation, viability		mouse xenograft model, primary human glioma cells, U87MG	23165409, 26152745, 27029345			PubChem Google
Ibudilast	3671	apoptosis, cell cycle arrest, proliferation, temozolomide enhancer	MIF			30814573	NCT03782415	PubChem Google
BT#9 (N-Carbamimidoyl-4-[(E)-(3-ethyl-2,4,4-trimethylcyclohex-2-en-1-ylidene)methyl]benzamide)	137630099	apoptosis, invasion, migration, proliferation, respiration	Magmas	D54MG, GL261 xenografts, U118MG, U251MG, U87MG	30414099
Atovaquone	74989	viability	STAT3	LN18, SF188, SJGBM2, U87MG	29783757			PubChem Google
Levetiracetam	5284583	temozolomide enhancer, viability	MGMT	A172, LN18, T98G, U138	20525765	31603723	NCT00629889, NCT02815410	PubChem Google
Psammaplin C	21726402		CAXII	orthotopic patient-derived xenografts	30254183			PubChem Google
Ponatinib	24826799	viability	Src family kinase, Abl, VEGFR2, FGFR1	LN229, mouse xenograft model, U87MG	25378936, 30219696, 30705592		NCT02478164	PubChem Google
ML00253764	9842665	proliferation	Melanocortin receptor4		28791594			PubChem Google
602306-29-6	16747683	proliferation	CDK1, CKD2, CDK9	A172, LN18, LNZ308, T98G, U373, U87MG	26585571			PubChem Google
Carvacrol	10364	proliferation, viability		U251MG	25913706			PubChem Google
2,5-Dimethylcelecoxib	11545682	angiogenesis, migration, proliferation	ET1	mouse xenograft model, TuBEC, U251MG, U87MG	20197398			PubChem Google
Naphtho[2,3-f]quinoxaline-7,12-dione (NSC745887)	12567021	apoptosis, prolifiration, viability	DcR3, ATM	U118MG, U87MG	29552282			PubChem Google
Savolitinib	68289010		cMET	mouse xenograft model, U87MG	25148209			PubChem Google
C1368	2777805	proliferation	Aurora A kinase	Daoy, MB 100, MB 47, ONS76	20232424			PubChem Google
GSK461364	15983966	proliferation	PLK1	LN18, mouse xenograft model, primary human glioma cells, U87MG	23790466, 24204733, 30304810, 30875975			PubChem Google
YM022	122130	invasion, proliferation	CCK2R	U87MG	19502590			PubChem Google
Verbascoside	5281800	apoptosis, invasion, migration, proliferation	COX2, NFkappaB, MAPK, SHP1, STAT3	C6, U87MG	19904526, 29961065			PubChem Google
Danthron	2950	apoptosis, viability	BCL2, Bax	GBM 8401	19784869			PubChem Google
SB203580	176155	proliferation	MAPK, RIGI, p38	C6, U373	17395328, 18346382, 18442089, 19133316, 19362079, 19427347, 20060865			PubChem Google
Hydroxycitrate	123908	clonogenicity, invasion, migration	ATP citrate lyase (ACLY)	U87MG	19795461			PubChem Google
Isofuranodiene	636458	apoptosis, cell cycle arrest, cytotoxic effect		T98G, U251MG, U87MG	30599912
PIK-75	10275789	apoptosis	PI3K	LN229, U87MG	18413797, 22802621			PubChem Google
Diazepam	3016	cell cycle arrest, proliferation	Rb	T98G, U87MG	16059654, 23519373			PubChem Google
Ginsenoside F1	9809542	invasion, migration	NFkappaB, p38MAPK	U251MG, U373MG, U87MG	29412148			Google
Mycophenolic acid	446541	cell cycle arrest	GFAP, guanine nucleotide biosynthesis	C6, U251MG	3304619			PubChem Google
Z-IETD-fmk	25108681		Casp8, RIP	U343MG	19432816			Google
Imatinib mesylate	123596	proliferation		G112, G130, G168, G44, GL261, LNZ308, RG, T98G, U87MG	18506689, 19159435, 19190128, 19629393, 19737945	18359865, 19768386		PubChem Google
S-Adenosyl-L-homocysteine	439155	proliferation	MMP2, ERK, PI3K, Akt	BV2, C6	19770485			PubChem Google
8-Bromo-cyclic AMP	32014	proliferation	PKA	A172, U373, U87MG	18498711, 24649161, 9484714			PubChem Google
AKBA	11168203	apoptosis, cell cycle arrest, invasion, migration, proliferation	p21, FOXM1, cyclin B1, Aurora B kinase, TOP2A	U251MG, U87MG	29970196			PubChem Google
Shikonin	479503	proliferation	TopoisomeRASe	U251MG, U87MG	23840441, 24303074, 25688715, 25891245			PubChem Google
Actinomycin D	2019	apoptosis	PIMT	U87MG	18582478, 19642173			PubChem Google
Cilengitide	176873	proliferation	?v?3, ?v?5	G28, G44, U251MG, U87MG	17277694, 18616418, 18981465, 19114005, 19199360, 19221171, 19351861, 20820929, 21788343, 22588883	17470857, 18981465, 20439646, 21739168, 25163906, 26008604	NCT00006093, NCT00085254, NCT00093964, NCT00112866, NCT00679354, NCT00689221, NCT00813943, NCT00979862, NCT01044225, NCT01122888, NCT01124240, NCT01517776, NCT01782976	PubChem Google
Moxifloxacin	152946	apoptosis, proliferation, viability	GSH, DNA intercalation, Casp3, Casp7	U87MG	30086267			PubChem Google
Difluorodeoxyuridine	129627896	radiosensitivity				19770758		Google
Galunisertib	10090485		TGFbeta receptor I kinase			24868575, 25424852, 25529192, 26902851	NCT01220271, NCT01582269	PubChem Google
SB-216763	176158	apoptosis	GSK3	BS125, LN18, LN319, U373, U87MG	18582478, 19823589			PubChem Google
Imatinib	5291	citotoxicity, invasion, migration, proliferation, viability	Multiple kinases	GL15, MOGGUVW, mouse model, SF767, T98G, U105MG, U251MG, U343MG, U373MG	16274936, 19048625, 19270491, 19417143, 20032406, 23736154		NCT00010049, NCT00039364, NCT00154375, NCT00171938, NCT00290771, NCT00354068, NCT00354913, NCT00387933, NCT00401024, NCT00615927	PubChem Google
Midazolam	4192	proliferation		A172, U118, U251MG, U87MG	27629139			PubChem Google
Phloroglucinol (BFP, (2,4-bis(4-fluorophenylacetyl)phloroglucinol)	359	apoptosis, cytotoxicity	benzenetriol, phenol derivative	C6, U251MG, U87MG	22819448			PubChem Google
Piplartine	637858	migration		LN229, U87MG	23796709, 24967005			PubChem Google
Tetrandrine	73078	viability		U251MG, U87MG	27909720, 30549224			PubChem Google
Z-LEHD	10032582	apoptosis	Casp9	U138MG	19002382			PubChem Google
Carnosol	442009	proliferation		T98G, U343MG, U87MG	26939786			PubChem Google
Ciprofloxacin	2764	apoptosis, proliferation, viability	GSH, DNA intercalation, Casp3, Casp7	U87MG	30086267			PubChem Google
3-Butylidenephthalide	62368	proliferation		DBTRG05MG, GBM8401, mouse xenograft model	21553143			PubChem Google
7-Ethyl-10-hydroxycamptothecin	104842	viability	TopoisomeRASe	A172, U87MG	28963609, 30521347			PubChem
Trametinib	11707110	viability	MEK	HEK293T, NIH3T3, primary human glioma cells	25431423, 30344944	29295876	NCT02684058, NCT03434262, NCT03919071, NCT03975829	PubChem Google
BIIB021	16736529	cross-resistance	Hsp90	SF268, U87MG	19244114			PubChem Google
Radicicol	6323491	migration	ACLY, Hsp90	LN229, SF268, U87MG	19244114, 19795461			PubChem Google
Dihydroartemisinin	456410	proliferation		BT325, C6	26722323			PubChem Google
LLNle	16760646	apoptosis	NOTCH	primary human glioblastoma cells	19861404			Google
761437-28-9	9934347	radiosensitization, viability	FAK	A172, DDHT7607, DDT4, LN229, U138MG, U343MG, U87MG	17219439, 19030106, 25625667			PubChem Google
Diclofenac sodium	5018304	proliferation	15PGDH, cyclin D1, p21	T98G, U118, U373	18757412			PubChem Google
BMS-599626	10437018	proliferation	EGFR, ERBB2	A549, BT474, N87	17062696		NCT00979173	PubChem Google
SN-50	101150673		NFkappaB	118MGC, U373MG	19201384			Google
