GBM Drug Bank

Drugs for Glioblastoma

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Compound Mode of Action (target)


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CompoundPubChem CIDReported EffectMoAPMIDClinical PMIDClinical Trials
Captopril44093invasion8572589NCT02770378
AT1338711955716mouse xenograft model, zebrafish xenograft modelHsp9028679777
Enzastaurin176167proliferationPKCbeta1991340820124186, 22291006NCT00295815, NCT00402116, NCT00509821, NCT00516607, NCT00586508
Talampanel16450919636006, 20143438NCT00062504, NCT00064363, NCT00267592
Triptolide107985viability24433351
Isoliquiritigenin638278viabilitytopoisomerase23229626, 26722447
Caudatin72948694proliferation25860846
Foretinib42642645mouse modelc-Met, VEGFR224658326
Clioquinol2788viability26725099
Gedatolisib44516953viabilityPI3K, mTOR24658109
USL31156961879NCT02765165
Dihydroartemisinin456410proliferation26722323
Fasudil3547viabilityROCK26725099
UMI-77992586viabilityMcl-128337703
AZD1152-HQPA16007391mouse xenograft model, proliferationAurora B22382783
Juglone 3806proliferation28388894, 28791366
Ascochlorin11258227invasion, migration28569433
109511-58-23006531proliferationMEK1, MEK226748241
Honokiol72303mouse xenograft model, viability25106108, 25763821, 27064011
Alisertib24771867mouse xenograft model, viabilityAurora A kinase24627220, 24879067, 25106428, 27797168, 29016820, 29396807
781661-94-711178236apoptosis, migration, proliferationSurvivin22770110, 23325792, 25201484, 27805285
Hypericin5281051viability2406606021456013
PF-0684000323063810
Fludarabine657237proliferation23165409NCT00990496
Fucoxanthin5281239mouse xenograft model, proliferation27394418
Hsp-99046216556, 16226182, 68275964apoptosis, mouse xenograft model, radiosenitisationHsp9023448094, 24500492
Hydroxyurea3657RNR19904263NCT00019058, NCT00154375, NCT00290771, NCT00354913, NCT00387933, NCT00613054, NCT00613132, NCT00615927
MRK00392043122, 15953832orthotopic mouse model, proliferationgamma secretase23630166, 25293440, 25920606, 26613556
PP24225243800migration, proliferationmTORC1, mTORC226719046
Alvespimycin5288674radiosenitisationHsp9024418474
Pyrazolanthrone8515viabilityJNK23210245
SF112666577114mouse xenograft modelPI3K25425962
Nilotinib644241
Teniposide452548proliferation23165409
GSK1838705A25182616mouse xenograft modelIGF-1R26238593
Apatinib11315474tyrosine kinase29245310
Artesunate105031radiosenitisation22560712
Convallatoxin441852proliferation23165409
4506-66-578260migration, orthotopic mouse model, proliferationFAK 23243059, 26883759
Tpi-287118797983viabilityMicrotubule29396807
JIB-046519698viabilityhistone lysine demethylase28432280
Antroquinonol24875259mouse model26517117
Puromycin439530proliferation23165409
Daporinad6914657viabilityNAMPT22119381, 26601421
602306-29-616747683proliferationCDK1, CKD2, CDK926585571
Navitoclax24978538viabilityBcl-2, Bcl-xL, BCL-w 24757258, 26474387, 29016820
Sertraline68617viability24433351NCT02770378
Pexidartinib25151352NCT01349036, NCT01790503
Riluzole5070proliferation23724064
Satraplatin6918220DNA
Idarubicin42890viability24433351
NVX-2079960374proliferation25361208
Alantolactone72724viability22837216
9-ING-4144582816orthotopic mouse modelGlycogen Synthase Kinase-328672195
TGX-2219907093proliferationp110-beta29048665
NSC23766409805viabilityRAC123736154
JNJ-101984099797370viabilityPLK124204733
Acetazolamide1986proliferationcarbonic anhydrase27702686
NMS-P71544556162mouse xenograft model, radiosenitisation25722303
TG0216739650orthotopic mouse model, viability29254993NCT02942264, NCT03224104
Ponatinib24826799mouse xenograft model, viabilitytyrosine kinase25378936NCT02478164
Acalabrutinib71226662tyrosine kinaseNCT02586857
Transcrocetinate sodium10287099rat model18447715
1134156-31-225195348proliferationHsp70, Hsp9026185541
BMS-77760724794418mouse xenograft modelAXL26848524
Sorafenib216239proliferation, radiosenitisationTyrosone protein kinase23324350, 24139873, 24911215, 24965413, 2754227321954442, 23099651, 23898124, 24786603, 28988377NCT00093613, NCT00329719, NCT00335764, NCT00445588, NCT00597493, NCT00734526, NCT00884416, NCT01183663, NCT01434602, NCT01441388, NCT01817751, NCT02599090
