GBM Drug Bank

Drugs for Glioblastoma

Compound Mode of Action (target)

Compound	PubChem CID	Reported Effect	MoA	PMID	Clinical PMID	Clinical Trials
Fucoxanthin	5281239	mouse xenograft model, proliferation		27394418
Cediranib	9933475	mouse xenograft model, viability	VEGFR	21095630, 25490024, 25676691, 26645398	20458050, 23940216, 26008604	NCT00305656, NCT00503204, NCT00662506, NCT00777153, NCT00979862, NCT01131234, NCT01310855
Acetazolamide	1986	proliferation	carbonic anhydrase	27702686
Pexidartinib	25151352					NCT01349036, NCT01790503
Celecoxib	2662	viability		21847707, 23280445	25239666	NCT00047281, NCT00047294, NCT00112502, NCT00504660, NCT02770378
Selinexor	71481097	orthotopic mouse model, viability	CRM1	25366336		NCT01607905, NCT01986348
Thapsigargin	446378	viability	SERCA	27993939
Milciclib	16718576	proliferation		23347136
Ardipusilloside I	197641	proliferation		24984215
AZD1152-HQPA	16007391	mouse xenograft model, proliferation	Aurora B	22382783
8-Bromo-cyclic AMP	32014	proliferation		24649161, 9484714
Riluzole	5070	proliferation		23724064
UNII-2AW48LAZ4I	72941968	orthotopic mouse model	telomerase	26183089
5-Nonyloxytryptamine	1797	viability		24433351
Fluorouracil	3385	viability	Nucleic Acid Synthesis	24391839, 6690037		NCT01183663
Digitonin	6474107	proliferation		23165409
UNC2025	73425588	orthotopic mouse model	MER, FLT3	27783662, 28605477
ZM447439	9914412	proliferation	Aurora kinase	22160182
Nelfinavir	64143				24194293	NCT00694837, NCT00915694, NCT01020292
Methyl gallate	7428	viability		23562553
Convallatoxin	441852	proliferation		23165409
Curcumin	969516	proliferation		26046466
Neratinib	9915743	orthotopic mouse model, viability	Her2, EGFR	26023796		NCT02977780
Tivozanib	9911830	invasion, proliferation	VEGFR	28287096		NCT01846871
KU60019	15953870	orthotopic mouse model, radiosenitisation	ATM	23620409, 24443327, 25091220
Casticin	5315263	viability		23816816
Prazosin	4893	orthotopic mouse model, viability	PRKCD	27138566
Oxibendazole	4622	proliferation		23165409
Panobinostat	6918837		HDAC		21984064, 25572329, 26821711	NCT00848523, NCT01115036
Digitoxin	441207	proliferation, viability		21184646, 23165409
Punicalagin	44584733	viability		24077634
Letrozole	3902	orthotopic mouse model, proliferation	Aromatase	25695958
Dibutyryl cAMP	9687	proliferation		9484714
Niclosamide	4477	proliferation, viability		23165409, 27029345
AC1MMYR2	3246569	orthotopic mouse model, proliferation		23811941
Eflornithine	3009	proliferation	ornithine decarboxylase	25935110
A-966492	16666333	radiosenitisation	PARP	28797568
Bufalin	9547215	viability		28787697
LB-100	45101433	mouse xenograft model, radiosenitisation	PP2A	25939762		NCT03027388
Imiquimod	57469	orthotopic mouse model	toll-like receptor 7	21389872		NCT01403285
Cabazitaxel	9854073	viability	Microtubule	27203678		NCT01740570, NCT01866449
GSK1838705A	25182616	mouse xenograft model	IGF-1R	26238593
Lys01	70673567	viability		22566612
Telomestatin	443590	viability	G-quadruplexes	26845351
Aurintricarboxylic acid	2259	invasion, migration		28103571
3-BrOP	11513992	viability		23132831
Naringin	442428	invasion, migration		26474590
Vinpocetine	443955	proliferation	PDE1	25620587
Sulindac sulfide	5352624	proliferation		23280445
Temsirolimus	6918289		mTOR	26748241	23099651, 23564811, 24470557	NCT00016328, NCT00022724, NCT00112736, NCT00329719, NCT00335764, NCT00784914, NCT00800917, NCT01019434, NCT01183663, NCT03158389
Clofazimine	2794	viability		24433351
JQ1	49871817	proliferation, rat xenograft model	BET	25056450, 27388964
Pristimerin	159516	proliferation		23165409
Deoxyglucose	108223	radiosenitisation	glycolysis	28756228
Omacetaxine	3628	viability		24433351
1134156-31-2	25195348	proliferation	Hsp70, Hsp90	26185541
beta-Peltatin	92122	proliferation		23165409
Denbinobin	10423984	viability		23123054
Melatonin	896	viability		28255276
Fenofibrate	3339	proliferation	PPARalpha	24493576, 25566967
LY341495	9819927	proliferation		23724064
8-Hydroxy-2-methyl-1H-quinazolin-4-one	63306	radiosenitisation	PARP-1	25182801
Astemizole	2247	viability		27029345
ZSTK474	11647372	mouse spontanious GBM model, mouse xenograft model, proliferation	PI3K	24297065, 27553832
Plumbagin	10205	proliferation, viability		23165409, 25528634
Carboplatin	10339178		DNA		28534153	NCT00005976, NCT00010036, NCT00014105, NCT00021307, NCT00352313, NCT00492687, NCT00541138, NCT00635557, NCT00650949, NCT00995007, NCT01317212, NCT01386710, NCT01837862, NCT01934361, NCT03149575
GSK J4	71729975	proliferation	JMJD3	28978140
MAZ51	9839842	proliferation		25268128
Mebendazole	4030	orthotopic mouse model, proliferation		23165409, 28386621		NCT01729260, NCT01837862, NCT02644291