STA-21	363709	proliferation	STAT3 inhibitor	GS622, GS72	19658181			PubChem Google
LLP3	56935694	viability		primary human glioma cells	23251006			Google
Abiraterone	132971	proliferation	CYP17A1	A172, primary human glioma cells, T98G	31527549		NCT02711137	PubChem Google
Bevacizumab	24801580	apoptosis, perifosine enhancer, proliferation, radiosensitization	VEGF, PI3K, Akt	C6, murine glioma xenografts, U251MG	19567589, 19584228, 28616662, 30881126	24552324, 30301554		Google
Phospho-valproic acid (MDC-1112)	129866270	proliferation	STAT3	intracranial xenograft model, LN18, LN229, subcutaneous GBM xenografts in mice, U118, U87MG	30994173			Google
ISO-1	4633677	migration, proliferation	MIF	Hs683, LN18, U373	19759012, 20038293			PubChem Google
NVX-207	9960374	proliferation		LN229, U251MG, U343MG	25361208			PubChem Google
Capmatinib	25145656		cMET	mouse xenograft model, U87MG	21918175		NCT01324479, NCT01870726, NCT02386826	PubChem Google
Dichloroacetate	25975	apoptosis, proliferation	HIF-2alpha, PDK, Hsp70	C6, primary human glioblastoma cells	18766181, 20463368, 23515860		NCT00540176, NCT00703859, NCT01111097	PubChem Google
L-365260	5311201	invasion, proliferation	CCK2R	U87MG	19502590			PubChem Google
Myricetin	5281672	invasion, migration, proliferation	PI3K, Akt, JNK	U87MG	19804834, 29886836			PubChem Google
Gamabufotalin	259803	apoptosis, autophagy, G2/M arrest	Aurora B, cdc25A, cdc25C, cdc2, Cyclin B1, survivi	U87	31610157			PubChem Google
NSC141562	422114	invasion, migration, proliferation	MIR155HG/miR155 axis		28371892			PubChem
5-aminolevulinic acid	123608					30644008	NCT01208909, NCT01310868, NCT01445691, NCT02119338, NCT03048240	PubChem Google
Nintedanib	135423438		VEGFR, FGFR, PDGFR			23184145, 25338318	NCT01251484	PubChem Google
n-butylidenephthalide	642376	apoptosis, proliferation	CKI	DBTRG05MG, RG2	16987298			PubChem Google
Monensin	441145	proliferation, viability		primary human glioma cells, U87MG	23165409, 27029345			PubChem Google
Amitriptyline	11065	inhibitors of cellular respiration, viability	MEK, MAPK	C6, IPSB18	11595754, 20332444			PubChem Google
Oxaliplatin	9887054	apoptosis, radiosensitization, temozolomide sensitivity	STAT3, MGMT, DNA, RNA synthesis	GL261luciferase, KR158, KR158luciferase, LN229, mouse xenograft model, primary human glioma cells, U87MG	17383816, 18329790, 30132163, 30219696			PubChem Google
3-Deazaneplanocin	73087	viability	HDAC	C6	24905315			PubChem Google
Thapsigargin	446378	viability	SERCA	C6, U251MG, U87MG, XO8	18599610, 19133225, 27993939			PubChem Google
Vmy-1-103	44626421	apoptosis	CDK	D556, Daoy	21885916			PubChem Google
Tilarginine	132862	apoptosis, viability	NOS	CRTMG, T98G	19748528, 9809627			PubChem Google
PI-103	9884685	radiosensitization, viability	PI3K, mTOR	LN229, T98G, U251MG, U373MG, U87MG	16697955, 18413797, 19177002, 19513541, 19584227, 19633683, 19737945, 22125077, 24418474			PubChem Google
MIM1	135691163	apoptosis, cell cycle arrest, temozolomide enhancer, viability	MCL1	U87MG	30134184			PubChem Google
Methyl gallate	7428	viability		C6, U373	23562553			PubChem Google
Convallatoxin	441852	proliferation		primary human glioma cells	23165409			PubChem Google
Pyridone 6	5494425	apoptosis	JAK, STAT	U251MG	19830690			PubChem Google
Trichostatin	444732	apoptosis, viability	HDAC, NAG1, GDF15	A172, C6, HEK, LN308, LNT229, T98G, U87MG	16383255, 16384639, 18483381, 18550052, 18607344, 18611290, 18801729, 18803327, 19062177, 19360904, 19728174, 19787267, 19847810, 23564772, 24905315			PubChem Google
AZD1480	16659841	proliferation	JAK1, JAK2	orthotopic mouse model, U251MG	22027691			PubChem Google
Carfilzomib	11556711	proliferation		GBM6, U87MG	29750582			PubChem Google
25-Hydroxycholesterol	65094	apoptosis		U87MG	20009104			PubChem Google
Bibu 1361	46861539	apoptosis	EGFR	A172, LN229, T98G, U87MG	22753156			Google
SGX-523	24779724		cMET	orthotopic mouse model	20015006			PubChem Google
PX-866	9849735	angiogenesis, autophagy	PI3K	LN18, LN229, mouse xenograft model, U251MG, U87MG	20156803	25605819	NCT01259869	PubChem Google
E-6087	9953093	radiosensitivity	COX2	GL261	19252746			PubChem Google
U46619	5311493	cell swelling	TXA2	1321N1	19772916			PubChem Google
Sildenafil	135398744	proliferation, viability	PDE5	rat brain tumor models		18674521	NCT01817751	PubChem Google
Tubacin	6675804	proliferation		LN229, U251MG	29845122			PubChem Google
Oleuropein	5281544	invasion, proliferation		A172, U251MG	27498673			PubChem Google
PF-04691502	25033539		PI3K, mTOR	mouse xenograft model, U87MG	21750219			PubChem Google
URB597	1383884		FAAH	C6	16997568, 19460156			PubChem Google
Albendazole	2082	proliferation		primary human glioma cells	23165409			PubChem Google
Bestatin	72172	proliferation	LTA4	A172	19919819			PubChem Google
Ginsenoside RG3	9918693	proliferation, viability	Wnt, beta-catenin, MGMT	T98G, U118	30431207			PubChem Google
E6201	10172827		MEK	mice	29437873			PubChem Google
AZD9291 (Osimertinib)	71496458	cell cycle arrest, colony formation, invasion, migration, proliferation	EGFR	LN18, LN229, T98G, U118, U251, U87	31122294		NCT03732352	Google
Wedelolactone	5281813	migration, proliferation	IKK	C6	19362079			PubChem Google
Podofilox	10607	proliferation		primary human glioma cells	23165409			PubChem Google
D609	4234241	proliferation			28802717			Google
Gitoxigenin	348482	proliferation		primary human glioma cells	23165409			PubChem Google
5-Nonyloxytryptamine	1797	viability		U87MG	24433351			PubChem Google
Quetiapine	5002	proliferation, temozolomide enhancer, viability	Wnt, beta-catenin	, GL261, xenograft model of glioblastoma in nude mice	28415586			PubChem Google
BIX01294	25150857	viability	histone methyltransfeRASe, G9a	C6, LN18, U251MG	24905315, 27748874, 27934912, 30450051			PubChem Google
Triacsin c	9576787	apoptosis	ACS (AcylCoA synthetase) inhibitor	SF268, U251MG	19459852			Google
SKI	66577038	proliferation	Sphingosine kinase	D54MG, U251MG	19597728			PubChem Google
MPEP (6-Methyl-2-(phenylethynyl)pyridine)	3025961	neuroprotection, proliferation, synaptic modulation	mGluR5	C6	19822193			PubChem Google
Epigallocathecin Gallate	65064	viability		T98G, U87MG	18948169, 19826036, 19894226			PubChem Google
Plumbagin	10205	proliferation, viability		A172, primary human glioma cells, SHG44, U251MG	23165409, 25528634			PubChem Google
HET-0016	2727594	proliferation	CYP4A, 20HETE, EGFR	9L, rat xenograft model, U251MG	16081682, 16352703			PubChem Google
Pargyline	4688	proliferation		LN229, T89G, U138, U87MG	23248157			PubChem Google
Ardipusilloside I	197641	proliferation		T98G, U373	24984215			Google
