GBM Drug Bank

Drugs for Glioblastoma

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Compound Mode of Action (target)


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CompoundPubChem CIDReported EffectMoAPMIDClinical PMIDClinical Trials
Fucoxanthin5281239mouse xenograft model, proliferation27394418
Cediranib9933475mouse xenograft model, viabilityVEGFR21095630, 25490024, 25676691, 2664539820458050, 23940216, 26008604NCT00305656, NCT00503204, NCT00662506, NCT00777153, NCT00979862, NCT01131234, NCT01310855
Acetazolamide1986proliferationcarbonic anhydrase27702686
Pexidartinib25151352NCT01349036, NCT01790503
Celecoxib2662viability21847707, 2328044525239666NCT00047281, NCT00047294, NCT00112502, NCT00504660, NCT02770378
Selinexor71481097orthotopic mouse model, viabilityCRM125366336NCT01607905, NCT01986348
Thapsigargin446378viabilitySERCA27993939
Milciclib16718576proliferation23347136
Ardipusilloside I197641proliferation24984215
AZD1152-HQPA16007391mouse xenograft model, proliferationAurora B22382783
8-Bromo-cyclic AMP32014proliferation24649161, 9484714
Riluzole5070proliferation23724064
UNII-2AW48LAZ4I72941968orthotopic mouse modeltelomerase26183089
5-Nonyloxytryptamine1797viability24433351
Fluorouracil3385viabilityNucleic Acid Synthesis24391839, 6690037NCT01183663
Digitonin6474107proliferation23165409
UNC202573425588orthotopic mouse modelMER, FLT327783662, 28605477
ZM4474399914412proliferationAurora kinase22160182
Nelfinavir6414324194293NCT00694837, NCT00915694, NCT01020292
Methyl gallate7428viability23562553
Convallatoxin441852proliferation23165409
Curcumin969516proliferation26046466
Neratinib9915743orthotopic mouse model, viabilityHer2, EGFR26023796NCT02977780
Tivozanib9911830invasion, proliferationVEGFR28287096NCT01846871
KU6001915953870orthotopic mouse model, radiosenitisationATM23620409, 24443327, 25091220
Casticin5315263viability23816816
Prazosin4893orthotopic mouse model, viabilityPRKCD27138566
Oxibendazole4622proliferation23165409
Panobinostat6918837HDAC21984064, 25572329, 26821711NCT00848523, NCT01115036
Digitoxin441207proliferation, viability21184646, 23165409
Punicalagin44584733viability24077634
Letrozole3902orthotopic mouse model, proliferationAromatase25695958
Dibutyryl cAMP9687proliferation9484714
Niclosamide4477proliferation, viability23165409, 27029345
AC1MMYR23246569orthotopic mouse model, proliferation23811941
Eflornithine3009proliferationornithine decarboxylase25935110
A-96649216666333radiosenitisationPARP28797568
Bufalin 9547215viability28787697
LB-100 45101433mouse xenograft model, radiosenitisationPP2A25939762NCT03027388
Imiquimod57469orthotopic mouse modeltoll-like receptor 721389872NCT01403285
Cabazitaxel9854073viabilityMicrotubule27203678NCT01740570, NCT01866449
GSK1838705A25182616mouse xenograft modelIGF-1R26238593
Lys0170673567viability22566612
Telomestatin443590viabilityG-quadruplexes26845351
Aurintricarboxylic acid2259invasion, migration28103571
3-BrOP11513992viability23132831
Naringin442428invasion, migration26474590
Vinpocetine443955proliferationPDE125620587
Sulindac sulfide5352624proliferation23280445
Temsirolimus6918289mTOR2674824123099651, 23564811, 24470557NCT00016328, NCT00022724, NCT00112736, NCT00329719, NCT00335764, NCT00784914, NCT00800917, NCT01019434, NCT01183663, NCT03158389
Clofazimine2794viability24433351
JQ149871817proliferation, rat xenograft modelBET25056450, 27388964
Pristimerin159516proliferation23165409
Deoxyglucose108223radiosenitisationglycolysis 28756228
Omacetaxine3628viability24433351
1134156-31-225195348proliferationHsp70, Hsp9026185541
beta-Peltatin92122proliferation23165409
Denbinobin10423984viability23123054
Melatonin896viability28255276
Fenofibrate3339proliferationPPARalpha24493576, 25566967
LY3414959819927proliferation23724064
8-Hydroxy-2-methyl-1H-quinazolin-4-one63306radiosenitisationPARP-125182801
Astemizole2247viability27029345
ZSTK47411647372mouse spontanious GBM model, mouse xenograft model, proliferationPI3K24297065, 27553832
Plumbagin10205proliferation, viability23165409, 25528634
Carboplatin10339178DNA28534153NCT00005976, NCT00010036, NCT00014105, NCT00021307, NCT00352313, NCT00492687, NCT00541138, NCT00635557, NCT00650949, NCT00995007, NCT01317212, NCT01386710, NCT01837862, NCT01934361, NCT03149575
GSK J471729975proliferationJMJD328978140
MAZ519839842proliferation25268128