Isotretinoin	5282379				25239666	NCT00003564, NCT00112502, NCT00555399, NCT01103375
Axitinib	6450551	mouse model	VEGFR, PDGFR	25213669, 27926485		NCT01441388, NCT01508117, NCT01562197, NCT03275558, NCT03291314
Cisplatin	84691	viability	DNA intercalation	24218165, 24953561, 27993939
Bimiralisib	58507717		PI3K, mTOR			NCT02850744
Idarubicin	42890	viability		24433351
Cardamonin	641785	mouse model, proliferation		26150336
Gedatolisib	44516953	viability	PI3K, mTOR	24658109
NSC141562	422114	invasion, migration, proliferation	MIR155HG/miR-155 axis	28371892
AMG-511	59548184	mouse xenograft model	PI3K	22897589
172889-27-9	4878	radiosenitisation	Src	26044161
Chloroquine	2719	radiosenitisation, viability		25434381, 27644442	17350410	NCT00224978, NCT02378532, NCT02432417, NCT03243461
THZ1	73602827	orthotopic mouse model	CDK7	28504693
Tesevatinib	10458325					NCT02844439
GSK461364	15983966	mouse xenograft model, proliferation	PLK1	23790466, 24204733
CUDC-101	24756910	proliferation	EGFR, HDAC	26032687
JS-K	9572720	mouse xenograft model		23370169, 28653883
Tnp-470	369976	angiogenesis		27542173
Midazolam	4192	proliferation		27629139
Amsacrine	2179	proliferation		23165409
Ridaforolimus	11520894		mTOR		22037923	NCT00087451, NCT01295632
Lapatinib	208908	proliferation	EGFR, HER2	24911215	23363814	NCT00095940, NCT00099060, NCT00107003, NCT00350727
Ancitabine	25051	proliferation		23165409
Honokiol	72303	mouse xenograft model, viability		25106108, 25763821, 27064011
Volasertib	10461508	radiosenitisation, viability	PLK1	24204733, 29535822
Hypericin	5281051	viability		24066060	21456013
Ruxolitinib	25126798		JAK
Caffeic acid phenethyl ester	5281787	apoptosis, proliferation		14637186, 23165409, 24997497
Cryptotanshinone	160254	mouse xenograft model		28492557
4egi-1	5717952	proliferation	EIF4E	26220902
Ceritinib	57379345					NCT02605746
PF-04691502	25033539	mouse xenograft model	PI3K, mTOR	21750219
Indatraline	126280	mobility	monoamine transporter	24333442
Pamiparib	71602594					NCT03150862
Veliparib	11960529	orthotopic mouse model, radiosenitisation	PARP	23510353, 28314386		NCT00770471, NCT01026493
Palbociclib	5330286	mouse xenograft model	CDK4, CDK66	24098593, 26149830, 26354993, 27370397, 28903422		NCT02255461, NCT03158389
Flavopiridol	5287969	mouse model, radiosenitisation	CDK	23943501, 27461656, 28111642
3-Deazaneplanocin	73087	viability	HDAC	24905315
MK-886	3651377	viability	Lipoxygenase	23261452
Schizandrin B	158103	invasion, proliferation		27977512
TG02	16739650	orthotopic mouse model, viability		29254993		NCT02942264, NCT03224104
Captopril	44093	invasion		8572589		NCT02770378
D609	4234241	proliferation		28802717
Nilotinib	644241
NBQX	3272524	proliferation	AMPA	23724064
Vinorelbine	5311497	viability		24433351
WP1130	11222830	apoptosis		26872380
Piplartine	637858	migration		24967005
Alvespimycin	5288674	radiosenitisation	Hsp90	24418474
Dactolisib	11977753	orthotopic mouse mode, proliferation, radiosenitisation	PI3K, mTOR	19671762, 23603977, 24366691, 25431423, 26188279, 27542970, 27553832		NCT01508104
Antimycin A	14957	proliferation		23165409
Trifluoperazine	5566	orthotopic mouse model, proliferation		23165409, 28870216
Ouabain	439501	viability		21184646
Lenvatinib	9823820	mouse model	multiple kinases	28901423		NCT01433991
Vandetanib	3081361	mouse xenograft model, proliferation	VEGFR, EGFR, RET-tyrosine kinase	19622715, 20371720, 21095630, 23799852	23099652	NCT00441142, NCT00613223, NCT00821080, NCT00995007
T56-LIMKi	9438169	viability	LIM kinase	25593987
Forskolin	47936	proliferation	adenylate cyclase	24649161, 9484714
Buparlisib	16654980	mouse xenograft model, proliferation, radiosenitisation	PI3K	22065080, 24500492, 24741074, 24900266, 25431423, 26846842, 27283525, 27363276		NCT01339052, NCT01349660, NCT01473901, NCT01576666, NCT01870726, NCT01934361
72926-24-0	2930014	proliferation	Eg5	28965307
Vatalanib	151194	orthotopic mouse model	VEGFR	15271251		NCT00128700, NCT00387933
Karenitecin	148202	radiosenitisation	topoisomerase	28111642		NCT00014521
PF-06840003	23063810
Indomethacin	3715	viability	COX	27988363
BIX-01294	25150857	viability	histone methyltransferase	24905315, 27748874, 27934912
Resveratrol	445154	mouse xenograft model		23651583
Cucurbitacin I	5281321	mouse xenograft model, proliferation		24599950, 25482928
AZD2014	25262792	radiosenitisation	mTOR	24311635		NCT02619864
Nintedanib	9809715		VEGFR, FGFR, PDGFR		23184145, 25338318	NCT01251484
Lenalidomide	216326			26891975	18513880	NCT00036894, NCT00165477, NCT00671801, NCT01183663, NCT02369367
781661-94-7	11178236	apoptosis, migration, proliferation	Survivin	22770110, 23325792, 25201484, 27805285