Terameprocol	476861	angiogenesis, apoptosis, cell cycle arrest, proliferation	SP1, cyclindependent kinase 1, survivin, VEGF	primary human glioma cells, SF188, T98G, U251MG, U343	18311658, 23299390	22323663	NCT00404248	PubChem Google
Daporinad	6914657	viability	NAMPT	C6	22119381, 26601421			PubChem Google
trans-ACUB	16038368	proliferation	sEH	U251MG, U87MG	22382785			PubChem Google
SAR405838	53476877		MDM2	GBM108, xenografts of human glioblastoma	29970480, 31619389			PubChem Google
JNJ-7706621	5330790	migration, proliferation, viability	CDK1, CDK2	LN18, SHG44, T98G, U251MG, U373, U87MG	28989042			PubChem Google
Paeoniflorin	442534	invasion, migration, proliferation	TGFbeta	T98G, U251MG, U87MG	29423667			PubChem Google
Verapamil	2520	apoptosis, proliferation, temozolomide enhancer	Bax, BCL2	U87MG	30003979			PubChem Google
Iodoacetic acid	5240	cell invasiveness	Cysteine protease	Daoy, Madsen, UW2282, UW2283	19847623			PubChem Google
Pyridoxyl-tryptophan methyl ester	129848754	proliferation	ODC	LN229	18922879			Google
Phenformin	8249			HF2587, orthotopic mouse model	27486821, 30186163			PubChem Google
KPT251	57519758	viability	CRM1	AGBM1, BT145, BT159, BT172	25366336			PubChem Google
Ibuprofen	3672	migration, proliferation		A172, HTZ349, U87MG	26485029			PubChem Google
Sulindac	1548887	differentiation, radiosensitization		U87MG	29788733			PubChem Google
Pregnenolone	8955	viability		C6, LN18, U87MG	25013479			PubChem Google
Dibutyryl cAMP	9687	proliferation	Cx43	A172, C6	16718685, 9484714			PubChem Google
Carvedilol	2585	apoptosis, proliferation	BrDULI, cAMP	C6	20198329		NCT03861598, NCT03980249	PubChem Google
Irinotecan	60838	migration, viability	TopoisomeRASe 1	A172, C6, LN443, U118, U251MG, U87MG	18784279, 19557511, 20415520, 24433351, 26830091, 30989436	21744079, 29245310	NCT00003301, NCT00003463, NCT00003484, NCT00005951, NCT00006025, NCT00010036, NCT00027612, NCT00039468, NCT00099125, NCT00132158, NCT00268359, NCT00345163, NCT00352521, NCT00412542, NCT00433381, NCT00463073, NCT00562419, NCT00597402, NCT00611728, NCT00612638, NCT00616005, NCT00671801, NCT00734682, NCT00762255, NCT00817284, NCT00967330, NCT00979017, NCT00984438, NCT01017653, NCT01022918, NCT01086345, NCT01308632, NCT01837862, NCT01999270, NCT02055196, NCT02192359, NCT03119064, NCT03607643, NCT03678883	PubChem Google
Salirasib	5469318	apoptosis, invasion, migration, proliferation	RAS	LN229, U1242MG, U251MG, U373MG, U87MG	16239932, 16985068, 17178866			PubChem Google
Sulforaphane	5350	apoptosis	Bax, BCL2, NFkappaB	T98G, U87MG	16765523			PubChem Google
Tagitinin C	11256548	viability		U373	21073931			Google
Cisplatin	84691	autophagy, viability	DNA intercalation, AMPK	C6, L929, MO59J, MO59K, U251MG, U343, U87MG, XO8	19408974, 20196784, 24218165, 24953561, 27993939			Google
Naringenin	932	invasion, migration, proliferation, viability	MMP2, MMP9, ERK	GBM8401, GBM8901	30431227			PubChem Google
Deguelin	107935	proliferation		primary human glioma cells	23165409			PubChem Google
Mangiferin	5281647	radiosensitization, viability	NHEJ, gamma?H2AX	U118MG, U87MG	30272350			PubChem Google
NK314	137699307	apoptosis	Topo2	U87MG	31020489			Google
Melatonin	896	apoptosis, viability		A172, T98G, U251MG, U87MG	19632770, 28255276, 29925764			PubChem Google
1-1-diphenyl-2-picrylhydrazyl	74358	cytotoxicity		U87MG	30617655			PubChem Google
YZ129	137628683	apoptosis, cell cycle arrest, migration, proliferation	Hsp90, PI3K, AKT, mTOR	U87MG	30639261	30639261		Google
Pomolic acid	382831	migration, viability	Reactive oxygen species		28849227			PubChem Google
SKI II	753704	radiosensitization	Sphingosine kinase	A172, LN18, LN229, T98G, U251MG, U87MG	25255218, 28494176			PubChem Google
Chamaejasmin	390362	cytotoxicity		U87MG	30836216			Google
VX-745	3038525	invasion	p38, MAPK	C6, IM3	29316898			PubChem Google
AMG-511	59548184		PI3K	mouse xenograft model, U87MG	22897589			PubChem Google
AZD2014	25262792	radiosensitization	mTOR	stemlike cells	24311635		NCT02619864	PubChem Google
Lithium	3028194	apoptosis, migration, viability	GSK3, PIMT	primary human glioma cells, U251MG, U373, U87MG	18582478, 18715951, 28359080			PubChem Google
Tacalcitol	5283734	migration, proliferation, viability		T98G	29575677			PubChem Google
PKI-402	44187953	proliferation, viability	PI3K, mTOR	human tumor xenograft models, U87MG	20371716			PubChem Google
Puromycin	439530	proliferation		primary human glioma cells	23165409			PubChem Google
Eflornithine	3009	proliferation	Ornithine decarboxylase	U251MG	19010902, 25935110			PubChem Google
PAI-1	3246941	angiogenesis	Serine protease			18383878		PubChem Google
Methotrexate	126941	proliferation	DHFR	primary human glioma cells	23165409	15735920	NCT00082797, NCT00463008	PubChem Google
Cycloguanil	9049	viability	CLIC1	GBM1, GBM2, GBM3, GBM4, GBM5, GBM6, GBM7	30186163			PubChem Google
ML298	53393916	invasion, migration	PLD2	U87MG	23445448			Google
Alisertib	24771867	viability	Aurora A kinase	GB169, GB30, GB9, KNS42, mouse xenograft model, primary human glioma cells, SF188, T98G, U1242, U87MG	24627220, 24879067, 25106428, 27797168, 29016820, 29396807		NCT02186509	PubChem Google
Alpha-cyano-4-hydroxycinnamic acid	5328791	invasion		mouse xenograft model, U251MG, U87MG	21750656			PubChem Google
F0911-7667	4192636	apoptosis, autophagy	SIRT1, AMPKmTORULK	T98G, U87MG	29991742			Google
Monoterpene perillyl alcohol (POH)	10819		RAS			20401670		PubChem Google
Bombesin	25078147	proliferation	GRPR	C6, U373MG, U87MG	18473825			Google
T56-LIMKi	9438169	viability	LIM kinase	U87MG	25593987			PubChem Google
E-64	123985	apoptosis	COX2, IL-1beta, TNFalpha, IL6, iNOS, Cathepsin B	BV2, SNB19, U251MG, UWR2	11494030, 19748528			PubChem Google
CKD 602	123773277	apoptosis, proliferation, viability	TopoisomeRASe	LN229, U251MG, U343MG, U87MG	19424618			Google
BMS-777607	24794418		AXL	mouse xenograft model, SF126, U118	26848524			PubChem Google
SK1-I	44815217	apoptosis, invasion, migration, proliferation	Sphingosine kinase 1	GBM6, LN229, U373	19723667			PubChem Google
Idebenone	3686	apoptosis, cell cycle arrest, migration, proliferation, temozolomide and oxaliplatin enhancer, viability	p21, Casp3	U373 MG, U87MG	30602587			PubChem Google
Anlotinib	25017411	inhibit tumor cell growth	Tyrosine kinase inhibitor			31145289	NCT04004975, NCT04119674, NCT04157478	PubChem Google
A861	70700216	proliferation	5Lipoxygenase	A172	19919819			Google
Etoposide	36462	proliferation, viability	TopoisomeRASe	A172, CD133, MO59J, MO59K, primary human glioma cells, T98G, U251MG, YKG1	18599610, 18614215, 19305157, 20388502, 23165409, 24953561, 30606517, 31020489		NCT00003996, NCT00047281, NCT00612430, NCT00613028, NCT00613223, NCT02372409, NCT02502708, NCT04049669	PubChem Google
MK-886	3651377	viability	Lipoxygenase	U373MG, U87MG	17949236, 19862483, 23261452			PubChem Google