Mebendazole4030orthotopic mouse model, proliferation23165409, 28386621NCT01729260, NCT01837862, NCT02644291
Isotretinoin528237925239666NCT00003564, NCT00112502, NCT00555399, NCT01103375
Axitinib6450551mouse modelVEGFR, PDGFR25213669, 27926485NCT01441388, NCT01508117, NCT01562197, NCT03275558, NCT03291314
Cisplatin84691viabilityDNA intercalation24218165, 24953561, 27993939
Bimiralisib58507717PI3K, mTORNCT02850744
Idarubicin42890viability24433351
Cardamonin641785mouse model, proliferation26150336
Gedatolisib44516953viabilityPI3K, mTOR24658109
NSC141562422114invasion, migration, proliferationMIR155HG/miR-155 axis28371892
AMG-51159548184mouse xenograft modelPI3K22897589
172889-27-94878radiosenitisationSrc26044161
Chloroquine2719radiosenitisation, viability25434381, 2764444217350410NCT00224978, NCT02378532, NCT02432417, NCT03243461
THZ173602827orthotopic mouse modelCDK728504693
Tesevatinib10458325NCT02844439
GSK46136415983966mouse xenograft model, proliferationPLK123790466, 24204733
CUDC-10124756910proliferationEGFR, HDAC26032687
JS-K9572720mouse xenograft model23370169, 28653883
Tnp-470369976angiogenesis27542173
Midazolam4192proliferation27629139
Amsacrine2179proliferation23165409
Ridaforolimus11520894mTOR22037923NCT00087451, NCT01295632
Lapatinib208908proliferationEGFR, HER22491121523363814NCT00095940, NCT00099060, NCT00107003, NCT00350727
Ancitabine25051proliferation23165409
Honokiol72303mouse xenograft model, viability25106108, 25763821, 27064011
Volasertib10461508radiosenitisation, viabilityPLK124204733, 29535822
Hypericin5281051viability2406606021456013
Ruxolitinib25126798JAK
Caffeic acid phenethyl ester5281787apoptosis, proliferation14637186, 23165409, 24997497
Cryptotanshinone160254mouse xenograft model28492557
4egi-15717952proliferationEIF4E26220902
Ceritinib57379345NCT02605746
PF-0469150225033539mouse xenograft modelPI3K, mTOR21750219
Indatraline126280mobilitymonoamine transporter24333442
Pamiparib71602594NCT03150862
Veliparib11960529orthotopic mouse model, radiosenitisationPARP23510353, 28314386NCT00770471, NCT01026493
Palbociclib5330286mouse xenograft modelCDK4, CDK6624098593, 26149830, 26354993, 27370397, 28903422NCT02255461, NCT03158389
Flavopiridol5287969mouse model, radiosenitisationCDK23943501, 27461656, 28111642
3-Deazaneplanocin73087viabilityHDAC24905315
MK-8863651377viabilityLipoxygenase 23261452
Schizandrin B158103invasion, proliferation27977512
TG0216739650orthotopic mouse model, viability29254993NCT02942264, NCT03224104
Captopril44093invasion8572589NCT02770378
D6094234241proliferation28802717
Nilotinib644241
NBQX3272524proliferationAMPA23724064
Vinorelbine5311497viability24433351
WP113011222830apoptosis26872380
Piplartine637858migration24967005
Alvespimycin5288674radiosenitisationHsp9024418474
Dactolisib11977753orthotopic mouse mode, proliferation, radiosenitisationPI3K, mTOR19671762, 23603977, 24366691, 25431423, 26188279, 27542970, 27553832NCT01508104
Antimycin A14957proliferation23165409
Trifluoperazine5566orthotopic mouse model, proliferation23165409, 28870216
Ouabain439501viability21184646
Lenvatinib9823820mouse modelmultiple kinases28901423NCT01433991
Vandetanib3081361mouse xenograft model, proliferationVEGFR, EGFR, RET-tyrosine kinase19622715, 20371720, 21095630, 2379985223099652NCT00441142, NCT00613223, NCT00821080, NCT00995007
T56-LIMKi9438169viabilityLIM kinase25593987
Forskolin47936proliferationadenylate cyclase24649161, 9484714
Buparlisib16654980mouse xenograft model, proliferation, radiosenitisationPI3K22065080, 24500492, 24741074, 24900266, 25431423, 26846842, 27283525, 27363276NCT01339052, NCT01349660, NCT01473901, NCT01576666, NCT01870726, NCT01934361
72926-24-02930014proliferationEg528965307
Vatalanib151194orthotopic mouse modelVEGFR15271251NCT00128700, NCT00387933
Karenitecin148202radiosenitisationtopoisomerase28111642NCT00014521
PF-0684000323063810
Indomethacin3715viabilityCOX27988363
BIX-0129425150857viabilityhistone methyltransferase24905315, 27748874, 27934912
Resveratrol445154mouse xenograft model23651583
Cucurbitacin I5281321mouse xenograft model, proliferation24599950, 25482928
AZD201425262792radiosenitisationmTOR24311635NCT02619864
Nintedanib9809715VEGFR, FGFR, PDGFR23184145, 25338318NCT01251484
Lenalidomide2163262689197518513880NCT00036894, NCT00165477, NCT00671801, NCT01183663, NCT02369367
781661-94-711178236apoptosis, migration, proliferationSurvivin22770110, 23325792, 25201484, 27805285