Hsp-990	46216556, 16226182, 68275964	apoptosis, mouse xenograft model, radiosenitisation	Hsp90	23448094, 24500492
SH5-07	72550504	mouse xenograft model, viability	STAT3	26088127
Cathepsin S Inhibitor	16760355	viability	Cathepsin S	24875536
Palomid 529	11998575	orthotopic mouse model	mTOR	23436212
TGX-221	9907093	proliferation	p110-beta	29048665
GW3965	447905	mouse xenograft model, proliferation	LXR	22059152
Digoxin	2724385	proliferation, viability		21184646, 23165409
Erlotinib	176870	proliferation	EGFR	26032687	22407177, 24470557, 24637230	NCT00030498, NCT00039494, NCT00045110, NCT00054496, NCT00086879, NCT00112736, NCT00124657, NCT00187486, NCT00227032, NCT00274833, NCT00301418, NCT00335764, NCT00337883, NCT00387894, NCT00445588, NCT00509431, NCT00525525, NCT00609999, NCT00671970, NCT00672243, NCT00720356, NCT01103375, NCT01110876, NCT01257594
Savolitinib	68289010, 68287718	mouse xenograft model	c-Met	25148209
Cycloheximide	6197	proliferation		21159181
Vindesine	40839	viability		24433351
Chlorpromazine	2726	mouse xenograft model, orthotopic mouse model, viability		23689352, 28455961
Sulfasalazine	5359476	proliferation, radiosenitisation		25798841, 25937318, 28929335
KPT276	71496742	orthotopic mouse model, viability	CRM1	25366336
PQ401	9549305	mouse xenograft model	IGF-1R	25971682
Pregnenolone	8955	viability		25013479
Tamoxifen	2733526	viability	ER	25554223		NCT00002608, NCT00006388, NCT00492687, NCT00541138
GW2974	6603857	invastion, migration, viability	EGFR, HER2	23115024
Ascochlorin	11258227	invasion, migration		28569433
RG7112	57406853	mouse model	MDM2	26482041
Caffeine	2519	migration, orthotopic mouse model		25011614, 27260469
Marizomib	11347535	mouse xenograft model, viability	proteasome	26681765, 26804704
Flubendazole	35802	viability		24433351
Birinapant	49836020	viability	IAP	26657652
carnosol	442009	proliferation		26939786
JIB-04	6519698	viability	histone lysine demethylase	28432280
Juglone	3806	proliferation		28388894, 28791366
Indirubin Derivative E804	6419764	proliferation		26386687
RapaLink-1	121231411	proliferation	mTOR	28292440
GSK3326595	90241742					NCT02783300
Alexidine	102678, 2090	viability		27029345
Abemaciclib	46220502	mouse xenograft model	CDK4, CDK6	26149830		NCT02977780, NCT02981940
Phenformin	8249	orthotopic mouse model		27486821
YU238259	121473004	proliferation	HDR	26116172
Olaparib	23725625	viability	PARP	25531448, 25576921, 26794465		NCT01390571
Oxamate	3017661	radiosenitisation	lactate dehydrogenase	28756228
Gitoxigenin	348482	proliferation		23165409
Enzastaurin	176167	proliferation	PKCbeta	19913408	20124186, 22291006	NCT00295815, NCT00402116, NCT00509821, NCT00516607, NCT00586508
Talampanel	164509				19636006, 20143438	NCT00062504, NCT00064363, NCT00267592
Patulin	4696	proliferation		23165409
Evodiamine	442088	mouse model		28514905
NSC23766	409805	viability	RAC1	23736154
SKI II	753704	radiosenitisation	SphK	25255218, 28494176
Enasidenib	89683805		IDH2
Gitoxin	91540	proliferation		23165409
Anthothecol	21596360	proliferation		23165409
Cilengitide	176873	proliferation	integrin	19114005, 22588883	17470857, 18981465, 20439646, 25163906, 26008604	NCT00006093, NCT00085254, NCT00112866, NCT00679354, NCT00689221, NCT00813943, NCT00979862, NCT01044225, NCT01122888, NCT01124240, NCT01517776, NCT01782976
Genistein	5280961	viability		19894226
Gambogenic Acid	10794070	apoptosis		21879332
Isobutylmethylxanthine	3758	proliferation, viability	PDE	22227470, 9484714
PCI-24781	11749858	proliferation	HDAC	25505847
MG-132	462382	mouse xenograft model, proliferation	proteasome	22367315, 27993939
CC-115	58298318					NCT01353625, NCT02977780
Oroxylin A	5320315	viability		25213258
Tpi-287	118797983	viability	Microtubule	29396807
717906-29-1	11598628	migration, proliferation	FAK	26883759
487020-03-1	1936439	mouse xenograft model	PBK	26081429
9-ING-41	44582816	orthotopic mouse model	Glycogen Synthase Kinase-3	28672195
Demethoxycurcumin	5469424	mouse xenograft model		27757851
SH-4-54	72188643	orthotopic mouse model, proliferation	STAT3	24900612
Epirubicin	41867	proliferation, viability	DNA intercalation	23165409, 24433351, 28963609
GDC-0941	17755052	mouse xenograft model, radiosenitisation, viability	PI3K	23427298, 24757258, 28147244
Abt-737	11228183	viability	Bcl-2	22393246
Scriptaid	5186	viability	HDAC	26032687
Repaglinide	65981	orthotopic mouse model		28476618
Disufenton sodium	11603334	rat model		23328810
Vismodegib	24776445					NCT00980343, NCT03158389
Sonidegib	24775005	viability	smoothened	23482671		NCT01576666
