GBM Drug Bank
Drugs for Glioblastoma
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Compound | PubChem CID | Reported Effect | MoA | Models | PMID | Clinical PMID | Clinical Trials | Patents |
---|---|---|---|---|---|---|---|---|
MRK003 | 15953832 | proliferation | Gamma secretase | HSRGBM1, JHH520, orthotopic mouse model, primary human glima cells, U251MG, U87MG | 23630166, 25293440, 25920606, 26613556 | PubChem Google | ||
Dactolisib | 11977753 | cell cycle, proliferation, radiosensitization | PI3K, mTOR | orthotopic mouse mode, primary human glioma cells, SHG44, T98G, U251MG, U87MG | 18606717, 19671762, 23603977, 24366691, 25431423, 26188279, 27542970, 27553832, 29685176, 30251117 | NCT01508104 | PubChem Google | |
Dimethyl fumarate | 637568 | proliferation | Rel, NFkappaB | A172, primary human glioma cells | 24404403, 25482938 | PubChem Google | ||
Daunorubicin | 30323 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Olanzapine | 135398745 | proliferation | LN229, mouse xenograft model, T98G | 25338992, 25524815 | PubChem Google | |||
Tagitinin C | 11256548 | viability | U373 | 21073931 | ||||
BDBM86691 | 57340709 | proliferation | ACAT1 | U251MG | 26252415 | |||
Selinexor | 71481097 | proliferation, viability | CRM1, XPO1 | AGBM1, BT145, BT159, BT172, LN229, orthotopic mouse model, primary human glioma cells, T98G, U87MG | 25366336, 30337641 | NCT01607905, NCT01986348, NCT02323880 | PubChem Google | |
2-benzoyloxycinnamaldehyde (BCA) | 54242917 | invasiveness, stemness, temozolomide enhancer, viability | Zeb1, Ncadherin, beta-catenin | GBM tumorspheres, mouse orthotopic xenograft model | 30887242 | PubChem Google | ||
Isoflurane | 3763 | apoptosis, proliferation | EAAT3, PKC, PI3K | C6 | 14639147 | PubChem Google | ||
Falcarindiol | 5281148 | apoptosis, differentiation | U373 | 30388862 | PubChem Google | |||
Galunisertib | 10090485 | TGFbeta receptor I kinase | 24868575, 25424852, 25529192, 26902851 | NCT01220271, NCT01582269 | PubChem Google | |||
Honokiol | 72303 | viability | PI3K, mTOR | DBTRG05MG, GBM8401, mouse xenograft model, U373MG, U87MG | 19483651, 25106108, 25763821, 27064011 | PubChem Google | ||
Hispidulin | 5281628 | apoptosis, proliferation | AMPK, mTOR | primary human glioma cells | 20698539 | PubChem Google | ||
Erlotinib | 176870 | apoptosis, proliferation | EGFR | BS153, C6, DKMG, LN229, primary human glioma cells, SF188, U87MG | 17804702, 18955445, 19301967, 19737945, 20456371, 26032687, 27546621, 30219696, 30989436 | 19562254, 19770758, 20615922, 20716591, 22407177, 24470557, 24637230 | NCT00030498, NCT00039494, NCT00045110, NCT00054496, NCT00086879, NCT00112736, NCT00124657, NCT00227032, NCT00274833, NCT00301418, NCT00335764, NCT00337883, NCT00387894, NCT00445588, NCT00509431, NCT00609999, NCT00671970, NCT00672243, NCT00720356, NCT01103375, NCT01110876, NCT01257594 | PubChem Google |
1-Methyl-L-tryptophan | 676159 | proliferation, suppression of enzyme activity | Indoleamine-2,3-dioxygenase (IDO) | LN229 | 19199463 | PubChem Google | ||
ICI118551 | 5484725 | mRNA synthesis inhibition | Selective b2AR antagonist | U373 | 18498711 | PubChem Google | ||
Sorafenib | 216239 | proliferation, radiosensitization, temozolomide enhancer, viability | Tyrosine protein kinase, VEGFR2, Raf, PDGFR, cKIT, | GBM12, GBM14, GBM5, GBM6, LN229, orthotopic mouse model, primary human glioma cells, U1242, U251MG, U87MG | 19001435, 20371721, 20470863, 23324350, 24139873, 24911215, 24965413, 27542273, 30219696, 30338715, 30469352, 30515262 | 20443129, 20564147, 21954442, 23099651, 23898124, 24786603, 28988377 | NCT00093613, NCT00329719, NCT00335764, NCT00445588, NCT00544817, NCT00597493, NCT00621686, NCT00734526, NCT00884416, NCT01183663, NCT01434602, NCT01441388, NCT01817751, NCT02599090 | PubChem Google |
Fotemustine | 104799 | DNA alkylation | 27165580 | NCT01474239 | PubChem Google | |||
MST-312 | 10385095 | cell cycle arrest, DNA damage, double strand breaks, viability | Telomerase inhibitor | KNS60, MO59K, ONS76 | 25307264 | PubChem Google | ||
(S)-3,5-Dihydroxyphenylglycine | 443586 | neuroprotection, proliferation, synaptic modulation | Selective group I mGlu agonist | C6 | 19822193 | PubChem Google | ||
Evofosfamide | 11984561 | DNA crosslinking | 29415215 | NCT02342379 | PubChem Google | |||
Alpha-Lipoic acid | 864 | apoptosis, proliferation | Glutathione Peroxidase 1,TRPA1 | MU1454, U87MG | 29925764, 30590317 | PubChem Google | ||
Ticlopidine | 5472 | apoptosis, viability | Akt, mTOR, EGF | primary human glioma cells | 26412325 | PubChem Google | ||
Ritonavir | 392622 | proliferation | Hu197, U87MG | 28319810 | NCT01095094, NCT02770378 | PubChem Google | ||
ZM447439 | 9914412 | proliferation | Aurora kinase | primary human glioma cells, U251MG, U343 | 22160182 | PubChem Google | ||
PD184352 | 6918454 | radiosensitivity, viability | MEK | SNB19 | 30647839 | PubChem Google | ||
CGS7181 | 656759 | apoptosis | BKCa channels | LN229 | 20065494 | |||
Enasidenib | 89683805 | proliferation, viability | IDH2 | 30069631 | PubChem Google | |||
Mevalonolactone | 10428 | oxidative stress response | ROS, MKD, MVK | U87MG | 29753116 | PubChem Google | ||
HU-331 | 11393311 | apoptosis | Topo2 | U87MG | 31020489 | PubChem Google | ||
Cryptotanshinone | 160254 | LN229, mouse xenograft model, U87MG | 28492557, 30021339 | PubChem Google | ||||
Tolbutamide | 5505 | proliferation | Cx43 | C6 | 11741589, 15781061, 16718685, 19176641 | PubChem Google | ||
BIX01294 | 25150857 | viability | histone methyltransfeRASe, G9a | C6, LN18, U251MG | 24905315, 27748874, 27934912, 30450051 | PubChem Google | ||
Berberine | 2353 | apoptosis, cytotoxicity | C6 | 19424587 | PubChem Google | |||
Hypericin | 3663 | viability | T98G, U251MG, U87MG | 24066060 | 21456013 | PubChem Google | ||
TG101209 | 16722832 | proliferation | JAK2 | primary human glioma cells | 26283544 | PubChem Google | ||
CCG-1423 | 2726015 | invasion | RhoA | T98GMG, U251MG | 29207169 | PubChem Google | ||
Clasto-Lactacystin .beta.-lactone (?-Clastolactacystin) | 91746126 | 20S proteasome | 118MGC, U373MG | 19201384 | ||||
Shikonin | 479503 | proliferation | TopoisomeRASe | U251MG, U87MG | 23840441, 24303074, 25688715, 25891245 | PubChem Google | ||
E-6087 | 9953093 | radiosensitivity | COX2 | GL261 | 19252746 | PubChem Google | ||
Pazopanib | 10113978 | Tyrosine kinase | 20200024, 23363814 | NCT00350727, NCT00459381, NCT01392352, NCT01931098, NCT02331498, NCT03275558 | PubChem Google | |||
Thioridazine | 5452 | autophagy | AMPK | U87MG | 25950483, 30289977 | PubChem Google | ||
Methotrexate | 126941 | proliferation | DHFR | primary human glioma cells | 23165409 | 15735920 | NCT00082797, NCT00463008 | PubChem Google |
Temozolomide | 5394 | viability | ATRCHK1, p21, NFkappaB | C6, LN229, LN229MGMT, LN308, mouse model, SF767, U105MG, U138, U251MG, U343MG, U87MG, XO8 | 23736154, 24647572, 27878252, 27993939, 29354058, 29454008, 30361254, 30569180, 30705757, 30853911, 30881038 | 31789 | NCT00003176, NCT00003464, NCT00003567, NCT00004113, NCT00004200, NCT00005637, NCT00005951, NCT00006025, NCT00006263, NCT00006353, NCT00006358, NCT00006474, NCT00014105, NCT00021307, NCT00025558, NCT00027625, NCT00028795, NCT00038493, NCT00039494, NCT00047294, NCT00049387, NCT00050986, NCT00052455, NCT00068952, NCT00083096, NCT00085254, NCT00086879, NCT00089427, NCT00099125, NCT00102648, NCT00112502, NCT00128700, NCT00187486, NCT00200161, NCT00238277, NCT00253487, NCT00262730, NCT00268385, NCT00274833, NCT00275067, NCT00302159, NCT00304031, NCT00305864, NCT00311857, NCT00316849, NCT00323115, NCT00335075, NCT00354068, NCT00365222, NCT00376103, NCT00385853, NCT00387400, NCT00390403, NCT00392171, NCT00394628, NCT00402116, NCT00431561, NCT00433381, NCT00436436, NCT00441142, NCT00458601, NCT00471653, NCT00481455, NCT00482677, NCT00486603, NCT00492687, NCT00498927, NCT00501891, NCT00504660, NCT00508456, NCT00516282, NCT00516607, NCT00521482, NCT00525525, NCT00544284, NCT00544817, NCT00548938, NCT00553150, NCT00555399, NCT00574964, NCT00575887, NCT00590681, NCT00597402, NCT00597493, NCT00610571, NCT00612339, NCT00612651, NCT00612989, NCT00613093, NCT00615186, NCT00616005, NCT00619112, NCT00626015, NCT00643097, NCT00643825, NCT00650923, NCT00657267, NCT00662506, NCT00669669, NCT00684567, NCT00686725, NCT00687765, NCT00689221, NCT00704080, NCT00704808, NCT00720564, NCT00723827, NCT00725010, NCT00731731, NCT00734526, NCT00756106, NCT00761280, NCT00768911, NCT00770471, NCT00782756, NCT00792012, NCT00805961, NCT00813943, NCT00817284, NCT00820963, NCT00841555, NCT00869401, NCT00883298, NCT00884741, NCT00904852, NCT00915694, NCT00916409, NCT00941460, NCT00943462, NCT00943826, NCT00960492, NCT00967330, NCT00977431, NCT00979017, NCT01004874, NCT01013285, NCT01019434, NCT01022918, NCT01026493, NCT01043536, NCT01044966, NCT01062399, NCT01062425, NCT01102595, NCT01110876, NCT01115491, NCT01119599, NCT01120639, NCT01149109, NCT01149850, NCT01164189, NCT01180816, NCT01181193, NCT01186406, NCT01209442, NCT01220271, NCT01222221, NCT01242566, NCT01269424, NCT01285414, NCT01294735, NCT01342757, NCT01345370, NCT01390571, NCT01402063, NCT01430351, NCT01466686, NCT01473901, NCT01478321, NCT01480050, NCT01480479, NCT01502241, NCT01514201, NCT01517776, NCT01587144, NCT01700569, NCT01702610, NCT01740258, NCT01752491, NCT01765088, NCT01777919, NCT01790503, NCT01800695, NCT01830101, NCT01837862, NCT01849146, NCT01860638, NCT01868906, NCT01907165, NCT01956734, NCT01957956, NCT01977677, NCT01985087, NCT02010606, NCT02029573, NCT02039778, NCT02046187, NCT02052648, NCT02085304, NCT02092038, NCT02137759, NCT02152982, NCT02168270, NCT02177578, NCT02179086, NCT02209948, NCT02227901, NCT02311920, NCT02315534, NCT02329795, NCT02330991, NCT02337426, NCT02340156, NCT02343406, NCT02343549, NCT02344355, NCT02364206, NCT02366728, NCT02378532, NCT02394665, NCT02395692, NCT02414165, NCT02455557, NCT02502708, NCT02510950, NCT02530502, NCT02573324, NCT02590263, NCT02599090, NCT02617589, NCT02649582, NCT02655601, NCT02661282, NCT02663440, NCT02667587, NCT02685605, NCT02715609, NCT02761070, NCT02770378, NCT02781792, NCT02799238, NCT02805179, NCT02843230, NCT02871843, NCT02880410, NCT02898012, NCT02928575, NCT02977780, NCT03008148, NCT03018288, NCT03034135, NCT03119064, NCT03137888, NCT03139916, NCT03149575, NCT03174197, NCT03197506, NCT03213002, NCT03224104, NCT03225963, NCT03232424, NCT03243461, NCT03246113, NCT03291990, NCT03310372, NCT03345095, NCT03363659, NCT03388372, NCT03405792, NCT03419403, NCT03426891, NCT03451799, NCT03463265, NCT03463733, NCT03466450, NCT03477110, NCT03480867, NCT03491683, NCT03514069, NCT03529448, NCT03535350, NCT03548571, NCT03576612, NCT03581292, NCT03587038, NCT03607643, NCT03631823, NCT03633552, NCT03643549, NCT03650257, NCT03660761, NCT03687034, NCT03688178, NCT03705351, NCT03746080, NCT03749187, NCT03776071, NCT03778294, NCT03780569, NCT03782415, NCT03914742, NCT03927222, NCT03970447, NCT04019262, NCT04047706, NCT04049669, NCT04077866, NCT04091503, NCT04105374, NCT04116411, NCT04119674, NCT04157478 | PubChem Google |
Y27632 | 448042 | migration, proliferation | ROCK | C6, LN18 | 18814230, 19331140, 19427347, 19772916 | PubChem Google | ||
Losartan | 3961 | apoptosis, proliferation | AT1 | C6 | 11720480, 15785746 | NCT01805453, NCT03951142 | PubChem Google | |
Gamolenic acid | 5280933 | angiogenesis, proliferation | Bax, Ku80, E2F1 | C6 | 19180667, 19292920 | PubChem Google | ||
5-Nonyloxytryptamine | 1797 | viability | U87MG | 24433351 | PubChem Google | |||
Archazolid B | 16757019 | cholesterol homeostasis, endosomal/lysosomal malfunction | H(+)ATPase | U87MG | 25218289 | |||
Isoquercitrin (Quercetin 3-glucoside) | 5280804 | proliferation | GBM95 | 19491660 | PubChem Google | |||
Depatuxizumab mafodotin | 86278355 | antimicrotubule agent | EGFR, MMAF | 29075855, 29077941, 29982805 | NCT01800695, NCT02343406, NCT02573324, NCT02590263, NCT03123952 | |||
Glutamate | 33032 | invasion, proliferation | AMPA | U87MG | 19997873 | PubChem Google | ||
Docosahexaenoic acid | 445580 | viability | C6 | 20192116, 29192322 | PubChem Google | |||
Savolitinib | 68289010 | cMET | mouse xenograft model, U87MG | 25148209 | PubChem Google | |||
Verbascoside | 5281800 | apoptosis, invasion, migration, proliferation | COX2, NFkappaB, MAPK, SHP1, STAT3 | C6, U87MG | 19904526, 29961065 | PubChem Google | ||
GSK J4 | 71729975 | proliferation | JMJD3 | U251MG, U87MG | 28978140 | PubChem Google | ||
C1368 | 2777805 | proliferation | Aurora A kinase | Daoy, MB 100, MB 47, ONS76 | 20232424 | PubChem Google | ||
Hispolon | 53395354, 10082188 | apoptosis, cell cycle arrest, viability | CDK, p21, p53 | U87MG | 28618133 | PubChem Google | ||
Cantharidine | 5944 | proliferation | GBM6, U87MG | 29750582 | PubChem Google | |||
PI-103 | 9884685 | radiosensitization, viability | PI3K, mTOR | LN229, T98G, U251MG, U373MG, U87MG | 16697955, 18413797, 19177002, 19513541, 19584227, 19633683, 19737945, 22125077, 24418474 | PubChem Google | ||
Go6983 | 3499 | invasion, proliferation | PKC | U87MG | 19502590 | PubChem Google | ||
Zidovudine | 35370 | radiosensitization | Telomerase | U251MG | 17223082 | PubChem Google | ||
AZ32 | 134814488 | apoptosis, radiosensitization | ATM | A172, CF5STTG1, H4, Hs683, LN18, M059J, SW1088, SW1783, T98G, U118MG, U138MG, U87MG | 29769307 | |||
ISO-1 | 4633677 | migration, proliferation | MIF | Hs683, LN18, U373 | 19759012, 20038293 | PubChem Google | ||
Palomid 529 | 11998575 | mTOR | orthotopic mouse model, U87MG | 23436212 | PubChem Google | |||
Noscapine | 275196 | angiogenesis, apoptosis | HIF1 | T98G, U87MG | 16596228, 18525314 | PubChem Google | ||
STF-62247 | 704473 | apoptosis | mTORC1 | MZ54 | 30250198 | PubChem Google | ||
Sulindac | 1548887 | differentiation, radiosensitization | U87MG | 29788733 | PubChem Google | |||
L-685458 | 5479543 | migration, survival | gamma-secretase | LN229, U87MG | 19690139 | PubChem Google | ||
KC7f2 | 16047442 | viability | HIF1 | U251MG, U87MGD | 19789328 | PubChem Google | ||
Mithramycin A | 163659 | proliferation | SP1 | U87MG | 19642173 | PubChem Google | ||
Decitabine | 451668 | viability | iNOS, DNA, FPR | C6, HEK, T98G, U87MG | 14725971, 18607344, 18793349, 18803327, 18976507, 19037090, 19047176, 19787267, 19847810, 19966297 | PubChem Google | ||
Tricetin | 5281701 | invasion, migration | 26245494 | PubChem Google | ||||
Valproic acid | 3121 | proliferation, radiosensitization, viability | HDAC | C6, G144, G166, G179, G361, GBM2, GBM7, GliNS2, LN229, SF295, SKNMC, T98G, U373MG, U87MG | 16373706, 18550052, 18582478, 18611290, 18679414, 18751431, 18765532, 19030781, 19239041, 19360904, 20332466, 23253698, 24348849, 25275596, 27802437, 28108734, 28962238, 30112328, 30243186, 30591460 | 23523186 | NCT02648633 | PubChem Google |
Acridine orange | 62344 | photosensitisation, proliferation, viability | U373MG | 29631084 | PubChem Google | |||
Combretastatin A-4 | 5351344 | apoptosis | Microtubules | T98G | 30268825 | PubChem Google | ||
Azacitidine | 9444 | apoptosis, migration, viability | CD31, PDGFRbeta | primary glioblastoma cells, U373MG, U87MG | 18679414, 29427211 | NCT02223052, NCT02711137, NCT03684811 | PubChem Google | |
Fingolimod | 107969 | invasion, migration | U251MG, U87MG | 25070489 | PubChem Google | |||
Xanthohumol | 639665 | apoptosis | T98G | 22111577 | PubChem Google | |||
Digitonin | 6474107 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
PAI-1 | 3246941 | angiogenesis | Serine protease | 18383878 | PubChem Google | |||
Fingolimod | 107970 | viability | A172, mouse xenograft model, SHG44, U251MG, U87MG | 25070489, 25939952 | NCT02490930 | PubChem Google | ||
EIPA | 1795 | cell swelling suppression | NHE | 1321N1 | 19772916 | PubChem Google | ||
Dactinomycin | 457193 | proliferation, viability | A172, LN443, primary human glioma cells, U118, U87MG | 23165409, 24433351 | PubChem Google | |||
A-966492 | 16666333 | radiosensitization | PARP | U87MG | 28797568 | PubChem Google | ||
Naringenin | 932 | invasion, migration, proliferation, viability | MMP2, MMP9, ERK | GBM8401, GBM8901 | 30431227 | PubChem Google | ||
KX2-361 | 11545920 | proliferation, viability | Src family kinase, tubulin | GL261 | 30238350 | PubChem Google | ||