Carmustine2578DNA alkylation24958095, 7013978NCT00002545, NCT00003176, NCT00003348, NCT00003417, NCT00003463, NCT00003484, NCT00003788, NCT00003876, NCT00003996, NCT00004028, NCT00004688, NCT00004892, NCT00005081, NCT00005637, NCT00005855, NCT00006386, NCT00006656, NCT00009854, NCT00017147, NCT00027612, NCT00046878, NCT00068952, NCT00076986, NCT00086879, NCT00362921, NCT00548938, NCT00761280, NCT00795665, NCT00984438, NCT01186406, NCT01310868, NCT01656980
NKTR-1027130072725935109
Adenosine dialdehyde99920proliferation23353701
Tamoxifen2733526viabilityER25554223NCT00002608, NCT00006388, NCT00492687, NCT00541138
Sonidegib24775005viabilitysmoothened23482671NCT01576666
LY3414959819927proliferation23724064
Epigallocathecin Gallate65064viability19894226
Trametinib11707110viabilityMEK2543142329295876NCT02684058
Forskolin47936proliferationadenylate cyclase24649161, 9484714
Sulfasalazine5359476proliferation, radiosenitisation25798841, 25937318, 28929335
AMG-92560202647proliferationFLT3, CDK426585571
Vemurafenib42611257BRAF24725538
Olanzapine4585mouse xenograft model, proliferation25338992
Salinomycin3085092apoptosis, mouse xenograft model, proliferation23165409, 28358414, 28498472
2-Amino-3H-phenoxazin-3-one72725viability24008433
Savolitinib68289010, 68287718mouse xenograft modelc-Met25148209
Cladribine20279viability24433351NCT00019071
Digoxin2724385proliferation, viability21184646, 23165409
Pegdinetanib86278317orthotopic mouse modelVEGFR22287570625388940
Docetaxel148124viability24433351NCT00049296
Sevoflurane5206invasion, migration27840895
Birinapant49836020viabilityIAP26657652
Carvacrol10364proliferation, viability25913706
CBL-013744519124orthotopic mouse model27370399
Vincristine5978orthotopic mouse model, proliferationmicrotubule23165409, 24433351, 2838662120855843, 225004NCT00052455, NCT01837862
717906-29-111598628migration, proliferationFAK 26883759
Chlorpromazine2726mouse xenograft model, orthotopic mouse model, viability23689352, 28455961
Tanespimycin6505803viabilityHsp9026185541, 28542269
Indirubin Derivative E8046419764proliferation26386687
Lovastatin53232proliferationHMG-CoA reductase25497898
Theophylline2153viabilityPDE22227470
Fenbendazole3334proliferation23165409
Casticin5315263viability23816816
Gartanin5281633proliferation27491646
Simvastatin54454proliferation23165409
Ceritinib57379345NCT02605746
TG10120916722832proliferationJAK226283544
Trichostatin444732viabilityHDAC23564772, 24905315
Bibu 136146861539apoptosisEGFR22753156
Glaucocalyxin A10471963proliferation24041957
Patulin4696proliferation23165409
SH5-0772550504mouse xenograft model, viabilitySTAT326088127
MK-8863651377viabilityLipoxygenase 23261452
Oligomycin78358496viability23523615
Ribociclib44631912CDK4, CDK6NCT02345824, NCT02933736
Tnp-470369976angiogenesis27542173
CPI-45578426698viabilityhistone lysine demethylase28432280
Lapatinib208908proliferationEGFR, HER22491121523363814NCT00095940, NCT00099060, NCT00107003, NCT00350727
SH-4-5472188643orthotopic mouse model, proliferationSTAT324900612
Terfenadine5405viability27029345
Midazolam4192proliferation27629139
Dinaciclib46926350proliferationCDK1, CDK2, CDK5, CDK926585571
Cryptotanshinone160254mouse xenograft model28492557
Farnesylthiosalicylic acid329799768invasion, migration, proliferationRas16985068, 17178866
8-Bromo-cyclic AMP32014proliferation24649161, 9484714
Dexanabinol107778NCT01654497
Andrographolide5318517proliferation22634579
Gossypol3503viability25375271
Chaetocin11657687viabilityHistone lysine methyltransferases24905315
GSK J471729975proliferationJMJD328978140
Nisoldipine4499viability24433351
AG-12089699486, 71657455viabilityIDH1 29670690
Tetraethylammonium5413proliferation25700359
Sulindac sulfide5352624proliferation23280445
Plumbagin10205proliferation, viability23165409, 25528634
Fluorouracil3385viabilityNucleic Acid Synthesis24391839, 6690037NCT01183663
R42846215462proliferationAXL25980499
Golvatinib16118392c-Met, VEGFR2NCT01433991
GDC-008457384863orthotopic mouse modelPI3K, mTOR27638506NCT01547546
Oroxindin3084961viability24970553
Paclitaxel36314proliferation, viabilitymicrotubule23165409, 28962238NCT00019019, NCT00479765
Celecoxib2662viability21847707, 2328044525239666NCT00047281, NCT00047294, NCT00112502, NCT00504660, NCT02770378
KPT27671496742orthotopic mouse model, viabilityCRM125366336
Genistein5280961viability19894226
7-Hydroxystaurosporine72271mouse xenograft model24810059
A-96649216666333radiosenitisationPARP28797568
Fingolimod107969invasion, migration25070489
Thapsigargin446378viabilitySERCA27993939
LOXO-195129103609TRK tyrosine kinaseNCT03215511