Carmustine	2578		DNA alkylation		24958095, 7013978	NCT00002545, NCT00003176, NCT00003348, NCT00003417, NCT00003463, NCT00003484, NCT00003788, NCT00003876, NCT00003996, NCT00004028, NCT00004688, NCT00004892, NCT00005081, NCT00005637, NCT00005855, NCT00006386, NCT00006656, NCT00009854, NCT00017147, NCT00027612, NCT00046878, NCT00068952, NCT00076986, NCT00086879, NCT00362921, NCT00548938, NCT00761280, NCT00795665, NCT00984438, NCT01186406, NCT01310868, NCT01656980
UMI-77	992586	viability	Mcl-1	28337703
NKTR-102	71300727				25935109
AMG 232	58573469
Temozolomide	5394	mouse model, viability	alkylating agent	23736154, 24647572, 27878252, 27993939	15758009, 19506159, 19636006, 20855843, 20934264, 21735117, 22035272, 22291006, 22578793, 23633392, 23725999, 23898124, 24194293, 24637230, 25239666, 26285766	NCT00003176, NCT00003464, NCT00004113, NCT00004200, NCT00005637, NCT00005951, NCT00006025, NCT00006353, NCT00006358, NCT00006474, NCT00014105, NCT00021307, NCT00027625, NCT00028795, NCT00038493, NCT00039494, NCT00047294, NCT00049387, NCT00050986, NCT00052455, NCT00068952, NCT00083096, NCT00085254, NCT00086879, NCT00089427, NCT00099125, NCT00102648, NCT00112502, NCT00128700, NCT00187486, NCT00200161, NCT00238277, NCT00253487, NCT00262730, NCT00274833, NCT00275067, NCT00304031, NCT00311857, NCT00335075, NCT00354068, NCT00365222, NCT00376103, NCT00385853, NCT00387400, NCT00390403, NCT00392171, NCT00394628, NCT00402116, NCT00431561, NCT00433381, NCT00436436, NCT00441142, NCT00458601, NCT00471653, NCT00481455, NCT00482677, NCT00486603, NCT00492687, NCT00498927, NCT00501891, NCT00504660, NCT00508456, NCT00516282, NCT00516607, NCT00521482, NCT00525525, NCT00544284, NCT00548938, NCT00553150, NCT00555399, NCT00575887, NCT00590681, NCT00597402, NCT00597493, NCT00610571, NCT00612339, NCT00612651, NCT00612989, NCT00613093, NCT00615186, NCT00616005, NCT00619112, NCT00643825, NCT00650923, NCT00657267, NCT00662506, NCT00686725, NCT00687765, NCT00689221, NCT00704080, NCT00720564, NCT00723827, NCT00725010, NCT00734526, NCT00756106, NCT00761280, NCT00768911, NCT00770471, NCT00813943, NCT00817284, NCT00820963, NCT00841555, NCT00869401, NCT00883298, NCT00904852, NCT00915694, NCT00941460, NCT00943826, NCT00960492, NCT00967330, NCT00977431, NCT00979017, NCT01004874, NCT01019434, NCT01022918, NCT01026493, NCT01044966, NCT01062399, NCT01102595, NCT01110876, NCT01115491, NCT01120639, NCT01149109, NCT01180816, NCT01186406, NCT01209442, NCT01220271, NCT01242566, NCT01285414, NCT01294735, NCT01342757, NCT01345370, NCT01390571, NCT01402063, NCT01430351, NCT01473901, NCT01478321, NCT01480050, NCT01480479, NCT01502241, NCT01517776, NCT01587144, NCT01700569, NCT01752491, NCT01765088, NCT01777919, NCT01790503, NCT01800695, NCT01830101, NCT01837862, NCT01860638, NCT01907165, NCT02029573, NCT02052648, NCT02092038, NCT02177578, NCT02209948, NCT02227901, NCT02315534, NCT02330991, NCT02337426, NCT02343406, NCT02344355, NCT02364206, NCT02378532, NCT02502708, NCT02573324, NCT02590263, NCT02599090, NCT02617589, NCT02655601, NCT02661282, NCT02667587, NCT02715609, NCT02761070, NCT02770378, NCT02781792, NCT02871843, NCT02898012, NCT02928575, NCT02977780, NCT03018288, NCT03119064, NCT03139916, NCT03149575, NCT03174197, NCT03213002, NCT03224104, NCT03243461, NCT03246113, NCT03291990
Gossypol	3503	viability		25375271
Ralimetinib	11570805, 11539025	mouse xenograft model	MAPK	24356814
Binimetinib	10288191	orthotopic mouse model, radiosenitisation	MAP2K	28958992
OTX-015	9936746	orthotopic mouse model	BET	27388964		NCT02296476
Fingolimod	107969	invasion, migration		25070489
Pimozide	16362	orthotopic mouse model	USP1	26032834
Ibrutinib	24821094	mouse xenograft model, proliferation	Bruton's tyrosine kinase	27564106, 28716053
Lonafarnib	148195	orthotopic mouse model, viability	farnesyl transferase	21246394	21735117, 23633392	NCT00038493, NCT00083096, NCT00102648
AMG-925	60202647	proliferation	FLT3, CDK4	26585571
Tocladesine	100299	apoptosis		12449730
JNJ-10198409	9797370	viability	PLK1	24204733
Anisomycin	253602	viability		21184646, 22684030, 23165409
MK-2206	24964624	proliferation	Akt	22057914, 28320338		NCT01295632
KU55933	5278396	orthotopic mouse model, radiosenitisation	ATM	25017126, 25205037
Oleuropein	5281544	invasion, proliferation		27498673
Reversan	2298706			26136652
Vincristine	5978	orthotopic mouse model, proliferation	microtubule	23165409, 24433351, 28386621	20855843, 225004	NCT00052455, NCT01837862
Proscillaridin A	222154	orthotopic mouse model, proliferation		25400117, 27029345
Pitavastatin	5282452	viability		24433351
Farnesylthiosalicylic acid	329799768	invasion, migration, proliferation	Ras	16985068, 17178866
Terfenadine	5405	viability		27029345
Fenbendazole	3334	proliferation		23165409