Imatinib | 5291 | citotoxicity, invasion, migration, proliferation, viability | Multiple kinases | GL15, MOGGUVW, mouse model, SF767, T98G, U105MG, U251MG, U343MG, U373MG | 16274936, 19048625, 19270491, 19417143, 20032406, 23736154 | NCT00010049, NCT00039364, NCT00154375, NCT00171938, NCT00290771, NCT00354068, NCT00354913, NCT00387933, NCT00401024, NCT00615927 | PubChem Google | |
Tipifarnib | 159324 | angiogenesis, radiosensitization | farnesyl protein transfeRASe | mice xenografts, U87MG | 14676133 | 16818651, 16877733, 18417739, 18725460, 20934264, 28988377 | NCT00005859, NCT00049387, NCT00050986, NCT00058097, NCT00209989, NCT00335764, NCT02227901 | PubChem Google |
Semustine | 5198 | DNA alkylation | 225004, 24248532, 26852708, 7013978 | NCT00335075 | PubChem Google | |||
Carmustine | 2578 | viability | DNA alkylation | 9L, rat models, U87MG | 19408974, 30605703, 30606517 | 19770758, 24958095, 7013978 | NCT00002545, NCT00003176, NCT00003348, NCT00003417, NCT00003463, NCT00003484, NCT00003567, NCT00003788, NCT00003876, NCT00003996, NCT00004028, NCT00004688, NCT00004892, NCT00005081, NCT00005637, NCT00005855, NCT00006386, NCT00006656, NCT00009854, NCT00014573, NCT00017147, NCT00027612, NCT00046878, NCT00068952, NCT00076986, NCT00086879, NCT00362921, NCT00548938, NCT00574964, NCT00669669, NCT00761280, NCT00795665, NCT00814593, NCT00984438, NCT01186406, NCT01310868, NCT01656980, NCT02348255, NCT03722355 | PubChem Google |
Sulforaphane | 5350 | apoptosis | Bax, BCL2, NFkappaB | T98G, U87MG | 16765523 | PubChem Google | ||
Indomethacin | 3715 | viability | COX | U251MG | 27988363 | PubChem Google | ||
AZD8055 | 25262965 | mTOR | mouse xenograft model, primary human glioma cells | 25316808 | NCT01316809 | PubChem Google | ||
7-Hydroxystaurosporine | 72271 | proliferation | PKC | mouse xenograft model, primary human glioma cells, U87MG | 15780200, 24810059 | PubChem Google | ||
PX-478 | 11234794 | radiosensitization | HIF1 | C6 | 19372568 | PubChem Google | ||
LGK974 | 46926973 | proliferation, temozolomide enhancer | porcupine, ALDH3A1 | GBM1, GBM10, JHH520, LN229, SF188 | 26222502, 29854309 | PubChem Google | ||
ARP101 | 11292680 | apoptosis, autophagy | MT1MMP | U87MG | 30291676 | PubChem Google | ||
LLP3 | 56935694 | viability | primary human glioma cells | 23251006 | ||||
Fenoterol | 3343 | mRNA synthesis inhibition | H1R | U373 | 18498711 | PubChem Google | ||
Peruvoside | 12314120 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Cyclopamine | 442972 | apoptosis | Hedgehog (Hh) signaling | CD34+, U251MG | 19245435, 29313231 | PubChem Google | ||
NSC23766 | 409805 | viability | RAC1 | GL15, SF767, U105MG, U251MG, U343MG, U373MG | 23736154 | PubChem Google | ||
Neratinib | 9915743 | viability | HER2, EGFR | DBTRG05MG, orthotopic mouse model, SF268, SKMG3 | 18765999, 26023796 | NCT02977780 | PubChem Google | |
Ribociclib | 44631912 | CDK4, CDK6 | 28351928 | NCT02345824, NCT02933736, NCT03355794, NCT03434262, NCT03834740 | PubChem Google | |||
Amlodipine | 2162 | viability | YAP, TAZ | LN18, LN229, T98G | 30082911 | PubChem Google | ||
Deguelin | 107935 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
bVAD-fmk | 25108682 | apoptosis | Pancaspase inhibitor | U343MG | 19432816 | |||
Escitalopram | 25379795 | proliferation | C6 | 146570 | ||||
RapaLink-1 | 121231411 | proliferation | mTOR | U87MG | 28292440 | PubChem Google | ||
Tunicamycin | 56927832 | proliferation | C6, U251MG | 18483264, 2706513 | ||||
CC-223 | 58298316 | mTOR | 26177599 | NCT01177397 | PubChem Google | |||
Boronophenylalanine | 150315 | viability | F98 | 30474719 | PubChem Google | |||
BMS-777607 | 24794418 | AXL | mouse xenograft model, SF126, U118 | 26848524 | PubChem Google | |||
Visudyne | 5362420 | proliferation, viability | YAP | LN229, SNB19, U343, U87MG | 28790340, 30254296, 30423822 | PubChem Google | ||
Methylene dibutyrate | 9855687 | apoptosis, proliferation | Histone deacetylase | murine xenograft glioma tumor, U251MG | 16373710 | PubChem Google | ||
3-Deazaneplanocin | 73087 | viability | HDAC | C6 | 24905315 | PubChem Google | ||
Cidofovir | 60613 | angiogenesis, survival | Cytomegalovirus (CMV) | MCMV+ mice | 30855281 | PubChem Google | ||
Oroxylin A | 5320315 | viability | U118, U251MG, U87MG | 25213258 | PubChem Google | |||
Rolipram | 5092 | proliferation | PDE4 | A172, mouse xenograft model, U87MG | 12432276, 17234775, 18719351, 19642024, 28202289 | PubChem Google | ||
Bimiralisib | 58507717 | proliferation | PI3K, mTOR | xenograft model in nude rats and mice | 28829592, 31618458 | NCT02850744 | PubChem Google | |
Romidepsin | 5352062 | proliferation, radiosensitization | Histone deacetylase | A172, GBM6, T98G, U138MG, U251MG, U87MG | 15024582, 27685789, 29750582 | 21377994 | NCT00085540 | PubChem Google |
72926-24-0 | 2930014 | proliferation | Eg5 | U251MG, U87MG | 28965307 | PubChem | ||
Daporinad | 6914657 | viability | NAMPT | C6 | 22119381, 26601421 | PubChem Google | ||
GDC-0941 | 17755052 | radiosensitization, viability | PI3K | A172, mouse xenograft model, SHG44, T98G, U373, U87MG | 19584227, 23427298, 24757258, 28147244, 30132519, 30920104 | PubChem Google | ||
Delta 9-tetrahydrocannabinol | 2978 | viability | E2F1 | U251MG, U87MG | 17934890 | PubChem Google | ||
NHI 1 | 779302 | apoptosis, cell cycle arrest, proliferation, viability | LDHA | U87MG | 26494310 | |||
Resveratrol | 445154 | apoptosis, radiosensitization | Akt, p53, STAT3, survivin, cyclin D1, COX2, c-Myc, | A172, mouse xenograft model, primary human glioma cells, T98G, U251MG, U87MG, UW2282, UW2283 | 15827328, 18592012, 19566920, 19827268, 21503893, 21743969, 23651583, 27419830, 30621053, 30984336 | PubChem Google | ||
Tesevatinib | 10458325 | 30030583 | NCT02844439 | PubChem Google | ||||
Prazosin | 4893 | viability | PRKCD | orthotopic mouse model, primary human glioma cells | 27138566 | PubChem Google | ||
Ibrutinib | 24821094 | proliferation, viability | Bruton\'s tyrosine kinase, Src | LN229, mouse xenograft model, primary human glioma cells, U87MG | 27564106, 28716053, 30219696 | NCT03535350 | PubChem Google | |
Rovalpituzumab tesirine | 131954443 | DLL3 | primary human glioma cells | 30397180 | ||||
AEE788 | 10297043 | apoptosis, proliferation | mTOR, EGFR/HER2 | D5MG, LN18 | 15657358, 19033391, 19199503 | NCT00107237, NCT00116376 | PubChem Google | |
MPEP (6-Methyl-2-(phenylethynyl)pyridine) | 3025961 | neuroprotection, proliferation, synaptic modulation | mGluR5 | C6 | 19822193 | PubChem Google | ||
DL-nordihydroguaiaretic acid | 688035 | differentiation | Alox5 | murine glioma xenografts, U87MG | 20809257 | |||
Paxilline | 105008 | apoptosis | DR5, CHOP, GADD153, cFLIPs | U251MG, U251MGN, U343, U87MG | 21150246 | PubChem Google | ||
Succinyl phosphonate | 46209593 | viability | OGDH, Reactive oxygen species | 1321N1, LN405, T98G, U87MG | 27027236 | |||
Pochoxime A | 24898672 | mouse model | 20643786 | PubChem Google | ||||
Arachidonic acid | 444899 | apoptosis | GSH, Casp3 | C6 | 17400255 | PubChem Google | ||
D-Glucosamine | 439213 | Thymidine kinase | C6 | 844039 | PubChem Google | |||
1134156-31-2 | 25195348 | proliferation | Hsp70, Hsp90 | U87MG | 26185541 | PubChem Google | ||
Selenium | 6326970 | apoptosis, viability | DBTRG | 30796690 | PubChem Google | |||
U0126 | 3006531 | apoptosis, migration, proliferation | MEK1, MEK2, ERK1, ERK2, MAPK, ERK | A1207, A172, C6, LN18, SKMG15, SKMG4, SKMG5, T98G, TC620, U178, U251MG, U373, U87MG | 17327470, 18834856, 19336886, 20809186, 21850371, 26748241 | PubChem Google | ||
Grisorixin | 12780142 | proliferation | COMI, VIPI stem cells | 29513090 | ||||
Isolinderalactone | 5318587 | apoptosis, DNA damage, proliferation, viability | BCL2, survivin, XIAP, PARP, Casp3, TUNEL | glioblastoma xenograft mouse model, U87MG | 30503550 | PubChem Google | ||
R428 | 46215462 | proliferation | AXL | SNB19, UP007 | 25980499 | PubChem Google | ||
Kaempferol | 5280863 | apoptosis, proliferation, viability | ERK, Akt | A172 | 18949556, 19001439 | PubChem Google | ||
Methyl Pyruvate | 11748 | GDH, Akt | SF188 | 19826036 | PubChem Google | |||
Pki-166 | 6918403 | apoptosis, proliferation | EGFR, HER2 | LN827, U87MG | 18677408 | PubChem Google | ||
Norclomipramine | 622606 | inhibitors of cellular respiration | IPSB18 | 20332444 | PubChem Google | |||
C75 | 4248455 | apoptosis | FAS inhibitor | U87MG | 20009104 | PubChem Google | ||
AMG-511 | 59548184 | PI3K | mouse xenograft model, U87MG | 22897589 | PubChem Google | |||
LY2109761 | 11655119 | TGFbeta receptor I kinase | mouse xenograft model, T98G, U87MG | 21677877 | PubChem Google | |||
NS-1619 | 4552 | enhanced drug delivery to brain-tumor cells | calcium dependent potassium (K(Ca)) channel agonis | xenograft model | 19738431 | PubChem Google | ||
LB-100 | 45101433 | radiosensitization | PP2A | mouse xenograft model, U251MG | 25939762 | NCT03027388 | PubChem Google | |
Carfilzomib | 11556711 | proliferation | GBM6, U87MG | 29750582 | PubChem Google | |||
Dexamethasone | 5743 | invasion, migration, proliferation, temozolomide enhancer | MIF, PKC | C6, U373MG | 17453149, 19759012, 30333749 | 19714445 | NCT01169415, NCT02031965, NCT04128774 | PubChem Google |
Daidzein | 5281708 | apoptosis, proliferation | BCL2 | LN229 | 19429088 | PubChem Google | ||
8-Hydroxy-2-methyl-1H-quinazolin-4-one | 135398517 | radiosensitization | PARP1 | D54, U251MG | 25182801 | PubChem Google | ||
SZ-685C | 12301973 | apoptosis, viability | Akt, FOXO transcription factors | LN444 | 20128807 | |||
Ponatinib | 24826799 | viability | Src family kinase, Abl, VEGFR2, FGFR1 | LN229, mouse xenograft model, U87MG | 25378936, 30219696, 30705592 | NCT02478164 | PubChem Google | |
Tanespimycin | 6505803 | apoptosis, migration, radiosensitization, viability | Hsp90 | M059K, SF268, U87MG | 16550610, 18462865, 18682579, 18974397, 19027068, 19244114, 19408974, 19671736, 19795461, 26185541, 28542269 | PubChem Google | ||
Hydroxyurea | 3657 | RNR | 19904263 | NCT00019058, NCT00154375, NCT00290771, NCT00354913, NCT00387933, NCT00613054, NCT00613132, NCT00615927, NCT03463733 | PubChem Google | |||
9-ING-41 | 44582816 | Glycogen Synthase Kinase3 | GBM12, GBM6, orthotopic mouse model | 28672195 | NCT03678883 | PubChem Google | ||
Glutathione | 124886 | prevented apoptosis | DAOY | 19633536 | PubChem Google | |||
YC-1 | 5712 | proliferation | factor1alpha | C6 | 18430796, 19108760 | PubChem Google | ||
SN-50 | 101150673 | NFkappaB | 118MGC, U373MG | 19201384 | ||||
Lactacystin | 6610292 | viability | Proteasome | C6, F98, mouse xenograft model | 16609837, 18539596, 19738049, 23569132 | PubChem Google | ||
Ascochlorin | 11258227 | invasion, migration | A172, U373MG | 28569433 | PubChem Google | |||
Genistein | 5280961 | apoptosis, mitochondrial swelling, viability | DNA synthesis | LN18, LN308, LNT229, T98G, U87MG | 18357397, 19639205, 19894226 | PubChem Google | ||
1-1-diphenyl-2-picrylhydrazyl | 74358 | cytotoxicity | U87MG | 30617655 | PubChem Google | |||
Dronabinol (Delta9-THC) | 16078 | apoptosis, cannabidiol enhancer, proliferation, viability | ERK, Reactive oxygen species | SF126, U251MG, U87MG | 17675107, 18339876, 20053780, 30597288 | PubChem Google | ||
Talampanel | 164509 | 19636006, 20143438 | NCT00062504, NCT00064363, NCT00267592 | PubChem Google | ||||
Baicalin | 64982 | invasion, migration, proliferation, viability | Calcium signaling, PI3K, Akt, mTOR | U251MG, U87MG | 30323558 | PubChem Google | ||
LLnL | 4332 | apoptosis, cell cycle | COX2, IL-1beta, TNFalpha, IL6, iNOS, p27, TRIAL, N | BV2, primary human glioblastoma cells | 10411338, 15504253, 19748528 | PubChem Google | ||
Birinapant | 49836020 | viability | IAP | primary human glioma cells | 26657652 | PubChem Google | ||
Citalopram | 2771 | SSRI, beta-arrestin1 | C6 | 21223624 | PubChem Google | |||
Lovastatin | 53232 | proliferation | HMGCoA reductase | U343, U87MG | 18566746, 25497898 | PubChem Google | ||
Phenformin | 8249 | HF2587, orthotopic mouse model | 27486821, 30186163 | PubChem Google | ||||
Amlexanox | 2161 | proliferation | IKBKE | U251MG, U87MG | 29048430 | PubChem Google | ||
Caffeine | 2519 | angiogenesis, migration, radiosensitization | IP(3)R3, PI3K, HIFs, PI3K, Akt, MAPK, ERK | C6, orthotopic mouse model, T98G, U87MG | 20103602, 20103623, 21229324, 25011614, 27260469, 29424319 | PubChem Google | ||
Propofol | 4943 | apoptosis | Reactive oxygen species | GBM 8401, LN299 | 28804952, 29928428 | PubChem Google | ||
Mitoxantrone | 4212 | proliferation, viability | TopoisomeRASe | primary human glioma cells, U87MG | 19340456, 21184646, 23165409 | PubChem Google | ||
Merlin | 84098 | and motility, proliferation, survival | NF2(Merlin) | 9L, A172, DBRG05MG, Hs683, LN18, LN229, M059K, M089J, SF126, SF188, SF210, SF268, SF295, SF539, SF763, SF797, SNB19, SNB75, U118MG, U138MG, U251MG, U343MG, U373MG, U87MG | 18632626 | PubChem Google | ||
D4476 | 6419753 | apoptosis | CK1 | Daoy | 19943845 | PubChem Google | ||
Idoxuridine | 5905 | proliferation, radiosensitization | C6, rat glioma model | 30170108 | PubChem Google | |||
Verapamil | 2520 | apoptosis, proliferation, temozolomide enhancer | Bax, BCL2 | U87MG | 30003979 | PubChem Google | ||
Triptolide | 107985 | viability | A172, LN443, U118, U87MG | 24433351 | PubChem Google | |||
Epirubicin | 41867 | proliferation, viability | DNA intercalation | A172, LN443, primary human glioma cells, U118, U87MG | 23165409, 24433351, 28963609 | PubChem Google | ||
Colchicine | 6167 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Anisomycin | 253602 | viability | primary human glioma cells, U251MG, U87MG | 21184646, 22684030, 23165409 | PubChem Google | |||
NSC-87877 | 92577 | proliferation | SHP2 PTPase | LN229.EGFRvIII, U87MG.EGFRvIII | 19427850 | PubChem Google | ||
Gamma-Secretase Inhibitor IX | 5311272 | proliferation, viability | Gamma secretase | GL15, LN229, SF767, SHG44, U105MG, U251MG, U343MG, U373MG, U87MG | 19690139, 23736154, 25063285 | PubChem Google | ||
Dehydroxymethylepoxyquinomicin | 9881652 | NFkappaB | mouse xenograft model, U251MG, U87MG | 21968049 | PubChem Google | |||
NVX-207 | 9960374 | proliferation | LN229, U251MG, U343MG | 25361208 | PubChem Google | |||
MAZ51 | 9839842 | proliferation | C6, U251MG | 25268128 | PubChem Google | |||
Minocycline | 54675783 | C6, mouse xenograft model | 21079420 | NCT02770378 | PubChem Google | |||
Panobinostat | 6918837 | proliferation | HDAC | primary human glioma cells, stemlike cells | 18445700, 30348136, 30515262 | 21984064, 25572329, 26821711 | NCT00848523, NCT01115036 | PubChem Google |
Terfenadine | 5405 | viability | U87MG | 27029345 | PubChem Google | |||
Pyrazolanthrone | 8515 | viability | JNK | C6, U251MG, U87MG | 18561312, 18813807, 19427347, 19517066, 19788921, 20060865, 23210245, 30229380 | PubChem Google | ||
Fenofibrate | 3339 | proliferation | PPARalpha | T98G, U251MG, U343, U87MG | 18546270, 24493576, 25566967 | PubChem Google | ||
Andrographolide | 5318517 | proliferation | U251MG, U87MG | 22634579 | PubChem Google | |||
PX-866 | 9849735 | angiogenesis, autophagy | PI3K | LN18, LN229, mouse xenograft model, U251MG, U87MG | 20156803 | 25605819 | NCT01259869 | PubChem Google |
Carnosol | 442009 | proliferation | T98G, U343MG, U87MG | 26939786 | PubChem Google | |||
Vinblastine | 13342 | proliferation | primary human glioma cells, U118 | 23165409, 6690037 | NCT00498979 | PubChem Google | ||
Chamaejasmin | 390362 | cytotoxicity | U87MG | 30836216 | ||||
Itraconazole | 55283 | viability | A172, U118, U87MG | 24433351 | NCT02770378 | PubChem Google | ||
KU60019 | 15953870 | radiosensitization | ATM | orthotopic mouse model, primary human glioma cells, U87MG | 23620409, 24443327, 25091220 | PubChem Google | ||
Vincristine | 5978 | proliferation | Microtubules | A172, GL261, LN229, LN443, orthotopic mouse model, primary human glioma cells, U118, U87MG | 23165409, 24433351, 28386621, 30219696 | 20855843, 225004 | NCT00005796, NCT00052455, NCT01837862, NCT02684058 | PubChem Google |
Z-VAD | 9845918 | apoptosis, viability | Pancaspase | U138MG | 18454276 | PubChem Google | ||
Bestatin | 72172 | proliferation | LTA4 | A172 | 19919819 | PubChem Google | ||
