GBM Drug Bank

Drugs for Glioblastoma

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CompoundPubChem CIDReported EffectMoAModelsPMIDClinical PMIDClinical TrialsPatents
Dacomitinib11511120viabilityErbBLN229, primary human glioma cells, U251MG, U373, U87MG24658109, 25939761, 30247945NCT01112527, NCT01520870 PubChem
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Clozapine135398737proliferationPKA, chloride channel 4, CDK5, PI3K, Akt, GSK-3betSHSY5Y, U87MG16542821, 25246152 PubChem
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WYE-13225260757apoptosis, proliferation, viabilitymTORU87MG20068177 PubChem
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Salvianolic acid B6451084viabilityU87MG23842993 PubChem
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Savolitinib68289010cMETmouse xenograft model, U87MG25148209 PubChem
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LB1134693726proliferation, viabilityPP2Amurine glioma xenografts, U251MG, U87MG20001590 Google
PF838025265312proliferationAutotaxinLN22923300119 PubChem
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BMS-59962610437018proliferationEGFR, ERBB2A549, BT474, N8717062696NCT00979173 PubChem
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Furin Inhibitor I16760442migration, survivalFurinLN229, U87MG19690139 Google
Dihydrotanshinone11425923cell cycle arrest, temozolomide enhancer, viabilityT98G, U87MG30399573 Google
SH-4-5472188643proliferationSTAT3orthotopic mouse model24900612 PubChem
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5-aminolevulinic acid12360830644008NCT01208909, NCT01310868, NCT01445691, NCT02119338, NCT03048240 PubChem
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BE-16627B132070apoptosisMMPU251MG, U373MG, U87MG14604227 Google
Lenvatinib9823820Multiple kinasesmouse model28901423NCT01433991, NCT03797326 PubChem
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KC7f216047442viabilityHIF1U251MG, U87MGD19789328 PubChem
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NS-16194552enhanced drug delivery to brain-tumor cellscalcium dependent potassium (K(Ca)) channel agonisxenograft model19738431 PubChem
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Tilarginine132862apoptosis, viabilityNOSCRTMG, T98G19748528, 9809627 PubChem
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Sinomenine5459308mouse model, U87MG28891980 PubChem
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Nocodazole4122apoptosisMicrotubulesT98G30268825 PubChem
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SH5-0772550504viabilitySTAT3mouse xenograft model, U251MG, U373MG, U87MG26088127 PubChem
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Hydroxycitrate123908clonogenicity, invasion, migrationATP citrate lyase (ACLY)U87MG19795461 PubChem
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Withaferin A265237apoptosis, G2/M arrestCDK1, ATF4-ATF3-CHOP, Bim, Badnude mice xenografts, U251, U8731642559 PubChem
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Clorgiline4380proliferationMAO AU251MG26871599 PubChem
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Avasimibe166558proliferation, viabilityACAT1A172, GL261, U87MG20404512 PubChem
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RO492909749867930Gamma secretaseIGRG121, mouse xenograft model25486598NCT01119599, NCT01122901, NCT01131234, NCT01189240, NCT01269411 PubChem
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Fenoterol3343mRNA synthesis inhibitionH1RU37318498711 PubChem
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PI-1039884685radiosensitization, viabilityPI3K, mTORLN229, T98G, U251MG, U373MG, U87MG16697955, 18413797, 19177002, 19513541, 19584227, 19633683, 19737945, 22125077, 24418474 PubChem
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Eflornithine3009proliferationOrnithine decarboxylaseU251MG19010902, 25935110 PubChem
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Alexidine2090viabilityU87MG27029345 PubChem
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Xanthohumol639665apoptosisT98G22111577 PubChem
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Gboxin137628664apoptosisF0F1 ATP synthaseglioblastoma allografts, patient-derived xenografts, primary mouse30842654 PubChem
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HJC015271719978apoptosis, chemosensitivity, motility, proliferationSTAT3xenograft tumors31105997 Google
PGE(2)5280360proliferationPKA, WntU87MG19804834, 20015475 PubChem
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Amlexanox2161proliferationIKBKEU251MG, U87MG29048430 PubChem
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Diazepam3016cell cycle arrest, proliferationRbT98G, U87MG16059654, 23519373 PubChem
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Altiratinib54576299cMET, TIE2, VEGFR2mouse xenograft model, primary human glioma cells26965451 PubChem
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AMG 90024856041proliferationAurora kinaseA172, U118MG, U87MG30221846 PubChem
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PJ344858viabilityPARPLN229, U87MG25531448, 25576921 PubChem
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Luminespib135539077viabilityHsp90mouse xenograft model, SF268, U87MG20457619 PubChem
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Go69833499invasion, proliferationPKCU87MG19502590 PubChem
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Deoxyglucose108223invasion, migration, radiosensitizationglycolysis, miR75p, TFF3A172, LN229, SF268, T98G, U373MG, U87MG18483381, 19244119, 19826036, 20009287, 20009289, 20009297, 28756228, 2962154220009294 PubChem
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L-6854585479543migration, survivalgamma-secretaseLN229, U87MG19690139 PubChem
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Fingolimod107970viabilityA172, mouse xenograft model, SHG44, U251MG, U87MG25070489, 25939952NCT02490930 PubChem
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25-Hydroxycholesterol65094apoptosisU87MG20009104 PubChem
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Hsp-99046216556, 16226182apoptosis, radiosensitizationHsp90LN18, mouse xenograft model, U251MG, U373MG, U87MG23448094, 24500492 PubChem
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Albendazole2082proliferationprimary human glioma cells23165409 PubChem
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Mefloquine40692apoptosisPARP, CHOP, GADD153LN229, U251MG, U87MG25727221NCT01430351 PubChem
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Toxin C3137185910water influx suppressionNicotinamide adenine dinucleotide (NAD)1321N119772916 Google
Ibrutinib24821094proliferation, viabilityBruton\'s tyrosine kinase, SrcLN229, mouse xenograft model, primary human glioma cells, U87MG27564106, 28716053, 30219696NCT03535350 PubChem
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Oxibendazole4622proliferationprimary human glioma cells23165409 PubChem
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Ellipticine3213apoptosis, proliferationU87MG, UKFNB321753906 PubChem
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Dabrafenib44462760BRAF26680369, 29039591, 29295876NCT02684058, NCT03919071, NCT03975829 PubChem
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Mercuric Chloride24085cell swelling suppressionAquaporin11321N119772916 PubChem
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Atovaquone74989viabilitySTAT3LN18, SF188, SJGBM2, U87MG29783757 PubChem
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2,5-Dihydroxybenzenesulfonate101209015apoptosisC6, orthotopic rat model21193016 Google
Glycitein5317750angiogenesis, invasionMMP3, MMP9U87MG20188714 PubChem
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Colchicine6167proliferationprimary human glioma cells23165409 PubChem
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Losartan 3961apoptosis, proliferationAT1C611720480, 15785746NCT01805453, NCT03951142 PubChem
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Epoxomicin11226684apoptosisProteasomeU251MG, U343, U373, U87MG18341587, 19201384, 19690139 PubChem
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Vinblastine13342proliferationprimary human glioma cells, U11823165409, 6690037NCT00498979 PubChem
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R42846215462proliferationAXLSNB19, UP00725980499 PubChem
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OTS96489675898viabilityTOPKU251MG, U87MG29423027 PubChem
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KHS101 71304818apoptosis, proliferationHSPD1, Mitochondrial energy disruptionGBM1, GBM11, GBM13, GBM14, GBM20, GBM4, murine xenograft glioma tumor30111643 PubChem
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Rutin5280805apoptosis, proliferationGBM95, U251MG19491660, 30868970 PubChem
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LY210976111655119TGFbeta receptor I kinasemouse xenograft model, T98G, U87MG21677877 PubChem
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Ginsenoside F19809542invasion, migrationNFkappaB, p38MAPKU251MG, U373MG, U87MG29412148 Google
KNK43746195007radiosensitizationHSPA17216966184 PubChem
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2-Amino-3H-phenoxazin-3-one72725viabilityLN22924008433 PubChem
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CGS7181 656759apoptosisBKCa channelsLN22920065494 Google
Bafetinib11387605Tyrosine kinase23380277NCT01234740 PubChem
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Imiquimod57469Toll like receptor 7 (TLR7)GL261, orthotopic mouse model21389872NCT01171469, NCT01403285, NCT01808820, NCT01902771 PubChem
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Nitidine25659apoptosis, proliferationpDok2C6, U87MG29329030 PubChem
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Tesevatinib1045832530030583NCT02844439 PubChem
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Aminolevulinic acid137apoptosis, viabilityNFkappaB, BIRC3, Casp3U87MG17335970NCT00752323, NCT00961090, NCT01148966, NCT01208909, NCT01310868, NCT01351519, NCT01445691, NCT01575275, NCT02119338 PubChem
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LLNle16760646apoptosisNOTCHprimary human glioblastoma cells19861404 Google
Sorafenib216239proliferation, radiosensitization, temozolomide enhancer, viabilityTyrosine protein kinase, VEGFR2, Raf, PDGFR, cKIT,GBM12, GBM14, GBM5, GBM6, LN229, orthotopic mouse model, primary human glioma cells, U1242, U251MG, U87MG19001435, 20371721, 20470863, 23324350, 24139873, 24911215, 24965413, 27542273, 30219696, 30338715, 30469352, 3051526220443129, 20564147, 21954442, 23099651, 23898124, 24786603, 28988377NCT00093613, NCT00329719, NCT00335764, NCT00445588, NCT00544817, NCT00597493, NCT00621686, NCT00734526, NCT00884416, NCT01183663, NCT01434602, NCT01441388, NCT01817751, NCT02599090 PubChem
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cis-Diaminedichloroplatinum (CDDP, cisplatin)2767chemosensitivityMetT98G, U251MG19435873 PubChem
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Montelukast 5281040invasion, migrationCysLT (cysteinyl leukotriene receptor)A172, U37328600709 PubChem
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Transcrocetinate10287099C6, rat model18447715 Google
Fludarabine657237proliferationprimary human glioma cells23165409NCT00990496, NCT01174121, NCT01454596, NCT02844062, NCT02937844, NCT03412877, NCT04102436 PubChem
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2,5-Dimethylcelecoxib11545682angiogenesis, migration, proliferationET1mouse xenograft model, TuBEC, U251MG, U87MG20197398 PubChem
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Pyridoxyl-tryptophan methyl ester129848754proliferationODCLN22918922879 Google
U466195311493cell swellingTXA21321N119772916 PubChem
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GSK2256098 46214930FAK29788497 PubChem