Diclofenac	3033	migration, proliferation		26485029
SF1126	66577114	mouse xenograft model	PI3K	25425962
Fluvoxamine	5324346	mouse model		26988603
Cladribine	20279	viability		24433351		NCT00019071
CBL-0137	44519124	orthotopic mouse model		27370399
Navitoclax	24978538	viability	Bcl-2, Bcl-xL, BCL-w	24757258, 26474387, 29016820
Satraplatin	6918220		DNA
Afatinib	10184653	mouse xenograft model	tyrosine kinase	25444177		NCT00977431, NCT02423525
Glasdegib	25166913		smoothened
SSR128129E	68853159	radiosenitisation	FGFR	24953334
Epigallocathecin Gallate	65064	viability		19894226
Fluvastatin	446155	proliferation		23165409
Dactinomycin	457193	proliferation, viability		23165409, 24433351
Peruvoside	12314120	proliferation		23165409
Dorsomorphin	11524144	viability		24419061
NVP-AEW541	11476171	mouse xenograft model	IGF-1R	21659463
Embelin	3218	viability		23514760, 23545899
Alisertib	24771867	mouse xenograft model, viability	Aurora A kinase	24627220, 24879067, 25106428, 27797168, 29016820, 29396807
Wortmannin	312145	proliferation	PI3K	23724064
Camptothecin	24360	proliferation, viability		23165409, 23736154, 27029345
Pomolic acid	382831	migration, viability	Reactive oxygen species	28849227
Simvastatin	54454	proliferation		23165409
Cabozantinib	25102847	mouse model, proliferation	multiple kinases	21926191, 23484006		NCT00704288, NCT00960492, NCT01068782, NCT02885324
Clorgiline	4380	proliferation	MAO A	26871599
Silibinin	31553	viability		25750273
Podofilox	10607	proliferation		23165409
Sinomenine	5459308	mouse model		28891980
Silmitasertib	24748573	mouse xenograft model	CK2	24036851
Methotrexate	126941	proliferation	DHFR	23165409	15735920	NCT00082797, NCT00463008
Capecitabine	60953		Nucleic Acid Synthesis		25290090	NCT00504660, NCT00717197, NCT00959946, NCT02669173, NCT03213002
STX-0119	4253236	mouse model, proliferation	STAT3	23612755, 24820265, 28716484
VAL-083	15942827	mouse xenograft model, proliferation		28216618		NCT01478178, NCT02717962, NCT03050736, NCT03149575
Ritonavir	392622	proliferation		28319810		NCT01095094, NCT02770378
Perilla alcohol	10819	proliferation		25497898
AXL1717	72435	mouse xenograft model, proliferation	IGF-1R	20150364, 23165409		NCT01721577
GANT61	421610	viability	GLI	27894350
Infigratinib	53235510		FGFR			NCT01975701
Guggulsterone	53394010	viability		23548480
NVX-207	9960374	proliferation		25361208
DB-074971	77068345	proliferation	survivin	23325792
Albendazole	2082	proliferation		23165409
Xanthohumol	639665	apoptosis		22111577
Lactacystin	6610292	mouse xenograft model, viability	proteasome	23569132
Doxazosin	3157	proliferation		27123999
GSK1904529A	25124816	mouse model	IGF-1R	26035416
WP1066	11210478	proliferation	JAK	23612755		NCT01904123
Tetraethylammonium	5413	proliferation		25700359
GK921	56682080	orthotopic mouse model	transglutaminase 2	28754668
Aldoxorubicin	129636048	mouse xenograft model	DNA intercalation	25379024		NCT02014844
Sanguinarine	5154	viability		26472194
Fludarabine	657237	proliferation		23165409		NCT00990496
Propofol	4943	apoptosis	Reactive oxygen species	28804952
Oroxindin	3084961	viability		24970553
Cyclophosphamide	2907		DNA crosslinking		15022289, 15735920	NCT00047281, NCT00990496, NCT01403285, NCT01903330
BI2536	11364421	orthotopic mouse model, viability	PLK1	22415968, 23713868, 24204733
Itraconazole	55283	viability		24433351		NCT02770378
Linifanib	11485656	orthotopic rat model	receptor tyrosine kinase	22080168
Harmol	68094	viability		23338618
Diazepinomicin	9868980		Ras		22048878	NCT00730262
PP242	25243800	migration, proliferation	mTORC1, mTORC2	26719046
Mibefradil	60663	rat model, viability	T-type calcium channels	23198803, 23287412	28371832	NCT01480050, NCT02202993
LGK974	46926973	proliferation	PORCN	26222502
Dimethylaminomicheliolide	54589107	rat model		25658946
Theobromine	5429	proliferation	PDEs	24547961
Tricetin	5281701	invasion, migration		26245494
AG-120	89699486, 71657455	viability	IDH1	29670690
Pegdinetanib	86278317	orthotopic mouse model	VEGFR2	22875706	25388940
R428	46215462	proliferation	AXL	25980499
Artesunate	105031	radiosenitisation		22560712
Pyrazolanthrone	8515	viability	JNK	23210245
Rucaparib	9931954	orthotopic mouse model	PARP	26438157
Etoposide	36462	proliferation		23165409, 24953561		NCT00003996, NCT00047281, NCT00612430, NCT00613028, NCT00613223
Cytarabine	6253	proliferation		23165409		NCT01044966
Andrographolide	5318517	proliferation		22634579
PI-103	9884685	radiosenitisation, viability	PI3K, mTOR	16697955, 22125077, 24418474
297157-92-7	2891837	mouse xenograft model		27993939
ML00253764	9842665	proliferation	melanocortin receptor-4	28791594
Fasudil	3547	viability	ROCK	26725099