SH-5	16760282	radiosensitivity	Akt	U87MG	19828040			PubChem Google
KHS101	71304818	apoptosis, proliferation	HSPD1, Mitochondrial energy disruption	GBM1, GBM11, GBM13, GBM14, GBM20, GBM4, murine xenograft glioma tumor	30111643			PubChem Google
Huperzine A	854026	viability	NFkappaB, iNOS, COX2, NO	C6	17257593			PubChem Google
ICI118551	5484725	mRNA synthesis inhibition	Selective b2AR antagonist	U373	18498711			PubChem Google
Fmoc-L-leucine	1549133	apoptosis	PPARgamma	U118 MG	30118847			PubChem Google
Antimycin A	14957	proliferation		primary human glioma cells	23165409			PubChem Google
Silibinin	31553	apoptosis, autophagy, proliferation, viability	Ca2+, ROS, MAPK, mTOR, YAP.	A172, LN229, U87MG	19263218, 21501525, 25750273, 29780826			PubChem Google
NHI 1	779302	apoptosis, cell cycle arrest, proliferation, viability	LDHA	U87MG	26494310			Google
Gedatolisib	44516953	viability	PI3K, mTOR	LN229, mouse xenograft model, U251MG, U373, U87MG	21325073, 24658109			PubChem Google
Acetazolamide	1986	proliferation	carbonic anhydRASe	U251MGN	27702686			PubChem Google
Aciclovir	2022	IFN-gamma enhancer, proliferation	PCNACdk2	SNB19, T98G, U373	10841074			PubChem Google
Pochoxime A	24898672			mouse model	20643786			PubChem Google
Minoxidil sulfate	4202	viability	Reactive oxygen species, RhoA, PI3K, PKB	A172, C6	14695207, 19027730, 23973310			Google
S3I-201	252682	proliferation	STAT3 inhibitor	GS622, GS72	19658181			PubChem Google
Sunitinib malate	6456015	viability	VEGFR, PDGFR, cKIT, FLT	LN229, primary human glioma cells, U87MG	30219696		NCT00611728, NCT00923117	PubChem Google
PGE(2)	5280360	proliferation	PKA, Wnt	U87MG	19804834, 20015475			PubChem Google
Elemene	6918391	cell cycle arrest		C6	18346382			PubChem Google
A-966492	16666333	radiosensitization	PARP	U87MG	28797568			PubChem Google
Docosahexaenoic acid	445580	viability		C6	20192116, 29192322			PubChem Google
Theophylline	2153	viability	PDE	A172, U87MG	22227470			PubChem Google
Pioglitazone	4829	apoptosis, proliferation, viability	Wnt, beta-catenin, PPARgamma	G144, G166, G179, GBM04, GBM2, GliNS2, primary human glioblastoma cells, T98G, U251MG, U87MG	21221726, 27313600		NCT01151670	PubChem Google
C-Met inhibitor	56650915	apoptosis	cMET	Daoy	19921488			PubChem Google
Arachidonic acid	444899	apoptosis	GSH, Casp3	C6	17400255			PubChem Google
Lbw242	11503417	radiosensitization		Gli36, LN827, U87MG	18677408, 21724651			PubChem Google
Jaceosidin	5379096	apoptosis, cell cycle arrest, proliferation, viability	p53, Bax	U87MG	22471459			PubChem Google
Milciclib	16718576	proliferation		SF268, SF539, U251MG, U87MG	23347136			PubChem Google
Grisorixin	12780142	proliferation		COMI, VIPI stem cells	29513090			Google
Calphostin C	2533	viability	PKC	U251MG, U87MG	19502590, 19724676, 19965895			PubChem Google
TG02	16739650	viability		GSC823, GSC923, LN18, orthotopic mouse model, U251MG	29254993		NCT02942264, NCT03224104	PubChem Google
Tempol	137994	migration/invasion	COX2, peroxide production	U87MG	19804834			PubChem Google
Oxamate	3017661	radiosensitization	LDHA	T98G, U87MG	28756228			PubChem Google
Boronophenylalanine	150315	viability		F98	30474719			PubChem Google
Oroxylin A	5320315	viability		U118, U251MG, U87MG	25213258			PubChem Google
Merlin	84098	and motility, proliferation, survival	NF2(Merlin)	9L, A172, DBRG05MG, Hs683, LN18, LN229, M059K, M089J, SF126, SF188, SF210, SF268, SF295, SF539, SF763, SF797, SNB19, SNB75, U118MG, U138MG, U251MG, U343MG, U373MG, U87MG	18632626			PubChem Google
Ridaforolimus	11520894		mTOR			22037923	NCT00087451, NCT01295632	PubChem Google
Cantharidine	5944	proliferation		GBM6, U87MG	29750582			PubChem Google
NCD-38	102222767		KDM1A	ortothopic mouse model, U251MG	27893719			Google
Carmustine	2578	viability	DNA alkylation	9L, rat models, U87MG	19408974, 30605703, 30606517	19770758, 24958095, 7013978	NCT00002545, NCT00003176, NCT00003348, NCT00003417, NCT00003463, NCT00003484, NCT00003567, NCT00003788, NCT00003876, NCT00003996, NCT00004028, NCT00004688, NCT00004892, NCT00005081, NCT00005637, NCT00005855, NCT00006386, NCT00006656, NCT00009854, NCT00014573, NCT00017147, NCT00027612, NCT00046878, NCT00068952, NCT00076986, NCT00086879, NCT00362921, NCT00548938, NCT00574964, NCT00669669, NCT00761280, NCT00795665, NCT00814593, NCT00984438, NCT01186406, NCT01310868, NCT01656980, NCT02348255, NCT03722355	PubChem Google
GW2974	6603857	invastion, migration, viability	EGFR, HER2	U251MG, U87MG	23115024			PubChem Google
Cycloheximide	6197	proliferation		C6	19808964, 21159181			PubChem Google
Sphingosine	5280335	apoptosis	ERK1, ERK2	C6	16302024, 8768300			PubChem Google
Folic acid	135398658	apoptosis, proliferation, temozolomide enhancer	S-adenosylmethionine	Ntva, U251MG, U373	19451595			PubChem Google
Phenethyl Isothiocyanate	16741	apoptosis, proliferation	MCL1, XIAP	GBM 8401, xenograft model of glioblastoma in nude mice	25582659, 30201893			PubChem Google
DB-074971	77068345	proliferation	Survivin	A172, LN18, LN229, LNZ308, LNZ428, T98G, U373	23325792			Google
Prazosin	4893	viability	PRKCD	orthotopic mouse model, primary human glioma cells	27138566			PubChem Google
2,5-Dihydroxybenzenesulfonate	101209015	apoptosis		C6, orthotopic rat model	21193016			Google
Bendamustine	65628					21626071, 28204914	NCT00823797	PubChem Google
Mitomycin	5746	proliferation		primary human glioma cells	23165409			PubChem Google
Ellagic Acid	5281855	apoptosis, Bevacizumab enhancer	MGMT	C6	31518741			PubChem Google
Fluphenazine	3372	apoptosis, proliferation, viability	Casp3	C6, glioblastoma stem-like cells	14997012, 26196249			PubChem Google
Carmofur	2577		Human acid ceramidase (AC)		30525581			PubChem Google
Caffeine	2519	angiogenesis, migration, radiosensitization	IP(3)R3, PI3K, HIFs, PI3K, Akt, MAPK, ERK	C6, orthotopic mouse model, T98G, U87MG	20103602, 20103623, 21229324, 25011614, 27260469, 29424319			PubChem Google
Erdafitinib	67462786		FGFR			26324363		PubChem Google
PQ401	9549305		IGF1R	mouse xenograft model, U87MG	25971682			PubChem Google
DWP0016	71660487	viability	HDAC	U251MG	23297003			Google
297157-92-7	2891837			mouse xenograft model, XO8	27993939			PubChem
GL-331	148091	apoptosis, radiosensitization	TopoisomeRASe 2	C6, T98G	16309217, 16827158			PubChem Google
ON123300	56649281	proliferation		U87MG	24568969			PubChem Google
Loperamide	3955	apoptosis	mTORC1	MZ54	30250198			PubChem Google
LB1	134693726	proliferation, viability	PP2A	murine glioma xenografts, U251MG, U87MG	20001590			Google
MRK003	15953832	proliferation	Gamma secretase	HSRGBM1, JHH520, orthotopic mouse model, primary human glima cells, U251MG, U87MG	23630166, 25293440, 25920606, 26613556			PubChem Google
Compound E	11306390	proliferation	Gamma secretase	zebrafish xenograft model	19199503			PubChem Google