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Ionomycin6912226apoptosis, proliferation, T cell activationIntracellular level of calciumU251MG, U87MG24130787 PubChem
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Fasudil3547viabilityRho, ROCKmouse xenograft model, T98G, U251MG, U87MG19427347, 20364104, 21166955, 26725099 PubChem
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zVAD-fmk5497171cytotoxicityT919247476 PubChem
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Bevacizumab 24801580apoptosis, perifosine enhancer, proliferation, radiosensitizationVEGF, PI3K, AktC6, murine glioma xenografts, U251MG19567589, 19584228, 28616662, 3088112624552324, 30301554 Google
NCD-38102222767KDM1Aortothopic mouse model, U251MG27893719 Google
ML0411640604proliferation, radiosensitizationEGFRU138MG, U87MG17210462 Google
Valproate35499803-bromopyruvate enhancer, apoptosisMRP2, BCRPT98G30138705NCT02648633 PubChem
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Mitoxantrone4212proliferation, viabilityTopoisomeRASeprimary human glioma cells, U87MG19340456, 21184646, 23165409 PubChem
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Vismodegib24776445proliferationHPI, PI3Kprimary human glioma cells19716296, 19726788, 21123452NCT00980343, NCT03158389 PubChem
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Bestatin72172proliferationLTA4A17219919819 PubChem
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Alpha-Lipoic acid864apoptosis, proliferationGlutathione Peroxidase 1,TRPA1MU1454, U87MG29925764, 30590317 PubChem
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D-Glucosamine439213Thymidine kinaseC6844039 PubChem
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trans-ACUB16038368proliferationsEHU251MG, U87MG22382785 PubChem
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Acetazolamide1986proliferationcarbonic anhydRASeU251MGN27702686 PubChem
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SU112749549297migrationMetLN229, U87MG19795461 PubChem
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T56-LIMKi9438169viabilityLIM kinaseU87MG25593987 PubChem
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AZ32134814488apoptosis, radiosensitizationATMA172, CF5STTG1, H4, Hs683, LN18, M059J, SW1088, SW1783, T98G, U118MG, U138MG, U87MG29769307 Google
Resveratrol445154apoptosis, radiosensitizationAkt, p53, STAT3, survivin, cyclin D1, COX2, c-Myc,A172, mouse xenograft model, primary human glioma cells, T98G, U251MG, U87MG, UW2282, UW228315827328, 18592012, 19566920, 19827268, 21503893, 21743969, 23651583, 27419830, 30621053, 30984336 PubChem
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Lonafarnib148195viabilityfarnesyl protein transfeRASeorthotopic mouse model, U87MG2124639421735117, 23633392NCT00038493, NCT00083096, NCT00102648 PubChem
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Oxamate3017661radiosensitizationLDHAT98G, U87MG28756228 PubChem
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Thallium acetate11247apoptosis, viabilityCDK2 LC615965099 PubChem
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Vindesine40839viabilityA172, LN443, U118, U87MG24433351 PubChem
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Dactolisib11977753cell cycle, proliferation, radiosensitizationPI3K, mTORorthotopic mouse mode, primary human glioma cells, SHG44, T98G, U251MG, U87MG18606717, 19671762, 23603977, 24366691, 25431423, 26188279, 27542970, 27553832, 29685176, 30251117NCT01508104 PubChem
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Nutlin-3a11433190apoptosisU87MG30574827 PubChem
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Apigenin5280443viabilityT98G, U87MG19894226 PubChem
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4-HPR5288209apoptosis, differentiationCasp8, tBid, BIRC, Calpain, Casp3C6, T98G, U87MG18602901, 19285047NCT00075491 PubChem
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Abemaciclib46220502CDK4, CDK6mouse xenograft model, U87MG26149830NCT02977780, NCT02981940, NCT04074785, NCT04118036 PubChem
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GSK J471729975proliferationJMJD3U251MG, U87MG28978140 PubChem
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Denbinobin10423984viabilityGBM8401, U87MG23123054 PubChem
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Entrectinib25141092Trk, ROS1, ALKmouse model28695888 PubChem
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Puromycin439530proliferationprimary human glioma cells23165409 PubChem
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Dexamethasone5743invasion, migration, proliferation, temozolomide enhancerMIF, PKCC6, U373MG17453149, 19759012, 3033374919714445NCT01169415, NCT02031965, NCT04128774 PubChem
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Carboplatin10339178DNA28534153NCT00002619, NCT00005976, NCT00006263, NCT00008086, NCT00010036, NCT00014105, NCT00021307, NCT00025558, NCT00352313, NCT00492687, NCT00541138, NCT00635557, NCT00650949, NCT00995007, NCT01317212, NCT01386710, NCT01837862, NCT01934361, NCT02253212, NCT02684058, NCT03149575, NCT03744026 Google
Wedelolactone5281813migration, proliferationIKKC619362079 PubChem
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Ibudilast3671apoptosis, cell cycle arrest, proliferation, temozolomide enhancerMIF30814573NCT03782415 PubChem
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Pioglitazone 4829apoptosis, proliferation, viabilityWnt, beta-catenin, PPARgammaG144, G166, G179, GBM04, GBM2, GliNS2, primary human glioblastoma cells, T98G, U251MG, U87MG21221726, 27313600NCT01151670 PubChem
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GL-331 148091apoptosis, radiosensitizationTopoisomeRASe 2C6, T98G16309217, 16827158 PubChem
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Adenosine dialdehyde99920proliferationC623353701 PubChem
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KU559335278396radiosensitizationATMorthotopic mouse model, primary human glioma cells, WK125017126, 2520503719931733 PubChem
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SU14985941539proliferation, viabilityVEGFR2A172, Gli06, SF126, T98G, U118MG, U251MG, U373MG, U87MG18719373 PubChem
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AR03698490Ape1SF76720504914 PubChem
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E-60879953093radiosensitivityCOX2GL26119252746 PubChem
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Ancitabine25051proliferationTopoisomeRASe 2primary human glioma cells23165409 PubChem
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Gartanin5281633proliferationT98G27491646 PubChem
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JTE01310223146invasionS1P(2)U37318819934 PubChem
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Pyridone 65494425apoptosisJAK, STATU251MG19830690 PubChem
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Rosiglitazone77999apoptosis, proliferationPPARgamma, COX2A172, C6, M059J, M059K, U251MG, U87MG14699130, 15254749 PubChem
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AMG-51159548184PI3Kmouse xenograft model, U87MG22897589 PubChem
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GDC-094117755052radiosensitization, viabilityPI3K A172, mouse xenograft model, SHG44, T98G, U373, U87MG19584227, 23427298, 24757258, 28147244, 30132519, 30920104 PubChem
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Actinomycin D2019apoptosisPIMT U87MG18582478, 19642173 PubChem
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Olanzapine135398745proliferationLN229, mouse xenograft model, T98G25338992, 25524815 PubChem
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Arenobufagin 12305198apoptosis, cell arrest, cytotoxicity, proliferationCdc25C, Cyclin B1, survivin, MAPKU87MG30272276 Google
Tunicamycin56927832proliferationC6, U251MG18483264, 2706513 Google
A86170700216proliferation5LipoxygenaseA17219919819 Google
H-89449241proliferationPKA inhibitorU87MG20015475 PubChem
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Phorbol 12-myristate 13-acetate27924proliferationPKCalpha, PKCdelta, PKCvarepsilonC6, U87MG18778746, 19357285, 19804834 PubChem
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Methotrexate126941proliferationDHFRprimary human glioma cells2316540915735920NCT00082797, NCT00463008 PubChem
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AM711650194proliferationMet, LCK, BTKMKN45, U87MG18055465 PubChem
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AXL171772435proliferationIGF1Rmouse xenograft model, primary human glioma cells, U563MG, U87MG20150364, 23165409NCT01721577 PubChem
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ML29956593054invasion, migrationPLD1, PLD2U87MG23445448 Google
GW3965447905proliferationLXRmouse xenograft model, U87MG22059152 PubChem
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Alisertib24771867viabilityAurora A kinaseGB169, GB30, GB9, KNS42, mouse xenograft model, primary human glioma cells, SF188, T98G, U1242, U87MG24627220, 24879067, 25106428, 27797168, 29016820, 29396807NCT02186509 PubChem
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Nintedanib135423438VEGFR, FGFR, PDGFR23184145, 25338318NCT01251484 PubChem
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Calcipotriol5288783migration, proliferation, viabilityT98G29575677 PubChem
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AMG 23258573469MDM2 31359240NCT03107780 PubChem
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Abt-73711228183viabilityBCL2LN18, LN229, LNZ42818663354, 22393246 PubChem
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Imatinib mesylate123596proliferationG112, G130, G168, G44, GL261, LNZ308, RG, T98G, U87MG18506689, 19159435, 19190128, 19629393, 1973794518359865, 19768386 PubChem
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Furegrelate3437angiogenesis, BCNU enhancer, proliferation, viabilityTXSAorthotopic human glioblastoma xenografts, U87MG18825315, 20165694 PubChem
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Indirubin Derivative E804135398511proliferationU251MG, U87MG26386687, 6419764 PubChem
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CEP-70559936664proliferation, temozolomide enhancer, viabilityVEGFRhuman glioblastoma xenografts16891460 PubChem
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Sandoz 58-035122215invasion, proliferationACATU87MG19502590 PubChem
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Roscovitine160355proliferationCDKA172, G2814724573, 19770587, 26151768 PubChem
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Carfilzomib 11556711proliferationGBM6, U87MG29750582 PubChem
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LAQ824 (Dacinostat)6445533apoptosisHDACHs683, LN401, SF767, U343, U37318483381 PubChem
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Tanespimycin6505803apoptosis, migration, radiosensitization, viabilityHsp90M059K, SF268, U87MG16550610, 18462865, 18682579, 18974397, 19027068, 19244114, 19408974, 19671736, 19795461, 26185541, 28542269 PubChem
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ON12330056649281proliferationU87MG24568969 PubChem