Chloroquine | 2719 | radiosensitization, viability | Ced3 | LN229, LN308, U118, U251MG, U87MG | 20406898, 25434381, 27644442, 30878553 | 17350410 | NCT00224978, NCT02378532, NCT02432417, NCT03243461 | PubChem Google |
GSK1904529A | 25124816 | IGF1R | mouse model, U87MG | 26035416 | PubChem Google | |||
VPC32183 | 44392752 | viability | LPA(1), LPA(3) | C6 | 18481020 | |||
Mangostin | 5281650 | autophagy, viability | AMPK | DBTRG05MG, GBM8401 | 21314123 | PubChem Google | ||
PQ401 | 9549305 | IGF1R | mouse xenograft model, U87MG | 25971682 | PubChem Google | |||
Quercetin | 5280343 | proliferation, viability | U251MG, U373MG, U87MG | 18971417, 19491660, 19804834, 24379902, 24902789 | PubChem Google | |||
Dimethyl-alpha-ketoglutarate | 25775 | GDH, Akt | SF188 | 19826036 | PubChem Google | |||
Gedatolisib | 44516953 | viability | PI3K, mTOR | LN229, mouse xenograft model, U251MG, U373, U87MG | 21325073, 24658109 | PubChem Google | ||
Phenethyl Isothiocyanate | 16741 | apoptosis, proliferation | MCL1, XIAP | GBM 8401, xenograft model of glioblastoma in nude mice | 25582659, 30201893 | PubChem Google | ||
Salvianolic acid B | 6451084 | viability | U87MG | 23842993 | PubChem Google | |||
Momelotinib | 25062766 | autophagy, proliferation, temozolomide enhancer | JAK2, STAT3 | U251MG | 30664175 | PubChem Google | ||
Rescovitine | 46881287 | migration | CDK5 | neural stem cells (F3), U87MG | 19351187 | |||
Perifosine | 148177 | apoptosis, cell cycle arrest, viability | Akt, PI3K | T98G, U251MG, U373MG, U87MG | 16103096, 19887560, 24065522 | NCT01051557, NCT02238496 | PubChem Google | |
Flubendazole | 35802 | viability | U87MG | 24433351 | PubChem Google | |||
Rotenone | 6758 | apoptosis | Mitochondrial respiratory chain complex I | DAOY | 19633536 | PubChem Google | ||
Hydroxycitrate | 123908 | clonogenicity, invasion, migration | ATP citrate lyase (ACLY) | U87MG | 19795461 | PubChem Google | ||
Pexidartinib | 25151352 | CSF-1R | 26449250, 31258629 | NCT01349036, NCT01790503 | PubChem Google | |||
Ionomycin | 6912226 | apoptosis, proliferation, T cell activation | Intracellular level of calcium | U251MG, U87MG | 24130787 | PubChem Google | ||
Vinpocetine | 443955 | proliferation | PDE1 | 25620587 | PubChem Google | |||
GSK1838705A | 25182616 | IGF1R | mouse xenograft model, U87MG | 26238593 | PubChem Google | |||
Pargyline | 4688 | proliferation | LN229, T89G, U138, U87MG | 23248157 | PubChem Google | |||
Patulin | 4696 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Captopril | 44093 | invasion | T98G | 8572589 | NCT02770378 | PubChem Google | ||
BIIB021 | 16736529 | cross-resistance | Hsp90 | SF268, U87MG | 19244114 | PubChem Google | ||
PHA-665752 | 10461815 | apoptosis | HGF, Casp3, Casp8, Casp9 | Daoy | 18992144 | PubChem Google | ||
PF-429242 | 23661637 | viability | Site1 protease | 28645614 | PubChem Google | |||
Pyrvinium pamoate | 54680693 | proliferation | GIC | GBM (primary human glioma cells), murine xenograft tumors | 26152745 | PubChem Google | ||
Chlorpromazine | 2726 | viability | Egr1 | A172, C6, LN443, mouse xenograft model, orthotopic mouse model, U118, U251MG, U87MG | 20368687, 23689352, 28455961 | PubChem Google | ||
Vatalanib | 151194 | angiogenesis, temozolomide enhancer | VEGFR, PDGFR, cKIT, cFms | orthotopic mouse model, U251MG | 15271251, 20090952 | 19248046, 19945857, 30382439 | NCT00128700, NCT00387933 | PubChem Google |
SH-5 | 16760282 | radiosensitivity | Akt | U87MG | 19828040 | PubChem Google | ||
TG02 | 16739650 | viability | GSC823, GSC923, LN18, orthotopic mouse model, U251MG | 29254993 | NCT02942264, NCT03224104 | PubChem Google | ||
Hydroxichloroquine | 3652 | apoptosis | PARP, CHOP, GADD153 | LN229, U251MG, U87MG | 25727221 | NCT00486603, NCT01602588 | PubChem Google | |
Pyridoxyl-tryptophan methyl ester | 129848754 | proliferation | ODC | LN229 | 18922879 | |||
Cerivastatin | 446156 | viability | A172, LN443, U118, U87MG | 24433351 | PubChem Google | |||
Panaxydol | 5283280 | proliferation | PI3K | C6 | 19040798, 19179079 | PubChem Google | ||
Navitoclax | 24978538 | proliferation, viability | BCL2, BclxL, BCLw, BH3mimetic | KNS42, LN229, SF188, T98G, U87MG | 24757258, 26474387, 29016820, 30337641 | PubChem Google | ||
Gefitinib | 123631 | apoptosis, elacridar enhancer, proliferation, radiosensitization, viability | EGFR, Akt | G111, G152, GL15, LN229, mouse model, primary human glioma cells, SF767, T98G, U105MG, U251MG, U343MG, U373MG, U87MG | 14643025, 16550610, 18386816, 18566746, 18803287, 19033425, 19435839, 19435898, 21744078, 23724064, 23736154, 24876095, 25368255, 30219696, 30875975 | 23182702 | NCT00014170, NCT00016991, NCT00025675, NCT00027625, NCT00042991, NCT00052208, NCT00085566, NCT00132158, NCT00238797, NCT01310855 | PubChem Google |
Digitoxigenin | 4369270 | viability | U87MG | 27029345, 29333657 | PubChem Google | |||
Luminespib | 135539077 | viability | Hsp90 | mouse xenograft model, SF268, U87MG | 20457619 | PubChem Google | ||
GANT61 | 421610 | viability | GLI | U251MG, U87MG | 27894350 | PubChem Google | ||
Alpha-cyano-4-hydroxycinnamic acid | 5328791 | invasion | mouse xenograft model, U251MG, U87MG | 21750656 | PubChem Google | |||
AKBA | 11168203 | apoptosis, cell cycle arrest, invasion, migration, proliferation | p21, FOXM1, cyclin B1, Aurora B kinase, TOP2A | U251MG, U87MG | 29970196 | PubChem Google | ||
Pravastatin | 54687 | viability | HMGCoA reductase, MAPK, ERK1, 2, RAS, PI3K, Akt, J | LN405, U138, U87MG | 21120479 | PubChem Google | ||
Phloretin | 4788 | cell swelling suppression | Aquaporin9 | 1321N1 | 19772916 | PubChem Google | ||
C-Met inhibitor | 56650915 | apoptosis | cMET | Daoy | 19921488 | PubChem Google | ||
Lapatinib | 208908 | proliferation, viability | EGFR, HER2 | , GBM12, GBM14, GBM5, GBM6, LN229, mouse and rat xenograft model, primary human glioma cells, U87MG | 19254954, 19603143, 24911215, 30219696 | 19499221, 20009104, 23363814 | NCT00095940, NCT00099060, NCT00107003, NCT00350727, NCT02101905 | PubChem Google |
Baicalein | 5281605 | apoptosis | ERK | C6, U87MG | 16814338, 19804834 | PubChem Google | ||
L-DOPA | 6047 | migration, proliferation | T98G | 30591448 | PubChem Google | |||
A-192621 | 5310991 | proliferation | ETRB | A375, LN229, SW1088, WM35 | 19040731 | PubChem Google | ||
VAL-083 | 15942827 | proliferation | LN229, mouse xenograft model, MU145, U251MG, U87MG | 28216618 | NCT01478178, NCT02717962, NCT03050736, NCT03149575 | PubChem Google | ||
Caudatin | 72948694 | proliferation | U251MG, U87MG | 25860846 | ||||
Epothilone B | 448013 | viability | P-glycoprotein | LNZ, T98G, U87MG | 18806741 | NCT00715013 | PubChem Google | |
Indatraline | 126280 | mobility | Monoamine transporter | primary human glioma cells | 24333442 | PubChem Google | ||
Irinotecan | 60838 | migration, viability | TopoisomeRASe 1 | A172, C6, LN443, U118, U251MG, U87MG | 18784279, 19557511, 20415520, 24433351, 26830091, 30989436 | 21744079, 29245310 | NCT00003301, NCT00003463, NCT00003484, NCT00005951, NCT00006025, NCT00010036, NCT00027612, NCT00039468, NCT00099125, NCT00132158, NCT00268359, NCT00345163, NCT00352521, NCT00412542, NCT00433381, NCT00463073, NCT00562419, NCT00597402, NCT00611728, NCT00612638, NCT00616005, NCT00671801, NCT00734682, NCT00762255, NCT00817284, NCT00967330, NCT00979017, NCT00984438, NCT01017653, NCT01022918, NCT01086345, NCT01308632, NCT01837862, NCT01999270, NCT02055196, NCT02192359, NCT03119064, NCT03607643, NCT03678883 | PubChem Google |
GL-331 | 148091 | apoptosis, radiosensitization | TopoisomeRASe 2 | C6, T98G | 16309217, 16827158 | PubChem Google | ||
11-deoxy-PGE1 | 5283055 | proliferation | ERK | U87MG | 20015475 | PubChem Google | ||
Calphostin C | 2533 | viability | PKC | U251MG, U87MG | 19502590, 19724676, 19965895 | PubChem Google | ||
Flavopiridol | 5287969 | radiosensitization | CDK | MO59K, mouse model, T98G, U87MG | 14712094, 23943501, 27461656, 28111642 | PubChem Google | ||
BDP-9066 | 132275018 | invasion, motility | MRCK | xenograft model of GBM | 30279244 | PubChem | ||
Fluvastatin | 446155 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
ML00253764 | 9842665 | proliferation | Melanocortin receptor4 | 28791594 | PubChem Google | |||
Penta-acetyl geniposide | 162083 | apoptosis | NSMase, NGF, p75, FasL, caspase cascades, PI3K, ER | C6 | 16763091, 19464279 | |||
Vmy-1-103 | 44626421 | apoptosis | CDK | D556, Daoy | 21885916 | PubChem Google | ||
Cathepsin S Inhibitor | 16760355 | viability | CatS | U251MG, U87MG | 24875536 | |||
Indirubin Derivative E804 | 135398511 | proliferation | U251MG, U87MG | 26386687, 6419764 | PubChem Google | |||
Decursin | 442126 | apoptosis, cell cycle arrest | JNK, p38, BCL2, CDK4, cyclin D1 | C6, U87MG | 30627007 | PubChem Google | ||
Valganciclovir | 135413535 | bevacizumab enhancer | 26893852 | NCT00400322, NCT04116411 | PubChem Google | |||
POCA | 54217 | fatty acid beta-oxidation | CPT1 | U87MG | 18470630 | PubChem Google | ||
N-Acetylcysteine | 12035 | apoptosis, invasion, migration, proliferation | NOTCH2, HES1, HEY1 | T98G, U251MG, U87MG | 19633536, 19836430, 30606241 | PubChem Google | ||
Sildenafil | 135398744 | proliferation, viability | PDE5 | rat brain tumor models | 18674521 | NCT01817751 | PubChem Google | |
Aprepitant | 135413536 | proliferation | NK1 | GAMG | 21054456, 26603162 | NCT02770378 | PubChem Google | |
Dapivirine | 214347 | apoptosis, induces stress, inhibits proliferation, proliferation | U87MG | 29290776 | PubChem Google | |||
Diazepinomicin | 9868980 | RAS | 22048878 | NCT00730262 | PubChem Google | |||
Iripallidal | 14335632 | viability | A172, LN229, T98G, U87MG | 20576128 | PubChem Google | |||
3,3'-Diindolylmethane | 3071 | apoptosis | U87MG | 30617655 | PubChem Google | |||
Rapamycin | 5284616 | radiosensitization, viability | mTOR | A172, CSCs5, CSCs7, Gli36 cells, mouse xenograft model, primary human glioma cells, T98G, U251MG, U87MG | 18519772, 19177002, 19190120, 19738049, 19808964, 19827268, 21367753, 23261661, 24043497, 25886314, 30569180 | NCT00047073, NCT00509431, NCT00672243, NCT00821080, NCT01522820 | PubChem Google | |
Buparlisib | 16654980 | proliferation, radiosensitization | PI3K | LN18, LN229, LNZ308, mouse xenograft model, primary human glioma cells, T98G, U1242, U251MG, U373MG, U87MG | 22065080, 24500492, 24741074, 24900266, 25431423, 26846842, 27283525, 27363276, 30018387 | 30715997 | NCT01339052, NCT01349660, NCT01473901, NCT01576666, NCT01870726, NCT01934361 | PubChem Google |
T56-LIMKi | 9438169 | viability | LIM kinase | U87MG | 25593987 | PubChem Google | ||
Xyloketal B | 10980896 | proliferation, viability | U251MG | 25913706 | ||||
Mebendazole | 4030 | proliferation | GL261, orthotopic mouse model, primary human glioma cells | 23165409, 28386621 | NCT01729260, NCT01837862, NCT02644291 | PubChem Google | ||
Fenbendazole | 3334 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
STA-21 | 363709 | proliferation | STAT3 inhibitor | GS622, GS72 | 19658181 | PubChem Google | ||
3-methylademine (3-MA) | 135398661 | autophagy, viability | PI3K | CD133+, U251MG | 19431142, 19566920, 19575007 | PubChem Google | ||
Parthenolide | 7251185 | cell resistance to TRAIL | IB phosphorylation | LN443 | 19432816 | PubChem Google | ||
Binimetinib | 10288191 | radiosensitization | MAP2K | GBM8, orthotopic mouse model, U87MG | 28958992 | NCT03973918 | PubChem Google | |
Atorvastatin | 60823 | proliferation, viability | HMGCoA reductase | A172, LN229, primary human glioma cells, T98G, U138, U373, U87MG | 20009104, 23165409, 28181188 | NCT02029573 | PubChem Google | |
781661-94-7 | 11178236 | apoptosis, migration, proliferation | Survivin | A172, LN18, LN229, LNZ308, LNZ428, M059J, M059K, T98G, U373, U87MG | 22770110, 23325792, 25201484, 27805285 | PubChem Google | ||
MK-2206 | 24964624 | proliferation | Akt | LN229, U87MG | 19828040, 22057914, 28320338, 29354058 | NCT01295632 | PubChem Google | |
Evodiamine | 442088 | mouse model, U87MG | 28514905 | PubChem Google | ||||
Thalidomide | 5426 | 25239666, 25427949 | NCT00006358, NCT00014443, NCT00039468, NCT00047281, NCT00047294, NCT00049296, NCT00079092, NCT00112502, NCT00412542, NCT00521482 | PubChem Google | ||||
Diclofenac | 3033 | migration, proliferation | A172, HTZ349, U87MG | 26485029 | PubChem Google | |||
Curcumin | 969516 | cell cycle arrest, proliferation | Wnt, beta-catenin, NFkappaB | U251MG, U373 | 26046466, 30585634, 30864499 | PubChem Google | ||
Temsirolimus | 6918289 | mTOR | T98G, U251MG | 26748241 | 15998902, 16012795, 23099651, 23564811, 24470557 | NCT00016328, NCT00022724, NCT00112736, NCT00316849, NCT00329719, NCT00335764, NCT00784914, NCT00800917, NCT01019434, NCT01051557, NCT01183663, NCT02238496, NCT03158389 | PubChem Google | |
3-(3,4-dichlorophenyl)-1-(3,4-dimethylphenyl)-1-(5-methyl-4,5-dihydro-1,3-thiazol-2-yl)urea | 613034 | mTORC2 | LN229, mouse xenograft model | 28453552 | ||||
UNII-2AW48LAZ4I | 72941968 | Telomerase | orthotopic mouse model, U87MG | 26183089 | ||||
Gadodiamide (Omniscan) | 24847884 | co-convection, cytotoxicity, efficacy, lack of toxicity, positive tissue pharmacokinetics | U87MG rat xenograft model | 19466380 | PubChem Google | |||
Diclofenac sodium | 5018304 | proliferation | 15PGDH, cyclin D1, p21 | T98G, U118, U373 | 18757412 | PubChem Google | ||
Peroxynitrite | 104806 | viability | NO, p53 | D54MG, LNZ308 | 14695179 | PubChem Google | ||
AG490 | 5328779 | invasion, migration, proliferation | JAK2, STAT3, survivin, cyclin D1, COX2, c-Myc | A172, MZ18, MZ256, MZ304, MZ54, U87MG, UW2282, UW2283 | 18592012, 19326989, 20589525 | PubChem Google | ||
Tilarginine | 132862 | apoptosis, viability | NOS | CRTMG, T98G | 19748528, 9809627 | PubChem Google | ||
Spironolactone | 5833 | apoptosis, proliferation, suppress DNA damage repair | EGFR-TKI | mouse xenograft model, patient derived cell lines GS-Y01 | 31614999 | PubChem Google | ||
Dasatinib | 3062316 | proliferation | Src family kinase, BcrAbl, cKIT | LN229, orthotopic mouse model, primary human glioblastoma cells, U87MG | 19098899, 19190119, 19318569, 19690143, 20226597, 30219696 | 22407177, 25758746 | NCT00423735, NCT00609999, NCT00869401, NCT00892177, NCT00895960, NCT00948389 | PubChem Google |
Tozasertib | 5494449 | radiosensitization, viability | Aurora kinase | GBM 8401, GBM 8901, mouse xenograft model, primary human glioma cells, U87MG | 23636005, 25522764 | PubChem Google | ||
2-Hydroxyoleic acid | 9796304 | viability | 1321N1, SF767, U118 | 23133576, 23471028 | NCT03867123 | PubChem Google | ||
Gartanin | 5281633 | proliferation | T98G | 27491646 | PubChem Google | |||
Raddeanin A | 174742 | apoptosis, viability | JNK | U251MG | 29843152 | |||
ON123300 | 56649281 | proliferation | U87MG | 24568969 | PubChem Google | |||
Kainic acid | 10255 | viability | AMPK, NFkappaB | C6 | 18445478 | PubChem Google | ||
6-Bromo-5-nitroquinoline | 280563 | apoptosis, proliferation | C6 | 30431695 | PubChem Google | |||
Mycophenolic acid | 446541 | cell cycle arrest | GFAP, guanine nucleotide biosynthesis | C6, U251MG | 3304619 | PubChem Google | ||
Fluphenazine | 3372 | apoptosis, proliferation, viability | Casp3 | C6, glioblastoma stem-like cells | 14997012, 26196249 | PubChem Google | ||
Roscovitine | 160355 | proliferation | CDK | A172, G28 | 14724573, 19770587, 26151768 | PubChem Google | ||
Everolimus | 6442177 | mTOR, IKK, NF?B, RAI14 | LN229, LN427, LN428, LN751, NCT00085566, NCT00107237, NCT00387400, NCT00515086, NCT00553150, NCT00805961, NCT01062399, NCT01434602, NCT01508104, NCT03355794, NCT03834740, U251MG, U87MG | 18483381, 18559622, 25371289, 30554401 | 20864273, 23725999, 25526733 | PubChem Google | ||
zVAD-fmk | 5497171 | cytotoxicity | T9 | 19247476 | PubChem Google | |||
PI-540 | 11669062 | proliferation | mTOR | U87MG | 19584227 | PubChem Google | ||
RC 3095 | 122127 | proliferation | GRPR | C6, U373MG, U87MG | 18473825 | PubChem Google | ||
AZD6482 | 44137675 | apoptosis, cell cycle arrest, proliferation | PI3Kbeta | U118, U87MG | 30542720 | PubChem Google | ||
Regorafenib | 11167602 | viability | VEGFR2TIE2 | GBM12, GBM14, GBM5, GBM6 | 24911215 | 30522967, 30820715 | NCT02926222, NCT03970447, NCT04051606 | PubChem Google |
Deoxyglucose | 108223 | invasion, migration, radiosensitization | glycolysis, miR75p, TFF3 | A172, LN229, SF268, T98G, U373MG, U87MG | 18483381, 19244119, 19826036, 20009287, 20009289, 20009297, 28756228, 29621542 | 20009294 | PubChem Google | |