BIX-0129425150857viabilityhistone methyltransferase24905315, 27748874, 27934912
Palomid 52911998575orthotopic mouse modelmTOR23436212
Altiratinib54576299mouse xenograft modelc-Met, TIE2, VEGFR226965451
Apigenin5280443viability19894226
Capecitabine60953Nucleic Acid Synthesis25290090NCT00504660, NCT00717197, NCT00959946, NCT02669173, NCT03213002
Daunorubicin30323proliferation23165409
3-Deazaneplanocin73087viabilityHDAC24905315
Tetrandrine73078viability27909720
8-Hydroxy-2-methyl-1H-quinazolin-4-one63306radiosenitisationPARP-125182801
Guggulsterone53394010viability23548480
carnosol442009proliferation26939786
Caffeine2519migration, orthotopic mouse model25011614, 27260469
Pomolic acid382831migration, viabilityReactive oxygen species28849227
Cytarabine6253proliferation23165409NCT01044966
4egi-15717952proliferationEIF4E26220902
Fluvoxamine5324346mouse model26988603
AXL171772435mouse xenograft model, proliferationIGF-1R20150364, 23165409NCT01721577
Palbociclib5330286mouse xenograft modelCDK4, CDK6624098593, 26149830, 26354993, 27370397, 28903422NCT02255461, NCT03158389
Mitoxantrone4212proliferation, viabilityTopoisomerase21184646, 23165409
Emetine10219proliferation23165409
LLP356935694viability23251006
Cabazitaxel9854073viabilityMicrotubule27203678NCT01740570, NCT01866449
D6094234241proliferation28802717
Bendamustine6562821626071, 28204914NCT00823797
Xyloketal B10980896proliferation, viability25913706
Bortezomib387447mouse xenograft model, proliferationproteasome23334228, 24093630, 24297065NCT00006773, NCT00544284, NCT00611325, NCT00641706, NCT00998010, NCT01435395
7-Ethyl-10-hydroxycamptothecin104842viabilitytopoisomerase28963609
ML00253764 9842665proliferationmelanocortin receptor-428791594
Punicalagin44584733viability24077634
NVP-AEW54111476171mouse xenograft modelIGF-1R21659463
Lactacystin6610292mouse xenograft model, viabilityproteasome23569132
Procarbazine491520855843, 225004NCT00003293, NCT00003564, NCT00003788, NCT00004004, NCT00052455, NCT00079092, NCT01737346
Pyrvinium5281035mouse xenograft model, proliferation, viability23165409, 26152745, 27029345
Omacetaxine3628viability24433351
Erdafitinib67462786FGFR
Gefitinib123631proliferation, radiosenitisation, viabilityEGFR14643025, 23724064, 23736154, 24876095, 2536825523182702NCT00014170, NCT00016991, NCT00025675, NCT00027625, NCT00042991, NCT00052208, NCT00085566, NCT00132158, NCT00238797, NCT01310855
Embelin3218viability23514760, 23545899
Dasatinib3062316orthotopic mouse modelSrc1909889922407177, 25758746NCT00423735, NCT00609999, NCT00869401, NCT00895960, NCT00948389, NCT02661113
Ridaforolimus11520894mTOR22037923NCT00087451, NCT01295632
Selumetinib10127622mouse xenograft modelsMEK1, MEK220806365, 22573716
Schizandrin B158103invasion, proliferation27977512
BAY 11-70825353431proliferationNFKB26137111
Cardamonin641785mouse model, proliferation26150336
Mibefradil60663rat model, viabilityT-type calcium channels23198803, 2328741228371832NCT01480050, NCT02202993
Vindesine40839viability24433351
Sunitinib5329102mouse model, prolifrationReceptor tyrosine kinases22449730, 2545801522832897, 24311637, 24424564NCT00499473, NCT00535379, NCT00606008, NCT00864864, NCT00923117, NCT01100177, NCT01441388, NCT02928575, NCT03025893, NCT03275558
Olaparib23725625viabilityPARP25531448, 25576921, 26794465NCT01390571
Terameprocol476861proliferation2329939022323663NCT00404248
GSK1904529A25124816mouse modelIGF-1R26035416
Vatalanib151194orthotopic mouse modelVEGFR15271251NCT00128700, NCT00387933
Ouabain439501viability21184646
Demethoxycurcumin5469424mouse xenograft model27757851
Ralimetinib11570805, 11539025mouse xenograft modelMAPK24356814
Xanthohumol639665apoptosis22111577
Antimycin A14957proliferation23165409
Afatinib10184653mouse xenograft modeltyrosine kinase25444177NCT00977431, NCT02423525
Aldoxorubicin129636048mouse xenograft modelDNA intercalation25379024NCT02014844
Atorvastatin60823proliferation, viabilityHMG-CoA reductase23165409, 28181188NCT02029573
XL76549867926mouse xenograft modelPI3K, mTOR2131720826019185NCT00704080, NCT01240460
Doxorubicin31703proliferationDNA intercalation23165409, 24433351, 27029345, 27993939, 28612256NCT00002608, NCT00944801, NCT02758366
Scriptaid5186viabilityHDAC26032687
Albendazole2082proliferation23165409