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Temozolomide5394viabilityATRCHK1, p21, NFkappaBC6, LN229, LN229MGMT, LN308, mouse model, SF767, U105MG, U138, U251MG, U343MG, U87MG, XO823736154, 24647572, 27878252, 27993939, 29354058, 29454008, 30361254, 30569180, 30705757, 30853911, 3088103831789NCT00003176, NCT00003464, NCT00003567, NCT00004113, NCT00004200, NCT00005637, NCT00005951, NCT00006025, NCT00006263, NCT00006353, NCT00006358, NCT00006474, NCT00014105, NCT00021307, NCT00025558, NCT00027625, NCT00028795, NCT00038493, NCT00039494, NCT00047294, NCT00049387, NCT00050986, NCT00052455, NCT00068952, NCT00083096, NCT00085254, NCT00086879, NCT00089427, NCT00099125, NCT00102648, NCT00112502, NCT00128700, NCT00187486, NCT00200161, NCT00238277, NCT00253487, NCT00262730, NCT00268385, NCT00274833, NCT00275067, NCT00302159, NCT00304031, NCT00305864, NCT00311857, NCT00316849, NCT00323115, NCT00335075, NCT00354068, NCT00365222, NCT00376103, NCT00385853, NCT00387400, NCT00390403, NCT00392171, NCT00394628, NCT00402116, NCT00431561, NCT00433381, NCT00436436, NCT00441142, NCT00458601, NCT00471653, NCT00481455, NCT00482677, NCT00486603, NCT00492687, NCT00498927, NCT00501891, NCT00504660, NCT00508456, NCT00516282, NCT00516607, NCT00521482, NCT00525525, NCT00544284, NCT00544817, NCT00548938, NCT00553150, NCT00555399, NCT00574964, NCT00575887, NCT00590681, NCT00597402, NCT00597493, NCT00610571, NCT00612339, NCT00612651, NCT00612989, NCT00613093, NCT00615186, NCT00616005, NCT00619112, NCT00626015, NCT00643097, NCT00643825, NCT00650923, NCT00657267, NCT00662506, NCT00669669, NCT00684567, NCT00686725, NCT00687765, NCT00689221, NCT00704080, NCT00704808, NCT00720564, NCT00723827, NCT00725010, NCT00731731, NCT00734526, NCT00756106, NCT00761280, NCT00768911, NCT00770471, NCT00782756, NCT00792012, NCT00805961, NCT00813943, NCT00817284, NCT00820963, NCT00841555, NCT00869401, NCT00883298, NCT00884741, NCT00904852, NCT00915694, NCT00916409, NCT00941460, NCT00943462, NCT00943826, NCT00960492, NCT00967330, NCT00977431, NCT00979017, NCT01004874, NCT01013285, NCT01019434, NCT01022918, NCT01026493, NCT01043536, NCT01044966, NCT01062399, NCT01062425, NCT01102595, NCT01110876, NCT01115491, NCT01119599, NCT01120639, NCT01149109, NCT01149850, NCT01164189, NCT01180816, NCT01181193, NCT01186406, NCT01209442, NCT01220271, NCT01222221, NCT01242566, NCT01269424, NCT01285414, NCT01294735, NCT01342757, NCT01345370, NCT01390571, NCT01402063, NCT01430351, NCT01466686, NCT01473901, NCT01478321, NCT01480050, NCT01480479, NCT01502241, NCT01514201, NCT01517776, NCT01587144, NCT01700569, NCT01702610, NCT01740258, NCT01752491, NCT01765088, NCT01777919, NCT01790503, NCT01800695, NCT01830101, NCT01837862, NCT01849146, NCT01860638, NCT01868906, NCT01907165, NCT01956734, NCT01957956, NCT01977677, NCT01985087, NCT02010606, NCT02029573, NCT02039778, NCT02046187, NCT02052648, NCT02085304, NCT02092038, NCT02137759, NCT02152982, NCT02168270, NCT02177578, NCT02179086, NCT02209948, NCT02227901, NCT02311920, NCT02315534, NCT02329795, NCT02330991, NCT02337426, NCT02340156, NCT02343406, NCT02343549, NCT02344355, NCT02364206, NCT02366728, NCT02378532, NCT02394665, NCT02395692, NCT02414165, NCT02455557, NCT02502708, NCT02510950, NCT02530502, NCT02573324, NCT02590263, NCT02599090, NCT02617589, NCT02649582, NCT02655601, NCT02661282, NCT02663440, NCT02667587, NCT02685605, NCT02715609, NCT02761070, NCT02770378, NCT02781792, NCT02799238, NCT02805179, NCT02843230, NCT02871843, NCT02880410, NCT02898012, NCT02928575, NCT02977780, NCT03008148, NCT03018288, NCT03034135, NCT03119064, NCT03137888, NCT03139916, NCT03149575, NCT03174197, NCT03197506, NCT03213002, NCT03224104, NCT03225963, NCT03232424, NCT03243461, NCT03246113, NCT03291990, NCT03310372, NCT03345095, NCT03363659, NCT03388372, NCT03405792, NCT03419403, NCT03426891, NCT03451799, NCT03463265, NCT03463733, NCT03466450, NCT03477110, NCT03480867, NCT03491683, NCT03514069, NCT03529448, NCT03535350, NCT03548571, NCT03576612, NCT03581292, NCT03587038, NCT03607643, NCT03631823, NCT03633552, NCT03643549, NCT03650257, NCT03660761, NCT03687034, NCT03688178, NCT03705351, NCT03746080, NCT03749187, NCT03776071, NCT03778294, NCT03780569, NCT03782415, NCT03914742, NCT03927222, NCT03970447, NCT04019262, NCT04047706, NCT04049669, NCT04077866, NCT04091503, NCT04105374, NCT04116411, NCT04119674, NCT04157478 PubChem
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2-Amino-1,3-propanediol68294angiogenesis, apoptosis, proliferationhTPU87MG30615449 PubChem
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Panaxydol 5283280proliferationPI3KC619040798, 19179079 PubChem
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Epothilone B448013viabilityP-glycoproteinLNZ, T98G, U87MG18806741NCT00715013 PubChem
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VER-50589135446210cross-resistanceHsp90SF268, U87MG19244114 PubChem
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BAY 11-70825353431proliferationNFkappaBC6, U251MG19788921, 26137111 PubChem
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Biochanin A5280373cell cycle arrest, proliferation, temozolomide enhancer, viabilityEGFR, pERK, pAKT, c-Myc, MTMMP1T98G, U87MG30591440 PubChem
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Celecoxib2662migration, proliferation, viabilityCOX2A127, C6, GOGCCM, T98G, U251MG, U373, U87MG18634847, 19664879, 20062571, 20193113, 21763744, 21847707, 2328044525239666NCT00047281, NCT00047294, NCT00068770, NCT00112502, NCT00504660, NCT02770378 PubChem
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Depatuxizumab mafodotin86278355antimicrotubule agentEGFR, MMAF29075855, 29077941, 29982805NCT01800695, NCT02343406, NCT02573324, NCT02590263, NCT03123952 Google
PD03259019826528, viabilityMEKLN229, mouse xenograft model, primary human glioma cells, U37319737945, 22573716, 25431423 PubChem
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Hydroxichloroquine 3652apoptosisPARP, CHOP, GADD153LN229, U251MG, U87MG25727221NCT00486603, NCT01602588 PubChem
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Psammaplin C21726402CAXIIorthotopic patient-derived xenografts30254183 PubChem
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UNII-2AW48LAZ4I72941968Telomeraseorthotopic mouse model, U87MG26183089
GK92156682080Transglutaminase 283NS, orthotopic mouse model28754668 PubChem
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KU6001915953870radiosensitizationATMorthotopic mouse model, primary human glioma cells, U87MG23620409, 24443327, 25091220 PubChem
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Farnesyl Pyrophosphate445713apoptosisJNKU87MG20298756 PubChem
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Anthothecol21596360proliferationprimary human glioma cells23165409 PubChem
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WP106611210478proliferationJAK, STAT3primary human glioma cells, U87MG17942891, 23612755NCT01904123 PubChem
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(S)-3,5-Dihydroxyphenylglycine443586neuroprotection, proliferation, synaptic modulationSelective group I mGlu agonistC619822193 PubChem
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Nitazoxanide41684autophagy, cycle arrest, proliferationING1A172, LN229, U87MG30302016 PubChem
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Lysophosphatidylserine42607474proliferationC617958326 PubChem
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L-DOPA6047migration, proliferationT98G30591448 PubChem
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BQ7883081333proliferationETRBA375, LN229, SW1088, WM3519040731 PubChem
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Repaglinide65981GL261, orthotopic mouse model28476618 PubChem
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Dichloroacetate25975apoptosis, proliferationHIF-2alpha, PDK, Hsp70C6, primary human glioblastoma cells18766181, 20463368, 23515860NCT00540176, NCT00703859, NCT01111097 PubChem
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Arachidonic acid 444899apoptosisGSH, Casp3C617400255 PubChem
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Indoximod405012viabilityIDOGL2612505406430415456NCT02052648, NCT02502708, NCT04049669 PubChem
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15Deoxy-delta-12,14-PGJ25283035apoptosisPPARgammaC6, U251MG14699130 PubChem
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Tricetin5281701invasion, migration26245494 PubChem
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Topotecan60700proliferation, radiosensitization, viabilityTopoisomeRASeA172, LN443, primary human glioma cells, U118, U251MG, U87MG18819996, 19466380, 19584228, 19812371, 23165409, 24303074, 24433351, 28797568NCT00002814, NCT00014443, NCT00541138, NCT00610571, NCT01004874, NCT01931098 PubChem
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LLP356935694viabilityprimary human glioma cells23251006 Google
Fmoc-L-leucine1549133apoptosisPPARgammaU118 MG30118847 PubChem
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Idarubicin42890viabilityU87MG24433351 PubChem
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Quetiapine5002proliferation, temozolomide enhancer, viabilityWnt, beta-catenin, GL261, xenograft model of glioblastoma in nude mice28415586 PubChem
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HOE-140 (Icatibant acetate)6918173inflammatory responseB(2) 1321N1, C6, U87MG19854233 PubChem
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Niclosamide4477proliferation, viabilityprimary human glioma cells, U87MG23165409, 27029345 PubChem
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Troglitazone 5591apoptosisPTPN1, pY705STAT3, glyoxalase I LN18, MG328, T98G, U87MG11719831, 16319070, 18346464, 19158480 PubChem
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Zoledronic acid68740viabilityRAS, Rho GTPAses, FDPSLN229, primary human glioma cells, U87MG30219696, 30333528NCT00301873 PubChem
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IC86621 (DNA-PK Inhibitor III)9859309apoptosisDNA-PKSCID mice19425167 PubChem
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CDK2 inhibitor II3551941apoptosisU87MG19549905 PubChem
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Homidium3624proliferationprimary human glioma cells23165409 PubChem
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MK-8863651377viabilityLipoxygenase U373MG, U87MG17949236, 19862483, 23261452 PubChem
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Masitinib10074640viabilityFAK, cKIT, PDGFR, FGFRLN229, primary human glioma cells, U87MG30219696 PubChem
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Compound E11306390proliferationGamma secretasezebrafish xenograft model19199503 PubChem
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Sulindac1548887differentiation, radiosensitizationU87MG29788733 PubChem
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Vatalanib151194angiogenesis, temozolomide enhancerVEGFR, PDGFR, cKIT, cFmsorthotopic mouse model, U251MG15271251, 2009095219248046, 19945857, 30382439NCT00128700, NCT00387933 PubChem
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Delta 9-tetrahydrocannabinol2978viabilityE2F1 U251MG, U87MG17934890 PubChem
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C13682777805proliferationAurora A kinaseDaoy, MB 100, MB 47, ONS7620232424 PubChem
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PIK-90135398491radiosensitization, viabilityp110alpha, PI3K LN229, SF126, SF210, U138MG, U251MG, U87MG18413797 PubChem
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n-butylidenephthalide642376apoptosis, proliferationCKIDBTRG05MG, RG216987298 PubChem
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URB597 1383884FAAHC616997568, 19460156 PubChem
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Oligomycin78358496viabilityT98G, U251MG, U87MG23523615 Google
HET-00162727594proliferationCYP4A, 20HETE, EGFR9L, rat xenograft model, U251MG16081682, 16352703 PubChem
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Methanandamide6321351apoptosisCOX2H416267630 PubChem
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Pifithrin-alpha9929138apoptosis, proliferationp53C619513548 Google
Pyrvinium5281035proliferation, viabilitymouse xenograft model, primary human glioma cells, U87MG23165409, 26152745, 27029345 PubChem
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Ruxolitinib25126798viabilityJAKLN229, primary human glioma cells, U87MG29788332, 30219696NCT02711137, NCT03514069 PubChem