Epothilone B	448013	viability	P-glycoprotein	LNZ, T98G, U87MG	18806741		NCT00715013	PubChem Google
Gamolenic acid	5280933	angiogenesis, proliferation	Bax, Ku80, E2F1	C6	19180667, 19292920			PubChem Google
KC7f2	16047442	viability	HIF1	U251MG, U87MGD	19789328			PubChem Google
Baicalin	64982	invasion, migration, proliferation, viability	Calcium signaling, PI3K, Akt, mTOR	U251MG, U87MG	30323558			PubChem Google
Pseudolaric acid B	6393431	apoptosis		U87MG	22778780			Google
Zidovudine	35370	radiosensitization	Telomerase	U251MG	17223082			PubChem Google
VAL-083	15942827	proliferation		LN229, mouse xenograft model, MU145, U251MG, U87MG	28216618		NCT01478178, NCT02717962, NCT03050736, NCT03149575	PubChem Google
717906-29-1	11598628	migration, proliferation	FAK	T98G, U118MG	26883759			PubChem Google
Buparlisib	16654980	proliferation, radiosensitization	PI3K	LN18, LN229, LNZ308, mouse xenograft model, primary human glioma cells, T98G, U1242, U251MG, U373MG, U87MG	22065080, 24500492, 24741074, 24900266, 25431423, 26846842, 27283525, 27363276, 30018387	30715997	NCT01339052, NCT01349660, NCT01473901, NCT01576666, NCT01870726, NCT01934361	PubChem Google
Glycyrrhizin	14982		Toll like receptor 2 (TLR2)	GL26, GL261	19143470			PubChem Google
9-ING-41	44582816		Glycogen Synthase Kinase3	GBM12, GBM6, orthotopic mouse model	28672195		NCT03678883	PubChem Google
Go6983	3499	invasion, proliferation	PKC	U87MG	19502590			PubChem Google
WP1130	11222830	apoptosis	JAK2, STAT3	GSC11, SF188, T98G, U251MG, U87MG	19899826, 26872380			PubChem Google
Lenvatinib	9823820		Multiple kinases	mouse model	28901423		NCT01433991, NCT03797326	PubChem Google
Carboplatin	10339178		DNA			28534153	NCT00002619, NCT00005976, NCT00006263, NCT00008086, NCT00010036, NCT00014105, NCT00021307, NCT00025558, NCT00352313, NCT00492687, NCT00541138, NCT00635557, NCT00650949, NCT00995007, NCT01317212, NCT01386710, NCT01837862, NCT01934361, NCT02253212, NCT02684058, NCT03149575, NCT03744026	Google
Vinpocetine	443955	proliferation	PDE1		25620587			PubChem Google
Dabrafenib	44462760		BRAF			26680369, 29039591, 29295876	NCT02684058, NCT03919071, NCT03975829	PubChem Google
Resveratrol	445154	apoptosis, radiosensitization	Akt, p53, STAT3, survivin, cyclin D1, COX2, c-Myc,	A172, mouse xenograft model, primary human glioma cells, T98G, U251MG, U87MG, UW2282, UW2283	15827328, 18592012, 19566920, 19827268, 21503893, 21743969, 23651583, 27419830, 30621053, 30984336			PubChem Google
Carbenoxolone	636403		GAP	C6	19360884			PubChem Google
Enasidenib	89683805	proliferation, viability	IDH2			30069631		PubChem Google
Chlorpromazine	2726	viability	Egr1	A172, C6, LN443, mouse xenograft model, orthotopic mouse model, U118, U251MG, U87MG	20368687, 23689352, 28455961			PubChem Google
Graphene oxide	124202900	apoptosis, proliferation, viability	STAT inhibitor, Wnt and Notch signaling	U118, U87MG	25708684, 25759581, 30544611, 30602369			Google
Evofosfamide	11984561		DNA crosslinking			29415215	NCT02342379	PubChem Google
Avasimibe	166558	proliferation, viability	ACAT1	A172, GL261, U87MG	20404512			PubChem Google
BI2536	11364421	proliferation, temozolomide enhancer, viability	PLK1	LN319, orthotopic mouse model, primary human glioma cells, T98G, U138MG, U251MG, U343MGa, U87MG	22415968, 23713868, 24204733, 30133120			PubChem Google
Montelukast	5281040	invasion, migration	CysLT (cysteinyl leukotriene receptor)	A172, U373	28600709			PubChem Google
1616632-77-9	73777259	viability		GBM152, GBM18, GBM67R, GBM8, T98G	26474387, 28767654		NCT02038699, NCT02525692	PubChem
CC-223	58298316		mTOR			26177599	NCT01177397	PubChem Google
UMI-77	992586	viability	MCL1	A172, U251MG, U87MG	28337703			PubChem Google
Nitazoxanide	41684	autophagy, cycle arrest, proliferation	ING1	A172, LN229, U87MG	30302016			PubChem Google
Romidepsin	5352062	proliferation, radiosensitization	Histone deacetylase	A172, GBM6, T98G, U138MG, U251MG, U87MG	15024582, 27685789, 29750582	21377994	NCT00085540	PubChem Google
Olaparib	23725625	viability	PARP	LN229, primary human glioma cells, U87MG	18954712, 19671736, 25531448, 25576921, 26794465		NCT01390571, NCT02974621, NCT03212274	PubChem Google
THZ1	73602827	proliferation	CDK7	mouse xenograft model, orthotopic mouse model, primary human glioma cells, U251MG, U87MG	28504693, 30532595			PubChem Google
Nelfinavir	64143				19190249	24194293	NCT00694837, NCT00915694, NCT01020292	PubChem
Valganciclovir	135413535	bevacizumab enhancer				26893852	NCT00400322, NCT04116411	PubChem Google
Givinostat	9804992	cell cycle arrest, proliferation	Histone deacetylase	U251MG, U87MG	30474756			PubChem Google
Alexidine	2090	viability		U87MG	27029345			PubChem Google
AG-120	89699486	viability	IDH1	U87MG	29670690			PubChem Google
Proteasome Inhibitor I	24906271	apoptosis	NFkappaB, Proteasome	118MGC, LN229, U251MG, U373MG	19190249, 19201384			Google
Furegrelate	3437	angiogenesis, BCNU enhancer, proliferation, viability	TXSA	orthotopic human glioblastoma xenografts, U87MG	18825315, 20165694			PubChem Google
Ionomycin	6912226	apoptosis, proliferation, T cell activation	Intracellular level of calcium	U251MG, U87MG	24130787			PubChem Google
Glutathione	124886	prevented apoptosis		DAOY	19633536			PubChem Google
VER-49009	4369536	cross-resistance	Hsp90	SF268, U87MG	19244114			PubChem Google
Pki-166	6918403	apoptosis, proliferation	EGFR, HER2	LN827, U87MG	18677408			PubChem Google
Vemurafenib	42611257		BRAF			24725538		PubChem Google
bVAD-fmk	25108682	apoptosis	Pancaspase inhibitor	U343MG	19432816			Google
B428	9797957	cell invasion	uPA	U1242	18355442			PubChem Google
KP1	141153	apoptosis, proliferation	PI3K, Akt	U251MG, U87MG	16546978			PubChem Google
MG-132	462382	proliferation	Proteasome	C6, LN229, mouse xenograft model, SHG44, U138MG, U373, U87MG, XO8	18341587, 18539596, 19190249, 19201384, 19575007, 19690139, 19808964, 19996297, 21499287, 22367315, 27993939			PubChem Google
Indatraline	126280	mobility	Monoamine transporter	primary human glioma cells	24333442			PubChem Google
6-MOMIPP	134155701	apoptosis, mitotic arrest, proliferation	Microtubules	murine glioma xenografts, U251MG	30426158			Google
Ouabain	439501	viability		LN229, U87MG	18795320, 19995221, 21184646			PubChem Google
Dapivirine	214347	apoptosis, induces stress, inhibits proliferation, proliferation		U87MG	29290776			PubChem Google
Bortezomib	387447	proliferation, temozolomide enhancer	Proteasome	D54MG, mouse xenograft model, primary human glioma cells, T98G, U118, U251MG, U87MG	17201170, 17545549, 18445700, 18625341, 18771084, 19190249, 19213072, 20192117, 23334228, 24093630, 24297065, 29750582, 30875688	19084346, 19770758	NCT00006773, NCT00544284, NCT00611325, NCT00641706, NCT00998010, NCT01435395, NCT03607643, NCT03643549	PubChem Google