Irinotecan60838migration, viabilitytopoisomerase 124433351, 2683009129245310NCT00003301, NCT00003463, NCT00003484, NCT00005951, NCT00006025, NCT00010036, NCT00027612, NCT00039468, NCT00099125, NCT00132158, NCT00345163, NCT00352521, NCT00412542, NCT00433381, NCT00463073, NCT00562419, NCT00597402, NCT00611728, NCT00612638, NCT00616005, NCT00671801, NCT00734682, NCT00762255, NCT00817284, NCT00967330, NCT00979017, NCT00984438, NCT01017653, NCT01022918, NCT01308632, NCT01837862, NCT01999270, NCT02369367, NCT03119064
Karenitecin148202radiosenitisationtopoisomerase28111642NCT00014521
Ixazomib25183872proteasomeNCT02630030
Milciclib16718576proliferation23347136
Wortmannin312145proliferationPI3K23724064
Crenolanib10366136viabilityPDGFRalpha25380967NCT02626364
GSK332659590241742NCT02783300
Disufenton sodium11603334rat model23328810
BDBM8669157340709proliferationACAT126252415
Monensin441145proliferation, viability23165409, 27029345
CC-11558298318NCT01353625, NCT02977780
Lorlatinib71731823mouse modelALK, ROS125733882
Shikonin479503proliferationtopoisomerase23840441, 24303074, 25688715, 25891245
PCI-2478111749858proliferationHDAC25505847
Panobinostat6918837HDAC21984064, 25572329, 26821711NCT00848523, NCT01115036
Vinblastine13342proliferation23165409, 6690037
Veliparib11960529orthotopic mouse model, radiosenitisationPARP23510353, 28314386NCT00770471, NCT01026493
LGK97446926973proliferationPORCN26222502
GDC-094117755052mouse xenograft model, radiosenitisation, viabilityPI3K 23427298, 24757258, 28147244
Eflornithine3009proliferationornithine decarboxylase25935110
WP106611210478proliferationJAK23612755NCT01904123
Lomustine3950orthotopic mouse modelalkylating agent27474153, 2867219520124186, 20855843, 23940216, 24958095NCT00003788, NCT00052455, NCT00068952, NCT00295815, NCT00503204, NCT00504660, NCT00761280, NCT00777153, NCT00948389, NCT01067469, NCT01149109, NCT01562197, NCT01582269, NCT01737346, NCT01860638, NCT01934361, NCT02343406, NCT02765165, NCT02926222, NCT03025893, NCT03149575
MAZ519839842proliferation25268128
Dovitinib9886808proliferationmultiple kinases2850078627100354NCT01753713, NCT01972750
Gamma-Secretase Inhibitor IX5311272proliferation, viabilitygamma-secretase23736154, 25063285
Repaglinide65981orthotopic mouse model28476618
Romidepsin5352062proliferationhistone deacetylases15024582, 27685789NCT00085540
YU238259121473004proliferationHDR26116172
Oxibendazole4622proliferation23165409
Ruxolitinib25126798JAK
Anthothecol21596360proliferation23165409
JQ149871817proliferation, rat xenograft modelBET25056450, 27388964
Tivozanib9911830invasion, proliferationVEGFR28287096NCT01846871
Digitoxin441207proliferation, viability21184646, 23165409
Vorinostat5311mouse model, radiosenitisation, viabilityhistone deacetylase17289901, 23962875, 25040548, 25275596, 26794465, 2786349019307505NCT00238303, NCT00555399, NCT00641706, NCT00762255, NCT01110876, NCT01266031, NCT01342757, NCT01378481, NCT01738646
Neratinib9915743orthotopic mouse model, viabilityHer2, EGFR26023796NCT02977780
Lenvatinib9823820mouse modelmultiple kinases28901423NCT01433991
Roscovitine160355proliferationCDK26151768
Niclosamide4477proliferation, viability23165409, 27029345
RO492909749867930mouse xenograft modelGamma secretase25486598NCT01122901, NCT01131234, NCT01189240, NCT01269411
Entrectinib25141092mouse modelTrk, ROS1, ALK28695888
MK-220624964624proliferationAkt22057914, 28320338NCT01295632
Cabozantinib25102847mouse model, proliferationmultiple kinases21926191, 23484006NCT00704288, NCT00960492, NCT01068782, NCT02885324
PD03259019826528mouse xenograft model, viabilityMEK22573716, 25431423
STX-01194253236mouse model, proliferationSTAT323612755, 24820265, 28716484
GK92156682080orthotopic mouse modeltransglutaminase 228754668
Pimozide16362orthotopic mouse modelUSP1 26032834
AZD148016659841orthotopic mouse model, proliferationJAK1, JAK222027691
THZ173602827orthotopic mouse modelCDK728504693
RapaLink-1121231411proliferationmTOR28292440
Imiquimod57469orthotopic mouse modeltoll-like receptor 721389872NCT01403285
Buparlisib16654980mouse xenograft model, proliferation, radiosenitisationPI3K22065080, 24500492, 24741074, 24900266, 25431423, 26846842, 27283525, 27363276NCT01339052, NCT01349660, NCT01473901, NCT01576666, NCT01870726, NCT01934361
Isobutylmethylxanthine3758proliferation, viabilityPDE22227470, 9484714
Deguelin107935proliferation23165409
Podofilox10607proliferation23165409
Infigratinib53235510FGFRNCT01975701
Volasertib10461508radiosenitisation, viabilityPLK124204733, 29535822