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AG4905328779invasion, migration, proliferationJAK2, STAT3, survivin, cyclin D1, COX2, c-MycA172, MZ18, MZ256, MZ304, MZ54, U87MG, UW2282, UW228318592012, 19326989, 20589525 PubChem
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Penfluridol33630apoptosisAktU87MG, xenograft model of glioblastoma in nude mice28380428 PubChem
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E-64123985apoptosisCOX2, IL-1beta, TNFalpha, IL6, iNOS, Cathepsin BBV2, SNB19, U251MG, UWR211494030, 19748528 PubChem
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Doxorubicin31703proliferationDNA intercalationA172, LN443, primary human glioma cells, SHSY5Y, U118, U373, U87MG, U87MGATCC19101989, 19564615, 19633683, 23165409, 24433351, 27029345, 27993939, 28612256, 30368972, 30448308, 30606517, 30639216, 30836216, 30869664NCT00002608, NCT00944801, NCT01851733, NCT02372409, NCT02758366 PubChem
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Antimycin A14957proliferationprimary human glioma cells23165409 PubChem
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Lysophosphatidic acid5497152proliferation, viabilityNHE1, PI3K, Akt, Rhoassociated kinase, PKC, MEK, EC616176063, 17499746, 18481020 PubChem
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POCA54217fatty acid beta-oxidationCPT1U87MG18470630 PubChem
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Valproic acid3121proliferation, radiosensitization, viabilityHDACC6, G144, G166, G179, G361, GBM2, GBM7, GliNS2, LN229, SF295, SKNMC, T98G, U373MG, U87MG16373706, 18550052, 18582478, 18611290, 18679414, 18751431, 18765532, 19030781, 19239041, 19360904, 20332466, 23253698, 24348849, 25275596, 27802437, 28108734, 28962238, 30112328, 30243186, 3059146023523186NCT02648633 PubChem
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SAR40583853476877MDM2GBM108, xenografts of human glioblastoma29970480, 31619389 PubChem
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Chrysin5281607invasion, migration, proliferation, viabilityMAPK , CDK2, CDK4, ERK, Nrf2C6, U87MG15869744, 29662304 PubChem
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Thioridazine 5452autophagyAMPKU87MG25950483, 30289977 PubChem
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APCP10442687proliferationecto5\'NT, CD73C6, U138MG18636315 PubChem
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Tezacitabine6435808proliferation, viabilityRR (ribonucleotide reductase)HS683, J889H, xenografts of human glioblastoma8542592 PubChem
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Podofilox10607proliferationprimary human glioma cells23165409 PubChem
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Donepezil 3152proliferationAcetylcholinesterase primary human glioma cells, T98G, U3731967946316549835NCT00070161, NCT00369785 PubChem
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717906-29-111598628migration, proliferationFAK T98G, U118MG26883759 PubChem
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PD1730741401migration, proliferationFGFRT98G, U118MG19340397, 26883759 PubChem
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Abiraterone132971proliferationCYP17A1A172, primary human glioma cells, T98G31527549NCT02711137 PubChem
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Rapamycin5284616radiosensitization, viabilitymTORA172, CSCs5, CSCs7, Gli36 cells, mouse xenograft model, primary human glioma cells, T98G, U251MG, U87MG18519772, 19177002, 19190120, 19738049, 19808964, 19827268, 21367753, 23261661, 24043497, 25886314, 30569180NCT00047073, NCT00509431, NCT00672243, NCT00821080, NCT01522820 PubChem
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Mebendazole4030proliferationGL261, orthotopic mouse model, primary human glioma cells23165409, 28386621NCT01729260, NCT01837862, NCT02644291 PubChem
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Methylene dibutyrate9855687apoptosis, proliferationHistone deacetylasemurine xenograft glioma tumor, U251MG16373710 PubChem
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Iodoacetic acid5240cell invasivenessCysteine proteaseDaoy, Madsen, UW2282, UW228319847623 PubChem
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Doxazosin3157apoptosis, proliferationRASC6, U138MG, U373MG27123999, 30370863 PubChem
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LY2940023973proliferation, radiosensitizationPI3K, PKB, Aktmice glioma cells, T98G, U251MG, U87MG15735908, 18473825, 18567800, 18676851, 19101213, 19435873, 19435898, 19827268, 19828040, 19836430, 19911116, 22086271, 25425962, 29354058 PubChem
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Zalcitabine24066proliferationHTB102542824 PubChem
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Meloxicam4051proliferation15PGDH, cyclin D1, p21T98G, U118, U37318757412 Google
Tanshinone IIA 164676LN22930021339 PubChem
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3,5-Dihydroxyphenylglycine (DHPG)108001neuroprotection, proliferation, synaptic modulationmGluR1, mGluR5C619822193 PubChem
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Loperamide 3955apoptosismTORC1MZ5430250198 PubChem
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8-Bromo-cyclic AMP32014proliferationPKAA172, U373, U87MG18498711, 24649161, 9484714 PubChem
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JNJ-101984099797370viabilityPLK1primary human glioma cells24204733 PubChem
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Atazanavir 148192apoptosisGRP78 (HSPA5), CHOPLN229, U251MG18006837 PubChem
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Cerivastatin446156viabilityA172, LN443, U118, U87MG24433351 PubChem
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RG283356654642Temozolomide enhancerHDAC1, HDAC327632183 PubChem
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Bendamustine6562821626071, 28204914NCT00823797 PubChem
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Naringin442428invasion, migrationU251MG26474590 PubChem
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Pegdinetanib86278317VEGFR2human tumor xenograft models, orthotopic mouse model, U87MG20190562, 2287570625388940 PubChem
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Decursin442126apoptosis, cell cycle arrestJNK, p38, BCL2, CDK4, cyclin D1C6, U87MG30627007 PubChem
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NCL-173755256proliferationKDM1ALN229, orthotopic mouse model, T89G, U138, U251MG, U87MG23248157, 27893719 Google
Tetraethylammonium5413proliferationC6, U87MG25700359 PubChem
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Acridine orange62344photosensitisation, proliferation, viabilityU373MG29631084 PubChem
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CPI-45578426698viabilityHistone lysine demethylaseA172, CAS1, DBTRG, U251MG, U87MG28432280 PubChem
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Caffeic acid phenethyl ester5281787apoptosis, proliferationC6, primary human glioma cells14637186, 15885897, 23165409, 24997497 PubChem
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Pargyline4688proliferationLN229, T89G, U138, U87MG23248157 PubChem
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GW9662644213viabilityPPARgammaC6, U251MG14699130 PubChem
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Propranolol4946mRNA synthesis inhibitionNonselective badrenoceptor antagonistU37318498711 PubChem
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AZD9291 (Osimertinib)71496458cell cycle arrest, colony formation, invasion, migration, proliferationEGFRLN18, LN229, T98G, U118, U251, U8731122294NCT03732352 Google
Hydroxyurea3657RNR19904263NCT00019058, NCT00154375, NCT00290771, NCT00354913, NCT00387933, NCT00613054, NCT00613132, NCT00615927, NCT03463733 PubChem
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Afatinib10184653viabilityEGFR, HER2A7, LN229, mouse xenograft model, U87MG19037840, 25444177, 30219696NCT00977431, NCT02423525 PubChem
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Quinine 3034034apoptosisPARP, CHOP, GADD153LN229, U251MG, U87MG25727221 PubChem
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RC 3095122127proliferationGRPRC6, U373MG, U87MG18473825 PubChem
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Ibuprofen3672migration, proliferationA172, HTZ349, U87MG26485029 PubChem
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VX-7453038525invasionp38, MAPKC6, IM329316898 PubChem
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Modafinil 4236proliferation, viabilityCYP3A4 GL261, SHSY5Y22434147 PubChem
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PKI-40244187953proliferation, viabilityPI3K, mTORhuman tumor xenograft models, U87MG20371716 PubChem
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Norclomipramine622606inhibitors of cellular respirationIPSB1820332444 PubChem
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Mangiferin5281647radiosensitization, viabilityNHEJ, gamma?H2AXU118MG, U87MG30272350 PubChem
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N-Acetylcysteine12035apoptosis, invasion, migration, proliferationNOTCH2, HES1, HEY1T98G, U251MG, U87MG19633536, 19836430, 30606241 PubChem
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D44766419753apoptosisCK1Daoy19943845 PubChem
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Chlorpromazine2726viabilityEgr1A172, C6, LN443, mouse xenograft model, orthotopic mouse model, U118, U251MG, U87MG20368687, 23689352, 28455961 PubChem
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Tempol137994migration/invasionCOX2, peroxide productionU87MG19804834 PubChem
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D6094234241proliferation28802717 Google
Baicalein5281605apoptosisERKC6, U87MG16814338, 19804834 PubChem
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Cannabidiol644019MK-886 enhancer, viability5Lipoxygenase, FAAHmurine xenograft glioma tumor, U87MG18028339NCT03607643 PubChem
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Trichostatin444732apoptosis, viabilityHDAC, NAG1, GDF15A172, C6, HEK, LN308, LNT229, T98G, U87MG16383255, 16384639, 18483381, 18550052, 18607344, 18611290, 18801729, 18803327, 19062177, 19360904, 19728174, 19787267, 19847810, 23564772, 24905315 PubChem
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Fenbendazole3334proliferationprimary human glioma cells23165409 PubChem
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Z-VAD9845918apoptosis, viabilityPancaspase U138MG18454276 PubChem
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Mevalonolactone10428oxidative stress responseROS, MKD, MVKU87MG29753116 PubChem
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SQ295485311448cell swelling suppressionTXA21321N119772916 Google
Aprepitant 135413536proliferationNK1GAMG21054456, 26603162NCT02770378 PubChem
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AZD148016659841proliferationJAK1, JAK2orthotopic mouse model, U251MG22027691 PubChem
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Escitalopram25379795proliferationC6146570 Google
Letrozole3902proliferationAromataseC6, LN229, orthotopic mouse model, T98G, U251MG, U373MG, U87MG25695958 PubChem
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Dibutyryl cAMP9687proliferationCx43A172, C616718685, 9484714 PubChem
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GSK46136415983966proliferationPLK1LN18, mouse xenograft model, primary human glioma cells, U87MG23790466, 24204733, 30304810, 30875975 PubChem
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761437-28-99934347radiosensitization, viabilityFAK A172, DDHT7607, DDT4, LN229, U138MG, U343MG, U87MG17219439, 19030106, 25625667 PubChem
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Harmol68094viabilityU251MG23338618 PubChem
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Oxymatrine114850apoptosis, proliferationEGFR, PI3K, Akt, mTOR, STAT3U251MG29989652 PubChem