Hsp-99046216556, 16226182, 68275964apoptosis, mouse xenograft model, radiosenitisationHsp9023448094, 24500492
SH5-0772550504mouse xenograft model, viabilitySTAT326088127
Cathepsin S Inhibitor16760355viabilityCathepsin S24875536
Palomid 52911998575orthotopic mouse modelmTOR23436212
TGX-2219907093proliferationp110-beta29048665
GW3965447905mouse xenograft model, proliferationLXR22059152
Digoxin2724385proliferation, viability21184646, 23165409
Erlotinib176870proliferationEGFR2603268722407177, 24470557, 24637230NCT00030498, NCT00039494, NCT00045110, NCT00054496, NCT00086879, NCT00112736, NCT00124657, NCT00187486, NCT00227032, NCT00274833, NCT00301418, NCT00335764, NCT00337883, NCT00387894, NCT00445588, NCT00509431, NCT00525525, NCT00609999, NCT00671970, NCT00672243, NCT00720356, NCT01103375, NCT01110876, NCT01257594
Savolitinib68289010, 68287718mouse xenograft modelc-Met25148209
Cycloheximide6197proliferation21159181
Vindesine40839viability24433351
Chlorpromazine2726mouse xenograft model, orthotopic mouse model, viability23689352, 28455961
Sulfasalazine5359476proliferation, radiosenitisation25798841, 25937318, 28929335
KPT27671496742orthotopic mouse model, viabilityCRM125366336
PQ4019549305mouse xenograft modelIGF-1R25971682
Pregnenolone8955viability25013479
Tamoxifen2733526viabilityER25554223NCT00002608, NCT00006388, NCT00492687, NCT00541138
GW29746603857invastion, migration, viabilityEGFR, HER223115024
Ascochlorin11258227invasion, migration28569433
RG711257406853mouse modelMDM2 26482041
Caffeine2519migration, orthotopic mouse model25011614, 27260469
Marizomib11347535mouse xenograft model, viabilityproteasome26681765, 26804704
Flubendazole35802viability24433351
Birinapant49836020viabilityIAP26657652
carnosol442009proliferation26939786
JIB-046519698viabilityhistone lysine demethylase28432280
Juglone 3806proliferation28388894, 28791366
Indirubin Derivative E8046419764proliferation26386687
RapaLink-1121231411proliferationmTOR28292440
GSK332659590241742NCT02783300
Alexidine102678, 2090viability27029345
Abemaciclib46220502mouse xenograft modelCDK4, CDK626149830NCT02977780, NCT02981940
Phenformin8249orthotopic mouse model27486821
YU238259121473004proliferationHDR26116172
Olaparib23725625viabilityPARP25531448, 25576921, 26794465NCT01390571
Oxamate3017661radiosenitisationlactate dehydrogenase28756228
Gitoxigenin348482proliferation23165409
Enzastaurin176167proliferationPKCbeta1991340820124186, 22291006NCT00295815, NCT00402116, NCT00509821, NCT00516607, NCT00586508
Talampanel16450919636006, 20143438NCT00062504, NCT00064363, NCT00267592
Patulin4696proliferation23165409
Evodiamine442088mouse model28514905
NSC23766409805viabilityRAC123736154
SKI II753704radiosenitisationSphK25255218, 28494176
Enasidenib89683805IDH2
Gitoxin91540proliferation23165409
Anthothecol21596360proliferation23165409
Cilengitide176873proliferationintegrin19114005, 2258888317470857, 18981465, 20439646, 25163906, 26008604NCT00006093, NCT00085254, NCT00112866, NCT00679354, NCT00689221, NCT00813943, NCT00979862, NCT01044225, NCT01122888, NCT01124240, NCT01517776, NCT01782976
Genistein5280961viability19894226
Gambogenic Acid10794070apoptosis21879332
Isobutylmethylxanthine3758proliferation, viabilityPDE22227470, 9484714
PCI-2478111749858proliferationHDAC25505847
MG-132462382mouse xenograft model, proliferationproteasome22367315, 27993939
CC-11558298318NCT01353625, NCT02977780
Oroxylin A5320315viability25213258
Tpi-287118797983viabilityMicrotubule29396807
717906-29-111598628migration, proliferationFAK 26883759
487020-03-11936439mouse xenograft modelPBK26081429
9-ING-4144582816orthotopic mouse modelGlycogen Synthase Kinase-328672195
Demethoxycurcumin5469424mouse xenograft model27757851
SH-4-5472188643orthotopic mouse model, proliferationSTAT324900612
Epirubicin41867proliferation, viabilityDNA intercalation23165409, 24433351, 28963609
GDC-094117755052mouse xenograft model, radiosenitisation, viabilityPI3K 23427298, 24757258, 28147244
Abt-73711228183viabilityBcl-222393246
Scriptaid5186viabilityHDAC26032687
Repaglinide65981orthotopic mouse model28476618
Disufenton sodium11603334rat model23328810
Vismodegib24776445NCT00980343, NCT03158389
Sonidegib24775005viabilitysmoothened23482671NCT01576666