RG2833 | 56654642 | Temozolomide enhancer | HDAC1, HDAC3 | 27632183 | PubChem Google | |||
KNK437 | 46195007 | radiosensitization | HSP | A172 | 16966184 | PubChem Google | ||
Furin Inhibitor I | 16760442 | migration, survival | Furin | LN229, U87MG | 19690139 | |||
Fasudil | 3547 | viability | Rho, ROCK | mouse xenograft model, T98G, U251MG, U87MG | 19427347, 20364104, 21166955, 26725099 | PubChem Google | ||
Theophylline | 2153 | viability | PDE | A172, U87MG | 22227470 | PubChem Google | ||
Bendamustine | 65628 | 21626071, 28204914 | NCT00823797 | PubChem Google | ||||
E6201 | 10172827 | MEK | mice | 29437873 | PubChem Google | |||
MLN4924 | 16720766 | NEDD8activating enzyme | orthotopic mouse model, U251MG | 25904638 | PubChem Google | |||
25-Hydroxycholesterol | 65094 | apoptosis | U87MG | 20009104 | PubChem Google | |||
Oxibendazole | 4622 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
TC-A 2317 hydrochloride | 46911725 | apoptosis, cell cycle, viability | Aurora A kinase | human glioblastoma neurosphere tumor xenografts | 25106428, 29396807 | |||
SSR128129E | 68853159 | radiosensitization | FGFR | SF763, U87MG | 24953334 | PubChem Google | ||
GW6471 | 446738 | proliferation | PPARalpha | primary human glioma cells | 29312541 | PubChem Google | ||
AMD3100 | 65015 | angiogenesis | SDF1, HIF1, CXCR4 | LN229, mouse xenograft model, U251MG, U87MG | 20157762, 20179352 | NCT00669669, NCT01339039, NCT01977677, NCT03746080 | PubChem Google | |
JIB-04 | 6519698 | viability | Histone lysine demethylase | A172, CAS1, DBTRG, U251MG, U87MG | 28432280 | PubChem Google | ||
Compound E | 11306390 | proliferation | Gamma secretase | zebrafish xenograft model | 19199503 | PubChem Google | ||
CEP-7055 | 9936664 | proliferation, temozolomide enhancer, viability | VEGFR | human glioblastoma xenografts | 16891460 | PubChem Google | ||
DB-074971 | 77068345 | proliferation | Survivin | A172, LN18, LN229, LNZ308, LNZ428, T98G, U373 | 23325792 | |||
Gambogic acid | 5353639 | apoptosis, proliferation | primary human glioma cells, U251MG | 21879332, 23165409 | PubChem Google | |||
Theobromine | 5429 | proliferation | PDEs | U87MG | 24547961 | PubChem Google | ||
Propranolol | 4946 | mRNA synthesis inhibition | Nonselective badrenoceptor antagonist | U373 | 18498711 | PubChem Google | ||
YM022 | 122130 | invasion, proliferation | CCK2R | U87MG | 19502590 | PubChem Google | ||
Tnp-470 | 369976 | angiogenesis | 9L | 27542173, 8615672 | PubChem Google | |||
Bosutinib | 5328940 | viability | Src family kinase, Akt | LN229, primary human glioma cells, U87MG | 30219696 | 25290090, 25411098 | NCT00959946, NCT01331291 | PubChem Google |
Cabazitaxel | 9854073 | viability | Microtubules | T98G, U87MG | 27203678, 29369439 | NCT01740570, NCT01866449 | PubChem Google | |
Pomolic acid | 382831 | migration, viability | Reactive oxygen species | 28849227 | PubChem Google | |||
602306-29-6 | 16747683 | proliferation | CDK1, CKD2, CDK9 | A172, LN18, LNZ308, T98G, U373, U87MG | 26585571 | PubChem Google | ||
Cisplatin | 84691 | autophagy, viability | DNA intercalation, AMPK | C6, L929, MO59J, MO59K, U251MG, U343, U87MG, XO8 | 19408974, 20196784, 24218165, 24953561, 27993939 | |||
AT13387 | 11955716 | Hsp90 | mouse xenograft model, primary human glioma cells, U251MGHFGFP, zebrafish xenograft model | 28679777 | PubChem Google | |||
BAY 11-7082 | 5353431 | proliferation | NFkappaB | C6, U251MG | 19788921, 26137111 | PubChem Google | ||
Silmitasertib | 24748573 | CK2, IRF3 | 42MGBA, E98, GBM8, GL261, mouse xenograft model, T98G, U251MG, U3013MG, U3017MG, U3024MG, U3031MG, U3054MG, U3084MG, U3086MG, U3117MG, U87MG | 24036851, 28208677, 28683323 | PubChem Google | |||
SKI | 66577038 | proliferation | Sphingosine kinase | D54MG, U251MG | 19597728 | PubChem Google | ||
Apatinib | 11315474 | Tyrosine kinase | 29245310 | NCT03567135, NCT03660761 | PubChem Google | |||
Fludarabine | 657237 | proliferation | primary human glioma cells | 23165409 | NCT00990496, NCT01174121, NCT01454596, NCT02844062, NCT02937844, NCT03412877, NCT04102436 | PubChem Google | ||
Olaparib | 23725625 | viability | PARP | LN229, primary human glioma cells, U87MG | 18954712, 19671736, 25531448, 25576921, 26794465 | NCT01390571, NCT02974621, NCT03212274 | PubChem Google | |
Punicalagin | 44584733 | viability | U87MG | 24077634 | ||||
Nobiletin | 72344 | proliferation | C6 | 23546290 | PubChem Google | |||
SK1-I | 44815217 | apoptosis, invasion, migration, proliferation | Sphingosine kinase 1 | GBM6, LN229, U373 | 19723667 | PubChem Google | ||
Quinine | 3034034 | apoptosis | PARP, CHOP, GADD153 | LN229, U251MG, U87MG | 25727221 | PubChem Google | ||
O(6)-benzylguanine | 4578 | apoptosis | MGMT | U87MG | 18812520 | NCT00002971, NCT00003348, NCT00003567, NCT00004892, NCT00005081, NCT00006474, NCT00017147, NCT00046878, NCT00253487, NCT00362921, NCT00436436, NCT00612989, NCT00613093, NCT00669669, NCT01269424 | PubChem Google | |
Naltrindole hydrochloride (NTI) | 24840086 | proliferation inhibition | Nonpeptide ?-opioid receptor | 1028S, U87MG | 19208828 | |||
Antimycin A | 14957 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Eupalmerin acetate | 5459169 | apoptosis | JNK | U373MG, U87MG | 17237278 | |||
BT#9 (N-Carbamimidoyl-4-[(E)-(3-ethyl-2,4,4-trimethylcyclohex-2-en-1-ylidene)methyl]benzamide) | 137630099 | apoptosis, invasion, migration, proliferation, respiration | Magmas | D54MG, GL261 xenografts, U118MG, U251MG, U87MG | 30414099 | |||
RG7112 | 57406853 | MDM2 | mouse model | 26482041 | PubChem Google | |||
Mefloquine | 40692 | apoptosis | PARP, CHOP, GADD153 | LN229, U251MG, U87MG | 25727221 | NCT01430351 | PubChem Google | |
Imatinib mesylate | 123596 | proliferation | G112, G130, G168, G44, GL261, LNZ308, RG, T98G, U87MG | 18506689, 19159435, 19190128, 19629393, 19737945 | 18359865, 19768386 | PubChem Google | ||
8-Bromo-cyclic AMP | 32014 | proliferation | PKA | A172, U373, U87MG | 18498711, 24649161, 9484714 | PubChem Google | ||
Dihydroartemisinin | 456410 | proliferation | BT325, C6 | 26722323 | PubChem Google | |||
Abt-737 | 11228183 | viability | BCL2 | LN18, LN229, LNZ428 | 18663354, 22393246 | PubChem Google | ||
Biochanin A | 5280373 | cell cycle arrest, proliferation, temozolomide enhancer, viability | EGFR, pERK, pAKT, c-Myc, MTMMP1 | T98G, U87MG | 30591440 | PubChem Google | ||
AMG 900 | 24856041 | proliferation | Aurora kinase | A172, U118MG, U87MG | 30221846 | PubChem Google | ||
Fucoxanthin | 5281239 | proliferation | mouse xenograft model, U251MG, U87MG | 27394418 | PubChem Google | |||
AZD1390 | 126689157 | radiosensitization | GL261, mouse xenograft model | 29938225 | NCT03423628 | PubChem Google | ||
JNJ-10198409 | 9797370 | viability | PLK1 | primary human glioma cells | 24204733 | PubChem Google | ||
Etomoxir | 9840324 | proliferation | Akt | U251MG, U373U, U87MG | 30574020 | PubChem Google | ||
Citral | 638011 | PHGDH | U251MG | 19089318 | PubChem Google | |||
Aminolevulinic acid | 137 | apoptosis, viability | NFkappaB, BIRC3, Casp3 | U87MG | 17335970 | NCT00752323, NCT00961090, NCT01148966, NCT01208909, NCT01310868, NCT01351519, NCT01445691, NCT01575275, NCT02119338 | PubChem Google | |
Diazepam | 3016 | cell cycle arrest, proliferation | Rb | T98G, U87MG | 16059654, 23519373 | PubChem Google | ||
WP1130 | 11222830 | apoptosis | JAK2, STAT3 | GSC11, SF188, T98G, U251MG, U87MG | 19899826, 26872380 | PubChem Google | ||
APCP | 10442687 | proliferation | ecto5\'NT, CD73 | C6, U138MG | 18636315 | PubChem Google | ||
Digoxin | 2724385 | proliferation, viability | primary human glioma cells, U87MG | 21184646, 23165409 | PubChem Google | |||
SH5-07 | 72550504 | viability | STAT3 | mouse xenograft model, U251MG, U373MG, U87MG | 26088127 | PubChem Google | ||
AMG-925 | 60202647 | proliferation | FLT3, CDK4 | A172, LN18, LNZ308, T98G, U373, U87MG | 26585571 | PubChem Google | ||
Iniparib | 9796068 | 26285766 | NCT00687765 | PubChem Google | ||||
Minoxidil sulfate | 4202 | viability | Reactive oxygen species, RhoA, PI3K, PKB | A172, C6 | 14695207, 19027730, 23973310 | |||
SAR-020106 | 44203948 | DNA damage | Chk1 | A172, DBTRG, LN405, P0297, P0306, T98G | 31639020 | PubChem Google | ||
1616632-77-9 | 73777259 | viability | GBM152, GBM18, GBM67R, GBM8, T98G | 26474387, 28767654 | NCT02038699, NCT02525692 | PubChem | ||
Isobutylmethylxanthine | 3758 | proliferation, viability | PDE | A172, U87MG | 22227470, 9484714 | PubChem Google | ||
Valproate | 3549980 | 3-bromopyruvate enhancer, apoptosis | MRP2, BCRP | T98G | 30138705 | NCT02648633 | PubChem Google | |
Tetrandrine | 73078 | viability | U251MG, U87MG | 27909720, 30549224 | PubChem Google | |||
GW9662 | 644213 | viability | PPARgamma | C6, U251MG | 14699130 | PubChem Google | ||
Axitinib | 6450551 | VEGFR, PDGFR | mouse model, U87MG | 25213669, 27926485 | NCT01441388, NCT01508117, NCT01562197, NCT03275558, NCT03291314 | PubChem Google | ||
Brilliant green | 12449 | proliferation | GBM6, U87MG | 29750582 | PubChem Google | |||
NF115 | 10000429 | proliferation | Synthetic glycolipid | C6, U373MG | 23245511 | |||
GF109203X | 2396 | proliferation | PKC | C6 | 18778746, 19822193, 19965895 | PubChem Google | ||
?/??Thujone | 91456 | angiogenesis, apoptosis, proliferation, viability | VEGF, Ang-4, CD31 | C6, U87MG | 26900077 | PubChem Google | ||
Germacrone | 6436348 | proliferation | U251MG, U87MG | 24889088 | PubChem Google | |||
Moxifloxacin | 152946 | apoptosis, proliferation, viability | GSH, DNA intercalation, Casp3, Casp7 | U87MG | 30086267 | PubChem Google | ||
Vindesine | 40839 | viability | A172, LN443, U118, U87MG | 24433351 | PubChem Google | |||
Proscillaridin A | 222154 | proliferation | GSK3beta | GBM6, GBM9, orthotopic mouse model, U251MG, U87MG | 25400117, 27029345, 30250248 | PubChem Google | ||
NU7026 | 9860529 | apoptosis | DNA-PK | KNS60, MO59K, ONS76, U87MG | 19435898, 25307264 | PubChem Google | ||
Nelfinavir | 64143 | 19190249 | 24194293 | NCT00694837, NCT00915694, NCT01020292 | PubChem | |||
PD153035 | 11246488 | proliferation | EGFR | U87MG | 19642173 | PubChem Google | ||
4,7-Dimethyl-1,10-phenanthroline | 72792 | cell invasiveness | Metalloproteinase | Daoy, Madsen, UW2282, UW2283 | 19847623 | PubChem Google | ||
DPI (Diphenyleneiodonium chloride) | 2733504 | migration/invasion | NADPH | U87MG | 19804834 | PubChem Google | ||
KT5720 | 454202 | mRNA synthesis inhibition | PKA, H1R | U373, U87MG | 18498711, 20015475 | PubChem Google | ||
Perphenazine | 4748 | apoptosis, proliferation, viability | Casp3 | C6, U87MG | 14997012, 20811727 | PubChem Google | ||
Furanodienone | 6442374 | apoptosis, cytokine levels, inflammatory responses, TMZ enhancer | CSPG4 | A172, U118, U251MG, U87MG | 31006910 | PubChem Google | ||
Haloperidol | 3559 | PER1, CRY1 | U87MG | 27746588 | PubChem Google | |||
Actinomycin D | 2019 | apoptosis | PIMT | U87MG | 18582478, 19642173 | PubChem Google | ||
VX-745 | 3038525 | invasion | p38, MAPK | C6, IM3 | 29316898 | PubChem Google | ||
Cyclosporine A | 5284373 | mPTP | T67 | 19570051 | PubChem Google | |||
Morphine | 5288826 | proteasome-mediated EAAC1 degradation | EAAC1 | C6, U87MG | 18539596 | PubChem Google | ||
Rosuvastatin | 446157 | viability | HMGCoA reductase, MAPK, ERK1, 2, RAS, PI3K, Akt, J | LN405, U138, U87MG | 21120479 | PubChem Google | ||
Schizandrin B | 158103 | invasion, proliferation | U251MG, U87MG | 27977512 | PubChem Google | |||
JQ1 | 46907787 | proliferation, temozolomide enhancer | BET | C6, rat xenograft model, U87MG | 25056450, 27388964, 29777137 | PubChem Google | ||
PF8380 | 25265312 | proliferation | Autotaxin | LN229 | 23300119 | PubChem Google | ||
PGE(2) | 5280360 | proliferation | PKA, Wnt | U87MG | 19804834, 20015475 | PubChem Google | ||
Atovaquone | 74989 | viability | STAT3 | LN18, SF188, SJGBM2, U87MG | 29783757 | PubChem Google | ||
OTS964 | 89675898 | viability | TOPK | U251MG, U87MG | 29423027 | PubChem Google | ||
trans-ACUB | 16038368 | proliferation | sEH | U251MG, U87MG | 22382785 | PubChem Google | ||
Pimozide | 16362 | apoptosis | USP1 | MZ54, orthotopic mouse model, primary human glioma cells | 26032834, 30250198 | PubChem Google | ||
ML04 | 11640604 | proliferation, radiosensitization | EGFR | U138MG, U87MG | 17210462 | |||
NCD-38 | 102222767 | KDM1A | ortothopic mouse model, U251MG | 27893719 | ||||
Alendronate | 2088 | proliferation, viability | FDPS | primary human glioma cells | 28646347, 30333528 | PubChem Google | ||
Nitazoxanide | 41684 | autophagy, cycle arrest, proliferation | ING1 | A172, LN229, U87MG | 30302016 | PubChem Google | ||
Carnosine | 439224 | proliferation | LDHA | primary human glioma cells, T98G | 19909581 | PubChem Google | ||
SF1126 | 66577114 | PI3K | mice glioma cells, mouse xenograft model | 25425962 | PubChem Google | |||
Tamoxifen | 2733526 | viability | ER-alpha66, ER-alpha36 | U118, U251MG, U87MG | 25554223, 30417588 | NCT00002608, NCT00006388, NCT00492687, NCT00541138 | PubChem Google | |
Afatinib | 10184653 | viability | EGFR, HER2 | A7, LN229, mouse xenograft model, U87MG | 19037840, 25444177, 30219696 | NCT00977431, NCT02423525 | PubChem Google | |
Capecitabine | 60953 | Nucleic Acid Synthesis | 25290090, 31600167 | NCT00504660, NCT00717197, NCT00959946, NCT02669173, NCT03213002 | PubChem Google | |||
Pivaloyloxymethyl | 60748 | apoptosis, proliferation | Histone deacetylase | murine xenograft glioma tumor, U251MG | 16373710 | PubChem Google | ||
Estradiol | 5757 | apoptosis, proliferation | JNK, cjun | C6, T98G | 22848302 | PubChem Google | ||
ML299 | 56593054 | invasion, migration | PLD1, PLD2 | U87MG | 23445448 | |||
Dinaciclib | 46926350 | proliferation | CDK1, CDK2, CDK5, CDK9 | A172, LN18, LNZ308, T98G, U373, U87MG | 26585571 | PubChem Google | ||
FK506 | 24978521 | apoptosis, proliferation, vincristine enhancer | MRP1 | C6, U87MG | 30208561 | |||
PD173074 | 1401 | migration, proliferation | FGFR | T98G, U118MG | 19340397, 26883759 | PubChem Google | ||
Monoterpene perillyl alcohol (POH) | 10819 | RAS | 20401670 | PubChem Google | ||||
Echinomycin | 3197 | angiogenesis, proliferation | HIF1 | U251MG | 16204079 | PubChem Google | ||
S-Adenosyl-L-homocysteine | 439155 | proliferation | MMP2, ERK, PI3K, Akt | BV2, C6 | 19770485 | PubChem Google | ||
Ginsenoside RG3 | 9918693 | proliferation, viability | Wnt, beta-catenin, MGMT | T98G, U118 | 30431207 | PubChem Google | ||
Mangiferin | 5281647 | radiosensitization, viability | NHEJ, gamma?H2AX | U118MG, U87MG | 30272350 | PubChem Google | ||
Crizotinib | 11626560 | prolifiration, viability | cMET | A172, LN18, mouse xenograft model, U373, U87MG | 23556031, 26517812, 29803091, 30201763 | NCT01441388, NCT02270034 | PubChem Google | |
Idebenone | 3686 | apoptosis, cell cycle arrest, migration, proliferation, temozolomide and oxaliplatin enhancer, viability | p21, Casp3 | U373 MG, U87MG | 30602587 | PubChem Google | ||
GW3965 | 447905 | proliferation | LXR | mouse xenograft model, U87MG | 22059152 | PubChem Google | ||
Denbinobin | 10423984 | viability | GBM8401, U87MG | 23123054 | PubChem Google | |||
Tacalcitol | 5283734 | migration, proliferation, viability | T98G | 29575677 | PubChem Google | |||
Harmol | 68094 | viability | U251MG | 23338618 | PubChem Google | |||
Ginsenoside F1 | 9809542 | invasion, migration | NFkappaB, p38MAPK | U251MG, U373MG, U87MG | 29412148 | |||
Amitriptyline | 11065 | inhibitors of cellular respiration, viability | MEK, MAPK | C6, IPSB18 | 11595754, 20332444 | PubChem Google | ||
Givinostat | 9804992 | cell cycle arrest, proliferation | Histone deacetylase | U251MG, U87MG | 30474756 | PubChem Google | ||
MG-262 | 490002 | apoptosis inhibition | Proteasome | LN229, U251MG | 19190249 | PubChem Google | ||
Vismodegib | 24776445 | proliferation | HPI, PI3K | primary human glioma cells | 19716296, 19726788, 21123452 | NCT00980343, NCT03158389 | PubChem Google | |
Glycyrrhizin | 14982 | Toll like receptor 2 (TLR2) | GL26, GL261 | 19143470 | PubChem Google | |||
6-HYDROXYQUINOLINE-4-CARBOXYLIC ACID | 71363454 | Proteasome | 4C8, mouse model | 26645398 | ||||
SB202190 | 5169 | chemosensitivity | p38, MAPK | T98G, U251MG | 19435873 | PubChem Google | ||