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Deguelin107935proliferationprimary human glioma cells23165409 PubChem
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Piplartine637858migrationLN229, U87MG23796709, 24967005 PubChem
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Methyl Pyruvate11748GDH, AktSF18819826036 PubChem
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PIK-7510275789apoptosisPI3KLN229, U87MG18413797, 22802621 PubChem
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Galangin5281616angiogenesis, invasion, migration, proliferationCD44U251, U8731528214 PubChem
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beta-Peltatin92122proliferationprimary human glioma cells23165409 Google
SB-216763176158apoptosisGSK3BS125, LN18, LN319, U373, U87MG18582478, 19823589 PubChem
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NU70269860529apoptosisDNA-PKKNS60, MO59K, ONS76, U87MG19435898, 25307264 PubChem
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1-1-diphenyl-2-picrylhydrazyl74358cytotoxicityU87MG30617655 PubChem
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Larotrectinib46188928TrkA, TrkB, TrkC.30220707 PubChem
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Alvespimycin5288674apoptosis, proliferation, radiosensitizationHsp90, AMPKC6, SF268, U251MG, U87MG19244114, 19805107, 24418474 PubChem
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PIK-10854751698radiosensitization, viabilityPKB, Akt, PI3K LN229, SF126, SF210, U138MG, U251MG, U87MG18413797 Google
Sulforaphane5350apoptosisBax, BCL2, NFkappaBT98G, U87MG16765523 PubChem
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Penta-acetyl geniposide 162083apoptosisNSMase, NGF, p75, FasL, caspase cascades, PI3K, ERC616763091, 19464279 Google
Ticlopidine 5472apoptosis, viabilityAkt, mTOR, EGFprimary human glioma cells26412325 PubChem
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AMG-92560202647proliferationFLT3, CDK4A172, LN18, LNZ308, T98G, U373, U87MG26585571 PubChem
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A-96649216666333radiosensitizationPARPU87MG28797568 PubChem
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YU238259121473004proliferationHDR, HRRU251MG, U87MG26116172, 31020489 PubChem
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LY3414959819927proliferationU87MG23724064 PubChem
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Selumetinib10127622MEK1, MEK2D456, D645, GBM2, LN229, mouse xenograft models, U37320806365, 22573716 PubChem
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Punicalagin44584733viabilityU87MG24077634 Google
Digoxin2724385proliferation, viabilityprimary human glioma cells, U87MG21184646, 23165409 PubChem
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Casticin5315263viabilityU251MG, U373, U87MG23816816 PubChem
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Doxepin667477inhibitors of cellular respirationIPSB1820332444 PubChem
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KPT25157519758viabilityCRM1AGBM1, BT145, BT159, BT17225366336 PubChem
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Gamabufotalin259803apoptosis, autophagy, G2/M arrestAurora B, cdc25A, cdc25C, cdc2, Cyclin B1, surviviU8731610157 PubChem
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JNJ-77066215330790migration, proliferation, viabilityCDK1, CDK2LN18, SHG44, T98G, U251MG, U373, U87MG28989042 PubChem
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E701611660296radiosensitivityPARP, HMGB1, TLR2U251MG19147766 PubChem
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Fluorouracil3385viabilityNucleic Acid SynthesisU118MG, U87MG24391839, 30989436, 6690037NCT01183663, NCT03607643 PubChem
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2-benzoyloxycinnamaldehyde (BCA)54242917invasiveness, stemness, temozolomide enhancer, viabilityZeb1, Ncadherin, beta-cateninGBM tumorspheres, mouse orthotopic xenograft model30887242 PubChem
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TC-A 2317 hydrochloride46911725apoptosis, cell cycle, viabilityAurora A kinasehuman glioblastoma neurosphere tumor xenografts25106428, 29396807 Google
PCI-2478111749858proliferationHDACLN18, LN229, U87MG25505847 PubChem
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Tozasertib5494449radiosensitization, viabilityAurora kinaseGBM 8401, GBM 8901, mouse xenograft model, primary human glioma cells, U87MG23636005, 25522764 PubChem
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NS-3984553inflammatory responseCyclooxygenase21321N1, C6, U87MG19804834, 19854233 PubChem
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Y27632448042migration, proliferationROCKC6, LN1818814230, 19331140, 19427347, 19772916 PubChem
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BDP-9066132275018invasion, motilityMRCKxenograft model of GBM30279244 PubChem
SF112666577114PI3Kmice glioma cells, mouse xenograft model25425962 PubChem
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Quercetin5280343proliferation, viabilityU251MG, U373MG, U87MG18971417, 19491660, 19804834, 24379902, 24902789 PubChem
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Folic acid135398658apoptosis, proliferation, temozolomide enhancerS-adenosylmethionineNtva, U251MG, U37319451595 PubChem
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602306-29-616747683proliferationCDK1, CKD2, CDK9A172, LN18, LNZ308, T98G, U373, U87MG26585571 PubChem
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C-Met inhibitor56650915apoptosiscMETDaoy19921488 PubChem
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Romidepsin5352062proliferation, radiosensitizationHistone deacetylaseA172, GBM6, T98G, U138MG, U251MG, U87MG15024582, 27685789, 2975058221377994NCT00085540 PubChem
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11-deoxy-PGE15283055proliferationERKU87MG20015475 PubChem
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DNQX3899541viabilityAMPA U87MG19997873 PubChem
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Estradiol5757apoptosis, proliferationJNK, cjunC6, T98G22848302 PubChem
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Terfenadine5405viabilityU87MG27029345 PubChem
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PHA-66575210461815apoptosisHGF, Casp3, Casp8, Casp9Daoy18992144 PubChem
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Gamolenic acid 5280933angiogenesis, proliferationBax, Ku80, E2F1C619180667, 19292920 PubChem
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Pexidartinib25151352CSF-1R26449250, 31258629NCT01349036, NCT01790503 PubChem
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NF11510000429proliferationSynthetic glycolipidC6, U373MG23245511 Google
Cyclosporine A5284373mPTPT6719570051 PubChem
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2-hydroxycinnamaldehyde (HCA)5318169invasiveness, stemness, temozolomide enhancer, viabilityZeb1, Ncadherin, beta-cateninGBM tumorspheres, mouse orthotopic xenograft model30887242 PubChem
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Cisplatin84691autophagy, viabilityDNA intercalation, AMPKC6, L929, MO59J, MO59K, U251MG, U343, U87MG, XO819408974, 20196784, 24218165, 24953561, 27993939 Google
GDC-008457384863PI3K, mTORorthotopic mouse model, U87MG27638506NCT01547546, NCT03522298, NCT03696355 PubChem
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Chamaejasmin390362cytotoxicityU87MG30836216 Google
Brilliant green12449proliferationGBM6, U87MG29750582 PubChem
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Enzastaurin176167apoptosis, proliferation, temozolomide enhancerPKCbeta, PI3K, AktA17216103100, 18448327, 18462865, 18662322, 1991340819417015, 20124186, 20150385, 20156802, 22291006NCT00295815, NCT00402116, NCT00509821, NCT00516607, NCT00586508, NCT03776071 PubChem
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Lonidamine39562proliferation, radiosensitization, viabilityglycolysis U373MG20009297 PubChem
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Simvastatin54454proliferationprimary human glioma cells23165409 PubChem
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Infigratinib53235510FGFRHEK293T30344944NCT01975701 PubChem
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Ki1642510367662viabilityLPA(1), LPA(3)C618481020 PubChem
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E620110172827MEKmice29437873 PubChem
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Cilengitide176873proliferation?v?3, ?v?5G28, G44, U251MG, U87MG17277694, 18616418, 18981465, 19114005, 19199360, 19221171, 19351861, 20820929, 21788343, 2258888317470857, 18981465, 20439646, 21739168, 25163906, 26008604NCT00006093, NCT00085254, NCT00093964, NCT00112866, NCT00679354, NCT00689221, NCT00813943, NCT00979862, NCT01044225, NCT01122888, NCT01124240, NCT01517776, NCT01782976 PubChem
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Dimethyl fumarate 637568proliferationRel, NFkappaBA172, primary human glioma cells24404403, 25482938 PubChem
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PD15303511246488proliferationEGFR U87MG19642173 PubChem
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Nilotinib644241Tyrosine kinase inhibitor18677408 PubChem
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U01263006531apoptosis, migration, proliferationMEK1, MEK2, ERK1, ERK2, MAPK, ERKA1207, A172, C6, LN18, SKMG15, SKMG4, SKMG5, T98G, TC620, U178, U251MG, U373, U87MG17327470, 18834856, 19336886, 20809186, 21850371, 26748241 PubChem
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AR-A014418448014apoptosis, proliferation, viabilityGSK3betaA172, T98G, U251MG, U87MG19188159 PubChem
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Phenylbutyrate5258radiosensitisationHDACD54, SKMG3, U251MG, U87MG17707275 PubChem
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Digitonin6474107proliferationprimary human glioma cells23165409 PubChem
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Foretinib42642645collagen invasion, migration, proliferation, SurvivalcMET, VEGFR2, ROS1, RTK, TAM, MerTK, Akt, ErkA172, mouse model, SF188, U251MG2465832624218589 PubChem
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Citral638011PHGDHU251MG19089318 PubChem
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Isotretinoin528237925239666NCT00003564, NCT00112502, NCT00555399, NCT01103375 PubChem
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SB203580176155proliferationMAPK, RIGI, p38C6, U37317395328, 18346382, 18442089, 19133316, 19362079, 19427347, 20060865 PubChem
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Cordycepin6303apoptosis, viabilityAMPK, AktC6, LN18, orthotopic mouse model, T98G, U251MG, U87MG26597532, 28068557, 30336060 PubChem
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Amentoflavone5281600apoptosis, viabilityNFkappaB, FAS, cFLIP, MCL1U87MG29475910 PubChem
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Capecitabine60953Nucleic Acid Synthesis25290090, 31600167NCT00504660, NCT00717197, NCT00959946, NCT02669173, NCT03213002 PubChem
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Wortmannin312145proliferationPI3KU87MG19208828, 19738049, 19997873, 23724064 PubChem
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Peroxynitrite104806viabilityNO, p53D54MG, LNZ30814695179 PubChem
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AZD648244137675apoptosis, cell cycle arrest, proliferationPI3KbetaU118, U87MG30542720 PubChem
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Echinomycin3197angiogenesis, proliferationHIF1U251MG16204079 PubChem
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Phloroglucinol (BFP, (2,4-bis(4-fluorophenylacetyl)phloroglucinol)359apoptosis, cytotoxicitybenzenetriol, phenol derivative C6, U251MG, U87MG22819448 PubChem