Carmustine2578DNA alkylation24958095, 7013978NCT00002545, NCT00003176, NCT00003348, NCT00003417, NCT00003463, NCT00003484, NCT00003788, NCT00003876, NCT00003996, NCT00004028, NCT00004688, NCT00004892, NCT00005081, NCT00005637, NCT00005855, NCT00006386, NCT00006656, NCT00009854, NCT00017147, NCT00027612, NCT00046878, NCT00068952, NCT00076986, NCT00086879, NCT00362921, NCT00548938, NCT00761280, NCT00795665, NCT00984438, NCT01186406, NCT01310868, NCT01656980
UMI-77992586viabilityMcl-128337703
NKTR-1027130072725935109
AMG 23258573469
Temozolomide5394mouse model, viabilityalkylating agent23736154, 24647572, 27878252, 2799393915758009, 19506159, 19636006, 20855843, 20934264, 21735117, 22035272, 22291006, 22578793, 23633392, 23725999, 23898124, 24194293, 24637230, 25239666, 26285766NCT00003176, NCT00003464, NCT00004113, NCT00004200, NCT00005637, NCT00005951, NCT00006025, NCT00006353, NCT00006358, NCT00006474, NCT00014105, NCT00021307, NCT00027625, NCT00028795, NCT00038493, NCT00039494, NCT00047294, NCT00049387, NCT00050986, NCT00052455, NCT00068952, NCT00083096, NCT00085254, NCT00086879, NCT00089427, NCT00099125, NCT00102648, NCT00112502, NCT00128700, NCT00187486, NCT00200161, NCT00238277, NCT00253487, NCT00262730, NCT00274833, NCT00275067, NCT00304031, NCT00311857, NCT00335075, NCT00354068, NCT00365222, NCT00376103, NCT00385853, NCT00387400, NCT00390403, NCT00392171, NCT00394628, NCT00402116, NCT00431561, NCT00433381, NCT00436436, NCT00441142, NCT00458601, NCT00471653, NCT00481455, NCT00482677, NCT00486603, NCT00492687, NCT00498927, NCT00501891, NCT00504660, NCT00508456, NCT00516282, NCT00516607, NCT00521482, NCT00525525, NCT00544284, NCT00548938, NCT00553150, NCT00555399, NCT00575887, NCT00590681, NCT00597402, NCT00597493, NCT00610571, NCT00612339, NCT00612651, NCT00612989, NCT00613093, NCT00615186, NCT00616005, NCT00619112, NCT00643825, NCT00650923, NCT00657267, NCT00662506, NCT00686725, NCT00687765, NCT00689221, NCT00704080, NCT00720564, NCT00723827, NCT00725010, NCT00734526, NCT00756106, NCT00761280, NCT00768911, NCT00770471, NCT00813943, NCT00817284, NCT00820963, NCT00841555, NCT00869401, NCT00883298, NCT00904852, NCT00915694, NCT00941460, NCT00943826, NCT00960492, NCT00967330, NCT00977431, NCT00979017, NCT01004874, NCT01019434, NCT01022918, NCT01026493, NCT01044966, NCT01062399, NCT01102595, NCT01110876, NCT01115491, NCT01120639, NCT01149109, NCT01180816, NCT01186406, NCT01209442, NCT01220271, NCT01242566, NCT01285414, NCT01294735, NCT01342757, NCT01345370, NCT01390571, NCT01402063, NCT01430351, NCT01473901, NCT01478321, NCT01480050, NCT01480479, NCT01502241, NCT01517776, NCT01587144, NCT01700569, NCT01752491, NCT01765088, NCT01777919, NCT01790503, NCT01800695, NCT01830101, NCT01837862, NCT01860638, NCT01907165, NCT02029573, NCT02052648, NCT02092038, NCT02177578, NCT02209948, NCT02227901, NCT02315534, NCT02330991, NCT02337426, NCT02343406, NCT02344355, NCT02364206, NCT02378532, NCT02502708, NCT02573324, NCT02590263, NCT02599090, NCT02617589, NCT02655601, NCT02661282, NCT02667587, NCT02715609, NCT02761070, NCT02770378, NCT02781792, NCT02871843, NCT02898012, NCT02928575, NCT02977780, NCT03018288, NCT03119064, NCT03139916, NCT03149575, NCT03174197, NCT03213002, NCT03224104, NCT03243461, NCT03246113, NCT03291990
Gossypol3503viability25375271
Ralimetinib11570805, 11539025mouse xenograft modelMAPK24356814
Binimetinib10288191orthotopic mouse model, radiosenitisationMAP2K28958992
OTX-0159936746orthotopic mouse modelBET27388964NCT02296476
Fingolimod107969invasion, migration25070489
Pimozide16362orthotopic mouse modelUSP1 26032834
Ibrutinib24821094mouse xenograft model, proliferationBruton's tyrosine kinase27564106, 28716053
Lonafarnib148195orthotopic mouse model, viabilityfarnesyl transferase2124639421735117, 23633392NCT00038493, NCT00083096, NCT00102648
AMG-92560202647proliferationFLT3, CDK426585571
Tocladesine100299apoptosis12449730
JNJ-101984099797370viabilityPLK124204733
Anisomycin253602viability21184646, 22684030, 23165409
MK-220624964624proliferationAkt22057914, 28320338NCT01295632
KU559335278396orthotopic mouse model, radiosenitisationATM25017126, 25205037
Oleuropein5281544invasion, proliferation27498673
Reversan229870626136652
Vincristine5978orthotopic mouse model, proliferationmicrotubule23165409, 24433351, 2838662120855843, 225004NCT00052455, NCT01837862
Proscillaridin A222154orthotopic mouse model, proliferation25400117, 27029345
Pitavastatin5282452viability24433351