Z-IETD-fmk | 25108681 | Casp8, RIP | U343MG | 19432816 | ||||
Gramicidin S | 73357 | proliferation | GBM6, U87MG | 29750582 | PubChem Google | |||
NVP-AEW541 | 11476171 | IGF1R | KNS42_A4, mouse xenograft model, primary human glioma cells | 18677408, 20378689, 20488164, 21659463 | PubChem Google | |||
Thymeleatoxin | 5476508 | proliferation | PKC, cPKC | C6 | 18778746 | |||
BQ788 | 3081333 | proliferation | ETRB | A375, LN229, SW1088, WM35 | 19040731 | PubChem Google | ||
WYE-132 | 25260757 | apoptosis, proliferation, viability | mTOR | U87MG | 20068177 | PubChem Google | ||
Salirasib | 5469318 | apoptosis, invasion, migration, proliferation | RAS | LN229, U1242MG, U251MG, U373MG, U87MG | 16239932, 16985068, 17178866 | PubChem Google | ||
Infigratinib | 53235510 | FGFR | HEK293T | 30344944 | NCT01975701 | PubChem Google | ||
Digoxigenin | 15478 | proliferation, viability | primary human glioma cells, U87MG | 23165409, 27029345 | PubChem Google | |||
4-HPR | 5288209 | apoptosis, differentiation | Casp8, tBid, BIRC, Calpain, Casp3 | C6, T98G, U87MG | 18602901, 19285047 | NCT00075491 | PubChem Google | |
RITA | 374536 | proliferation, temozolomide enhancer | ASK1 | U251MG, U87MG | 30562758 | PubChem Google | ||
Paeoniflorin | 442534 | invasion, migration, proliferation | TGFbeta | T98G, U251MG, U87MG | 29423667 | PubChem Google | ||
Gamma-aminobutyric acid | 119 | neuroinflammation | IL6 | C6 | 18679050 | PubChem Google | ||
Fludarabine phosphate | 30751 | viability | DNA, RNA synthesis | LN229, primary human glioma cells, U87MG | 30219696 | PubChem Google | ||
Methyl gallate | 7428 | viability | C6, U373 | 23562553 | PubChem Google | |||
SAR405838 | 53476877 | MDM2 | GBM108, xenografts of human glioblastoma | 29970480, 31619389 | PubChem Google | |||
JWH?133 | 6918505 | migration, proliferation, viability | VEGF, VEGFR?2, HIF-1alpha | C6, T98G, U87MG | 15313899, 24204703 | PubChem Google | ||
Zafirlukast | 5717 | invasion, migration | CysLT (cysteinyl leukotriene receptor) | A172, U373 | 28600709 | PubChem Google | ||
Ralimetinib | 11570805 | MAPK | mouse xenograft model, U87MG | 24356814 | NCT02364206 | PubChem Google | ||
Trabedersen | 132472120 | 20980335 | NCT00761280 | |||||
Alvespimycin | 5288674 | apoptosis, proliferation, radiosensitization | Hsp90, AMPK | C6, SF268, U251MG, U87MG | 19244114, 19805107, 24418474 | PubChem Google | ||
beta-Peltatin | 92122 | proliferation | primary human glioma cells | 23165409 | ||||
5-aminolevulinic acid | 123608 | 30644008 | NCT01208909, NCT01310868, NCT01445691, NCT02119338, NCT03048240 | PubChem Google | ||||
RO4929097 | 49867930 | Gamma secretase | IGRG121, mouse xenograft model | 25486598 | NCT01119599, NCT01122901, NCT01131234, NCT01189240, NCT01269411 | PubChem Google | ||
Farnesyl Pyrophosphate | 445713 | apoptosis | JNK | U87MG | 20298756 | PubChem Google | ||
Arginyl-glycyl-aspartic acid | 104802 | migration | PKB phosphorylation | glioblastoma stem-like cells | 30280197 | PubChem Google | ||
Lopinavir | 92727 | ritonavir enhancer | 20683757 | NCT01095094 | PubChem Google | |||
Eribulin | 11354606 | survival, tumour growth | (TERT)-RNA-dependent RNA polymerase | mouse brain tumor xenograft with U87MG | 31099446 | PubChem Google | ||
Demethoxycurcumin | 5469424 | mouse xenograft model, primary human glioma cells | 27757851 | PubChem Google | ||||
Larotrectinib | 46188928 | TrkA, TrkB, TrkC. | 30220707 | PubChem Google | ||||
Lorlatinib | 71731823 | ALK, ROS1 | mouse model | 25733882 | PubChem Google | |||
alpha-Bisabolol | 442343 | apoptosis | mPTP | C6, T67, U87MG | 14975741, 19570051 | PubChem Google | ||
Thymoquinone | 10281 | proliferation | T98G, U87MG | 24039814, 29651429, 30197342 | PubChem Google | |||
Glycitein | 5317750 | angiogenesis, invasion | MMP3, MMP9 | U87MG | 20188714 | PubChem Google | ||
Bafetinib | 11387605 | Tyrosine kinase | 23380277 | NCT01234740 | PubChem Google | |||
Scriptaid | 5186 | apoptosis, viability | HDAC, JNK | BS153, DKMG | 19583803, 26032687 | PubChem Google | ||
Terameprocol | 476861 | angiogenesis, apoptosis, cell cycle arrest, proliferation | SP1, cyclindependent kinase 1, survivin, VEGF | primary human glioma cells, SF188, T98G, U251MG, U343 | 18311658, 23299390 | 22323663 | NCT00404248 | PubChem Google |
Arctigenin | 64981 | proliferation | T98G, U87MG | 28356992 | PubChem Google | |||
Casticin | 5315263 | viability | U251MG, U373, U87MG | 23816816 | PubChem Google | |||
Sonidegib | 24775005 | viability | Smoothened, Gli1, Gli2, Patched1, Patched2 | primary human glioma cells | 23482671, 30251117 | NCT01576666, NCT03434262 | PubChem Google | |
Prochlorperazine | 4917 | viability | U87MG | 29441946 | PubChem Google | |||
Baicalein-5,6,7-trimethylether | 442583 | peroxisomal fatty acid beta-oxidation | ACSVL1 | U87MG | 18470630 | PubChem Google | ||
KU55933 | 5278396 | radiosensitization | ATM | orthotopic mouse model, primary human glioma cells, WK1 | 25017126, 25205037 | 19931733 | PubChem Google | |
Meloxicam | 4051 | proliferation | 15PGDH, cyclin D1, p21 | T98G, U118, U373 | 18757412 | |||
Embelin | 3218 | viability | LN18, T98G, U87MG | 19409438, 19649204, 23514760, 23545899, 29384188 | PubChem Google | |||
Bevacizumab | 24801580 | apoptosis, perifosine enhancer, proliferation, radiosensitization | VEGF, PI3K, Akt | C6, murine glioma xenografts, U251MG | 19567589, 19584228, 28616662, 30881126 | 24552324, 30301554 | ||
5,7-dihydroxy-4'-methoxy-6,8-diprenylisoflavone | 44403741 | cytotoxicity | U87MG | 30836216 | ||||
L-NAME | 39836 | migration | Nitric oxide synthases (NOS) | T98G, U87MG | 19629394 | PubChem Google | ||
6-MOMIPP | 134155701 | apoptosis, mitotic arrest, proliferation | Microtubules | murine glioma xenografts, U251MG | 30426158 | |||
3-BrOP | 11513992 | viability | primaru human glioma cells | 23132831 | PubChem Google | |||
Caffeic acid phenethyl ester | 5281787 | apoptosis, proliferation | C6, primary human glioma cells | 14637186, 15885897, 23165409, 24997497 | PubChem Google | |||
HET-0016 | 2727594 | proliferation | CYP4A, 20HETE, EGFR | 9L, rat xenograft model, U251MG | 16081682, 16352703 | PubChem Google | ||
KP1 | 141153 | apoptosis, proliferation | PI3K, Akt | U251MG, U87MG | 16546978 | PubChem Google | ||
PJ34 | 4858 | viability | PARP | LN229, U87MG | 25531448, 25576921 | PubChem Google | ||
AG-1478 | 2051 | proliferation | EGFR | mice xenografts, U87MG | 16522318, 19828040 | PubChem Google | ||
SKI II | 753704 | radiosensitization | Sphingosine kinase | A172, LN18, LN229, T98G, U251MG, U87MG | 25255218, 28494176 | PubChem Google | ||
Trichostatin | 444732 | apoptosis, viability | HDAC, NAG1, GDF15 | A172, C6, HEK, LN308, LNT229, T98G, U87MG | 16383255, 16384639, 18483381, 18550052, 18607344, 18611290, 18801729, 18803327, 19062177, 19360904, 19728174, 19787267, 19847810, 23564772, 24905315 | PubChem Google | ||
Oligomycin | 78358496 | viability | T98G, U251MG, U87MG | 23523615 | ||||
Ellipticine | 3213 | apoptosis, proliferation | U87MG, UKFNB3 | 21753906 | PubChem Google | |||
Disulfiram | 3117 | proliferation | primary human glioma cells | 23165409 | NCT01777919, NCT01907165, NCT02678975, NCT02715609, NCT02770378, NCT03151772, NCT03363659 | PubChem Google | ||
Dibutyryl cAMP | 9687 | proliferation | Cx43 | A172, C6 | 16718685, 9484714 | PubChem Google | ||
Strophanthidin | 6185 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Cannabidiol | 644019 | MK-886 enhancer, viability | 5Lipoxygenase, FAAH | murine xenograft glioma tumor, U87MG | 18028339 | NCT03607643 | PubChem Google | |
Isotretinoin | 5282379 | 25239666 | NCT00003564, NCT00112502, NCT00555399, NCT01103375 | PubChem Google | ||||
Milciclib | 16718576 | proliferation | SF268, SF539, U251MG, U87MG | 23347136 | PubChem Google | |||
Clozapine | 135398737 | proliferation | PKA, chloride channel 4, CDK5, PI3K, Akt, GSK-3bet | SHSY5Y, U87MG | 16542821, 25246152 | PubChem Google | ||
PLX-4720 | 24180719 | BRAF | DBTRG05MG, orthotopic mouse model | 26023796 | PubChem Google | |||
Imipramine | 3696 | apoptosis, autophagy | PI3K, Akt, mTOR | T98G, U87MG | 21889492, 26412325, 28500556 | PubChem Google | ||
Sinomenine | 5459308 | mouse model, U87MG | 28891980 | PubChem Google | ||||
Volasertib | 10461508 | radiosensitization, viability | PLK1 | primary human glioma cells | 24204733, 29535822 | PubChem Google | ||
Dynole 34-2 | 44157463 | migration, neurosphere formation, viability | GTPase dynamin 2 | GSCs, U251MG, U87MG | 30907150 | |||
Marizomib | 11347535 | viability | Proteasome | LN18, mouse xenograft model, SNB19, U251MG, U87MG | 20165695, 21247382, 26681765, 26804704 | NCT03345095 | PubChem Google | |
AR03 | 698490 | Ape1 | SF767 | 20504914 | PubChem Google | |||
Ibuprofen | 3672 | migration, proliferation | A172, HTZ349, U87MG | 26485029 | PubChem Google | |||
Vemurafenib | 42611257 | BRAF | 24725538 | PubChem Google | ||||
Chloramphenicol | 5959 | proliferation | ALDH | U87MG | 15777731, 19500061 | PubChem Google | ||
Nutlin-3a | 11433190 | apoptosis | U87MG | 30574827 | PubChem Google | |||
Nintedanib | 135423438 | VEGFR, FGFR, PDGFR | 23184145, 25338318 | NCT01251484 | PubChem Google | |||
Luteolin | 5280445 | invasion, migration, proliferation, viability | Musashi1 | U251MG, U343, U87MG | 28927111, 30362859, 30374718 | PubChem Google | ||
Difluorodeoxyuridine | 129627896 | radiosensitivity | 19770758 | |||||
Neurostatin | 71716390 | mouse xenograft model, U373 | 20801220 | |||||
Clofazimine | 2794 | viability | A172, LN443, U118, U87MG | 24433351 | PubChem Google | |||
Chrysin | 5281607 | invasion, migration, proliferation, viability | MAPK , CDK2, CDK4, ERK, Nrf2 | C6, U87MG | 15869744, 29662304 | PubChem Google | ||
Candidaspongiolide | 102471178 | apoptosis | PKR, eIF2alpha, casp12 | U251MG | 18728285 | |||
GM6001 | 132519 | migration, survival | MMP, ADAM | LN229, U373, U87MG | 19220854, 19690139 | PubChem Google | ||
Sphingosine | 5280335 | apoptosis | ERK1, ERK2 | C6 | 16302024, 8768300 | PubChem Google | ||
SH-4-54 | 72188643 | proliferation | STAT3 | orthotopic mouse model | 24900612 | PubChem Google | ||
Cycloheximide | 6197 | proliferation | C6 | 19808964, 21159181 | PubChem Google | |||
Glaucocalyxin A | 10471963 | proliferation | U87MG | 24041957 | ||||
761437-28-9 | 9934347 | radiosensitization, viability | FAK | A172, DDHT7607, DDT4, LN229, U138MG, U343MG, U87MG | 17219439, 19030106, 25625667 | PubChem Google | ||
CPI-455 | 78426698 | viability | Histone lysine demethylase | A172, CAS1, DBTRG, U251MG, U87MG | 28432280 | PubChem Google | ||
Dermaseptin-PS1 | 16130489 | apoptosis, proliferation | Bax, BCL2, LDH | U251MG | 30461197 | |||
PP242 | 135565635 | migration, proliferation | mTORC1, mTORC2 | LN18 | 25243800, 26719046 | PubChem Google | ||
IC86621 (DNA-PK Inhibitor III) | 9859309 | apoptosis | DNA-PK | SCID mice | 19425167 | PubChem Google | ||
VER-50589 | 135446210 | cross-resistance | Hsp90 | SF268, U87MG | 19244114 | PubChem Google | ||
Nisoldipine | 4499 | viability | U87MG | 24433351 | PubChem Google | |||
Tivantinib | 11494412 | proliferation | PI3K/Akt, mTOR | T98MG, U251 | 31575848 | PubChem Google | ||
Hsp-990 | 46216556, 16226182 | apoptosis, radiosensitization | Hsp90 | LN18, mouse xenograft model, U251MG, U373MG, U87MG | 23448094, 24500492 | PubChem Google | ||
Nicardipine | 4474 | apoptosis | ABCG2 | CD133+ | 19340456 | PubChem Google | ||
Tanshinone IIA | 164676 | LN229 | 30021339 | PubChem Google | ||||
Doxycycline | 54671203 | proliferation, viability | MMP2 | LNT229, T98G, U343 | 19828040, 28112361, 29772845 | PubChem Google | ||
Cytarabine | 6253 | proliferation | primary human glioma cells | 23165409 | NCT01044966 | PubChem Google | ||
Gitoxigenin | 348482 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Bufalin | 9547215 | proliferation, viability | ATP1A1 | murine xenografts, U251MG, U87MG | 28787697, 29653366 | PubChem Google | ||
Iodoacetic acid | 5240 | cell invasiveness | Cysteine protease | Daoy, Madsen, UW2282, UW2283 | 19847623 | PubChem Google | ||
Ki16425 | 10367662 | viability | LPA(1), LPA(3) | C6 | 18481020 | PubChem Google | ||
Otx-008 | 11953346 | viability | galectin1 | U87MG | 23978989 | |||
Sanguinarine | 5154 | viability | U118MG, U87MG | 26472194 | PubChem Google | |||
Lomustine | 3950 | OIP5 | GBM12, GBM6, orthotopic mouse model | 27474153, 28672195, 30284228 | 20124186, 20855843, 23940216, 24958095, 30522967 | NCT00003788, NCT00005796, NCT00052455, NCT00068952, NCT00295815, NCT00503204, NCT00504660, NCT00761280, NCT00777153, NCT00948389, NCT01067469, NCT01149109, NCT01290939, NCT01562197, NCT01582269, NCT01737346, NCT01860638, NCT01934361, NCT02076152, NCT02343406, NCT02414165, NCT02765165, NCT02843230, NCT02926222, NCT03022578, NCT03025893, NCT03149575, NCT03463265, NCT03678883, NCT03970447, NCT04049669 | PubChem Google | |
NS-398 | 4553 | inflammatory response | Cyclooxygenase2 | 1321N1, C6, U87MG | 19804834, 19854233 | PubChem Google | ||
Cyclophosphamide | 2907 | DNA crosslinking | 15022289, 15735920 | NCT00003185, NCT00008008, NCT00014573, NCT00047281, NCT00990496, NCT01174121, NCT01403285, NCT01454596, NCT01903330, NCT02502708, NCT02844062, NCT02937844, NCT03152318, NCT03412877, NCT04049669, NCT04102436 | PubChem Google | |||
Aciclovir | 2022 | IFN-gamma enhancer, proliferation | PCNACdk2 | SNB19, T98G, U373 | 10841074 | PubChem Google | ||
Furegrelate | 3437 | angiogenesis, BCNU enhancer, proliferation, viability | TXSA | orthotopic human glioblastoma xenografts, U87MG | 18825315, 20165694 | PubChem Google | ||
SB-216763 | 176158 | apoptosis | GSK3 | BS125, LN18, LN319, U373, U87MG | 18582478, 19823589 | PubChem Google | ||
2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid | 115288 | apoptosis, proliferation | LAT1 | A1207, C6, nude mice xenografts, U178MG, U87MG | 18382329, 18520037 | PubChem Google | ||
Phospho-valproic acid (MDC-1112) | 129866270 | proliferation | STAT3 | intracranial xenograft model, LN18, LN229, subcutaneous GBM xenografts in mice, U118, U87MG | 30994173 | |||
Montelukast | 5281040 | invasion, migration | CysLT (cysteinyl leukotriene receptor) | A172, U373 | 28600709 | PubChem Google | ||
Ciprofloxacin | 2764 | apoptosis, proliferation, viability | GSH, DNA intercalation, Casp3, Casp7 | U87MG | 30086267 | PubChem Google | ||
Naringin | 442428 | invasion, migration | U251MG | 26474590 | PubChem Google | |||
cis-Diaminedichloroplatinum (CDDP, cisplatin) | 2767 | chemosensitivity | Met | T98G, U251MG | 19435873 | PubChem Google | ||
Nimustine | 91657 | apoptosis, rapamycin enhancer, viability | mTOR | U251MG | 17390104, 18614215 | PubChem Google | ||
Bortezomib | 387447 | proliferation, temozolomide enhancer | Proteasome | D54MG, mouse xenograft model, primary human glioma cells, T98G, U118, U251MG, U87MG | 17201170, 17545549, 18445700, 18625341, 18771084, 19190249, 19213072, 20192117, 23334228, 24093630, 24297065, 29750582, 30875688 | 19084346, 19770758 | NCT00006773, NCT00544284, NCT00611325, NCT00641706, NCT00998010, NCT01435395, NCT03607643, NCT03643549 | PubChem Google |
Aspirin | 2244 | proliferation, viability | SK?N?SH (N) | 31429199 | NCT00790452 | PubChem Google | ||
Clomipramine | 68539 | inhibitors of cellular respiration | IPSB18 | 20332444 | PubChem Google | |||
GSK-3 inhibitor IX | 448949 | apoptosis, proliferation | GSK-3, EGFR, NF-kB | U87MG | 30984989 | PubChem Google | ||
Camptothecin | 24360 | proliferation, viability | GL15, primary human glioma cells, SF767, U105MG U251MG, U343MG, U373MG, U87MG | 16356833, 19633536, 23165409, 23736154, 27029345 | PubChem Google | |||
Osajin | 95168 | cytotoxicity | U87MG | 30836216 | PubChem Google | |||
UniPR1331 | 134817215 | angiogenesis | Ephrin | U87MG | 29849945 | |||
Troglitazone | 5591 | apoptosis | PTPN1, pY705STAT3, glyoxalase I | LN18, MG328, T98G, U87MG | 11719831, 16319070, 18346464, 19158480 | PubChem Google | ||
Albendazole | 2082 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Tigecycline | 54686904 | apoptosis, proliferation | HES1, PI3K, Akt | U87MG | 26823491 | PubChem Google | ||
3,5-Dihydroxyphenylglycine (DHPG) | 108001 | neuroprotection, proliferation, synaptic modulation | mGluR1, mGluR5 | C6 | 19822193 | PubChem Google | ||