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NK314137699307apoptosisTopo2U87MG31020489 Google
Trametinib11707110viabilityMEKHEK293T, NIH3T3, primary human glioma cells25431423, 3034494429295876NCT02684058, NCT03434262, NCT03919071, NCT03975829 PubChem
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Digoxigenin15478proliferation, viabilityprimary human glioma cells, U87MG23165409, 27029345 PubChem
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Trolox40634apoptosis, viabilityCasp9U138MG19002382 PubChem
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Kaempferol5280863apoptosis, proliferation, viabilityERK, AktA17218949556, 19001439 PubChem
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A-1926215310991proliferationETRBA375, LN229, SW1088, WM3519040731 PubChem
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Paroxetine 43815apoptosisSSRIsC6, SHSY5Y16055945 PubChem
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Tranylcypromine19493proliferationU87MG30591460 PubChem
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4egi-15717952proliferationeIF4EU251MG26220902 PubChem
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Ouabain439501viabilityLN229, U87MG18795320, 19995221, 21184646 PubChem
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Pyrazolanthrone8515viabilityJNKC6, U251MG, U87MG18561312, 18813807, 19427347, 19517066, 19788921, 20060865, 23210245, 30229380 PubChem
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72926-24-02930014proliferationEg5U251MG, U87MG28965307 PubChem
YM022122130invasion, proliferationCCK2RU87MG19502590 PubChem
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Perampanel9924495proliferationAMPAHROG02, HROG05, HROG15, HROG2430716120 PubChem
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Baicalein-5,6,7-trimethylether442583peroxisomal fatty acid beta-oxidationACSVL1U87MG18470630 PubChem
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7-Ethyl-10-hydroxycamptothecin104842viabilityTopoisomeRASeA172, U87MG28963609, 30521347 PubChem
PF-42924223661637viabilitySite1 protease28645614 PubChem
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Gossypol3503viabilityU251MG, U343, U373, U87MGluc220587533, 25375271 PubChem
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Metformin4091invasion, proliferationAktprimary human glioma cells, SF268, U87MG24965413, 3004651330980539NCT01430351, NCT02149459, NCT02780024, NCT03151772 PubChem
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GANT61421610viabilityGLIU251MG, U87MG27894350 PubChem
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AG-12089699486viabilityIDH1 U87MG29670690 PubChem
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Luteolin5280445invasion, migration, proliferation, viabilityMusashi1U251MG, U343, U87MG28927111, 30362859, 30374718 PubChem
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Z-LEHD10032582apoptosisCasp9U138MG19002382 PubChem
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SKI II753704radiosensitizationSphingosine kinase A172, LN18, LN229, T98G, U251MG, U87MG25255218, 28494176 PubChem
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Fludarabine phosphate30751viabilityDNA, RNA synthesisLN229, primary human glioma cells, U87MG30219696 PubChem
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CCG-14232726015invasionRhoAT98GMG, U251MG29207169 PubChem
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PD980594713migration, proliferationMEK1, MEK2C6, T98G, U37317327470, 18346464, 18411719, 18636433, 18975108, 19108760, 19158403, 19362079, 19435873 PubChem
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Germacrone6436348proliferationU251MG, U87MG24889088 PubChem
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Demethoxycurcumin5469424mouse xenograft model, primary human glioma cells27757851 PubChem
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Aciclovir 2022IFN-gamma enhancer, proliferationPCNACdk2SNB19, T98G, U37310841074 PubChem
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Osthol10228apoptosis, invasion, proliferationTE671, U87MG25368248, 26082082, 29301373 PubChem
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Lys0170673567viabilityLN22922566612 PubChem
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Cabozantinib25102847proliferationMultiple kinasesE98, mouse model20127563, 21926191, 2348400629016998, 29036345, 29687244NCT00704288, NCT00960492, NCT01068782, NCT02885324 PubChem
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Talampanel16450919636006, 20143438NCT00062504, NCT00064363, NCT00267592 PubChem
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Glasdegib25166913Smoothened22223823NCT03466450 PubChem
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Dapivirine214347apoptosis, induces stress, inhibits proliferation, proliferationU87MG29290776 PubChem
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AZD805525262965mTORmouse xenograft model, primary human glioma cells25316808NCT01316809 PubChem
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Amsacrine2179proliferationprimary human glioma cells23165409 PubChem
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Nobiletin72344proliferationC623546290 PubChem
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Triapine9571836radiosensitization, viabilityRR (ribonucleotide reductase)U251MG16675588 PubChem
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Docetaxel148124viabilityMicrotubulesLN229, primary human glioma cells, U87MG24433351, 30219696, 30318217, 30796690NCT00049296 PubChem
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Pazopanib10113978Tyrosine kinase20200024, 23363814NCT00350727, NCT00459381, NCT01392352, NCT01931098, NCT02331498, NCT03275558 PubChem
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Ispinesib6851740proliferationKSP, HsEg5mouse xenograft model19554570 PubChem
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Indomethacin3715viabilityCOXU251MG27988363 PubChem
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Sulfasalazine5359476proliferation, radiosensitizationMAPK, NFkappaBA172, D54MG, D65MG, GBM62, GM1, GM2, GM3, GM4, GM5, LN18, STTG1, U251MG, U87MG15328202, 16079392, 19015640, 25798841, 25937318, 2892933519840379 PubChem
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RapaLink-1121231411proliferationmTORU87MG28292440 PubChem
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Lomeguatrib3025944apoptosisMGMT19770758 PubChem
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Moroxydine71655proliferation, viabilityCLIC1GBM1, GBM2, GBM3, GBM4, GBM5, GBM6, GBM730186163 PubChem
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Cediranib9933475apoptosis, proliferation, viabilityVEGFR4C8, mouse xenograft model18814988, 19332720, 19671039, 21095630, 25490024, 25676691, 26645398, 3042382217222792, 19549889, 20458050, 23940216, 26008604NCT00305656, NCT00458731, NCT00503204, NCT00662506, NCT00777153, NCT00979862, NCT01062425, NCT01131234, NCT01310855, NCT02974621 PubChem
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Caudatin72948694proliferationU251MG, U87MG25860846 Google
Binimetinib10288191radiosensitizationMAP2KGBM8, orthotopic mouse model, U87MG28958992NCT03973918 PubChem
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Paeoniflorin442534invasion, migration, proliferationTGFbetaT98G, U251MG, U87MG29423667 PubChem
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Gamma-Secretase Inhibitor IX5311272proliferation, viabilityGamma secretaseGL15, LN229, SF767, SHG44, U105MG, U251MG, U343MG, U373MG, U87MG19690139, 23736154, 25063285 PubChem
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MG-132462382proliferationProteasomeC6, LN229, mouse xenograft model, SHG44, U138MG, U373, U87MG, XO818341587, 18539596, 19190249, 19201384, 19575007, 19690139, 19808964, 19996297, 21499287, 22367315, 27993939 PubChem
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AMD310065015angiogenesisSDF1, HIF1, CXCR4LN229, mouse xenograft model, U251MG, U87MG20157762, 20179352NCT00669669, NCT01339039, NCT01977677, NCT03746080 PubChem
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Marimastat119031cell invasivenessMetalloproteinaseDaoy, Madsen, UW2282, UW228319847623 PubChem
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Momelotinib25062766autophagy, proliferation, temozolomide enhancerJAK2, STAT3U251MG30664175 PubChem
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Cucurbitacin I5281321apoptosis, cell cycle arrest, proliferationJAK, STAT3A172, LN18, LN229, LNZ308, mouse xenograft model, T98G, U251MG, U87MG, U87MGEGFRviii18487947, 18829483, 24599950, 25482928 PubChem
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Vinpocetine443955proliferationPDE125620587 PubChem
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Aurintricarboxylic acid2259invasion, migrationA172, GBM44, T98G28103571 PubChem
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Cycloguanil9049viabilityCLIC1GBM1, GBM2, GBM3, GBM4, GBM5, GBM6, GBM730186163 PubChem
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Captopril44093invasionT98G8572589NCT02770378 PubChem
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Anisomycin253602viabilityprimary human glioma cells, U251MG, U87MG21184646, 22684030, 23165409 PubChem
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Mibefradil60663viabilityT type calcium channelsC6, rat model, T98G, U251MG, U87MG23198803, 2328741228371832NCT01480050, NCT02202993 PubChem
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Perphenazine 4748apoptosis, proliferation, viabilityCasp3C6, U87MG14997012, 20811727 PubChem
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3-(3,4-dichlorophenyl)-1-(3,4-dimethylphenyl)-1-(5-methyl-4,5-dihydro-1,3-thiazol-2-yl)urea613034mTORC2LN229, mouse xenograft model28453552
MST-31210385095cell cycle arrest, DNA damage, double strand breaks, viabilityTelomerase inhibitorKNS60, MO59K, ONS7625307264 PubChem
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KPT27671496742viabilityCRM1AGBM1, BT145, BT159, BT172, orthotopic mouse model25366336 PubChem
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Verapamil 2520apoptosis, proliferation, temozolomide enhancerBax, BCL2U87MG30003979 PubChem
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Propofol4943apoptosisReactive oxygen speciesGBM 8401, LN29928804952, 29928428 PubChem
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Nisoldipine4499viabilityU87MG24433351 PubChem
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MIM1135691163apoptosis, cell cycle arrest, temozolomide enhancer, viabilityMCL1U87MG30134184 PubChem
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Emetine10219proliferationprimary human glioma cells23165409 PubChem
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THZ173602827proliferationCDK7mouse xenograft model, orthotopic mouse model, primary human glioma cells, U251MG, U87MG28504693, 30532595 PubChem
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Vincristine5978proliferationMicrotubulesA172, GL261, LN229, LN443, orthotopic mouse model, primary human glioma cells, U118, U87MG23165409, 24433351, 28386621, 3021969620855843, 225004NCT00005796, NCT00052455, NCT01837862, NCT02684058 PubChem
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SKI66577038proliferationSphingosine kinase D54MG, U251MG19597728 PubChem
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BIX0129425150857viabilityhistone methyltransfeRASe, G9aC6, LN18, U251MG24905315, 27748874, 27934912, 30450051 PubChem
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Crenolanib10366136viabilityPDGFRalphaprimary human glioma cells25380967NCT02626364 PubChem
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Ardipusilloside I197641proliferationT98G, U37324984215 Google
Tivantinib11494412proliferationPI3K/Akt, mTORT98MG, U25131575848 PubChem