Sirolimus	5284616	mouse xenograft model, viability	mTOR	23261661, 24043497, 25886314		NCT00047073, NCT00509431, NCT00672243, NCT00821080
Vorinostat	5311	mouse model, radiosenitisation, viability	histone deacetylase	17289901, 23962875, 25040548, 25275596, 26794465, 27863490	19307505	NCT00238303, NCT00555399, NCT00641706, NCT00762255, NCT01110876, NCT01266031, NCT01342757, NCT01378481, NCT01738646
Thalidomide	5426				25239666, 25427949	NCT00006358, NCT00014443, NCT00039468, NCT00047281, NCT00047294, NCT00049296, NCT00079092, NCT00112502, NCT00412542, NCT00521482
Doxorubicin	31703	proliferation	DNA intercalation	23165409, 24433351, 27029345, 27993939, 28612256		NCT00002608, NCT00944801, NCT02758366
Nobiletin	72344	proliferation		23546290
PLX-4720	24180719	orthotopic mouse model	BRAF	26023796
Crenolanib	10366136	viability	PDGFRalpha	25380967		NCT02626364
Regorafenib	11167602	viability		24911215		NCT02926222
MLN4924	16720766	orthotopic mouse model	NEDD8-activating enzyme	25904638
Antroquinonol	24875259	mouse model		26517117
PIK-75	10275789	apoptosis	PI3K	22802621
Larotrectinib	46188928					NCT02576431
ML298	53393916	invasion, migration	PLD2	23445448
Vemurafenib	42611257		BRAF		24725538
Mitomycin	5746	proliferation		23165409
Oligomycin	78358496	viability		23523615
LY294002	3973	proliferation	PI3K	22086271, 25425962
Galunisertib	10090485		TGFBR1		24868575, 25424852, 25529192, 26902851	NCT01220271, NCT01582269
Dabrafenib	44462760		BRAF		26680369, 29039591, 29295876	NCT02684058
Triptolide	107985	viability		24433351
Rottlerin	5281847	proliferation		27626499
Tetrandrine	73078	viability		27909720
Irinotecan	60838	migration, viability	topoisomerase 1	24433351, 26830091	29245310	NCT00003301, NCT00003463, NCT00003484, NCT00005951, NCT00006025, NCT00010036, NCT00027612, NCT00039468, NCT00099125, NCT00132158, NCT00345163, NCT00352521, NCT00412542, NCT00433381, NCT00463073, NCT00562419, NCT00597402, NCT00611728, NCT00612638, NCT00616005, NCT00671801, NCT00734682, NCT00762255, NCT00817284, NCT00967330, NCT00979017, NCT00984438, NCT01017653, NCT01022918, NCT01308632, NCT01837862, NCT01999270, NCT02369367, NCT03119064
Epigallocathecin	72277	viability		19894226
AEE788	10297043	proliferation	mTOR	15657358		NCT00107237, NCT00116376
Trichostatin	444732	viability	HDAC	23564772, 24905315
Trametinib	11707110	viability	MEK	25431423	29295876	NCT02684058
Lanatoside C	3879	viability		21184646, 27029345
Nisoldipine	4499	viability		24433351
Ponatinib	24826799	mouse xenograft model, viability	tyrosine kinase	25378936		NCT02478164
Ibuprofen	3672	migration, proliferation		26485029
Shikonin	479503	proliferation	topoisomerase	23840441, 24303074, 25688715, 25891245
Strophanthidin	6185	proliferation		23165409
Glaucocalyxin A	10471963	proliferation		24041957
Lovastatin	53232	proliferation	HMG-CoA reductase	25497898
Tipifarnib	159324		farnesyl protein transferase		18725460, 20934264, 28988377	NCT00005859, NCT00049387, NCT00050986, NCT00058097, NCT00209989, NCT00335764, NCT02227901
2-Hydroxyoleic acid	9796304	viability		23133576, 23471028
Lorlatinib	71731823	mouse model	ALK, ROS1	25733882
Acalabrutinib	71226662		tyrosine kinase			NCT02586857
NCL-1	73755256	orthotopic mouse model, proliferation	KDM1A	23248157, 27893719
Gefitinib	123631	proliferation, radiosenitisation, viability	EGFR	14643025, 23724064, 23736154, 24876095, 25368255	23182702	NCT00014170, NCT00016991, NCT00025675, NCT00027625, NCT00042991, NCT00052208, NCT00085566, NCT00132158, NCT00238797, NCT01310855
LLP3	56935694	viability		23251006
Paclitaxel	36314	proliferation, viability	microtubule	23165409, 28962238		NCT00019019, NCT00479765
Chaetocin	11657687	viability	Histone lysine methyltransferases	24905315
109511-58-2	3006531	proliferation	MEK1, MEK2	26748241
602306-29-6	16747683	proliferation	CDK1, CKD2, CDK9	26585571
Ixazomib	25183872		proteasome			NCT02630030
RG2833	56654642	Temozolomide enhancer	HDAC1, HDAC3	27632183
Bortezomib	387447	mouse xenograft model, proliferation	proteasome	23334228, 24093630, 24297065		NCT00006773, NCT00544284, NCT00611325, NCT00641706, NCT00998010, NCT01435395
Salinomycin	3085092	apoptosis, mouse xenograft model, proliferation		23165409, 28358414, 28498472
Cordycepin	6303	orthotopic mouse model		26597532, 28068557
Bafetinib	11387605		tyrosine kinase		23380277	NCT01234740
Gartanin	5281633	proliferation		27491646
Imatinib	5291	mouse model, viability	multiple kinases	16274936, 23736154		NCT00010049, NCT00039364, NCT00154375, NCT00171938, NCT00290771, NCT00354068, NCT00354913, NCT00387933, NCT00401024, NCT00615927
PF8380	25265312	proliferation	Autotaxin	23300119
3-(3,4-dichlorophenyl)-1-(3,4-dimethylphenyl)-1-(5	613034	mouse xenograft model	mTORC2	28453552