Vitexin | 5280441 | apoptosis, cell cycle arrest, viability | Akt, mTOR | LN18 | 29328424 | PubChem Google | ||
Antroquinonol | 24875259 | C6, mouse model | 26517117 | PubChem Google | ||||
Palbociclib | 5330286 | CDK4, CDK6 | mouse xenograft model | 20354191, 24098593, 26149830, 26354993, 27370397, 28903422 | 30151703 | NCT02255461, NCT03158389 | PubChem Google | |
Cucurbitacin I | 5281321 | apoptosis, cell cycle arrest, proliferation | JAK, STAT3 | A172, LN18, LN229, LNZ308, mouse xenograft model, T98G, U251MG, U87MG, U87MGEGFRviii | 18487947, 18829483, 24599950, 25482928 | PubChem Google | ||
Lomeguatrib | 3025944 | apoptosis | MGMT | 19770758 | PubChem Google | |||
Riluzole | 5070 | proliferation | MEK, ERK, CREB | C6, U87MG | 16524382, 21295555, 23724064, 30591460 | PubChem Google | ||
Elemene | 6918391 | cell cycle arrest | C6 | 18346382 | PubChem Google | |||
Oxymatrine | 114850 | apoptosis, proliferation | EGFR, PI3K, Akt, mTOR, STAT3 | U251MG | 29989652 | PubChem Google | ||
Artesunate | 65664 | cell cycle arrest, proliferation, radiosensitization | CDK2, CDK4, cyclin D1, cyclin B1 | A172, LN229, U251MG, U87MG | 22560712, 29600654 | PubChem Google | ||
NMS-P715 | 44556162 | radiosensitization | mouse xenograft model, U251MG | 25722303 | PubChem Google | |||
A861 | 70700216 | proliferation | 5Lipoxygenase | A172 | 19919819 | |||
Ouabain | 439501 | viability | LN229, U87MG | 18795320, 19995221, 21184646 | PubChem Google | |||
Repaglinide | 65981 | GL261, orthotopic mouse model | 28476618 | PubChem Google | ||||
Guggulsterone | 53394010 | viability | A172, T98G, U87MG | 23548480 | PubChem Google | |||
Pyrvinium | 5281035 | proliferation, viability | mouse xenograft model, primary human glioma cells, U87MG | 23165409, 26152745, 27029345 | PubChem Google | |||
Rosiglitazone | 77999 | apoptosis, proliferation | PPARgamma, COX2 | A172, C6, M059J, M059K, U251MG, U87MG | 14699130, 15254749 | PubChem Google | ||
Trametinib | 11707110 | viability | MEK | HEK293T, NIH3T3, primary human glioma cells | 25431423, 30344944 | 29295876 | NCT02684058, NCT03434262, NCT03919071, NCT03975829 | PubChem Google |
Tempol | 137994 | migration/invasion | COX2, peroxide production | U87MG | 19804834 | PubChem Google | ||
UMI-77 | 992586 | viability | MCL1 | A172, U251MG, U87MG | 28337703 | PubChem Google | ||
Niclosamide | 4477 | proliferation, viability | primary human glioma cells, U87MG | 23165409, 27029345 | PubChem Google | |||
Chaetocin | 11657687 | viability | Histone lysine methyltransfeRASes | C6 | 24905315 | PubChem Google | ||
Naphtho[2,3-f]quinoxaline-7,12-dione (NSC745887) | 12567021 | apoptosis, prolifiration, viability | DcR3, ATM | U118MG, U87MG | 29552282 | PubChem Google | ||
2,5-Dihydroxybenzenesulfonate | 101209015 | apoptosis | C6, orthotopic rat model | 21193016 | ||||
Vasculostatin | 12617 | angiogenesis, proliferation | CD36 | U87MG | 19176395 | PubChem Google | ||
Sulfasalazine | 5359476 | proliferation, radiosensitization | MAPK, NFkappaB | A172, D54MG, D65MG, GBM62, GM1, GM2, GM3, GM4, GM5, LN18, STTG1, U251MG, U87MG | 15328202, 16079392, 19015640, 25798841, 25937318, 28929335 | 19840379 | PubChem Google | |
Bibu 1361 | 46861539 | apoptosis | EGFR | A172, LN229, T98G, U87MG | 22753156 | |||
E7016 | 11660296 | radiosensitivity | PARP, HMGB1, TLR2 | U251MG | 19147766 | PubChem Google | ||
AZD1480 | 16659841 | proliferation | JAK1, JAK2 | orthotopic mouse model, U251MG | 22027691 | PubChem Google | ||
Phenylbutyrate | 5258 | radiosensitisation | HDAC | D54, SKMG3, U251MG, U87MG | 17707275 | PubChem Google | ||
Letrozole | 3902 | proliferation | Aromatase | C6, LN229, orthotopic mouse model, T98G, U251MG, U373MG, U87MG | 25695958 | PubChem Google | ||
Thallium acetate | 11247 | apoptosis, viability | CDK2 | LC6 | 15965099 | PubChem Google | ||
Endothelin-1 | 16212950 | proliferation | ERK | C6 | 18975108 | |||
Midazolam | 4192 | proliferation | A172, U118, U251MG, U87MG | 27629139 | PubChem Google | |||
Rottlerin | 5281847 | proliferation | SNB19, U251MG | 18778746, 19965895, 27626499 | PubChem Google | |||
Carmofur | 2577 | Human acid ceramidase (AC) | 30525581 | PubChem Google | ||||
Selumetinib | 10127622 | MEK1, MEK2 | D456, D645, GBM2, LN229, mouse xenograft models, U373 | 20806365, 22573716 | PubChem Google | |||
WP1066 | 11210478 | proliferation | JAK, STAT3 | primary human glioma cells, U87MG | 17942891, 23612755 | NCT01904123 | PubChem Google | |
Go6976 | 3501 | proliferation | cPKC | C6 | 18778746, 19357285 | PubChem Google | ||
Carbenoxolone | 636403 | GAP | C6 | 19360884 | PubChem Google | |||
KP2 | 10537176 | apoptosis, proliferation | PI3K, Akt | U251MG, U87MG | 16546978 | |||
Cladribine | 20279 | viability | A172, U118, U87MG | 24433351 | NCT00019071 | PubChem Google | ||
STX-0119 | 4253236 | proliferation | STAT3 | mouse model, primary human glioma cells, U87MG | 23612755, 24820265, 28716484 | PubChem Google | ||
CBL-0137 | 44519124 | apoptosis, proliferation | SSRP1, SOX2, OCT4, NANOG, OLIG2, CD133, FACT, p53, | A1207, orthotopic mouse model, primary human glioma cells, U87MG | 26921329, 27370399, 30581774 | NCT01905228 | PubChem Google | |
KPT251 | 57519758 | viability | CRM1 | AGBM1, BT145, BT159, BT172 | 25366336 | PubChem Google | ||
Reversan | 2298706 | 26136652 | PubChem Google | |||||
Cycloguanil | 9049 | viability | CLIC1 | GBM1, GBM2, GBM3, GBM4, GBM5, GBM6, GBM7 | 30186163 | PubChem Google | ||
Capmatinib | 25145656 | cMET | mouse xenograft model, U87MG | 21918175 | NCT01324479, NCT01870726, NCT02386826 | PubChem Google | ||
Melatonin | 896 | apoptosis, viability | A172, T98G, U251MG, U87MG | 19632770, 28255276, 29925764 | PubChem Google | |||
Tezacitabine | 6435808 | proliferation, viability | RR (ribonucleotide reductase) | HS683, J889H, xenografts of human glioblastoma | 8542592 | PubChem Google | ||
ML298 | 53393916 | invasion, migration | PLD2 | U87MG | 23445448 | |||
F0911-7667 | 4192636 | apoptosis, autophagy | SIRT1, AMPKmTORULK | T98G, U87MG | 29991742 | |||
DNQX | 3899541 | viability | AMPA | U87MG | 19997873 | PubChem Google | ||
Rutin | 5280805 | apoptosis, proliferation | GBM95, U251MG | 19491660, 30868970 | PubChem Google | |||
Moroxydine | 71655 | proliferation, viability | CLIC1 | GBM1, GBM2, GBM3, GBM4, GBM5, GBM6, GBM7 | 30186163 | PubChem Google | ||
Alisertib | 24771867 | viability | Aurora A kinase | GB169, GB30, GB9, KNS42, mouse xenograft model, primary human glioma cells, SF188, T98G, U1242, U87MG | 24627220, 24879067, 25106428, 27797168, 29016820, 29396807 | NCT02186509 | PubChem Google | |
Triciribine, Akt inhibitor V | 65399 | proliferation inhibition | Akt | 1028S, U87MG | 19208828 | PubChem Google | ||
Dioleoyl phosphatidic acid | 9547172 | radiosensitization | Calcium signaling | C6 | 17499746, 18481020 | PubChem Google | ||
NBQX | 3272524 | proliferation | AMPA | U87MG | 23724064 | PubChem Google | ||
AXL1717 | 72435 | proliferation | IGF1R | mouse xenograft model, primary human glioma cells, U563MG, U87MG | 20150364, 23165409 | NCT01721577 | PubChem Google | |
Digitoxin | 441207 | proliferation, viability | primary human glioma cells, U87MG | 21184646, 23165409 | PubChem Google | |||
U46619 | 5311493 | cell swelling | TXA2 | 1321N1 | 19772916 | PubChem Google | ||
Cardamonin | 641785 | proliferation | mouse model, primary human glioma cells, U87MG | 26150336 | PubChem Google | |||
Lenvatinib | 9823820 | Multiple kinases | mouse model | 28901423 | NCT01433991, NCT03797326 | PubChem Google | ||
TGX-221 | 9907093 | proliferation | p110beta | U251MG, U87MG | 29048665 | PubChem Google | ||
Ruxolitinib | 25126798 | viability | JAK | LN229, primary human glioma cells, U87MG | 29788332, 30219696 | NCT02711137, NCT03514069 | PubChem Google | |
Monensin | 441145 | proliferation, viability | primary human glioma cells, U87MG | 23165409, 27029345 | PubChem Google | |||
Bombesin | 25078147 | proliferation | GRPR | C6, U373MG, U87MG | 18473825 | |||
MK-886 | 3651377 | viability | Lipoxygenase | U373MG, U87MG | 17949236, 19862483, 23261452 | PubChem Google | ||
Methanandamide | 6321351 | apoptosis | COX2 | H4 | 16267630 | PubChem Google | ||
Pseudolaric acid B | 6393431 | apoptosis | U87MG | 22778780 | ||||
4506-66-5 | 78260 | migration, proliferation | FAK | DBTRG, orthotopic mouse model, T98G, U118MG, U87MG | 23243059, 23387973, 26883759 | PubChem Google | ||
Linifanib | 11485656 | apoptosis | VEGFR2, PDGFRbeta, Receptor tyrosine kinase | murine glioma models, orthotopic rat model | 16648571, 22080168 | PubChem Google | ||
Radicicol | 6323491 | migration | ACLY, Hsp90 | LN229, SF268, U87MG | 19244114, 19795461 | PubChem Google | ||
Celastrol | 122724 | C6, mouse xenograft model, SHG44, U251MG, U373MG | 18343027, 19909582, 20007406, 21786165, 24810052 | PubChem Google | ||||
Carvacrol | 10364 | proliferation, viability | U251MG | 25913706 | PubChem Google | |||
Triapine | 9571836 | radiosensitization, viability | RR (ribonucleotide reductase) | U251MG | 16675588 | PubChem Google | ||
A-443654 | 10172943 | apoptosis, proliferation inhibition | Akt | 1028S, U87MG | 19208828 | PubChem Google | ||
Masitinib | 10074640 | viability | FAK, cKIT, PDGFR, FGFR | LN229, primary human glioma cells, U87MG | 30219696 | PubChem Google | ||
Jaceosidin | 5379096 | apoptosis, cell cycle arrest, proliferation, viability | p53, Bax | U87MG | 22471459 | PubChem Google | ||
Mitomycin | 5746 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Piplartine | 637858 | migration | LN229, U87MG | 23796709, 24967005 | PubChem Google | |||
SGX-523 | 24779724 | cMET | orthotopic mouse model | 20015006 | PubChem Google | |||
Bisacodyl | 2391 | viability | WNK1 kinase, Akt, SGK1, NBCfamily Na+, HCO3 | primary human glioblastoma cells | 29930759 | PubChem Google | ||
Sunitinib | 5329102 | angiogenesis, invasion, proliferation | Receptor tyrosine kinases, STAT3, Akt | Daoy, F98, mouse model, T98G, U251MG, U87MG | 17622648, 19101989, 19603143, 20179017, 22449730, 25458015, 30472587 | 20053726, 20872043, 21744079, 22832897, 24311637, 24424564 | NCT00499473, NCT00535379, NCT00606008, NCT00864864, NCT00923117, NCT01100177, NCT01441388, NCT02928575, NCT03025893, NCT03275558 | PubChem Google |
Modafinil | 4236 | proliferation, viability | CYP3A4 | GL261, SHSY5Y | 22434147 | PubChem Google | ||
AZD2014 | 25262792 | radiosensitization | mTOR | stemlike cells | 24311635 | NCT02619864 | PubChem Google | |
Convallatoxin | 441852 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Erdafitinib | 67462786 | FGFR | 26324363 | PubChem Google | ||||
Foretinib | 42642645 | collagen invasion, migration, proliferation, Survival | cMET, VEGFR2, ROS1, RTK, TAM, MerTK, Akt, Erk | A172, mouse model, SF188, U251MG | 24658326 | 24218589 | PubChem Google | |
Atazanavir | 148192 | apoptosis | GRP78 (HSPA5), CHOP | LN229, U251MG | 18006837 | PubChem Google | ||
Dorsomorphin | 11524144 | viability | A172, T98G, U87MG | 19428322, 24419061 | PubChem Google | |||
S3I-201 | 252682 | proliferation | STAT3 inhibitor | GS622, GS72 | 19658181 | PubChem Google | ||
Cabozantinib | 25102847 | proliferation | Multiple kinases | E98, mouse model | 20127563, 21926191, 23484006 | 29016998, 29036345, 29687244 | NCT00704288, NCT00960492, NCT01068782, NCT02885324 | PubChem Google |
Avasimibe | 166558 | proliferation, viability | ACAT1 | A172, GL261, U87MG | 20404512 | PubChem Google | ||
Levetiracetam | 5284583 | temozolomide enhancer, viability | MGMT | A172, LN18, T98G, U138 | 20525765 | 31603723 | NCT00629889, NCT02815410 | PubChem Google |
Akt Inhibitor IV | 5719375 | proliferation inhibition | Akt | 1028S, U87MG | 19208828 | |||
Aclidinium bromide | 11519741 | apoptosis, invasion, migration, proliferation | Long-acting muscarinic antagonist (LAMA) | U251, U87 | 29940755 | PubChem Google | ||
SB203580 | 176155 | proliferation | MAPK, RIGI, p38 | C6, U373 | 17395328, 18346382, 18442089, 19133316, 19362079, 19427347, 20060865 | PubChem Google | ||
Lipoxin A4 | 5280914 | anti-inflammatory effects, proliferation | 1321N1 | 19357230 | PubChem Google | |||
NSC141562 | 422114 | invasion, migration, proliferation | MIR155HG/miR155 axis | 28371892 | PubChem | |||
Mdivi-1 | 3825829 | apoptosis | DRP1 | U87MG | 29229477 | PubChem Google | ||
Etoposide | 36462 | proliferation, viability | TopoisomeRASe | A172, CD133, MO59J, MO59K, primary human glioma cells, T98G, U251MG, YKG1 | 18599610, 18614215, 19305157, 20388502, 23165409, 24953561, 30606517, 31020489 | NCT00003996, NCT00047281, NCT00612430, NCT00613028, NCT00613223, NCT02372409, NCT02502708, NCT04049669 | PubChem Google | |
AM7 | 11650194 | proliferation | Met, LCK, BTK | MKN45, U87MG | 18055465 | PubChem Google | ||
Doxazosin | 3157 | apoptosis, proliferation | RAS | C6, U138MG, U373MG | 27123999, 30370863 | PubChem Google | ||
Gemcitabine | 60750 | radiosensitivity | DNA and RNA | 19770758 | NCT02711137, NCT03434262, NCT03607643, NCT03678883, NCT03684811 | PubChem Google | ||
Loperamide | 3955 | apoptosis | mTORC1 | MZ54 | 30250198 | PubChem Google | ||
NKTR-102 | 71300727 | 25935109 | ||||||
PIK-108 | 54751698 | radiosensitization, viability | PKB, Akt, PI3K | LN229, SF126, SF210, U138MG, U251MG, U87MG | 18413797 | |||
PIK-90 | 135398491 | radiosensitization, viability | p110alpha, PI3K | LN229, SF126, SF210, U138MG, U251MG, U87MG | 18413797 | PubChem Google | ||
AMG 232 | 58573469 | MDM2 | 31359240 | NCT03107780 | PubChem Google | |||
ES936 | 4470790 | resistance, sensitivity | NQO1 | SF268, U87MG | 19244114 | PubChem Google | ||
GSK2256098 | 46214930 | FAK | 29788497 | PubChem Google | ||||
Withaferin A | 265237 | apoptosis, G2/M arrest | CDK1, ATF4-ATF3-CHOP, Bim, Bad | nude mice xenografts, U251, U87 | 31642559 | PubChem Google | ||
VER-49009 | 4369536 | cross-resistance | Hsp90 | SF268, U87MG | 19244114 | PubChem Google | ||
Arenobufagin | 12305198 | apoptosis, cell arrest, cytotoxicity, proliferation | Cdc25C, Cyclin B1, survivin, MAPK | U87MG | 30272276 | |||
NU7441 | 11327430 | radiosensitivity | DNA-PK inhibitor, NHEJ | U87MG | 19770758 | PubChem Google | ||
KHS101 | 71304818 | apoptosis, proliferation | HSPD1, Mitochondrial energy disruption | GBM1, GBM11, GBM13, GBM14, GBM20, GBM4, murine xenograft glioma tumor | 30111643 | PubChem Google | ||
Linsidomine | 5219 | viability | NO, p53 | BV2, CRTMG, D54MG, LNZ308 | 14695179, 19748528 | PubChem Google | ||
MP470 | 11282283 | apoptosis, radiosensitization, viability | cMET | murine xenograft tumor, SF126, SF188, SF210, SF268, SF295, SF767, SSF763, U87MG | 20028557 | PubChem Google | ||
Omacetaxine | 3628 | viability | LN443, U118, U87MG | 24433351 | PubChem Google | |||
E-64 | 123985 | apoptosis | COX2, IL-1beta, TNFalpha, IL6, iNOS, Cathepsin B | BV2, SNB19, U251MG, UWR2 | 11494030, 19748528 | PubChem Google | ||
Juglone | 3806 | proliferation | U251MG | 18697955, 28388894, 28791366 | PubChem Google | |||
SU1498 | 5941539 | proliferation, viability | VEGFR2 | A172, Gli06, SF126, T98G, U118MG, U251MG, U373MG, U87MG | 18719373 | PubChem Google | ||
Dovitinib | 135398510 | proliferation | Multiple kinases | primary human glioma cells | 28500786 | 27100354 | NCT01753713, NCT01972750 | PubChem Google |
Allopregnanolone | 92786 | proliferation | ESF1, RIF1 | U87MG | 29543748 | PubChem Google | ||
Lbw242 | 11503417 | radiosensitization | Gli36, LN827, U87MG | 18677408, 21724651 | PubChem Google | |||
Bafilomycin A1 | 6436223 | autophagy, cytotoxicity, radiosensitization, viability | H(+)ATPase | CD133+, U251MG | 19431142, 19566920 | PubChem Google | ||
Thapsigargin | 446378 | viability | SERCA | C6, U251MG, U87MG, XO8 | 18599610, 19133225, 27993939 | PubChem Google | ||
Fluvoxamine | 5324346 | mouse model | 26988603 | PubChem Google | ||||
YU238259 | 121473004 | proliferation | HDR, HRR | U251MG, U87MG | 26116172, 31020489 | PubChem Google | ||
Dihydrotanshinone | 11425923 | cell cycle arrest, temozolomide enhancer, viability | T98G, U87MG | 30399573 | ||||
Emetine | 10219 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Ibudilast | 3671 | apoptosis, cell cycle arrest, proliferation, temozolomide enhancer | MIF | 30814573 | NCT03782415 | PubChem Google | ||
Pifithrin-alpha | 9929138 | apoptosis, proliferation | p53 | C6 | 19513548 | |||