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ICI1185515484725mRNA synthesis inhibitionSelective b2AR antagonistU37318498711 PubChem
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Zidovudine 35370radiosensitizationTelomeraseU251MG17223082 PubChem
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JWH?1336918505migration, proliferation, viabilityVEGF, VEGFR?2, HIF-1alphaC6, T98G, U87MG15313899, 24204703 PubChem
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Levetiracetam 5284583temozolomide enhancer, viabilityMGMTA172, LN18, T98G, U1382052576531603723NCT00629889, NCT02815410 PubChem
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AT1338711955716Hsp90mouse xenograft model, primary human glioma cells, U251MGHFGFP, zebrafish xenograft model28679777 PubChem
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Merlin84098and motility, proliferation, survivalNF2(Merlin)9L, A172, DBRG05MG, Hs683, LN18, LN229, M059K, M089J, SF126, SF188, SF210, SF268, SF295, SF539, SF763, SF797, SNB19, SNB75, U118MG, U138MG, U251MG, U343MG, U373MG, U87MG18632626 PubChem
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Allopregnanolone 92786proliferationESF1, RIF1U87MG29543748 PubChem
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Pki-1666918403apoptosis, proliferationEGFR, HER2LN827, U87MG18677408 PubChem
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Rescovitine46881287migrationCDK5neural stem cells (F3), U87MG19351187 Google
Succinyl phosphonate46209593viabilityOGDH, Reactive oxygen species1321N1, LN405, T98G, U87MG27027236 Google
3-Butylidenephthalide62368proliferationDBTRG05MG, GBM8401, mouse xenograft model21553143 PubChem
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Otx-00811953346viabilitygalectin1U87MG23978989 Google
Tagitinin C11256548viabilityU37321073931 Google
Everolimus6442177mTOR, IKK, NF?B, RAI14LN229, LN427, LN428, LN751, NCT00085566, NCT00107237, NCT00387400, NCT00515086, NCT00553150, NCT00805961, NCT01062399, NCT01434602, NCT01508104, NCT03355794, NCT03834740, U251MG, U87MG18483381, 18559622, 25371289, 3055440120864273, 23725999, 25526733 PubChem
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gamma-Tocopherol92729apoptosis, proliferationPKC, ERKC616843827 PubChem
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Etomoxir9840324proliferationAktU251MG, U373U, U87MG30574020 PubChem
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BMS-77760724794418AXLmouse xenograft model, SF126, U11826848524 PubChem
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Marizomib11347535viabilityProteasomeLN18, mouse xenograft model, SNB19, U251MG, U87MG20165695, 21247382, 26681765, 26804704NCT03345095 PubChem
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Cathepsin S Inhibitor16760355viabilityCatSU251MG, U87MG24875536 Google
Danthron2950apoptosis, viabilityBCL2, BaxGBM 840119784869 PubChem
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UMI-77992586viabilityMCL1A172, U251MG, U87MG28337703 PubChem
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Cimetidine2756proliferationGSK3betaprimary human glioblastoma cells28423558 PubChem
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Pochoxime A24898672mouse model20643786 PubChem
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Guggulsterone53394010viabilityA172, T98G, U87MG23548480 PubChem
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4,7-Dimethyl-1,10-phenanthroline72792cell invasivenessMetalloproteinaseDaoy, Madsen, UW2282, UW228319847623 PubChem
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Jaceosidin5379096apoptosis, cell cycle arrest, proliferation, viabilityp53, BaxU87MG22471459 PubChem
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TGX-2219907093proliferationp110betaU251MG, U87MG29048665 PubChem
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Lenalidomide2163262689197518513880NCT00036894, NCT00165477, NCT00671801, NCT01183663 PubChem
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Aspirin2244proliferation, viabilitySK?N?SH (N)31429199NCT00790452 PubChem
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Triciribine, Akt inhibitor V65399proliferation inhibitionAkt1028S, U87MG19208828 PubChem
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ML29853393916invasion, migrationPLD2U87MG23445448 Google
Latrunculin B6436219apoptosis?v?3, ?v?5D293MED, D54MG, D645MG, UW228220124512 PubChem
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Sertraline68617viabilityA172, LN443, U118, U87MG24433351NCT02770378 PubChem
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Difluorodeoxyuridine129627896radiosensitivity19770758 Google
Lorlatinib71731823ALK, ROS1mouse model25733882 PubChem
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Noscapine 275196angiogenesis, apoptosisHIF1T98G, U87MG16596228, 18525314 PubChem
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Tamoxifen2733526viabilityER-alpha66, ER-alpha36U118, U251MG, U87MG25554223, 30417588NCT00002608, NCT00006388, NCT00492687, NCT00541138 PubChem
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Parthenolide7251185cell resistance to TRAILIB phosphorylationLN44319432816 PubChem
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Alpha-cyano-4-hydroxycinnamic acid5328791invasionmouse xenograft model, U251MG, U87MG21750656 PubChem
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Procarbazine491520855843, 225004NCT00003293, NCT00003564, NCT00003788, NCT00004004, NCT00005796, NCT00052455, NCT00079092, NCT01737346 PubChem
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MG-262490002apoptosis inhibitionProteasomeLN229, U251MG19190249 PubChem
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DL-nordihydroguaiaretic acid688035differentiationAlox5murine glioma xenografts, U87MG20809257 Google
NKTR-1027130072725935109 Google
Dimethyl-alpha-ketoglutarate25775GDH, AktSF18819826036 PubChem
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Aldoxorubicin9810709DNA intercalationmouse xenograft model, U87MG25379024NCT02014844 PubChem
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UniPR1331134817215angiogenesisEphrinU87MG29849945 Google
Epigallocathecin Gallate65064viabilityT98G, U87MG18948169, 19826036, 19894226 PubChem
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Go69763501proliferationcPKCC618778746, 19357285 PubChem
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KP1141153apoptosis, proliferationPI3K, AktU251MG, U87MG16546978 PubChem
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C754248455apoptosisFAS inhibitorU87MG20009104 PubChem
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Oroxylin A5320315viabilityU118, U251MG, U87MG25213258 PubChem
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Ribavirin 37542apoptosis, migration, proliferation, viabilityeIF4E, EZH2, ERK1113, GB1A, LN18, murine glioma models, U251MG, U87MG27941882 PubChem
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Curcumin969516cell cycle arrest, proliferationWnt, beta-catenin, NFkappaBU251MG, U37326046466, 30585634, 30864499 PubChem
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YC-15712proliferationfactor1alphaC618430796, 19108760 PubChem
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Akt inhibitor VIII (Akti-1/2)135398501proliferation inhibitionAkt1028S, U87MG19208828 PubChem
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Oxaliplatin9887054apoptosis, radiosensitization, temozolomide sensitivitySTAT3, MGMT, DNA, RNA synthesisGL261luciferase, KR158, KR158luciferase, LN229, mouse xenograft model, primary human glioma cells, U87MG17383816, 18329790, 30132163, 30219696 PubChem
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TG0216739650viabilityGSC823, GSC923, LN18, orthotopic mouse model, U251MG29254993NCT02942264, NCT03224104 PubChem
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Enasidenib89683805proliferation, viabilityIDH230069631 PubChem
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Eupalmerin acetate5459169apoptosisJNKU373MG, U87MG17237278 Google
Raddeanin A174742apoptosis, viabilityJNKU251MG29843152 Google
NVP-AEW54111476171IGF1RKNS42_A4, mouse xenograft model, primary human glioma cells18677408, 20378689, 20488164, 21659463 PubChem
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Shikonin479503proliferationTopoisomeRASeU251MG, U87MG23840441, 24303074, 25688715, 25891245 PubChem
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Dimethylaminomicheliolide54589107proliferationPKM2C6, rat model, SF126, SHG-44, U118MG, U251MG, U87MG25658946, 31632919 Google
KU006379416736978viabilitymTORU373MG22125077 PubChem
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Proteasome inhibitor IX11639443apoptosis inhibitionProteasomeLN229, U251MG19190249 PubChem
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Teniposide452548proliferationprimary human glioma cells, U37319559015, 23165409 PubChem
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OSU03012 10027278apoptosis, proliferationPDK1, PI3K, AktD283 MED, D324 MED, D458 MED, MEBMED8A, medulloblastoma human xenograft tumors, PFSK1, UW228316622074, 16675657, 20028853 PubChem
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Oleuropein5281544invasion, proliferationA172, U251MG27498673 PubChem
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Hellebrigenin 259577apoptosis, proliferationCdc25C, Cyclin B1, survivin, MAPKU87MG30272276 PubChem
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Anlotinib25017411inhibit tumor cell growthTyrosine kinase inhibitor31145289NCT04004975, NCT04119674, NCT04157478 PubChem
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Pimozide16362apoptosisUSP1 MZ54, orthotopic mouse model, primary human glioma cells26032834, 30250198 PubChem
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Dehydroxymethylepoxyquinomicin9881652NFkappaBmouse xenograft model, U251MG, U87MG21968049 PubChem
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Doxycycline54671203proliferation, viabilityMMP2LNT229, T98G, U34319828040, 28112361, 29772845 PubChem
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JQ146907787proliferation, temozolomide enhancerBETC6, rat xenograft model, U87MG25056450, 27388964, 29777137 PubChem
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Mdivi-13825829apoptosisDRP1U87MG29229477 PubChem
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Sphingosine5280335apoptosisERK1, ERK2C616302024, 8768300 PubChem
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Proscillaridin A222154proliferationGSK3betaGBM6, GBM9, orthotopic mouse model, U251MG, U87MG25400117, 27029345, 30250248 PubChem
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Carmofur2577Human acid ceramidase (AC)30525581 PubChem
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MP47011282283apoptosis, radiosensitization, viabilitycMETmurine xenograft tumor, SF126, SF188, SF210, SF268, SF295, SF767, SSF763, U87MG20028557 PubChem
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NHI 251355147apoptosis, cell cycle arrest, proliferationLDHAU87MG26494310 PubChem
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SK1-I44815217apoptosis, invasion, migration, proliferationSphingosine kinase 1GBM6, LN229, U37319723667 PubChem
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Monoterpene perillyl alcohol (POH)10819RAS20401670 PubChem
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MLN492416720766NEDD8activating enzymeorthotopic mouse model, U251MG25904638 PubChem
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Furanodienone6442374apoptosis, cytokine levels, inflammatory responses, TMZ enhancerCSPG4A172, U118, U251MG, U87MG31006910 PubChem
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Phloretin4788cell swelling suppressionAquaporin91321N119772916 PubChem
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Cytarabine6253proliferationprimary human glioma cells23165409NCT01044966 PubChem