ON123300	56649281	proliferation		24568969
KU0063794	16736978	viability	mTOR	22125077
Homidium	3624	proliferation		23165409
Evofosfamide	11984561		DNA crosslinking		29415215	NCT02342379
Vinblastine	13342	proliferation		23165409, 6690037
Dehydroxymethylepoxyquinomicin	9881652	mouse xenograft model	NFKB	21968049
Adavosertib	24856436	mouse xenograft model, viability	WEE1	21992793, 25609063
USL311	56961879					NCT02765165
Celastrol	122724	mouse xenograft model		18343027, 19909582, 24810052
Salvianolic acid B	6451084	viability		23842993
Dexanabinol	107778					NCT01654497
Tozasertib	5494449	mouse xenograft model, radiosenitisation, viability	Aurora kinase	23636005, 25522764
6-HYDROXYQUINOLINE-4-CARBOXYLIC ACID	71363454	mouse model	proteasome	26645398
TG101209	16722832	proliferation	JAK2	26283544
Docetaxel	148124	viability		24433351		NCT00049296
Sorafenib	216239	proliferation, radiosenitisation	Tyrosone protein kinase	23324350, 24139873, 24911215, 24965413, 27542273	21954442, 23099651, 23898124, 24786603, 28988377	NCT00093613, NCT00329719, NCT00335764, NCT00445588, NCT00597493, NCT00734526, NCT00884416, NCT01183663, NCT01434602, NCT01441388, NCT01817751, NCT02599090
Deguelin	107935	proliferation		23165409
Olanzapine	4585	mouse xenograft model, proliferation		25338992
Bendamustine	65628				21626071, 28204914	NCT00823797
Fingolimod	107970	mouse xenograft model, viability		25070489, 25939952		NCT02490930
Atorvastatin	60823	proliferation, viability	HMG-CoA reductase	23165409, 28181188		NCT02029573
Gambogic acid	5353639	proliferation		23165409
PJ34	4858	viability	PARP	25531448, 25576921
DWP0016	71660487	viability	HDAC	23297003
Cerivastatin	446156	viability		24433351
trans-ACUB	16038368	proliferation	sEH	22382785
Metformin	4091	proliferation		24965413		NCT01430351, NCT02780024, NCT03151772
Topotecan	60700	proliferation, radiosenitisation, viability	topoisomerase	23165409, 24303074, 24433351, 28797568		NCT00014443, NCT00541138, NCT00610571, NCT01004874, NCT01931098
Sertraline	68617	viability		24433351		NCT02770378
Procarbazine	4915				20855843, 225004	NCT00003293, NCT00003564, NCT00003788, NCT00004004, NCT00052455, NCT00079092, NCT01737346
Caudatin	72948694	proliferation		25860846
AZD1480	16659841	orthotopic mouse model, proliferation	JAK1, JAK2	22027691
Sevoflurane	5206	invasion, migration		27840895
NCD-38	102222767	ortothopic mouse model	KDM1A	27893719
Pseudolaric acid B	6393431	apoptosis		22778780
Entrectinib	25141092	mouse model	Trk, ROS1, ALK	28695888
Iniparib	9796068				26285766	NCT00687765
PD173074	1401	migration, proliferation	FGFR	19340397, 26883759
Pyrvinium	5281035	mouse xenograft model, proliferation, viability		23165409, 26152745, 27029345
Apatinib	11315474		tyrosine kinase		29245310
Xyloketal B	10980896	proliferation, viability		25913706
Mepacrine	237	viability		25490024, 27029345
Dinaciclib	46926350	proliferation	CDK1, CDK2, CDK5, CDK9	26585571
761437-28-9	9934347	radiosenitisation, viability	FAK	25625667
Pazopanib	10113978		tyrosine kinase		20200024, 23363814	NCT00350727, NCT00459381, NCT01392352, NCT01931098, NCT02331498, NCT03275558
CC-223	58298316		mTOR			NCT01177397
Disufenton sodium	6440181	orthotopic mouse model, rat model		23328810, 26248280
Carvacrol	10364	proliferation, viability		25913706
BDBM86691	57340709	proliferation	ACAT1	26252415
Alantolactone	72724	viability		22837216
Oxaliplatin	9887054	mouse xenograft model, radiosenitisation	DNA	17383816, 18329790
7-Ethyl-10-hydroxycamptothecin	104842	viability	topoisomerase	28963609
MRK003	92043122, 15953832	orthotopic mouse model, proliferation	gamma secretase	23630166, 25293440, 25920606, 26613556
GDC-0084	57384863	orthotopic mouse model	PI3K, mTOR	27638506		NCT01547546
AZD8055	25262965	mouse xenograft model	mTOR	25316808		NCT01316809
Theophylline	2153	viability	PDE	22227470
Everolimus	6442177		mTOR	25371289	23725999, 25526733	NCT00085566, NCT00107237, NCT00387400, NCT00515086, NCT00553150, NCT01062399, NCT01434602, NCT01508104
Dacomitinib	11511120	viability	ErbB	24658109, 25939761		NCT01112527, NCT01520870
Mitoxantrone	4212	proliferation, viability	Topoisomerase	21184646, 23165409
1616632-77-9	73777259	viability		26474387, 28767654		NCT02038699, NCT02525692
Adenosine dialdehyde	99920	proliferation		23353701
Crizotinib	11626560	mouse xenograft model, viability		23556031, 26517812		NCT00939770, NCT01441388, NCT02270034
7-Hydroxystaurosporine	72271	mouse xenograft model		24810059
Tanespimycin	6505803	viability	Hsp90	26185541, 28542269
Romidepsin	5352062	proliferation	histone deacetylases	15024582, 27685789		NCT00085540
Visudyne	5362420	proliferation		28790340