Farnesylthiosalicylic acid329799768invasion, migration, proliferationRas16985068, 17178866
Terfenadine5405viability27029345
Fenbendazole3334proliferation23165409
Diclofenac3033migration, proliferation26485029
SF112666577114mouse xenograft modelPI3K25425962
Fluvoxamine5324346mouse model26988603
Cladribine20279viability24433351NCT00019071
CBL-013744519124orthotopic mouse model27370399
Navitoclax24978538viabilityBcl-2, Bcl-xL, BCL-w 24757258, 26474387, 29016820
Satraplatin6918220DNA
Afatinib10184653mouse xenograft modeltyrosine kinase25444177NCT00977431, NCT02423525
Glasdegib25166913smoothened
SSR128129E68853159radiosenitisationFGFR24953334
Epigallocathecin Gallate65064viability19894226
Fluvastatin446155proliferation23165409
Dactinomycin457193proliferation, viability23165409, 24433351
Peruvoside12314120proliferation23165409
Dorsomorphin11524144viability24419061
NVP-AEW54111476171mouse xenograft modelIGF-1R21659463
Embelin3218viability23514760, 23545899
Alisertib24771867mouse xenograft model, viabilityAurora A kinase24627220, 24879067, 25106428, 27797168, 29016820, 29396807
Wortmannin312145proliferationPI3K23724064
Camptothecin24360proliferation, viability23165409, 23736154, 27029345
Pomolic acid382831migration, viabilityReactive oxygen species28849227
Simvastatin54454proliferation23165409
Cabozantinib25102847mouse model, proliferationmultiple kinases21926191, 23484006NCT00704288, NCT00960492, NCT01068782, NCT02885324
Clorgiline4380proliferationMAO A26871599
Silibinin31553viability25750273
Podofilox10607proliferation23165409
Sinomenine5459308mouse model28891980
Silmitasertib24748573mouse xenograft modelCK224036851
Methotrexate126941proliferationDHFR2316540915735920NCT00082797, NCT00463008
Capecitabine60953Nucleic Acid Synthesis25290090NCT00504660, NCT00717197, NCT00959946, NCT02669173, NCT03213002
STX-01194253236mouse model, proliferationSTAT323612755, 24820265, 28716484
VAL-08315942827mouse xenograft model, proliferation28216618NCT01478178, NCT02717962, NCT03050736, NCT03149575
Ritonavir392622proliferation28319810NCT01095094, NCT02770378
Perilla alcohol10819proliferation25497898
AXL171772435mouse xenograft model, proliferationIGF-1R20150364, 23165409NCT01721577
GANT61421610viabilityGLI27894350
Infigratinib53235510FGFRNCT01975701
Guggulsterone53394010viability23548480
NVX-2079960374proliferation25361208
DB-07497177068345proliferationsurvivin23325792
Albendazole2082proliferation23165409
Xanthohumol639665apoptosis22111577
Lactacystin6610292mouse xenograft model, viabilityproteasome23569132
Doxazosin3157proliferation27123999
GSK1904529A25124816mouse modelIGF-1R26035416
WP106611210478proliferationJAK23612755NCT01904123
Tetraethylammonium5413proliferation25700359
GK92156682080orthotopic mouse modeltransglutaminase 228754668
Aldoxorubicin129636048mouse xenograft modelDNA intercalation25379024NCT02014844
Sanguinarine5154viability26472194
Fludarabine657237proliferation23165409NCT00990496
Propofol4943apoptosisReactive oxygen species28804952
Oroxindin3084961viability24970553
Cyclophosphamide2907DNA crosslinking15022289, 15735920NCT00047281, NCT00990496, NCT01403285, NCT01903330
BI253611364421orthotopic mouse model, viabilityPLK122415968, 23713868, 24204733
Itraconazole55283viability24433351NCT02770378
Linifanib11485656orthotopic rat modelreceptor tyrosine kinase22080168
Harmol68094viability23338618
Diazepinomicin9868980Ras22048878NCT00730262
PP24225243800migration, proliferationmTORC1, mTORC226719046
Mibefradil60663rat model, viabilityT-type calcium channels23198803, 2328741228371832NCT01480050, NCT02202993
LGK97446926973proliferationPORCN26222502
Dimethylaminomicheliolide54589107rat model25658946
Theobromine5429proliferationPDEs24547961
Tricetin5281701invasion, migration26245494
AG-12089699486, 71657455viabilityIDH1 29670690
Pegdinetanib86278317orthotopic mouse modelVEGFR22287570625388940
R42846215462proliferationAXL25980499
Artesunate105031radiosenitisation22560712
Pyrazolanthrone8515viabilityJNK23210245
Rucaparib9931954orthotopic mouse modelPARP26438157
Etoposide36462proliferation23165409, 24953561NCT00003996, NCT00047281, NCT00612430, NCT00613028, NCT00613223
Cytarabine6253proliferation23165409NCT01044966
Andrographolide5318517proliferation22634579
PI-1039884685radiosenitisation, viabilityPI3K, mTOR16697955, 22125077, 24418474
297157-92-72891837mouse xenograft model27993939
ML00253764 9842665proliferationmelanocortin receptor-428791594