5-Nonyloxytryptamine1797viability24433351
Alexidine102678, 2090viability27029345
ML29956593054invasion, migrationPLD1, PLD223445448
Pamiparib71602594NCT03150862
AZD805525262965mouse xenograft modelmTOR25316808NCT01316809
Curcumin969516proliferation26046466
NCL-173755256orthotopic mouse model, proliferationKDM1A23248157, 27893719
PLX-472024180719orthotopic mouse modelBRAF26023796
Lys0170673567viability22566612
Tipifarnib159324farnesyl protein transferase18725460, 20934264, 28988377NCT00005859, NCT00049387, NCT00050986, NCT00058097, NCT00209989, NCT00335764, NCT02227901
Sinomenine5459308mouse model28891980
Bosutinib5328940Src25290090, 25411098NCT00959946, NCT01331291
Telomestatin443590viabilityG-quadruplexes26845351
Denbinobin10423984viability23123054
Dibutyryl cAMP9687proliferation9484714
Ritonavir392622proliferation28319810NCT01095094, NCT02770378
Proscillaridin A222154orthotopic mouse model, proliferation25400117, 27029345
Rucaparib9931954orthotopic mouse modelPARP26438157
SSR128129E68853159radiosenitisationFGFR24953334
Iniparib979606826285766NCT00687765
PIK-7510275789apoptosisPI3K22802621
Erlotinib176870proliferationEGFR2603268722407177, 24470557, 24637230NCT00030498, NCT00039494, NCT00045110, NCT00054496, NCT00086879, NCT00112736, NCT00124657, NCT00187486, NCT00227032, NCT00274833, NCT00301418, NCT00335764, NCT00337883, NCT00387894, NCT00445588, NCT00509431, NCT00525525, NCT00609999, NCT00671970, NCT00672243, NCT00720356, NCT01103375, NCT01110876, NCT01257594
Amsacrine2179proliferation23165409
Metformin4091proliferation24965413NCT01430351, NCT02780024, NCT03151772
Abt-73711228183viabilityBcl-222393246
Dactolisib11977753orthotopic mouse mode, proliferation, radiosenitisationPI3K, mTOR19671762, 23603977, 24366691, 25431423, 26188279, 27542970, 27553832NCT01508104
Ibuprofen3672migration, proliferation26485029
Fingolimod107970mouse xenograft model, viability25070489, 25939952NCT02490930
Pseudolaric acid B6393431apoptosis22778780
Disufenton sodium6440181orthotopic mouse model, rat model23328810, 26248280
JS-K9572720mouse xenograft model23370169, 28653883
Cerivastatin446156viability24433351
Epigallocathecin72277viability19894226
Disulfiram3117proliferation23165409NCT01777919, NCT01907165, NCT02678975, NCT02715609, NCT02770378, NCT03151772
SGX-52324779724orthotopic mouse modelc-Met20015006
Itraconazole55283viability24433351NCT02770378
GANT61421610viabilityGLI27894350
Camptothecin24360proliferation, viability23165409, 23736154, 27029345
Galunisertib10090485TGFBR124868575, 25424852, 25529192, 26902851NCT01220271, NCT01582269
Pazopanib10113978tyrosine kinase20200024, 23363814NCT00350727, NCT00459381, NCT01392352, NCT01931098, NCT02331498, NCT03275558
Diazepinomicin9868980Ras22048878NCT00730262
72926-24-02930014proliferationEg528965307
CUDC-10124756910proliferationEGFR, HDAC26032687
Carboplatin10339178DNA28534153NCT00005976, NCT00010036, NCT00014105, NCT00021307, NCT00352313, NCT00492687, NCT00541138, NCT00635557, NCT00650949, NCT00995007, NCT01317212, NCT01386710, NCT01837862, NCT01934361, NCT03149575
Fluvastatin446155proliferation23165409
Dacomitinib11511120viabilityErbB24658109, 25939761NCT01112527, NCT01520870
ON12330056649281proliferation24568969
Rolipram5092mouse xenograft model, proliferationPDE412432276, 17234775, 28202289
Oxamate3017661radiosenitisationlactate dehydrogenase28756228
3-BrOP11513992viability23132831
Linifanib11485656orthotopic rat modelreceptor tyrosine kinase22080168
Naringin442428invasion, migration26474590
Peruvoside12314120proliferation23165409
Chloroquine2719radiosenitisation, viability25434381, 2764444217350410NCT00224978, NCT02378532, NCT02432417, NCT03243461
487020-03-11936439mouse xenograft modelPBK26081429
Mebendazole4030orthotopic mouse model, proliferation23165409, 28386621NCT01729260, NCT01837862, NCT02644291
Tocladesine100299apoptosis12449730
PJ344858viabilityPARP25531448, 25576921
Thalidomide542625239666, 25427949NCT00006358, NCT00014443, NCT00039468, NCT00047281, NCT00047294, NCT00049296, NCT00079092, NCT00112502, NCT00412542, NCT00521482
trans-ACUB16038368proliferationsEH22382785
Valproic Acid3121radiosenitisation, viability23253698, 24348849, 25275596, 27802437, 2896223823523186
Rottlerin5281847proliferation27626499
Ancitabine25051proliferation23165409
Tricetin5281701invasion, migration26245494
AZD-745125115967