Sunitinib	5329102	mouse model, prolifration	Receptor tyrosine kinases	22449730, 25458015	22832897, 24311637, 24424564	NCT00499473, NCT00535379, NCT00606008, NCT00864864, NCT00923117, NCT01100177, NCT01441388, NCT02928575, NCT03025893, NCT03275558
LEQ506	45100669		smoothened
Daporinad	6914657	viability	NAMPT	22119381, 26601421
Arctigenin	64981	proliferation		28356992
4506-66-5	78260	migration, orthotopic mouse model, proliferation	FAK	23243059, 26883759
KPT251	57519758	viability	CRM1	25366336
Teniposide	452548	proliferation		23165409
10-Hydroxycamptothecin	97226	proliferation		23165409
Germacrone	6436348	proliferation		24889088
Colchicine	6167	proliferation		23165409
Perifosine	148177	viability	Akt, PI3K	16103096, 24065522
Otx-008	11953346	viability	galectin-1	23978989
Bosutinib	5328940		Src		25290090, 25411098	NCT00959946, NCT01331291
Tandutinib	3038522	mouse xenograft model, transgenic mouse model	multiple kinases	22146535, 23638177
Amlexanox	2161	proliferation	IKBKE	29048430
Foretinib	42642645	mouse model	c-Met, VEGFR2	24658326
SGX-523	24779724	orthotopic mouse model	c-Met	20015006
Monensin	441145	proliferation, viability		23165409, 27029345
Dihydroartemisinin	456410	proliferation		26722323
2-Amino-3H-phenoxazin-3-one	72725	viability		24008433
LOXO-195	129103609		TRK tyrosine kinase			NCT03215511
PD0325901	9826528	mouse xenograft model, viability	MEK	22573716, 25431423
BMS-536924	11353973	mouse model	IGF-1R, IR	25897243
Digitoxigenin	4369270	viability		27029345
Hispolon	53395354	viability		28618133
Lomustine	3950	orthotopic mouse model	alkylating agent	27474153, 28672195	20124186, 20855843, 23940216, 24958095	NCT00003788, NCT00052455, NCT00068952, NCT00295815, NCT00503204, NCT00504660, NCT00761280, NCT00777153, NCT00948389, NCT01067469, NCT01149109, NCT01562197, NCT01582269, NCT01737346, NCT01860638, NCT01934361, NCT02343406, NCT02765165, NCT02926222, NCT03025893, NCT03149575
Roscovitine	160355	proliferation	CDK	26151768
AZD-7451	25115967
Terameprocol	476861	proliferation		23299390	22323663	NCT00404248
Emetine	10219	proliferation		23165409
Ribociclib	44631912		CDK4, CDK6			NCT02345824, NCT02933736
Thymoquinone	10281	proliferation		24039814
Daunorubicin	30323	proliferation		23165409
Gamma-Secretase Inhibitor IX	5311272	proliferation, viability	gamma-secretase	23736154, 25063285
XL765	49867926	mouse xenograft model	PI3K, mTOR	21317208	26019185	NCT00704080, NCT01240460
BMS-777607	24794418	mouse xenograft model	AXL	26848524
RO4929097	49867930	mouse xenograft model	Gamma secretase	25486598		NCT01122901, NCT01131234, NCT01189240, NCT01269411
ML299	56593054	invasion, migration	PLD1, PLD2	23445448
NMS-P715	44556162	mouse xenograft model, radiosenitisation		25722303
Luteolin	5280445	migration		28927111
Disulfiram	3117	proliferation		23165409		NCT01777919, NCT01907165, NCT02678975, NCT02715609, NCT02770378, NCT03151772
Erdafitinib	67462786		FGFR
CPI-455	78426698	viability	histone lysine demethylase	28432280
Apigenin	5280443	viability		19894226
Capmatinib	25145656	mouse xenograft model	cMET	21918175		NCT01324479, NCT01870726, NCT02386826
Fotemustine	104799		DNA alkylation		27165580	NCT01474239
Digoxigenin	15478	proliferation, viability		23165409, 27029345
Golvatinib	16118392		c-Met, VEGFR2			NCT01433991
Rolipram	5092	mouse xenograft model, proliferation	PDE4	12432276, 17234775, 28202289
Valproic Acid	3121	radiosenitisation, viability		23253698, 24348849, 25275596, 27802437, 28962238	23523186
Isoliquiritigenin	638278	viability	topoisomerase	23229626, 26722447
PX-866	9849735	mouse xenograft model	PI3K	20156803	25605819	NCT01259869
Transcrocetinate sodium	10287099	rat model		18447715
Semustine	5198		DNA alkylation		225004, 7013978	NCT00335075
Altiratinib	54576299	mouse xenograft model	c-Met, TIE2, VEGFR2	26965451
Clioquinol	2788	viability		26725099
Puromycin	439530	proliferation		23165409
Pargyline	4688	proliferation		23248157
AT13387	11955716	mouse xenograft model, zebrafish xenograft model	Hsp90	28679777
Selumetinib	10127622	mouse xenograft models	MEK1, MEK2	20806365, 22573716
Dasatinib	3062316	orthotopic mouse model	Src	19098899	22407177, 25758746	NCT00423735, NCT00609999, NCT00869401, NCT00895960, NCT00948389, NCT02661113
BAY 11-7082	5353431	proliferation	NFKB	26137111
Hydroxyurea	3657		RNR		19904263	NCT00019058, NCT00154375, NCT00290771, NCT00354913, NCT00387933, NCT00613054, NCT00613132, NCT00615927
PF-429242	23661637	viability	Site-1 protease	28645614
Dovitinib	9886808	proliferation	multiple kinases	28500786	27100354	NCT01753713, NCT01972750
Bibu 1361	46861539	apoptosis	EGFR	22753156
Quercetin	5280343	viability		24379902, 24902789