Fasudil3547viabilityROCK26725099
Sirolimus5284616mouse xenograft model, viabilitymTOR23261661, 24043497, 25886314NCT00047073, NCT00509431, NCT00672243, NCT00821080
Vorinostat5311mouse model, radiosenitisation, viabilityhistone deacetylase17289901, 23962875, 25040548, 25275596, 26794465, 2786349019307505NCT00238303, NCT00555399, NCT00641706, NCT00762255, NCT01110876, NCT01266031, NCT01342757, NCT01378481, NCT01738646
Thalidomide542625239666, 25427949NCT00006358, NCT00014443, NCT00039468, NCT00047281, NCT00047294, NCT00049296, NCT00079092, NCT00112502, NCT00412542, NCT00521482
Doxorubicin31703proliferationDNA intercalation23165409, 24433351, 27029345, 27993939, 28612256NCT00002608, NCT00944801, NCT02758366
Nobiletin72344proliferation23546290
PLX-472024180719orthotopic mouse modelBRAF26023796
Crenolanib10366136viabilityPDGFRalpha25380967NCT02626364
Regorafenib11167602viability24911215NCT02926222
MLN492416720766orthotopic mouse modelNEDD8-activating enzyme25904638
Antroquinonol24875259mouse model26517117
PIK-7510275789apoptosisPI3K22802621
Larotrectinib46188928NCT02576431
ML29853393916invasion, migrationPLD223445448
Vemurafenib42611257BRAF24725538
Mitomycin5746proliferation23165409
Oligomycin78358496viability23523615
LY2940023973proliferationPI3K22086271, 25425962
Galunisertib10090485TGFBR124868575, 25424852, 25529192, 26902851NCT01220271, NCT01582269
Dabrafenib44462760BRAF26680369, 29039591, 29295876NCT02684058
Triptolide107985viability24433351
Rottlerin5281847proliferation27626499
Tetrandrine73078viability27909720
Irinotecan60838migration, viabilitytopoisomerase 124433351, 2683009129245310NCT00003301, NCT00003463, NCT00003484, NCT00005951, NCT00006025, NCT00010036, NCT00027612, NCT00039468, NCT00099125, NCT00132158, NCT00345163, NCT00352521, NCT00412542, NCT00433381, NCT00463073, NCT00562419, NCT00597402, NCT00611728, NCT00612638, NCT00616005, NCT00671801, NCT00734682, NCT00762255, NCT00817284, NCT00967330, NCT00979017, NCT00984438, NCT01017653, NCT01022918, NCT01308632, NCT01837862, NCT01999270, NCT02369367, NCT03119064
Epigallocathecin72277viability19894226
AEE78810297043proliferationmTOR15657358NCT00107237, NCT00116376
Trichostatin444732viabilityHDAC23564772, 24905315
Trametinib11707110viabilityMEK2543142329295876NCT02684058
Lanatoside C3879viability21184646, 27029345
Nisoldipine4499viability24433351
Ponatinib24826799mouse xenograft model, viabilitytyrosine kinase25378936NCT02478164
Ibuprofen3672migration, proliferation26485029
Shikonin479503proliferationtopoisomerase23840441, 24303074, 25688715, 25891245
Strophanthidin6185proliferation23165409
Glaucocalyxin A10471963proliferation24041957
Lovastatin53232proliferationHMG-CoA reductase25497898
Tipifarnib159324farnesyl protein transferase18725460, 20934264, 28988377NCT00005859, NCT00049387, NCT00050986, NCT00058097, NCT00209989, NCT00335764, NCT02227901
2-Hydroxyoleic acid9796304viability23133576, 23471028
Lorlatinib71731823mouse modelALK, ROS125733882
Acalabrutinib71226662tyrosine kinaseNCT02586857
NCL-173755256orthotopic mouse model, proliferationKDM1A23248157, 27893719
Gefitinib123631proliferation, radiosenitisation, viabilityEGFR14643025, 23724064, 23736154, 24876095, 2536825523182702NCT00014170, NCT00016991, NCT00025675, NCT00027625, NCT00042991, NCT00052208, NCT00085566, NCT00132158, NCT00238797, NCT01310855
LLP356935694viability23251006
Paclitaxel36314proliferation, viabilitymicrotubule23165409, 28962238NCT00019019, NCT00479765
Chaetocin11657687viabilityHistone lysine methyltransferases24905315
109511-58-23006531proliferationMEK1, MEK226748241
602306-29-616747683proliferationCDK1, CKD2, CDK926585571
Ixazomib25183872proteasomeNCT02630030
RG283356654642Temozolomide enhancerHDAC1, HDAC327632183
Bortezomib387447mouse xenograft model, proliferationproteasome23334228, 24093630, 24297065NCT00006773, NCT00544284, NCT00611325, NCT00641706, NCT00998010, NCT01435395
Salinomycin3085092apoptosis, mouse xenograft model, proliferation23165409, 28358414, 28498472
Cordycepin6303orthotopic mouse model26597532, 28068557
Bafetinib11387605tyrosine kinase23380277NCT01234740
Gartanin5281633proliferation27491646
Imatinib5291mouse model, viabilitymultiple kinases16274936, 23736154NCT00010049, NCT00039364, NCT00154375, NCT00171938, NCT00290771, NCT00354068, NCT00354913, NCT00387933, NCT00401024, NCT00615927
PF838025265312proliferationAutotaxin23300119