172889-27-9 | 4878 | radiosensitization | Src family kinase | T98G, U251MG | 26044161 | PubChem Google | ||
LY294002 | 3973 | proliferation, radiosensitization | PI3K, PKB, Akt | mice glioma cells, T98G, U251MG, U87MG | 15735908, 18473825, 18567800, 18676851, 19101213, 19435873, 19435898, 19827268, 19828040, 19836430, 19911116, 22086271, 25425962, 29354058 | PubChem Google | ||
AT101 (Gossypol acetate) | 227456 | apoptosis | Bax, BCL2, BclxL | LN229 | 29858681 | PubChem Google | ||
Entrectinib | 25141092 | Trk, ROS1, ALK | mouse model | 28695888 | PubChem Google | |||
NK314 | 137699307 | apoptosis | Topo2 | U87MG | 31020489 | |||
Manumycin | 6438330 | apoptosis | STAT3, Reactive oxygen species | A172, T98G, U87MG | 19409983 | PubChem Google | ||
Fluorouracil | 3385 | viability | Nucleic Acid Synthesis | U118MG, U87MG | 24391839, 30989436, 6690037 | NCT01183663, NCT03607643 | PubChem Google | |
Tubacin | 6675804 | proliferation | LN229, U251MG | 29845122 | PubChem Google | |||
Proteasome inhibitor IX | 11639443 | apoptosis inhibition | Proteasome | LN229, U251MG | 19190249 | PubChem Google | ||
Oleuropein | 5281544 | invasion, proliferation | A172, U251MG | 27498673 | PubChem Google | |||
Latrunculin B | 6436219 | apoptosis | ?v?3, ?v?5 | D293MED, D54MG, D645MG, UW2282 | 20124512 | PubChem Google | ||
Cucurbitacin B | 5281316 | invasion, proliferation | CIP2A, PP2A, Akt, JNK, JUN | DBTRG05MG, LN229, T98G, U118MG, U251MG, U87MG | 18561312, 29393542 | PubChem Google | ||
Sandoz 58-035 | 122215 | invasion, proliferation | ACAT | U87MG | 19502590 | PubChem Google | ||
Dimethylaminomicheliolide | 54589107 | proliferation | PKM2 | C6, rat model, SF126, SHG-44, U118MG, U251MG, U87MG | 25658946, 31632919 | |||
Myricetin | 5281672 | invasion, migration, proliferation | PI3K, Akt, JNK | U87MG | 19804834, 29886836 | PubChem Google | ||
Ivermectin | 6321424 | apoptosis | Akt, mTOR | T98G, U87MG, xenograft mouse models | 27771251 | PubChem Google | ||
Transcrocetinate | 10287099 | C6, rat model | 18447715 | |||||
NOX-A12 | 86278354 | angiogenesis, viability | CXCL12, SDF1alfa | C6, human G12 glioblastomas, rat brain tumor models | 24335554, 27940247 | |||
Adenosine dialdehyde | 99920 | proliferation | C6 | 23353701 | PubChem Google | |||
Aloe emodin | 10207 | apoptosis, proliferation | ERK | C6, U87MG | 15747063, 30218594 | PubChem Google | ||
Tocladesine | 100299 | apoptosis | U87MG | 12449730 | PubChem Google | |||
Enzastaurin | 176167 | apoptosis, proliferation, temozolomide enhancer | PKCbeta, PI3K, Akt | A172 | 16103100, 18448327, 18462865, 18662322, 19913408 | 19417015, 20124186, 20150385, 20156802, 22291006 | NCT00295815, NCT00402116, NCT00509821, NCT00516607, NCT00586508, NCT03776071 | PubChem Google |
Astemizole | 2247 | viability | U87MG | 27029345 | PubChem Google | |||
Isoliquiritigenin | 638278 | viability | TopoisomeRASe | U87MG | 23229626, 26722447 | PubChem Google | ||
Epigallocathecin Gallate | 65064 | viability | T98G, U87MG | 18948169, 19826036, 19894226 | PubChem Google | |||
Fluoxetine | 3386 | apoptosis | AMPAR | C6, SHSY5Y, U87MG, xenograft model of glioblastoma in nude mice | 16055945, 20811727, 25671301 | PubChem Google | ||
Forskolin | 47936 | proliferation | Adenylate cyclase, Hedgehog (Hh) signaling | A172, C62B, NB19, U87MG | 18719351, 20015475, 21472212, 24649161, 6199388, 9484714 | PubChem Google | ||
Procarbazine | 4915 | 20855843, 225004 | NCT00003293, NCT00003564, NCT00003788, NCT00004004, NCT00005796, NCT00052455, NCT00079092, NCT01737346 | PubChem Google | ||||
D609 | 4234241 | proliferation | 28802717 | |||||
487020-03-1 | 1936439 | PBK | mouse xenograft model, primary human glioma cells | 26081429 | PubChem Google | |||
Cimetidine | 2756 | proliferation | GSK3beta | primary human glioblastoma cells | 28423558 | PubChem Google | ||
JS-K | 9572720 | mouse xenograft model, U87MG | 23370169, 28653883 | PubChem Google | ||||
2,5-Dimethylcelecoxib | 11545682 | angiogenesis, migration, proliferation | ET1 | mouse xenograft model, TuBEC, U251MG, U87MG | 20197398 | PubChem Google | ||
Triacsin c | 9576787 | apoptosis | ACS (AcylCoA synthetase) inhibitor | SF268, U251MG | 19459852 | |||
CA074 methyl ester | 6610318 | apoptosis, proliferation | CatB, Clik148 | BV2, U87MG | 19748528, 20302512 | PubChem Google | ||
Wedelolactone | 5281813 | migration, proliferation | IKK | C6 | 19362079 | PubChem Google | ||
Lys01 | 70673567 | viability | LN229 | 22566612 | PubChem Google | |||
Tetraethylammonium | 5413 | proliferation | C6, U87MG | 25700359 | PubChem Google | |||
Arsenic trioxide | 14888 | metabolic activity reduction, proliferation and colony formation, viability | CatB, CatL | A172mouse xenograft model, U118, U87MG | 20302512, 21594580, 29274334 | PubChem Google | ||
Ganciclovir | 135398740 | cytotoxicity | U251MG | 19300472 | NCT00002824 | PubChem Google | ||
Akt inhibitor VIII (Akti-1/2) | 135398501 | proliferation inhibition | Akt | 1028S, U87MG | 19208828 | PubChem Google | ||
AZD9291 (Osimertinib) | 71496458 | cell cycle arrest, colony formation, invasion, migration, proliferation | EGFR | LN18, LN229, T98G, U118, U251, U87 | 31122294 | NCT03732352 | ||
Amiodarone | 2157 | apoptosis | CHOP | U251MG | 21292685 | PubChem Google | ||
Zoledronic acid | 68740 | viability | RAS, Rho GTPAses, FDPS | LN229, primary human glioma cells, U87MG | 30219696, 30333528 | NCT00301873 | PubChem Google | |
Oxaliplatin | 9887054 | apoptosis, radiosensitization, temozolomide sensitivity | STAT3, MGMT, DNA, RNA synthesis | GL261luciferase, KR158, KR158luciferase, LN229, mouse xenograft model, primary human glioma cells, U87MG | 17383816, 18329790, 30132163, 30219696 | PubChem Google | ||
Amsacrine | 2179 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Altiratinib | 54576299 | cMET, TIE2, VEGFR2 | mouse xenograft model, primary human glioma cells | 26965451 | PubChem Google | |||
SU11274 | 9549297 | migration | Met | LN229, U87MG | 19795461 | PubChem Google | ||
Nigericin | 16760591 | proliferation | Mitochondrial ATPase | COMI, VIPI stem cells | 29513090 | |||
Perampanel | 9924495 | proliferation | AMPA | HROG02, HROG05, HROG15, HROG24 | 30716120 | PubChem Google | ||
Lenalidomide | 216326 | 26891975 | 18513880 | NCT00036894, NCT00165477, NCT00671801, NCT01183663 | PubChem Google | |||
Lonafarnib | 148195 | viability | farnesyl protein transfeRASe | orthotopic mouse model, U87MG | 21246394 | 21735117, 23633392 | NCT00038493, NCT00083096, NCT00102648 | PubChem Google |
Topotecan | 60700 | proliferation, radiosensitization, viability | TopoisomeRASe | A172, LN443, primary human glioma cells, U118, U251MG, U87MG | 18819996, 19466380, 19584228, 19812371, 23165409, 24303074, 24433351, 28797568 | NCT00002814, NCT00014443, NCT00541138, NCT00610571, NCT01004874, NCT01931098 | PubChem Google | |
BI2536 | 11364421 | proliferation, temozolomide enhancer, viability | PLK1 | LN319, orthotopic mouse model, primary human glioma cells, T98G, U138MG, U251MG, U343MGa, U87MG | 22415968, 23713868, 24204733, 30133120 | PubChem Google | ||
ZSTK474 | 11647372 | proliferation | PI3K | mouse spontanious GBM model, mouse xenograft model, U118, U87MG | 24297065, 27553832 | PubChem Google | ||
NHI 2 | 51355147 | apoptosis, cell cycle arrest, proliferation | LDHA | U87MG | 26494310 | PubChem Google | ||
Trolox | 40634 | apoptosis, viability | Casp9 | U138MG | 19002382 | PubChem Google | ||
Lysophosphatidylserine | 42607474 | proliferation | C6 | 17958326 | PubChem Google | |||
Phorbol 12-myristate 13-acetate | 27924 | proliferation | PKCalpha, PKCdelta, PKCvarepsilon | C6, U87MG | 18778746, 19357285, 19804834 | PubChem Google | ||
Z-LEHD | 10032582 | apoptosis | Casp9 | U138MG | 19002382 | PubChem Google | ||
Disufenton | 11603334 | angiogenesis, apoptosis, proliferation, temozolomide enhancer, viability | TGF-beta1, IDO1, SUMO2, PFN1 | F98, human G55 GBM orthotopic xenograft model, IC3752GBM, orthotopic mouse model, rat model, U87MG | 23328810, 26248280, 30468988 | PubChem Google | ||
MG-132 | 462382 | proliferation | Proteasome | C6, LN229, mouse xenograft model, SHG44, U138MG, U373, U87MG, XO8 | 18341587, 18539596, 19190249, 19201384, 19575007, 19690139, 19808964, 19996297, 21499287, 22367315, 27993939 | PubChem Google | ||
CKD 602 | 123773277 | apoptosis, proliferation, viability | TopoisomeRASe | LN229, U251MG, U343MG, U87MG | 19424618 | |||
Isofuranodiene | 636458 | apoptosis, cell cycle arrest, cytotoxic effect | T98G, U251MG, U87MG | 30599912 | ||||
Osthol | 10228 | apoptosis, invasion, proliferation | TE671, U87MG | 25368248, 26082082, 29301373 | PubChem Google | |||
Cediranib | 9933475 | apoptosis, proliferation, viability | VEGFR | 4C8, mouse xenograft model | 18814988, 19332720, 19671039, 21095630, 25490024, 25676691, 26645398, 30423822 | 17222792, 19549889, 20458050, 23940216, 26008604 | NCT00305656, NCT00458731, NCT00503204, NCT00662506, NCT00777153, NCT00979862, NCT01062425, NCT01131234, NCT01310855, NCT02974621 | PubChem Google |
XL765 | 49867926 | PI3K, mTOR | mouse xenograft model | 21317208 | 26019185 | NCT00704080, NCT01240460 | PubChem Google | |
Clioquinol | 2788 | viability | U87MG | 26725099 | PubChem Google | |||
NCL-1 | 73755256 | proliferation | KDM1A | LN229, orthotopic mouse model, T89G, U138, U251MG, U87MG | 23248157, 27893719 | |||
Docetaxel | 148124 | viability | Microtubules | LN229, primary human glioma cells, U87MG | 24433351, 30219696, 30318217, 30796690 | NCT00049296 | PubChem Google | |
Ancitabine | 25051 | proliferation | TopoisomeRASe 2 | primary human glioma cells | 23165409 | PubChem Google | ||
Clomifene | 1548953 | apoptosis | IDH1, D2HG | C6 | 15289732 | PubChem Google | ||
Toxin C3 | 137185910 | water influx suppression | Nicotinamide adenine dinucleotide (NAD) | 1321N1 | 19772916 | |||
Acetazolamide | 1986 | proliferation | carbonic anhydRASe | U251MGN | 27702686 | PubChem Google | ||
Vinorelbine | 5311497 | viability | U87MG | 24433351 | PubChem Google | |||
KPT276 | 71496742 | viability | CRM1 | AGBM1, BT145, BT159, BT172, orthotopic mouse model | 25366336 | PubChem Google | ||
Rucaparib | 9931954 | PARP | GBM12, GBM39, orthotopic mouse model | 26438157 | NCT02711137 | PubChem Google | ||
F90 | 68343 | proliferation | EGFR, ERK1, JNK, p38, BCL2, p53 | SHG44 | 19024103 | PubChem Google | ||
Tpi-287 | 118797983 | viability | Microtubules | GB30, U1242, U87MG | 29396807 | PubChem Google | ||
JTE013 | 10223146 | invasion | S1P(2) | U373 | 18819934 | PubChem Google | ||
Telomestatin | 443590 | viability | Gquadruplexes | GBM146, GBM157 | 26845351 | PubChem Google | ||
Dabrafenib | 44462760 | BRAF | 26680369, 29039591, 29295876 | NCT02684058, NCT03919071, NCT03975829 | PubChem Google | |||
Podofilox | 10607 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Simvastatin | 54454 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
GK921 | 56682080 | Transglutaminase 2 | 83NS, orthotopic mouse model | 28754668 | PubChem Google | |||
Puromycin | 439530 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Abiraterone | 132971 | proliferation | CYP17A1 | A172, primary human glioma cells, T98G | 31527549 | NCT02711137 | PubChem Google | |
Eckol | 145937 | BACE1 beta-secretase 1 (human) | U373MG, U87MG | 21514314 | PubChem Google | |||
PD98059 | 4713 | migration, proliferation | MEK1, MEK2 | C6, T98G, U373 | 17327470, 18346464, 18411719, 18636433, 18975108, 19108760, 19158403, 19362079, 19435873 | PubChem Google | ||
Asiatic acid | 119034 | apoptosis, necrosis | Calcium signaling | U87MG | 16897440 | PubChem Google | ||
4egi-1 | 5717952 | proliferation | eIF4E | U251MG | 26220902 | PubChem Google | ||
Carboplatin | 10339178 | DNA | 28534153 | NCT00002619, NCT00005976, NCT00006263, NCT00008086, NCT00010036, NCT00014105, NCT00021307, NCT00025558, NCT00352313, NCT00492687, NCT00541138, NCT00635557, NCT00650949, NCT00995007, NCT01317212, NCT01386710, NCT01837862, NCT01934361, NCT02253212, NCT02684058, NCT03149575, NCT03744026 | ||||
Dehydroeburicoic acid | 15250826 | apoptosis, proliferation | Calpain, Calcium signaling | U87MG | 19848398 | PubChem Google | ||
Wortmannin | 312145 | proliferation | PI3K | U87MG | 19208828, 19738049, 19997873, 23724064 | PubChem Google | ||
Aldoxorubicin | 9810709 | DNA intercalation | mouse xenograft model, U87MG | 25379024 | NCT02014844 | PubChem Google | ||
Karenitecin | 148202 | radiosensitization | TopoisomeRASe | MO59K, T98G | 28111642 | NCT00014521 | PubChem Google | |
Psammaplin C | 21726402 | CAXII | orthotopic patient-derived xenografts | 30254183 | PubChem Google | |||
Clorgiline | 4380 | proliferation | MAO A | U251MG | 26871599 | PubChem Google | ||
Mibefradil | 60663 | viability | T type calcium channels | C6, rat model, T98G, U251MG, U87MG | 23198803, 23287412 | 28371832 | NCT01480050, NCT02202993 | PubChem Google |
BMS-536924 | 135440466 | IGF1R, IR | M059K, mouse model | 25897243 | PubChem Google | |||
Salinomycin | 3085092 | apoptosis, proliferation | mouse xenograft model, primary human glioma cells, U251MG, U87MG | 23165409, 28358414, 28498472, 29925966 | PubChem Google | |||
gamma-Tocopherol | 92729 | apoptosis, proliferation | PKC, ERK | C6 | 16843827 | PubChem Google | ||
Tranylcypromine | 19493 | proliferation | U87MG | 30591460 | PubChem Google | |||
LY341495 | 9819927 | proliferation | U87MG | 23724064 | PubChem Google | |||
Zalcitabine | 24066 | proliferation | HTB10 | 2542824 | PubChem Google | |||
Trifluoperazine | 5566 | proliferation | Calcium signaling, D2 receptors | orthotopic mouse model, P3, primary human glioma cells, U251MG, U87MG | 23165409, 28062709, 28870216, 29580626, 30980364 | PubChem Google | ||
n-butylidenephthalide | 642376 | apoptosis, proliferation | CKI | DBTRG05MG, RG2 | 16987298 | PubChem Google | ||
717906-29-1 | 11598628 | migration, proliferation | FAK | T98G, U118MG | 26883759 | PubChem Google | ||
Carvedilol | 2585 | apoptosis, proliferation | BrDULI, cAMP | C6 | 20198329 | NCT03861598, NCT03980249 | PubChem Google | |
Marimastat | 119031 | cell invasiveness | Metalloproteinase | Daoy, Madsen, UW2282, UW2283 | 19847623 | PubChem Google | ||
Lonidamine | 39562 | proliferation, radiosensitization, viability | glycolysis | U373MG | 20009297 | PubChem Google | ||
Cilengitide | 176873 | proliferation | ?v?3, ?v?5 | G28, G44, U251MG, U87MG | 17277694, 18616418, 18981465, 19114005, 19199360, 19221171, 19351861, 20820929, 21788343, 22588883 | 17470857, 18981465, 20439646, 21739168, 25163906, 26008604 | NCT00006093, NCT00085254, NCT00093964, NCT00112866, NCT00679354, NCT00689221, NCT00813943, NCT00979862, NCT01044225, NCT01122888, NCT01124240, NCT01517776, NCT01782976 | PubChem Google |
UNC2025 | 73425588 | MER, FLT3 | A172, orthotopic mouse model, SF188, U251MG | 27783662, 28605477 | PubChem Google | |||
PD0325901 | 9826528 | , viability | MEK | LN229, mouse xenograft model, primary human glioma cells, U373 | 19737945, 22573716, 25431423 | PubChem Google | ||
Lysophosphatidic acid | 5497152 | proliferation, viability | NHE1, PI3K, Akt, Rhoassociated kinase, PKC, MEK, E | C6 | 16176063, 17499746, 18481020 | PubChem Google | ||
Epigallocathecin | 72277 | viability | T98G, U87MG | 19894226 | PubChem Google | |||
SQ29548 | 5311448 | cell swelling suppression | TXA2 | 1321N1 | 19772916 | |||
Vandetanib | 3081361 | proliferation, temozolomide enhancer | VEGFR, EGFR, RETtyrosine kinase | GBM6, GBM8, U251MG, U87MG | 15305185, 16061883, 16299247, 19622715, 20371720, 20811710, 21095630, 23799852 | 20137866, 23099652 | NCT00441142, NCT00613223, NCT00821080, NCT00995007 | PubChem Google |
10-Hydroxycamptothecin | 97226 | proliferation | Inhibitor of Topoisomerase 1 | primary human glioma cells | 23165409 | PubChem Google | ||
PCI-24781 | 11749858 | proliferation | HDAC | LN18, LN229, U87MG | 25505847 | PubChem Google | ||
Idarubicin | 42890 | viability | U87MG | 24433351 | PubChem Google | |||
PKI-402 | 44187953 | proliferation, viability | PI3K, mTOR | human tumor xenograft models, U87MG | 20371716 | PubChem Google | ||
Metformin | 4091 | invasion, proliferation | Akt | primary human glioma cells, SF268, U87MG | 24965413, 30046513 | 30980539 | NCT01430351, NCT02149459, NCT02780024, NCT03151772 | PubChem Google |
URB597 | 1383884 | FAAH | C6 | 16997568, 19460156 | PubChem Google | |||