LY2109761	11655119		TGFbeta receptor I kinase	mouse xenograft model, T98G, U87MG	21677877			PubChem Google
Mithramycin A	163659	proliferation	SP1	U87MG	19642173			PubChem Google
CX614	6451148	viability	AMPAR	U87MG	29277782			PubChem Google
4,7-Dimethyl-1,10-phenanthroline	72792	cell invasiveness	Metalloproteinase	Daoy, Madsen, UW2282, UW2283	19847623			PubChem Google
Cladribine	20279	viability		A172, U118, U87MG	24433351		NCT00019071	PubChem Google
Chrysin	5281607	invasion, migration, proliferation, viability	MAPK , CDK2, CDK4, ERK, Nrf2	C6, U87MG	15869744, 29662304			PubChem Google
Brilliant green	12449	proliferation		GBM6, U87MG	29750582			PubChem Google
GW9662	644213	viability	PPARgamma	C6, U251MG	14699130			PubChem Google
Hydroxyurea	3657		RNR			19904263	NCT00019058, NCT00154375, NCT00290771, NCT00354913, NCT00387933, NCT00613054, NCT00613132, NCT00615927, NCT03463733	PubChem Google
Triciribine, Akt inhibitor V	65399	proliferation inhibition	Akt	1028S, U87MG	19208828			PubChem Google
Lonafarnib	148195	viability	farnesyl protein transfeRASe	orthotopic mouse model, U87MG	21246394	21735117, 23633392	NCT00038493, NCT00083096, NCT00102648	PubChem Google
Silmitasertib	24748573		CK2, IRF3	42MGBA, E98, GBM8, GL261, mouse xenograft model, T98G, U251MG, U3013MG, U3017MG, U3024MG, U3031MG, U3054MG, U3084MG, U3086MG, U3117MG, U87MG	24036851, 28208677, 28683323			PubChem Google
Roscovitine	160355	proliferation	CDK	A172, G28	14724573, 19770587, 26151768			PubChem Google
OTX-015	9936746		BET	orthotopic mouse model, U87MG	27388964, 29764852, 30515262		NCT02296476	PubChem Google
Dasatinib	3062316	proliferation	Src family kinase, BcrAbl, cKIT	LN229, orthotopic mouse model, primary human glioblastoma cells, U87MG	19098899, 19190119, 19318569, 19690143, 20226597, 30219696	22407177, 25758746	NCT00423735, NCT00609999, NCT00869401, NCT00892177, NCT00895960, NCT00948389	PubChem Google
KP2	10537176	apoptosis, proliferation	PI3K, Akt	U251MG, U87MG	16546978			Google
Candidaspongiolide	102471178	apoptosis	PKR, eIF2alpha, casp12	U251MG	18728285			Google
CUDC-101	24756910	proliferation	EGFR, HDAC	BS153, DKMG	26032687			PubChem Google
3-(3,4-dichlorophenyl)-1-(3,4-dimethylphenyl)-1-(5-methyl-4,5-dihydro-1,3-thiazol-2-yl)urea	613034		mTORC2	LN229, mouse xenograft model	28453552
Luteolin	5280445	invasion, migration, proliferation, viability	Musashi1	U251MG, U343, U87MG	28927111, 30362859, 30374718			PubChem Google
HOE-140 (Icatibant acetate)	6918173	inflammatory response	B(2)	1321N1, C6, U87MG	19854233			PubChem Google
Mdivi-1	3825829	apoptosis	DRP1	U87MG	29229477			PubChem Google
Hsp-990	46216556, 16226182	apoptosis, radiosensitization	Hsp90	LN18, mouse xenograft model, U251MG, U373MG, U87MG	23448094, 24500492			PubChem Google
Dronabinol (Delta9-THC)	16078	apoptosis, cannabidiol enhancer, proliferation, viability	ERK, Reactive oxygen species	SF126, U251MG, U87MG	17675107, 18339876, 20053780, 30597288			PubChem Google
Axitinib	6450551		VEGFR, PDGFR	mouse model, U87MG	25213669, 27926485		NCT01441388, NCT01508117, NCT01562197, NCT03275558, NCT03291314	PubChem Google
Dimethylaminomicheliolide	54589107	proliferation	PKM2	C6, rat model, SF126, SHG-44, U118MG, U251MG, U87MG	25658946, 31632919			Google
Abt-737	11228183	viability	BCL2	LN18, LN229, LNZ428	18663354, 22393246			PubChem Google
KX2-361	11545920	proliferation, viability	Src family kinase, tubulin	GL261	30238350			PubChem Google
Fluvoxamine	5324346			mouse model	26988603			PubChem Google
Indomethacin	3715	viability	COX	U251MG	27988363			PubChem Google
SAR-020106	44203948	DNA damage	Chk1	A172, DBTRG, LN405, P0297, P0306, T98G	31639020			PubChem Google
Tranylcypromine	19493	proliferation		U87MG	30591460			PubChem Google
JWH?133	6918505	migration, proliferation, viability	VEGF, VEGFR?2, HIF-1alpha	C6, T98G, U87MG	15313899, 24204703			PubChem Google
Honokiol	72303	viability	PI3K, mTOR	DBTRG05MG, GBM8401, mouse xenograft model, U373MG, U87MG	19483651, 25106108, 25763821, 27064011			PubChem Google
CPI-455	78426698	viability	Histone lysine demethylase	A172, CAS1, DBTRG, U251MG, U87MG	28432280			PubChem Google
Trifluoperazine	5566	proliferation	Calcium signaling, D2 receptors	orthotopic mouse model, P3, primary human glioma cells, U251MG, U87MG	23165409, 28062709, 28870216, 29580626, 30980364			PubChem Google
Vitexin	5280441	apoptosis, cell cycle arrest, viability	Akt, mTOR	LN18	29328424			PubChem Google
PIK-90	135398491	radiosensitization, viability	p110alpha, PI3K	LN229, SF126, SF210, U138MG, U251MG, U87MG	18413797			PubChem Google
Teniposide	452548	proliferation		primary human glioma cells, U373	19559015, 23165409			PubChem Google
Denbinobin	10423984	viability		GBM8401, U87MG	23123054			PubChem Google
Ibrutinib	24821094	proliferation, viability	Bruton\'s tyrosine kinase, Src	LN229, mouse xenograft model, primary human glioma cells, U87MG	27564106, 28716053, 30219696		NCT03535350	PubChem Google
NMS-P715	44556162	radiosensitization		mouse xenograft model, U251MG	25722303			PubChem Google
Spironolactone	5833	apoptosis, proliferation, suppress DNA damage repair	EGFR-TKI	mouse xenograft model, patient derived cell lines GS-Y01	31614999			PubChem Google
Citalopram	2771		SSRI, beta-arrestin1	C6	21223624			PubChem Google
Lysophosphatidic acid	5497152	proliferation, viability	NHE1, PI3K, Akt, Rhoassociated kinase, PKC, MEK, E	C6	16176063, 17499746, 18481020			PubChem Google
Isoliquiritigenin	638278	viability	TopoisomeRASe	U87MG	23229626, 26722447			PubChem Google
487020-03-1	1936439		PBK	mouse xenograft model, primary human glioma cells	26081429			PubChem Google
Tanespimycin	6505803	apoptosis, migration, radiosensitization, viability	Hsp90	M059K, SF268, U87MG	16550610, 18462865, 18682579, 18974397, 19027068, 19244114, 19408974, 19671736, 19795461, 26185541, 28542269			PubChem Google
Tipifarnib	159324	angiogenesis, radiosensitization	farnesyl protein transfeRASe	mice xenografts, U87MG	14676133	16818651, 16877733, 18417739, 18725460, 20934264, 28988377	NCT00005859, NCT00049387, NCT00050986, NCT00058097, NCT00209989, NCT00335764, NCT02227901	PubChem Google
AR-A014418	448014	apoptosis, proliferation, viability	GSK3beta	A172, T98G, U251MG, U87MG	19188159			PubChem Google
BAY 11-7082	5353431	proliferation	NFkappaB	C6, U251MG	19788921, 26137111			PubChem Google
Nimustine	91657	apoptosis, rapamycin enhancer, viability	mTOR	U251MG	17390104, 18614215			PubChem Google
Tocladesine	100299	apoptosis		U87MG	12449730			PubChem Google
Regorafenib	11167602	viability	VEGFR2TIE2	GBM12, GBM14, GBM5, GBM6	24911215	30522967, 30820715	NCT02926222, NCT03970447, NCT04051606	PubChem Google