3-(3,4-dichlorophenyl)-1-(3,4-dimethylphenyl)-1-(5613034mouse xenograft modelmTORC228453552
ON12330056649281proliferation24568969
KU006379416736978viabilitymTOR22125077
Homidium3624proliferation23165409
Evofosfamide11984561DNA crosslinking29415215NCT02342379
Vinblastine13342proliferation23165409, 6690037
Dehydroxymethylepoxyquinomicin9881652mouse xenograft modelNFKB21968049
Adavosertib24856436mouse xenograft model, viabilityWEE121992793, 25609063
USL31156961879NCT02765165
Celastrol122724mouse xenograft model18343027, 19909582, 24810052
Salvianolic acid B6451084viability23842993
Dexanabinol107778NCT01654497
Tozasertib5494449mouse xenograft model, radiosenitisation, viabilityAurora kinase23636005, 25522764
6-HYDROXYQUINOLINE-4-CARBOXYLIC ACID71363454mouse modelproteasome26645398
TG10120916722832proliferationJAK226283544
Docetaxel148124viability24433351NCT00049296
Sorafenib216239proliferation, radiosenitisationTyrosone protein kinase23324350, 24139873, 24911215, 24965413, 2754227321954442, 23099651, 23898124, 24786603, 28988377NCT00093613, NCT00329719, NCT00335764, NCT00445588, NCT00597493, NCT00734526, NCT00884416, NCT01183663, NCT01434602, NCT01441388, NCT01817751, NCT02599090
Deguelin107935proliferation23165409
Olanzapine4585mouse xenograft model, proliferation25338992
Bendamustine6562821626071, 28204914NCT00823797
Fingolimod107970mouse xenograft model, viability25070489, 25939952NCT02490930
Atorvastatin60823proliferation, viabilityHMG-CoA reductase23165409, 28181188NCT02029573
Gambogic acid5353639proliferation23165409
PJ344858viabilityPARP25531448, 25576921
DWP0016 71660487viabilityHDAC23297003
Cerivastatin446156viability24433351
trans-ACUB16038368proliferationsEH22382785
Metformin4091proliferation24965413NCT01430351, NCT02780024, NCT03151772
Topotecan60700proliferation, radiosenitisation, viabilitytopoisomerase23165409, 24303074, 24433351, 28797568NCT00014443, NCT00541138, NCT00610571, NCT01004874, NCT01931098
Sertraline68617viability24433351NCT02770378
Procarbazine491520855843, 225004NCT00003293, NCT00003564, NCT00003788, NCT00004004, NCT00052455, NCT00079092, NCT01737346
Caudatin72948694proliferation25860846
AZD148016659841orthotopic mouse model, proliferationJAK1, JAK222027691
Sevoflurane5206invasion, migration27840895
NCD-38102222767ortothopic mouse modelKDM1A27893719
Pseudolaric acid B6393431apoptosis22778780
Entrectinib25141092mouse modelTrk, ROS1, ALK28695888
Iniparib979606826285766NCT00687765
PD1730741401migration, proliferationFGFR19340397, 26883759
Pyrvinium5281035mouse xenograft model, proliferation, viability23165409, 26152745, 27029345
Apatinib11315474tyrosine kinase29245310
Xyloketal B10980896proliferation, viability25913706
Mepacrine237viability25490024, 27029345
Dinaciclib46926350proliferationCDK1, CDK2, CDK5, CDK926585571
761437-28-99934347radiosenitisation, viabilityFAK 25625667
Pazopanib10113978tyrosine kinase20200024, 23363814NCT00350727, NCT00459381, NCT01392352, NCT01931098, NCT02331498, NCT03275558
CC-22358298316mTORNCT01177397
Disufenton sodium6440181orthotopic mouse model, rat model23328810, 26248280
Carvacrol10364proliferation, viability25913706
BDBM8669157340709proliferationACAT126252415
Alantolactone72724viability22837216
Oxaliplatin9887054mouse xenograft model, radiosenitisationDNA17383816, 18329790
7-Ethyl-10-hydroxycamptothecin104842viabilitytopoisomerase28963609
MRK00392043122, 15953832orthotopic mouse model, proliferationgamma secretase23630166, 25293440, 25920606, 26613556
GDC-008457384863orthotopic mouse modelPI3K, mTOR27638506NCT01547546
AZD805525262965mouse xenograft modelmTOR25316808NCT01316809
Theophylline2153viabilityPDE22227470
Everolimus6442177mTOR2537128923725999, 25526733NCT00085566, NCT00107237, NCT00387400, NCT00515086, NCT00553150, NCT01062399, NCT01434602, NCT01508104
Dacomitinib11511120viabilityErbB24658109, 25939761NCT01112527, NCT01520870
Mitoxantrone4212proliferation, viabilityTopoisomerase21184646, 23165409
1616632-77-973777259viability26474387, 28767654NCT02038699, NCT02525692
Adenosine dialdehyde99920proliferation23353701
Crizotinib11626560mouse xenograft model, viability23556031, 26517812NCT00939770, NCT01441388, NCT02270034
7-Hydroxystaurosporine72271mouse xenograft model24810059
Tanespimycin6505803viabilityHsp9026185541, 28542269
Romidepsin5352062proliferationhistone deacetylases15024582, 27685789NCT00085540