Gambogenic Acid10794070apoptosis21879332
beta-Peltatin92122proliferation23165409
CC-22358298316mTORNCT01177397
Perifosine148177viabilityAkt, PI3K16103096, 24065522
Cathepsin S Inhibitor16760355viabilityCathepsin S24875536
Phenformin8249orthotopic mouse model27486821
AZD201425262792radiosenitisationmTOR24311635NCT02619864
Crizotinib11626560mouse xenograft model, viability23556031, 26517812NCT00939770, NCT01441388, NCT02270034
Flavopiridol5287969mouse model, radiosenitisationCDK23943501, 27461656, 28111642
Ardipusilloside I197641proliferation24984215
Germacrone6436348proliferation24889088
3-(3,4-dichlorophenyl)-1-(3,4-dimethylphenyl)-1-(5613034mouse xenograft modelmTORC228453552
Cordycepin6303orthotopic mouse model26597532, 28068557
Bufalin 9547215viability28787697
DWP0016 71660487viabilityHDAC23297003
Deoxyglucose108223radiosenitisationglycolysis 28756228
2-Hydroxyoleic acid9796304viability23133576, 23471028
Astemizole2247viability27029345
Evofosfamide11984561DNA crosslinking29415215NCT02342379
Caffeic acid phenethyl ester5281787apoptosis, proliferation14637186, 23165409, 24997497
OTX-0159936746orthotopic mouse modelBET27388964NCT02296476
Dimethylaminomicheliolide54589107rat model25658946
UNC202573425588orthotopic mouse modelMER, FLT327783662, 28605477
Hispolon53395354viability28618133
Homidium3624proliferation23165409
Dabrafenib44462760BRAF26680369, 29039591, 29295876NCT02684058
Clorgiline4380proliferationMAO A26871599
Silibinin31553viability25750273
Diclofenac3033migration, proliferation26485029
Perilla alcohol10819proliferation25497898
Tesevatinib10458325NCT02844439
Reversan229870626136652
Mitomycin5746proliferation23165409
Digitoxigenin4369270viability27029345
PI-1039884685radiosenitisation, viabilityPI3K, mTOR16697955, 22125077, 24418474
6-HYDROXYQUINOLINE-4-CARBOXYLIC ACID71363454mouse modelproteasome26645398
PF-42924223661637viabilitySite-1 protease28645614
AC1MMYR23246569orthotopic mouse model, proliferation23811941
NBQX3272524proliferationAMPA23724064
Clofazimine2794viability24433351
Doxazosin3157proliferation27123999
Digoxigenin15478proliferation, viability23165409, 27029345
Adavosertib24856436mouse xenograft model, viabilityWEE121992793, 25609063
Piplartine637858migration24967005
Strophanthidin6185proliferation23165409
Anisomycin253602viability21184646, 22684030, 23165409
Vismodegib24776445NCT00980343, NCT03158389
Capmatinib25145656mouse xenograft modelcMET21918175NCT01324479, NCT01870726, NCT02386826
Pristimerin159516proliferation23165409
Lanatoside C3879viability21184646, 27029345
Harmol68094viability23338618
Cilengitide176873proliferationintegrin19114005, 2258888317470857, 18981465, 20439646, 25163906, 26008604NCT00006093, NCT00085254, NCT00112866, NCT00679354, NCT00689221, NCT00813943, NCT00979862, NCT01044225, NCT01122888, NCT01124240, NCT01517776, NCT01782976
AMG 23258573469
LY2940023973proliferationPI3K22086271, 25425962
PF-0469150225033539mouse xenograft modelPI3K, mTOR21750219
UNII-2AW48LAZ4I72941968orthotopic mouse modeltelomerase26183089
Melatonin896viability28255276
Salvianolic acid B6451084viability23842993
RG711257406853mouse modelMDM2 26482041
Bafetinib11387605tyrosine kinase23380277NCT01234740
Methotrexate126941proliferationDHFR2316540915735920NCT00082797, NCT00463008
Cycloheximide6197proliferation21159181
KU559335278396orthotopic mouse model, radiosenitisationATM25017126, 25205037
NSC141562422114invasion, migration, proliferationMIR155HG/miR-155 axis28371892
Amlexanox2161proliferationIKBKE29048430
Epirubicin41867proliferation, viabilityDNA intercalation23165409, 24433351, 28963609
Lonafarnib148195orthotopic mouse model, viabilityfarnesyl transferase2124639421735117, 23633392NCT00038493, NCT00083096, NCT00102648
ZSTK47411647372mouse spontanious GBM model, mouse xenograft model, proliferationPI3K24297065, 27553832
Oleuropein5281544invasion, proliferation27498673
BMS-53692411353973mouse modelIGF-1R, IR25897243
761437-28-99934347radiosenitisation, viabilityFAK 25625667
KPT25157519758viabilityCRM125366336
Digitonin6474107proliferation23165409
WP113011222830apoptosis26872380
Imatinib5291mouse model, viabilitymultiple kinases16274936, 23736154NCT00010049, NCT00039364, NCT00154375, NCT00171938, NCT00290771, NCT00354068, NCT00354913, NCT00387933, NCT00401024, NCT00615927
T56-LIMKi9438169viabilityLIM kinase25593987
Aurintricarboxylic acid2259invasion, migration28103571