Memantine | 4054 | autophagy, proliferation | NMDAR1, LC3II, LC3I, beclin1 | T98G, U251MG | 28264232 | NCT01260467, NCT01430351 | PubChem Google | |
SB-415286 | 4210951 | apoptosis | GSK3 | U87MG | 18582478 | PubChem Google | ||
Ardipusilloside I | 197641 | proliferation | T98G, U373 | 24984215 | ||||
Ciglitazone | 2750 | viability | PPARgamma | C6, U251MG | 14699130 | PubChem Google | ||
Apigenin | 5280443 | viability | T98G, U87MG | 19894226 | PubChem Google | |||
H-89 | 449241 | proliferation | PKA inhibitor | U87MG | 20015475 | PubChem Google | ||
GDC-0084 | 57384863 | PI3K, mTOR | orthotopic mouse model, U87MG | 27638506 | NCT01547546, NCT03522298, NCT03696355 | PubChem Google | ||
Silibinin | 31553 | apoptosis, autophagy, proliferation, viability | Ca2+, ROS, MAPK, mTOR, YAP. | A172, LN229, U87MG | 19263218, 21501525, 25750273, 29780826 | PubChem Google | ||
THZ1 | 73602827 | proliferation | CDK7 | mouse xenograft model, orthotopic mouse model, primary human glioma cells, U251MG, U87MG | 28504693, 30532595 | PubChem Google | ||
Indoximod | 405012 | viability | IDO | GL261 | 25054064 | 30415456 | NCT02052648, NCT02502708, NCT04049669 | PubChem Google |
SNS-032 | 3025986 | angiogenesis, proliferation, radiosensitization | VEGF, HIF1A | U87MG | 17534442, 19287962 | PubChem Google | ||
Donepezil | 3152 | proliferation | Acetylcholinesterase | primary human glioma cells, T98G, U373 | 19679463 | 16549835 | NCT00070161, NCT00369785 | PubChem Google |
Cordycepin | 6303 | apoptosis, viability | AMPK, Akt | C6, LN18, orthotopic mouse model, T98G, U251MG, U87MG | 26597532, 28068557, 30336060 | PubChem Google | ||
Celecoxib | 2662 | migration, proliferation, viability | COX2 | A127, C6, GOGCCM, T98G, U251MG, U373, U87MG | 18634847, 19664879, 20062571, 20193113, 21763744, 21847707, 23280445 | 25239666 | NCT00047281, NCT00047294, NCT00068770, NCT00112502, NCT00504660, NCT02770378 | PubChem Google |
Pyridone 6 | 5494425 | apoptosis | JAK, STAT | U251MG | 19830690 | PubChem Google | ||
Oroxindin | 3084961 | viability | A172, SHG44, U251MG, U87MG | 24970553 | PubChem Google | |||
PIK-75 | 10275789 | apoptosis | PI3K | LN229, U87MG | 18413797, 22802621 | PubChem Google | ||
2-Amino-3H-phenoxazin-3-one | 72725 | viability | LN229 | 24008433 | PubChem Google | |||
A939572 | 24905400 | proliferation, proliferation inhibition, viability | SCD1 | T98GR, U87MGR | 29354058 | PubChem Google | ||
Gboxin | 137628664 | apoptosis | F0F1 ATP synthase | glioblastoma allografts, patient-derived xenografts, primary mouse | 30842654 | PubChem Google | ||
Lanatoside C | 3879 | viability | U87MG | 21184646, 27029345 | PubChem Google | |||
LAQ824 (Dacinostat) | 6445533 | apoptosis | HDAC | Hs683, LN401, SF767, U343, U373 | 18483381 | PubChem Google | ||
Pegdinetanib | 86278317 | VEGFR2 | human tumor xenograft models, orthotopic mouse model, U87MG | 20190562, 22875706 | 25388940 | PubChem Google | ||
Hellebrigenin | 259577 | apoptosis, proliferation | Cdc25C, Cyclin B1, survivin, MAPK | U87MG | 30272276 | PubChem Google | ||
Paclitaxel | 36314 | apoptosis, proliferation, viability | Microtubules | C6, G144, G166, G179, GBM2, GBM7, GliNS2, LN229, primary human glioma cells, U87MG | 18599610, 18804099, 19285047, 23165409, 28962238, 30219696, 30321641, 30633585 | NCT00002814, NCT00014573, NCT00019019, NCT00479765, NCT02711137 | PubChem Google | |
JNJ-7706621 | 5330790 | migration, proliferation, viability | CDK1, CDK2 | LN18, SHG44, T98G, U251MG, U373, U87MG | 28989042 | PubChem Google | ||
Ellagic Acid | 5281855 | apoptosis, Bevacizumab enhancer | MGMT | C6 | 31518741 | PubChem Google | ||
Huperzine A | 854026 | viability | NFkappaB, iNOS, COX2, NO | C6 | 17257593 | PubChem Google | ||
Tandutinib | 3038522 | Multiple kinases | mouse xenograft model, transgenic mouse model | 22146535, 23638177 | NCT00379080, NCT00667394 | PubChem Google | ||
Gamabufotalin | 259803 | apoptosis, autophagy, G2/M arrest | Aurora B, cdc25A, cdc25C, cdc2, Cyclin B1, survivi | U87 | 31610157 | PubChem Google | ||
Homidium | 3624 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Ortataxel | 6918412 | 30726533 | NCT01989884 | PubChem Google | ||||
Amentoflavone | 5281600 | apoptosis, viability | NFkappaB, FAS, cFLIP, MCL1 | U87MG | 29475910 | PubChem Google | ||
Epoxomicin | 11226684 | apoptosis | Proteasome | U251MG, U343, U373, U87MG | 18341587, 19201384, 19690139 | PubChem Google | ||
BMS-599626 | 10437018 | proliferation | EGFR, ERBB2 | A549, BT474, N87 | 17062696 | NCT00979173 | PubChem Google | |
297157-92-7 | 2891837 | mouse xenograft model, XO8 | 27993939 | PubChem | ||||
Anthothecol | 21596360 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Danthron | 2950 | apoptosis, viability | BCL2, Bax | GBM 8401 | 19784869 | PubChem Google | ||
Dobesilate | 29963 | apoptosis, proliferation | FGF, MAPK | C6 | 16551428, 16563234 | PubChem Google | ||
CDK2 inhibitor II | 3551941 | apoptosis | U87MG | 19549905 | PubChem Google | |||
B428 | 9797957 | cell invasion | uPA | U1242 | 18355442 | PubChem Google | ||
DWP0016 | 71660487 | viability | HDAC | U251MG | 23297003 | |||
Sertraline | 68617 | viability | A172, LN443, U118, U87MG | 24433351 | NCT02770378 | PubChem Google | ||
Graphene oxide | 124202900 | apoptosis, proliferation, viability | STAT inhibitor, Wnt and Notch signaling | U118, U87MG | 25708684, 25759581, 30544611, 30602369 | |||
Doxorubicin | 31703 | proliferation | DNA intercalation | A172, LN443, primary human glioma cells, SHSY5Y, U118, U373, U87MG, U87MGATCC | 19101989, 19564615, 19633683, 23165409, 24433351, 27029345, 27993939, 28612256, 30368972, 30448308, 30606517, 30639216, 30836216, 30869664 | NCT00002608, NCT00944801, NCT01851733, NCT02372409, NCT02758366 | PubChem Google | |
GSK461364 | 15983966 | proliferation | PLK1 | LN18, mouse xenograft model, primary human glioma cells, U87MG | 23790466, 24204733, 30304810, 30875975 | PubChem Google | ||
Magnolol | 72300 | cell cycle arrest, proliferation | CDK2/p21, Cip1 | U373 | 19645506 | PubChem Google | ||
Phloroglucinol (BFP, (2,4-bis(4-fluorophenylacetyl)phloroglucinol) | 359 | apoptosis, cytotoxicity | benzenetriol, phenol derivative | C6, U251MG, U87MG | 22819448 | PubChem Google | ||
Dichloroacetate | 25975 | apoptosis, proliferation | HIF-2alpha, PDK, Hsp70 | C6, primary human glioblastoma cells | 18766181, 20463368, 23515860 | NCT00540176, NCT00703859, NCT01111097 | PubChem Google | |
Pitavastatin | 5282452 | radiosensitization, viability | NFkappaB | A172, LN443, U118, U87MG | 19046042, 24433351 | PubChem Google | ||
LB1 | 134693726 | proliferation, viability | PP2A | murine glioma xenografts, U251MG, U87MG | 20001590 | |||
AC1MMYR2 | 3246569 | proliferation | LN229, orthotopic mouse model, U87MG | 23811941 | ||||
PF-04691502 | 25033539 | PI3K, mTOR | mouse xenograft model, U87MG | 21750219 | PubChem Google | |||
Crenolanib | 10366136 | viability | PDGFRalpha | primary human glioma cells | 25380967 | NCT02626364 | PubChem Google | |
Penfluridol | 33630 | apoptosis | Akt | U87MG, xenograft model of glioblastoma in nude mice | 28380428 | PubChem Google | ||
Actinonin | 443600 | angiogenesis | N, CD13 | U87MG | 19264392 | PubChem Google | ||
Lithium | 3028194 | apoptosis, migration, viability | GSK3, PIMT | primary human glioma cells, U251MG, U373, U87MG | 18582478, 18715951, 28359080 | PubChem Google | ||
CX614 | 6451148 | viability | AMPAR | U87MG | 29277782 | PubChem Google | ||
Teniposide | 452548 | proliferation | primary human glioma cells, U373 | 19559015, 23165409 | PubChem Google | |||
2-hydroxycinnamaldehyde (HCA) | 5318169 | invasiveness, stemness, temozolomide enhancer, viability | Zeb1, Ncadherin, beta-catenin | GBM tumorspheres, mouse orthotopic xenograft model | 30887242 | PubChem Google | ||
Galangin | 5281616 | angiogenesis, invasion, migration, proliferation | CD44 | U251, U87 | 31528214 | PubChem Google | ||
LLNle | 16760646 | apoptosis | NOTCH | primary human glioblastoma cells | 19861404 | |||
Anlotinib | 25017411 | inhibit tumor cell growth | Tyrosine kinase inhibitor | 31145289 | NCT04004975, NCT04119674, NCT04157478 | PubChem Google | ||
Pioglitazone | 4829 | apoptosis, proliferation, viability | Wnt, beta-catenin, PPARgamma | G144, G166, G179, GBM04, GBM2, GliNS2, primary human glioblastoma cells, T98G, U251MG, U87MG | 21221726, 27313600 | NCT01151670 | PubChem Google | |
BE-16627B | 132070 | apoptosis | MMP | U251MG, U373MG, U87MG | 14604227 | |||
HOE-140 (Icatibant acetate) | 6918173 | inflammatory response | B(2) | 1321N1, C6, U87MG | 19854233 | PubChem Google | ||
HJC0152 | 71719978 | apoptosis, chemosensitivity, motility, proliferation | STAT3 | xenograft tumors | 31105997 | |||
Dacomitinib | 11511120 | viability | ErbB | LN229, primary human glioma cells, U251MG, U373, U87MG | 24658109, 25939761, 30247945 | NCT01112527, NCT01520870 | PubChem Google | |
Adavosertib | 24856436 | viability | WEE1 | GBM22, mouse xenograft model, T98G, U251MG | 21992793, 25609063 | 29798906 | NCT01849146, NCT01922076, NCT02207010 | PubChem Google |
Quetiapine | 5002 | proliferation, temozolomide enhancer, viability | Wnt, beta-catenin | , GL261, xenograft model of glioblastoma in nude mice | 28415586 | PubChem Google | ||
Oxamate | 3017661 | radiosensitization | LDHA | T98G, U87MG | 28756228 | PubChem Google | ||
CUDC-101 | 24756910 | proliferation | EGFR, HDAC | BS153, DKMG | 26032687 | PubChem Google | ||
Imiquimod | 57469 | Toll like receptor 7 (TLR7) | GL261, orthotopic mouse model | 21389872 | NCT01171469, NCT01403285, NCT01808820, NCT01902771 | PubChem Google | ||
Semaxanib | 5329098 | angiogenesis, apoptosis, proliferation | Flk1, KDR | GS9L, rat models | 11733657 | NCT00004868 | PubChem Google | |
Nocodazole | 4122 | apoptosis | Microtubules | T98G | 30268825 | PubChem Google | ||
Ribavirin | 37542 | apoptosis, migration, proliferation, viability | eIF4E, EZH2, ERK | 1113, GB1A, LN18, murine glioma models, U251MG, U87MG | 27941882 | PubChem Google | ||
Pregnenolone | 8955 | viability | C6, LN18, U87MG | 25013479 | PubChem Google | |||
Folic acid | 135398658 | apoptosis, proliferation, temozolomide enhancer | S-adenosylmethionine | Ntva, U251MG, U373 | 19451595 | PubChem Google | ||
Gitoxin | 91540 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
AG-120 | 89699486 | viability | IDH1 | U87MG | 29670690 | PubChem Google | ||
Vorinostat | 5311 | proliferation, radiosensitization, viability | Histone deacetylase, SN38 | GL26, LN18, LN229, mouse model, primary human glioma cells, T98G, U251MG, U373MG, U87MG | 17289901, 19622715, 20135194, 23962875, 25040548, 25275596, 26794465, 27863490, 29384188, 30878553 | 19307505 | NCT00238303, NCT00268385, NCT00555399, NCT00641706, NCT00731731, NCT00762255, NCT01110876, NCT01189266, NCT01266031, NCT01342757, NCT01378481, NCT01738646, NCT03426891 | PubChem Google |
Pristimerin | 159516 | proliferation | primary human glioma cells | 23165409 | PubChem Google | |||
Abemaciclib | 46220502 | CDK4, CDK6 | mouse xenograft model, U87MG | 26149830 | NCT02977780, NCT02981940, NCT04074785, NCT04118036 | PubChem Google | ||
AZD1152-HQPA | 16007391 | proliferation | Aurora B kinase | mouse xenograft model, T98G, U118, U251MG, U373 | 22382783 | PubChem Google | ||
Isoprenaline | 3779 | papaverine enhancer, proliferation | cAMP | C6 | 6254438 | PubChem Google | ||
Eflornithine | 3009 | proliferation | Ornithine decarboxylase | U251MG | 19010902, 25935110 | PubChem Google | ||
Ridaforolimus | 11520894 | mTOR | 22037923 | NCT00087451, NCT01295632 | PubChem Google | |||
Calcipotriol | 5288783 | migration, proliferation, viability | T98G | 29575677 | PubChem Google | |||
Fmoc-L-leucine | 1549133 | apoptosis | PPARgamma | U118 MG | 30118847 | PubChem Google | ||
AR-A014418 | 448014 | apoptosis, proliferation, viability | GSK3beta | A172, T98G, U251MG, U87MG | 19188159 | PubChem Google | ||
3-Butylidenephthalide | 62368 | proliferation | DBTRG05MG, GBM8401, mouse xenograft model | 21553143 | PubChem Google | |||
Papaverine | 4680 | inhibitors of cellular respiration | ADP, ATP, cyclic nucleotide phosphodiesteRASe | C6 | 4367754 | PubChem Google | ||
Sunitinib malate | 6456015 | viability | VEGFR, PDGFR, cKIT, FLT | LN229, primary human glioma cells, U87MG | 30219696 | NCT00611728, NCT00923117 | PubChem Google | |
SU6656 | 5312137 | invasion | Src family kinase | U251MG | 15561776 | PubChem Google | ||
Glasdegib | 25166913 | Smoothened | 22223823 | NCT03466450 | PubChem Google | |||
OSU03012 | 10027278 | apoptosis, proliferation | PDK1, PI3K, Akt | D283 MED, D324 MED, D458 MED, MEBMED8A, medulloblastoma human xenograft tumors, PFSK1, UW2283 | 16622074, 16675657, 20028853 | PubChem Google | ||
Ms-275 | 4261 | apoptosis, proliferation | DR4, DR5 | D283, Daoy | 19148581 | PubChem Google | ||
Paroxetine | 43815 | apoptosis | SSRIs | C6, SHSY5Y | 16055945 | PubChem Google | ||
KU0063794 | 16736978 | viability | mTOR | U373MG | 22125077 | PubChem Google | ||
OSI-420 | 18924996 | viability | EGFR | LN229, primary human glioma cells, U87MG | 30219696 | PubChem Google | ||
Finasteride | 57363 | proliferation | ESF1, RIF1 | U87MG | 29543748 | PubChem Google | ||
Proteasome Inhibitor I | 24906271 | apoptosis | NFkappaB, Proteasome | 118MGC, LN229, U251MG, U373MG | 19190249, 19201384 | |||
Z-VAD (OMe)-FMK | 5497174 | apoptosis | NOS, BCL2 | CGNH-89, CGNH-NM, CRTMG | 19748528, 24678780 | PubChem Google | ||
Doxepin | 667477 | inhibitors of cellular respiration | IPSB18 | 20332444 | PubChem Google | |||
Nitidine | 25659 | apoptosis, proliferation | pDok2 | C6, U87MG | 29329030 | PubChem Google | ||
SH-6 | 16760283 | apoptosis | Akt | LNZ308, U251MG | 17041888, 18802038, 19808964, 19827268 | |||
2-Amino-1,3-propanediol | 68294 | angiogenesis, apoptosis, proliferation | hTP | U87MG | 30615449 | PubChem Google | ||
Plumbagin | 10205 | proliferation, viability | A172, primary human glioma cells, SHG44, U251MG | 23165409, 25528634 | PubChem Google | |||
GW2974 | 6603857 | invastion, migration, viability | EGFR, HER2 | U251MG, U87MG | 23115024 | PubChem Google | ||
Alantolactone | 72724 | viability | LN229, U373, U87MG | 22837216 | PubChem Google | |||
Ispinesib | 6851740 | proliferation | KSP, HsEg5 | mouse xenograft model | 19554570 | PubChem Google | ||
Sevoflurane | 5206 | invasion, migration | U251MG | 27840895 | PubChem Google | |||
Gossypol | 3503 | viability | U251MG, U343, U373, U87MGluc2 | 20587533, 25375271 | PubChem Google | |||
Aurintricarboxylic acid | 2259 | invasion, migration | A172, GBM44, T98G | 28103571 | PubChem Google | |||
7-Ethyl-10-hydroxycamptothecin | 104842 | viability | TopoisomeRASe | A172, U87MG | 28963609, 30521347 | PubChem | ||
15Deoxy-delta-12,14-PGJ2 | 5283035 | apoptosis | PPARgamma | C6, U251MG | 14699130 | PubChem Google | ||
YZ129 | 137628683 | apoptosis, cell cycle arrest, migration, proliferation | Hsp90, PI3K, AKT, mTOR | U87MG | 30639261 | 30639261 | ||
Alexidine | 2090 | viability | U87MG | 27029345 | PubChem Google | |||
MIM1 | 135691163 | apoptosis, cell cycle arrest, temozolomide enhancer, viability | MCL1 | U87MG | 30134184 | PubChem Google | ||
Capsaicin | 1548943 | apoptosis | DR5 | SNU444, T98G, U251MG, U251MGN, U343, U87MG | 19939880 | PubChem Google | ||
Mercuric Chloride | 24085 | cell swelling suppression | Aquaporin1 | 1321N1 | 19772916 | PubChem Google | ||
Mepacrine | 237 | viability | 4C8, U87MG | 25490024, 25727221, 27029345 | PubChem Google | |||
L-365260 | 5311201 | invasion, proliferation | CCK2R | U87MG | 19502590 | PubChem Google | ||
Veliparib | 11960529 | radiosensitization, temozolomide enhancer | PARP | LN18, orthotopic mouse model, primary human glioma cells, T98G, U251MG, U87MG | 19174557, 23510353, 28314386 | NCT00770471, NCT01026493, NCT01514201, NCT02152982, NCT03581292 | PubChem Google | |
OTX-015 | 9936746 | BET | orthotopic mouse model, U87MG | 27388964, 29764852, 30515262 | NCT02296476 | PubChem Google | ||
Tivozanib | 9911830 | invasion, proliferation | VEGFR | A172, T98G, U87MG | 28287096 | NCT01846871 | PubChem Google | |
Proguanil | 6178111 | viability | CLIC1 | GBM1, GBM2, GBM3, GBM4, GBM5, GBM6, GBM7 | 30186163 | PubChem Google | ||
Nilotinib | 644241 | Tyrosine kinase inhibitor | 18677408 | PubChem Google |