Visudyne5362420proliferation28790340
Sunitinib5329102mouse model, prolifrationReceptor tyrosine kinases22449730, 2545801522832897, 24311637, 24424564NCT00499473, NCT00535379, NCT00606008, NCT00864864, NCT00923117, NCT01100177, NCT01441388, NCT02928575, NCT03025893, NCT03275558
LEQ50645100669smoothened
Daporinad6914657viabilityNAMPT22119381, 26601421
Arctigenin64981proliferation28356992
4506-66-578260migration, orthotopic mouse model, proliferationFAK 23243059, 26883759
KPT25157519758viabilityCRM125366336
Teniposide452548proliferation23165409
10-Hydroxycamptothecin97226proliferation23165409
Germacrone6436348proliferation24889088
Colchicine6167proliferation23165409
Perifosine148177viabilityAkt, PI3K16103096, 24065522
Otx-00811953346viabilitygalectin-123978989
Bosutinib5328940Src25290090, 25411098NCT00959946, NCT01331291
Tandutinib3038522mouse xenograft model, transgenic mouse modelmultiple kinases22146535, 23638177
Amlexanox2161proliferationIKBKE29048430
Foretinib42642645mouse modelc-Met, VEGFR224658326
SGX-52324779724orthotopic mouse modelc-Met20015006
Monensin441145proliferation, viability23165409, 27029345
Dihydroartemisinin456410proliferation26722323
2-Amino-3H-phenoxazin-3-one72725viability24008433
LOXO-195129103609TRK tyrosine kinaseNCT03215511
PD03259019826528mouse xenograft model, viabilityMEK22573716, 25431423
BMS-53692411353973mouse modelIGF-1R, IR25897243
Digitoxigenin4369270viability27029345
Hispolon53395354viability28618133
Lomustine3950orthotopic mouse modelalkylating agent27474153, 2867219520124186, 20855843, 23940216, 24958095NCT00003788, NCT00052455, NCT00068952, NCT00295815, NCT00503204, NCT00504660, NCT00761280, NCT00777153, NCT00948389, NCT01067469, NCT01149109, NCT01562197, NCT01582269, NCT01737346, NCT01860638, NCT01934361, NCT02343406, NCT02765165, NCT02926222, NCT03025893, NCT03149575
Roscovitine160355proliferationCDK26151768
AZD-745125115967
Terameprocol476861proliferation2329939022323663NCT00404248
Emetine10219proliferation23165409
Ribociclib44631912CDK4, CDK6NCT02345824, NCT02933736
Thymoquinone10281proliferation24039814
Daunorubicin30323proliferation23165409
Gamma-Secretase Inhibitor IX5311272proliferation, viabilitygamma-secretase23736154, 25063285
XL76549867926mouse xenograft modelPI3K, mTOR2131720826019185NCT00704080, NCT01240460
BMS-77760724794418mouse xenograft modelAXL26848524
RO492909749867930mouse xenograft modelGamma secretase25486598NCT01122901, NCT01131234, NCT01189240, NCT01269411
ML29956593054invasion, migrationPLD1, PLD223445448
NMS-P71544556162mouse xenograft model, radiosenitisation25722303
Luteolin5280445migration28927111
Disulfiram3117proliferation23165409NCT01777919, NCT01907165, NCT02678975, NCT02715609, NCT02770378, NCT03151772
Erdafitinib67462786FGFR
CPI-45578426698viabilityhistone lysine demethylase28432280
Apigenin5280443viability19894226
Capmatinib25145656mouse xenograft modelcMET21918175NCT01324479, NCT01870726, NCT02386826
Fotemustine104799DNA alkylation27165580NCT01474239
Digoxigenin15478proliferation, viability23165409, 27029345
Golvatinib16118392c-Met, VEGFR2NCT01433991
Rolipram5092mouse xenograft model, proliferationPDE412432276, 17234775, 28202289
Valproic Acid3121radiosenitisation, viability23253698, 24348849, 25275596, 27802437, 2896223823523186
Isoliquiritigenin638278viabilitytopoisomerase23229626, 26722447
PX-8669849735mouse xenograft modelPI3K2015680325605819NCT01259869
Transcrocetinate sodium10287099rat model18447715
Semustine5198DNA alkylation225004, 7013978NCT00335075
Altiratinib54576299mouse xenograft modelc-Met, TIE2, VEGFR226965451
Clioquinol2788viability26725099
Puromycin439530proliferation23165409
Pargyline4688proliferation23248157
AT1338711955716mouse xenograft model, zebrafish xenograft modelHsp9028679777
Selumetinib10127622mouse xenograft modelsMEK1, MEK220806365, 22573716
Dasatinib3062316orthotopic mouse modelSrc1909889922407177, 25758746NCT00423735, NCT00609999, NCT00869401, NCT00895960, NCT00948389, NCT02661113
BAY 11-70825353431proliferationNFKB26137111
Hydroxyurea3657RNR19904263NCT00019058, NCT00154375, NCT00290771, NCT00354913, NCT00387933, NCT00613054, NCT00613132, NCT00615927
PF-42924223661637viabilitySite-1 protease28645614
Dovitinib9886808proliferationmultiple kinases2850078627100354NCT01753713, NCT01972750
Bibu 136146861539apoptosisEGFR22753156
Quercetin5280343viability24379902, 24902789