Propofol4943apoptosisReactive oxygen species28804952
Flubendazole35802viability24433351
172889-27-94878radiosenitisationSrc26044161
Mepacrine237viability25490024, 27029345
KU006379416736978viabilitymTOR22125077
Fenofibrate3339proliferationPPARalpha24493576, 25566967
Evodiamine442088mouse model28514905
Lenalidomide2163262689197518513880NCT00036894, NCT00165477, NCT00671801, NCT01183663, NCT02369367
Quercetin5280343viability24379902, 24902789
1616632-77-973777259viability26474387, 28767654NCT02038699, NCT02525692
Cyclophosphamide2907DNA crosslinking15022289, 15735920NCT00047281, NCT00990496, NCT01403285, NCT01903330
Cisplatin84691viabilityDNA intercalation24218165, 24953561, 27993939
DB-07497177068345proliferationsurvivin23325792
Visudyne5362420proliferation28790340
RG283356654642Temozolomide enhancerHDAC1, HDAC327632183
Oroxylin A5320315viability25213258
Larotrectinib46188928NCT02576431
Vandetanib3081361mouse xenograft model, proliferationVEGFR, EGFR, RET-tyrosine kinase19622715, 20371720, 21095630, 2379985223099652NCT00441142, NCT00613223, NCT00821080, NCT00995007
SKI II753704radiosenitisationSphK25255218, 28494176
Indomethacin3715viabilityCOX27988363
297157-92-72891837mouse xenograft model27993939
PX-8669849735mouse xenograft modelPI3K2015680325605819NCT01259869
Dorsomorphin11524144viability24419061
Dehydroxymethylepoxyquinomicin9881652mouse xenograft modelNFKB21968049
Tozasertib5494449mouse xenograft model, radiosenitisation, viabilityAurora kinase23636005, 25522764
Nobiletin72344proliferation23546290
10-Hydroxycamptothecin97226proliferation23165409
Otx-00811953346viabilitygalectin-123978989
Topotecan60700proliferation, radiosenitisation, viabilitytopoisomerase23165409, 24303074, 24433351, 28797568NCT00014443, NCT00541138, NCT00610571, NCT01004874, NCT01931098
LB-100 45101433mouse xenograft model, radiosenitisationPP2A25939762NCT03027388
Binimetinib10288191orthotopic mouse model, radiosenitisationMAP2K28958992
Nelfinavir6414324194293NCT00694837, NCT00915694, NCT01020292
NCD-38102222767ortothopic mouse modelKDM1A27893719
Methyl gallate7428viability23562553
Bimiralisib58507717PI3K, mTORNCT02850744
Axitinib6450551mouse modelVEGFR, PDGFR25213669, 27926485NCT01441388, NCT01508117, NCT01562197, NCT03275558, NCT03291314
Selinexor71481097orthotopic mouse model, viabilityCRM125366336NCT01607905, NCT01986348
Oxaliplatin9887054mouse xenograft model, radiosenitisationDNA17383816, 18329790
Semustine5198DNA alkylation225004, 7013978NCT00335075
Everolimus6442177mTOR2537128923725999, 25526733NCT00085566, NCT00107237, NCT00387400, NCT00515086, NCT00553150, NCT01062399, NCT01434602, NCT01508104
ZM4474399914412proliferationAurora kinase22160182
Vinorelbine5311497viability24433351
Temsirolimus6918289mTOR2674824123099651, 23564811, 24470557NCT00016328, NCT00022724, NCT00112736, NCT00329719, NCT00335764, NCT00784914, NCT00800917, NCT01019434, NCT01183663, NCT03158389
Letrozole3902orthotopic mouse model, proliferationAromatase25695958
Sanguinarine5154viability26472194
Pargyline4688proliferation23248157
Trifluoperazine5566orthotopic mouse model, proliferation23165409, 28870216
GW3965447905mouse xenograft model, proliferationLXR22059152
Isotretinoin528237925239666NCT00003564, NCT00112502, NCT00555399, NCT01103375
MLN492416720766orthotopic mouse modelNEDD8-activating enzyme25904638
Sirolimus5284616mouse xenograft model, viabilitymTOR23261661, 24043497, 25886314NCT00047073, NCT00509431, NCT00672243, NCT00821080
Indatraline126280mobilitymonoamine transporter24333442
Prazosin4893orthotopic mouse model, viabilityPRKCD27138566
Gitoxin91540proliferation23165409
Pregnenolone8955viability25013479
Thymoquinone10281proliferation24039814
Celastrol122724mouse xenograft model18343027, 19909582, 24810052
Dactinomycin457193proliferation, viability23165409, 24433351
GW29746603857invastion, migration, viabilityEGFR, HER223115024
VAL-08315942827mouse xenograft model, proliferation28216618NCT01478178, NCT02717962, NCT03050736, NCT03149575
Glasdegib25166913smoothened
Marizomib11347535mouse xenograft model, viabilityproteasome26681765, 26804704
Resveratrol445154mouse xenograft model23651583
Abemaciclib46220502mouse xenograft modelCDK4, CDK626149830NCT02977780, NCT02981940
PF838025265312proliferationAutotaxin23300119
KU6001915953870orthotopic mouse model, radiosenitisationATM23620409, 24443327, 25091220