Methylene dibutyrate	9855687	apoptosis, proliferation	Histone deacetylase	murine xenograft glioma tumor, U251MG	16373710			PubChem Google
SF1126	66577114		PI3K	mice glioma cells, mouse xenograft model	25425962			PubChem Google
Alpha-Lipoic acid	864	apoptosis, proliferation	Glutathione Peroxidase 1,TRPA1	MU1454, U87MG	29925764, 30590317			PubChem Google
Perifosine	148177	apoptosis, cell cycle arrest, viability	Akt, PI3K	T98G, U251MG, U373MG, U87MG	16103096, 19887560, 24065522		NCT01051557, NCT02238496	PubChem Google
Dihydrotanshinone	11425923	cell cycle arrest, temozolomide enhancer, viability		T98G, U87MG	30399573			Google
MG-262	490002	apoptosis inhibition	Proteasome	LN229, U251MG	19190249			PubChem Google
Allopregnanolone	92786	proliferation	ESF1, RIF1	U87MG	29543748			PubChem Google
Alvespimycin	5288674	apoptosis, proliferation, radiosensitization	Hsp90, AMPK	C6, SF268, U251MG, U87MG	19244114, 19805107, 24418474			PubChem Google
Neurostatin	71716390			mouse xenograft model, U373	20801220			Google
SQ29548	5311448	cell swelling suppression	TXA2	1321N1	19772916			Google
Marimastat	119031	cell invasiveness	Metalloproteinase	Daoy, Madsen, UW2282, UW2283	19847623			PubChem Google
PJ34	4858	viability	PARP	LN229, U87MG	25531448, 25576921			PubChem Google
Punicalagin	44584733	viability		U87MG	24077634			Google
Vindesine	40839	viability		A172, LN443, U118, U87MG	24433351			PubChem Google
Norclomipramine	622606	inhibitors of cellular respiration		IPSB18	20332444			PubChem Google
Fasudil	3547	viability	Rho, ROCK	mouse xenograft model, T98G, U251MG, U87MG	19427347, 20364104, 21166955, 26725099			PubChem Google
FK506	24978521	apoptosis, proliferation, vincristine enhancer	MRP1	C6, U87MG	30208561			Google
SU11274	9549297	migration	Met	LN229, U87MG	19795461			PubChem Google
Fenofibrate	3339	proliferation	PPARalpha	T98G, U251MG, U343, U87MG	18546270, 24493576, 25566967			PubChem Google
AT101 (Gossypol acetate)	227456	apoptosis	Bax, BCL2, BclxL	LN229	29858681			PubChem Google
Clofazimine	2794	viability		A172, LN443, U118, U87MG	24433351			PubChem Google
Rotenone	6758	apoptosis	Mitochondrial respiratory chain complex I	DAOY	19633536			PubChem Google
10-Hydroxycamptothecin	97226	proliferation	Inhibitor of Topoisomerase 1	primary human glioma cells	23165409			PubChem Google
Galangin	5281616	angiogenesis, invasion, migration, proliferation	CD44	U251, U87	31528214			PubChem Google
Morphine	5288826	proteasome-mediated EAAC1 degradation	EAAC1	C6, U87MG	18539596			PubChem Google
2-benzoyloxycinnamaldehyde (BCA)	54242917	invasiveness, stemness, temozolomide enhancer, viability	Zeb1, Ncadherin, beta-catenin	GBM tumorspheres, mouse orthotopic xenograft model	30887242			PubChem Google
Panobinostat	6918837	proliferation	HDAC	primary human glioma cells, stemlike cells	18445700, 30348136, 30515262	21984064, 25572329, 26821711	NCT00848523, NCT01115036	PubChem Google
Z-VAD (OMe)-FMK	5497174	apoptosis	NOS, BCL2	CGNH-89, CGNH-NM, CRTMG	19748528, 24678780			PubChem Google
Cyclophosphamide	2907		DNA crosslinking			15022289, 15735920	NCT00003185, NCT00008008, NCT00014573, NCT00047281, NCT00990496, NCT01174121, NCT01403285, NCT01454596, NCT01903330, NCT02502708, NCT02844062, NCT02937844, NCT03152318, NCT03412877, NCT04049669, NCT04102436	PubChem Google
Sonidegib	24775005	viability	Smoothened, Gli1, Gli2, Patched1, Patched2	primary human glioma cells	23482671, 30251117		NCT01576666, NCT03434262	PubChem Google
Patulin	4696	proliferation		primary human glioma cells	23165409			PubChem Google
Arginyl-glycyl-aspartic acid	104802	migration	PKB phosphorylation	glioblastoma stem-like cells	30280197			PubChem Google
Scriptaid	5186	apoptosis, viability	HDAC, JNK	BS153, DKMG	19583803, 26032687			PubChem Google
Depatuxizumab mafodotin	86278355	antimicrotubule agent	EGFR, MMAF			29075855, 29077941, 29982805	NCT01800695, NCT02343406, NCT02573324, NCT02590263, NCT03123952	Google
ZM447439	9914412	proliferation	Aurora kinase	primary human glioma cells, U251MG, U343	22160182			PubChem Google
Ortataxel	6918412					30726533	NCT01989884	PubChem Google
Arsenic trioxide	14888	metabolic activity reduction, proliferation and colony formation, viability	CatB, CatL	A172mouse xenograft model, U118, U87MG	20302512, 21594580, 29274334			PubChem Google
3-methylademine (3-MA)	135398661	autophagy, viability	PI3K	CD133+, U251MG	19431142, 19566920, 19575007			PubChem Google
Eckol	145937		BACE1 beta-secretase 1 (human)	U373MG, U87MG	21514314			PubChem Google
Nitidine	25659	apoptosis, proliferation	pDok2	C6, U87MG	29329030			PubChem Google
Lenalidomide	216326				26891975	18513880	NCT00036894, NCT00165477, NCT00671801, NCT01183663	PubChem Google
cis-Diaminedichloroplatinum (CDDP, cisplatin)	2767	chemosensitivity	Met	T98G, U251MG	19435873			PubChem Google
Ms-275	4261	apoptosis, proliferation	DR4, DR5	D283, Daoy	19148581			PubChem Google
Go6976	3501	proliferation	cPKC	C6	18778746, 19357285			PubChem Google
Pifithrin-alpha	9929138	apoptosis, proliferation	p53	C6	19513548			Google
Ganciclovir	135398740	cytotoxicity		U251MG	19300472		NCT00002824	PubChem Google
Telomestatin	443590	viability	Gquadruplexes	GBM146, GBM157	26845351			PubChem Google
Vincristine	5978	proliferation	Microtubules	A172, GL261, LN229, LN443, orthotopic mouse model, primary human glioma cells, U118, U87MG	23165409, 24433351, 28386621, 30219696	20855843, 225004	NCT00005796, NCT00052455, NCT01837862, NCT02684058	PubChem Google
Strophanthidin	6185	proliferation		primary human glioma cells	23165409			PubChem Google
8-Hydroxy-2-methyl-1H-quinazolin-4-one	135398517	radiosensitization	PARP1	D54, U251MG	25182801			PubChem Google
Lysophosphatidylserine	42607474	proliferation		C6	17958326			PubChem Google
Captopril	44093	invasion		T98G	8572589		NCT02770378	PubChem Google
Niclosamide	4477	proliferation, viability		primary human glioma cells, U87MG	23165409, 27029345			PubChem Google
Gamma-Secretase Inhibitor IX	5311272	proliferation, viability	Gamma secretase	GL15, LN229, SF767, SHG44, U105MG, U251MG, U343MG, U373MG, U87MG	19690139, 23736154, 25063285			PubChem Google
Oxymatrine	114850	apoptosis, proliferation	EGFR, PI3K, Akt, mTOR, STAT3	U251MG	29989652			PubChem Google
Ivermectin	6321424	apoptosis	Akt, mTOR	T98G, U87MG, xenograft mouse models	27771251			PubChem Google
Omacetaxine	3628	viability		LN443, U118, U87MG	24433351			PubChem Google
Amsacrine	2179	proliferation		primary human glioma cells	23165409			PubChem Google
Tozasertib	5494449	radiosensitization, viability	Aurora kinase	GBM 8401, GBM 8901, mouse xenograft model, primary human glioma cells, U87MG	23636005, 25522764			PubChem Google
2-hydroxycinnamaldehyde (HCA)	5318169	invasiveness, stemness, temozolomide enhancer, viability	Zeb1, Ncadherin, beta-catenin	GBM tumorspheres, mouse orthotopic xenograft model	30887242			PubChem Google