Temozolomide5394mouse model, viabilityalkylating agent23736154, 24647572, 27878252, 2799393915758009, 19506159, 19636006, 20855843, 20934264, 21735117, 22035272, 22291006, 22578793, 23633392, 23725999, 23898124, 24194293, 24637230, 25239666, 26285766NCT00003176, NCT00003464, NCT00004113, NCT00004200, NCT00005637, NCT00005951, NCT00006025, NCT00006353, NCT00006358, NCT00006474, NCT00014105, NCT00021307, NCT00027625, NCT00028795, NCT00038493, NCT00039494, NCT00047294, NCT00049387, NCT00050986, NCT00052455, NCT00068952, NCT00083096, NCT00085254, NCT00086879, NCT00089427, NCT00099125, NCT00102648, NCT00112502, NCT00128700, NCT00187486, NCT00200161, NCT00238277, NCT00253487, NCT00262730, NCT00274833, NCT00275067, NCT00304031, NCT00311857, NCT00335075, NCT00354068, NCT00365222, NCT00376103, NCT00385853, NCT00387400, NCT00390403, NCT00392171, NCT00394628, NCT00402116, NCT00431561, NCT00433381, NCT00436436, NCT00441142, NCT00458601, NCT00471653, NCT00481455, NCT00482677, NCT00486603, NCT00492687, NCT00498927, NCT00501891, NCT00504660, NCT00508456, NCT00516282, NCT00516607, NCT00521482, NCT00525525, NCT00544284, NCT00548938, NCT00553150, NCT00555399, NCT00575887, NCT00590681, NCT00597402, NCT00597493, NCT00610571, NCT00612339, NCT00612651, NCT00612989, NCT00613093, NCT00615186, NCT00616005, NCT00619112, NCT00643825, NCT00650923, NCT00657267, NCT00662506, NCT00686725, NCT00687765, NCT00689221, NCT00704080, NCT00720564, NCT00723827, NCT00725010, NCT00734526, NCT00756106, NCT00761280, NCT00768911, NCT00770471, NCT00813943, NCT00817284, NCT00820963, NCT00841555, NCT00869401, NCT00883298, NCT00904852, NCT00915694, NCT00941460, NCT00943826, NCT00960492, NCT00967330, NCT00977431, NCT00979017, NCT01004874, NCT01019434, NCT01022918, NCT01026493, NCT01044966, NCT01062399, NCT01102595, NCT01110876, NCT01115491, NCT01120639, NCT01149109, NCT01180816, NCT01186406, NCT01209442, NCT01220271, NCT01242566, NCT01285414, NCT01294735, NCT01342757, NCT01345370, NCT01390571, NCT01402063, NCT01430351, NCT01473901, NCT01478321, NCT01480050, NCT01480479, NCT01502241, NCT01517776, NCT01587144, NCT01700569, NCT01752491, NCT01765088, NCT01777919, NCT01790503, NCT01800695, NCT01830101, NCT01837862, NCT01860638, NCT01907165, NCT02029573, NCT02052648, NCT02092038, NCT02177578, NCT02209948, NCT02227901, NCT02315534, NCT02330991, NCT02337426, NCT02343406, NCT02344355, NCT02364206, NCT02378532, NCT02502708, NCT02573324, NCT02590263, NCT02599090, NCT02617589, NCT02655601, NCT02661282, NCT02667587, NCT02715609, NCT02761070, NCT02770378, NCT02781792, NCT02871843, NCT02898012, NCT02928575, NCT02977780, NCT03018288, NCT03119064, NCT03139916, NCT03149575, NCT03174197, NCT03213002, NCT03224104, NCT03243461, NCT03246113, NCT03291990
Cediranib9933475mouse xenograft model, viabilityVEGFR21095630, 25490024, 25676691, 2664539820458050, 23940216, 26008604NCT00305656, NCT00503204, NCT00662506, NCT00777153, NCT00979862, NCT01131234, NCT01310855
PD1730741401migration, proliferationFGFR19340397, 26883759
Fotemustine104799DNA alkylation27165580NCT01474239
Gitoxigenin348482proliferation23165409
Etoposide36462proliferation23165409, 24953561NCT00003996, NCT00047281, NCT00612430, NCT00613028, NCT00613223
Gambogic acid5353639proliferation23165409
BI253611364421orthotopic mouse model, viabilityPLK122415968, 23713868, 24204733
Tandutinib3038522mouse xenograft model, transgenic mouse modelmultiple kinases22146535, 23638177
Pitavastatin5282452viability24433351
Ibrutinib24821094mouse xenograft model, proliferationBruton's tyrosine kinase27564106, 28716053
MG-132462382mouse xenograft model, proliferationproteasome22367315, 27993939
Vinpocetine443955proliferationPDE125620587
Cucurbitacin I5281321mouse xenograft model, proliferation24599950, 25482928
Luteolin5280445migration28927111
Theobromine5429proliferationPDEs24547961
AEE78810297043proliferationmTOR15657358NCT00107237, NCT00116376
ML29853393916invasion, migrationPLD223445448
Arctigenin64981proliferation28356992
Nintedanib9809715VEGFR, FGFR, PDGFR23184145, 25338318NCT01251484
AMG-51159548184mouse xenograft modelPI3K22897589
Enasidenib89683805IDH2
Silmitasertib24748573mouse xenograft modelCK224036851
LEQ50645100669smoothened
PQ4019549305mouse xenograft modelIGF-1R25971682
GSK46136415983966mouse xenograft model, proliferationPLK123790466, 24204733
Regorafenib11167602viability24911215NCT02926222
Colchicine6167proliferation23165409