DL-nordihydroguaiaretic acid	688035	differentiation	Alox5	murine glioma xenografts, U87MG	20809257			Google
PD173074	1401	migration, proliferation	FGFR	T98G, U118MG	19340397, 26883759			PubChem Google
Dermaseptin-PS1	16130489	apoptosis, proliferation	Bax, BCL2, LDH	U251MG	30461197			Google
Gboxin	137628664	apoptosis	F0F1 ATP synthase	glioblastoma allografts, patient-derived xenografts, primary mouse	30842654			PubChem Google
PF8380	25265312	proliferation	Autotaxin	LN229	23300119			PubChem Google
Tpi-287	118797983	viability	Microtubules	GB30, U1242, U87MG	29396807			PubChem Google
Ribavirin	37542	apoptosis, migration, proliferation, viability	eIF4E, EZH2, ERK	1113, GB1A, LN18, murine glioma models, U251MG, U87MG	27941882			PubChem Google
Echinomycin	3197	angiogenesis, proliferation	HIF1	U251MG	16204079			PubChem Google
Clorgiline	4380	proliferation	MAO A	U251MG	26871599			PubChem Google
Gadodiamide (Omniscan)	24847884	co-convection, cytotoxicity, efficacy, lack of toxicity, positive tissue pharmacokinetics		U87MG rat xenograft model	19466380			PubChem Google
PF-429242	23661637	viability	Site1 protease		28645614			PubChem Google
E7016	11660296	radiosensitivity	PARP, HMGB1, TLR2	U251MG	19147766			PubChem Google
Nigericin	16760591	proliferation	Mitochondrial ATPase	COMI, VIPI stem cells	29513090			Google
AR03	698490		Ape1	SF767	20504914			PubChem Google
Bimiralisib	58507717	proliferation	PI3K, mTOR	xenograft model in nude rats and mice	28829592, 31618458		NCT02850744	PubChem Google
CGS7181	656759	apoptosis	BKCa channels	LN229	20065494			Google
Cordycepin	6303	apoptosis, viability	AMPK, Akt	C6, LN18, orthotopic mouse model, T98G, U251MG, U87MG	26597532, 28068557, 30336060			PubChem Google
L-685458	5479543	migration, survival	gamma-secretase	LN229, U87MG	19690139			PubChem Google
Panaxydol	5283280	proliferation	PI3K	C6	19040798, 19179079			PubChem Google
Rovalpituzumab tesirine	131954443		DLL3	primary human glioma cells	30397180			Google
Nutlin-3a	11433190	apoptosis		U87MG	30574827			PubChem Google
15Deoxy-delta-12,14-PGJ2	5283035	apoptosis	PPARgamma	C6, U251MG	14699130			PubChem Google
Endothelin-1	16212950	proliferation	ERK	C6	18975108			Google
Idoxuridine	5905	proliferation, radiosensitization		C6, rat glioma model	30170108			PubChem Google
Genistein	5280961	apoptosis, mitochondrial swelling, viability	DNA synthesis	LN18, LN308, LNT229, T98G, U87MG	18357397, 19639205, 19894226			PubChem Google
Proguanil	6178111	viability	CLIC1	GBM1, GBM2, GBM3, GBM4, GBM5, GBM6, GBM7	30186163			PubChem Google
NS-1619	4552	enhanced drug delivery to brain-tumor cells	calcium dependent potassium (K(Ca)) channel agonis	xenograft model	19738431			PubChem Google
Indirubin Derivative E804	135398511	proliferation		U251MG, U87MG	26386687, 6419764			PubChem Google
Lomeguatrib	3025944	apoptosis	MGMT			19770758		PubChem Google
D-Glucosamine	439213		Thymidine kinase	C6	844039			PubChem Google
N-Acetylcysteine	12035	apoptosis, invasion, migration, proliferation	NOTCH2, HES1, HEY1	T98G, U251MG, U87MG	19633536, 19836430, 30606241			PubChem Google
Crizotinib	11626560	prolifiration, viability	cMET	A172, LN18, mouse xenograft model, U373, U87MG	23556031, 26517812, 29803091, 30201763		NCT01441388, NCT02270034	PubChem Google
Capecitabine	60953		Nucleic Acid Synthesis			25290090, 31600167	NCT00504660, NCT00717197, NCT00959946, NCT02669173, NCT03213002	PubChem Google
Bafilomycin A1	6436223	autophagy, cytotoxicity, radiosensitization, viability	H(+)ATPase	CD133+, U251MG	19431142, 19566920			PubChem Google
Cucurbitacin B	5281316	invasion, proliferation	CIP2A, PP2A, Akt, JNK, JUN	DBTRG05MG, LN229, T98G, U118MG, U251MG, U87MG	18561312, 29393542			PubChem Google
Letrozole	3902	proliferation	Aromatase	C6, LN229, orthotopic mouse model, T98G, U251MG, U373MG, U87MG	25695958			PubChem Google
Transcrocetinate	10287099			C6, rat model	18447715			Google
BMS-536924	135440466		IGF1R, IR	M059K, mouse model	25897243			PubChem Google
Selumetinib	10127622		MEK1, MEK2	D456, D645, GBM2, LN229, mouse xenograft models, U373	20806365, 22573716			PubChem Google
Selinexor	71481097	proliferation, viability	CRM1, XPO1	AGBM1, BT145, BT159, BT172, LN229, orthotopic mouse model, primary human glioma cells, T98G, U87MG	25366336, 30337641		NCT01607905, NCT01986348, NCT02323880	PubChem Google
GW6471	446738	proliferation	PPARalpha	primary human glioma cells	29312541			PubChem Google
Ellipticine	3213	apoptosis, proliferation		U87MG, UKFNB3	21753906			PubChem Google
Lorlatinib	71731823		ALK, ROS1	mouse model	25733882			PubChem Google
Delta 9-tetrahydrocannabinol	2978	viability	E2F1	U251MG, U87MG	17934890			PubChem Google
Gitoxin	91540	proliferation		primary human glioma cells	23165409			PubChem Google
Cerivastatin	446156	viability		A172, LN443, U118, U87MG	24433351			PubChem Google
Trolox	40634	apoptosis, viability	Casp9	U138MG	19002382			PubChem Google
Theobromine	5429	proliferation	PDEs	U87MG	24547961			PubChem Google
Imiquimod	57469		Toll like receptor 7 (TLR7)	GL261, orthotopic mouse model	21389872		NCT01171469, NCT01403285, NCT01808820, NCT01902771	PubChem Google
Gambogic acid	5353639	apoptosis, proliferation		primary human glioma cells, U251MG	21879332, 23165409			PubChem Google
Farnesyl Pyrophosphate	445713	apoptosis	JNK	U87MG	20298756			PubChem Google
Akt Inhibitor IV	5719375	proliferation inhibition	Akt	1028S, U87MG	19208828			Google
2-Amino-3H-phenoxazin-3-one	72725	viability		LN229	24008433			PubChem Google
Actinonin	443600	angiogenesis	N, CD13	U87MG	19264392			PubChem Google
A939572	24905400	proliferation, proliferation inhibition, viability	SCD1	T98GR, U87MGR	29354058			PubChem Google
Osthol	10228	apoptosis, invasion, proliferation		TE671, U87MG	25368248, 26082082, 29301373			PubChem Google
AZD8055	25262965		mTOR	mouse xenograft model, primary human glioma cells	25316808		NCT01316809	PubChem Google
Tricetin	5281701	invasion, migration			26245494			PubChem Google
Tezacitabine	6435808	proliferation, viability	RR (ribonucleotide reductase)	HS683, J889H, xenografts of human glioblastoma	8542592			PubChem Google
Dimethyl-alpha-ketoglutarate	25775		GDH, Akt	SF188	19826036			PubChem Google
Riluzole	5070	proliferation	MEK, ERK, CREB	C6, U87MG	16524382, 21295555, 23724064, 30591460			PubChem Google
Biochanin A	5280373	cell cycle arrest, proliferation, temozolomide enhancer, viability	EGFR, pERK, pAKT, c-Myc, MTMMP1	T98G, U87MG	30591440			PubChem Google
Aprepitant	135413536	proliferation	NK1	GAMG	21054456, 26603162		NCT02770378	PubChem Google
NU7026	9860529	apoptosis	DNA-PK	KNS60, MO59K, ONS76, U87MG	19435898, 25307264			PubChem Google