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Gitoxin91540proliferationprimary human glioma cells23165409 PubChem
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Gemcitabine60750radiosensitivityDNA and RNA19770758NCT02711137, NCT03434262, NCT03607643, NCT03678883, NCT03684811 PubChem
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Vorinostat5311proliferation, radiosensitization, viabilityHistone deacetylase, SN38GL26, LN18, LN229, mouse model, primary human glioma cells, T98G, U251MG, U373MG, U87MG17289901, 19622715, 20135194, 23962875, 25040548, 25275596, 26794465, 27863490, 29384188, 3087855319307505NCT00238303, NCT00268385, NCT00555399, NCT00641706, NCT00731731, NCT00762255, NCT01110876, NCT01189266, NCT01266031, NCT01342757, NCT01378481, NCT01738646, NCT03426891 PubChem
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RITA374536proliferation, temozolomide enhancerASK1U251MG, U87MG30562758 PubChem
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Pyrvinium pamoate 54680693proliferationGICGBM (primary human glioma cells), murine xenograft tumors26152745 PubChem
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PX-8669849735angiogenesis, autophagyPI3KLN18, LN229, mouse xenograft model, U251MG, U87MG2015680325605819NCT01259869 PubChem
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Cryptotanshinone160254LN229, mouse xenograft model, U87MG28492557, 30021339 PubChem
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Daidzein5281708apoptosis, proliferationBCL2LN22919429088 PubChem
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PX-47811234794radiosensitizationHIF1C619372568 PubChem
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Embelin3218viabilityLN18, T98G, U87MG19409438, 19649204, 23514760, 23545899, 29384188 PubChem
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CBL-013744519124apoptosis, proliferationSSRP1, SOX2, OCT4, NANOG, OLIG2, CD133, FACT, p53,A1207, orthotopic mouse model, primary human glioma cells, U87MG26921329, 27370399, 30581774NCT01905228 PubChem
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Xyloketal B10980896proliferation, viabilityU251MG25913706 Google
Clasto-Lactacystin .beta.-lactone (?-Clastolactacystin)9174612620S proteasome 118MGC, U373MG19201384 Google
VAL-08315942827proliferationLN229, mouse xenograft model, MU145, U251MG, U87MG28216618NCT01478178, NCT02717962, NCT03050736, NCT03149575 PubChem
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9-ING-4144582816Glycogen Synthase Kinase3GBM12, GBM6, orthotopic mouse model28672195NCT03678883 PubChem
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Lapatinib208908proliferation, viabilityEGFR, HER2, GBM12, GBM14, GBM5, GBM6, LN229, mouse and rat xenograft model, primary human glioma cells, U87MG19254954, 19603143, 24911215, 3021969619499221, 20009104, 23363814NCT00095940, NCT00099060, NCT00107003, NCT00350727, NCT02101905 PubChem
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PAI-13246941angiogenesisSerine protease18383878 PubChem
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BI253611364421proliferation, temozolomide enhancer, viabilityPLK1LN319, orthotopic mouse model, primary human glioma cells, T98G, U138MG, U251MG, U343MGa, U87MG22415968, 23713868, 24204733, 30133120 PubChem
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Mepacrine237viability4C8, U87MG25490024, 25727221, 27029345 PubChem
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Tubacin6675804proliferationLN229, U251MG29845122 PubChem
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Decitabine451668viabilityiNOS, DNA, FPRC6, HEK, T98G, U87MG14725971, 18607344, 18793349, 18803327, 18976507, 19037090, 19047176, 19787267, 19847810, 19966297 PubChem
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VER-490094369536cross-resistanceHsp90SF268, U87MG19244114 PubChem
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Verbascoside5281800apoptosis, invasion, migration, proliferationCOX2, NFkappaB, MAPK, SHP1, STAT3C6, U87MG19904526, 29961065 PubChem
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Dihydroartemisinin456410proliferationBT325, C626722323 PubChem
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OSI-42018924996viabilityEGFRLN229, primary human glioma cells, U87MG30219696 PubChem
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Sevoflurane5206invasion, migrationU251MG27840895 PubChem
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Andrographolide5318517proliferationU251MG, U87MG22634579 PubChem
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NOX-A1286278354angiogenesis, viabilityCXCL12, SDF1alfaC6, human G12 glioblastomas, rat brain tumor models24335554, 27940247 Google
PLX-472024180719BRAFDBTRG05MG, orthotopic mouse model26023796 PubChem
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Papaverine 4680inhibitors of cellular respirationADP, ATP, cyclic nucleotide phosphodiesteRASeC64367754 PubChem
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Bufalin 9547215proliferation, viabilityATP1A1murine xenografts, U251MG, U87MG28787697, 29653366 PubChem
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Rovalpituzumab tesirine131954443DLL3primary human glioma cells30397180 Google
Dynole 34-244157463migration, neurosphere formation, viabilityGTPase dynamin 2GSCs, U251MG, U87MG30907150 Google
Thymeleatoxin5476508proliferationPKC, cPKCC618778746 Google
Trabedersen13247212020980335NCT00761280 Google
Glaucocalyxin A10471963proliferationU87MG24041957 Google
Magnolol 72300cell cycle arrest, proliferationCDK2/p21, Cip1U37319645506 PubChem
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Adavosertib24856436viabilityWEE1GBM22, mouse xenograft model, T98G, U251MG21992793, 2560906329798906NCT01849146, NCT01922076, NCT02207010 PubChem
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Dobesilate29963apoptosis, proliferationFGF, MAPKC616551428, 16563234 PubChem
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Linsidomine5219viabilityNO, p53BV2, CRTMG, D54MG, LNZ30814695179, 19748528 PubChem
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Cladribine20279viabilityA172, U118, U87MG24433351NCT00019071 PubChem
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SZ-685C12301973apoptosis, viabilityAkt, FOXO transcription factorsLN44420128807 Google
Eribulin11354606survival, tumour growth(TERT)-RNA-dependent RNA polymerasemouse brain tumor xenograft with U87MG31099446 PubChem
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alpha-Bisabolol442343apoptosismPTPC6, T67, U87MG14975741, 19570051 PubChem
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Tocladesine100299apoptosisU87MG12449730 PubChem
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Ganciclovir135398740cytotoxicityU251MG19300472NCT00002824 PubChem
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Tetrandrine73078viabilityU251MG, U87MG27909720, 30549224 PubChem
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Gefitinib123631apoptosis, elacridar enhancer, proliferation, radiosensitization, viabilityEGFR, AktG111, G152, GL15, LN229, mouse model, primary human glioma cells, SF767, T98G, U105MG, U251MG, U343MG, U373MG, U87MG14643025, 16550610, 18386816, 18566746, 18803287, 19033425, 19435839, 19435898, 21744078, 23724064, 23736154, 24876095, 25368255, 30219696, 3087597523182702NCT00014170, NCT00016991, NCT00025675, NCT00027625, NCT00042991, NCT00052208, NCT00085566, NCT00132158, NCT00238797, NCT01310855 PubChem
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Melatonin896apoptosis, viabilityA172, T98G, U251MG, U87MG19632770, 28255276, 29925764 PubChem
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Bibu 136146861539apoptosisEGFRA172, LN229, T98G, U87MG22753156 Google
Mithramycin A163659proliferationSP1U87MG19642173 PubChem
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Trifluoperazine5566proliferationCalcium signaling, D2 receptorsorthotopic mouse model, P3, primary human glioma cells, U251MG, U87MG23165409, 28062709, 28870216, 29580626, 30980364 PubChem
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Etoposide36462proliferation, viabilityTopoisomeRASeA172, CD133, MO59J, MO59K, primary human glioma cells, T98G, U251MG, YKG118599610, 18614215, 19305157, 20388502, 23165409, 24953561, 30606517, 31020489NCT00003996, NCT00047281, NCT00612430, NCT00613028, NCT00613223, NCT02372409, NCT02502708, NCT04049669 PubChem
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Dioleoyl phosphatidic acid9547172radiosensitizationCalcium signalingC617499746, 18481020 PubChem
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Candidaspongiolide102471178apoptosisPKR, eIF2alpha, casp12U251MG18728285 Google
Lomustine3950OIP5GBM12, GBM6, orthotopic mouse model27474153, 28672195, 3028422820124186, 20855843, 23940216, 24958095, 30522967NCT00003788, NCT00005796, NCT00052455, NCT00068952, NCT00295815, NCT00503204, NCT00504660, NCT00761280, NCT00777153, NCT00948389, NCT01067469, NCT01149109, NCT01290939, NCT01562197, NCT01582269, NCT01737346, NCT01860638, NCT01934361, NCT02076152, NCT02343406, NCT02414165, NCT02765165, NCT02843230, NCT02926222, NCT03022578, NCT03025893, NCT03149575, NCT03463265, NCT03678883, NCT03970447, NCT04049669 PubChem
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3,3'-Diindolylmethane3071apoptosisU87MG30617655 PubChem
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Rucaparib9931954PARPGBM12, GBM39, orthotopic mouse model26438157NCT02711137 PubChem
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Itraconazole55283viabilityA172, U118, U87MG24433351NCT02770378 PubChem
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Vasculostatin12617angiogenesis, proliferationCD36U87MG19176395 PubChem
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CUDC-10124756910proliferationEGFR, HDACBS153, DKMG26032687 PubChem
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Celastrol122724C6, mouse xenograft model, SHG44, U251MG, U373MG18343027, 19909582, 20007406, 21786165, 24810052 PubChem
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Givinostat9804992cell cycle arrest, proliferationHistone deacetylaseU251MG, U87MG30474756 PubChem
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L-3652605311201invasion, proliferationCCK2RU87MG19502590 PubChem
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Memantine 4054autophagy, proliferationNMDAR1, LC3II, LC3I, beclin1T98G, U251MG28264232NCT01260467, NCT01430351 PubChem
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Amiodarone2157apoptosisCHOPU251MG21292685 PubChem
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Digitoxigenin4369270viabilityU87MG27029345, 29333657 PubChem
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Vinorelbine5311497viabilityU87MG24433351 PubChem
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Nigericin16760591proliferationMitochondrial ATPaseCOMI, VIPI stem cells29513090 Google
EIPA1795cell swelling suppressionNHE1321N119772916 PubChem
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Pivaloyloxymethyl 60748apoptosis, proliferationHistone deacetylasemurine xenograft glioma tumor, U251MG16373710 PubChem
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Fluoxetine 3386apoptosisAMPARC6, SHSY5Y, U87MG, xenograft model of glioblastoma in nude mice16055945, 20811727, 25671301 PubChem
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Rolipram5092proliferationPDE4A172, mouse xenograft model, U87MG12432276, 17234775, 18719351, 19642024, 28202289 PubChem
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Alantolactone72724viabilityLN229, U373, U87MG22837216 PubChem
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Sunitinib malate6456015viabilityVEGFR, PDGFR, cKIT, FLTLN229, primary human glioma cells, U87MG30219696NCT00611728, NCT00923117 PubChem
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RG711257406853MDM2 mouse model26482041 PubChem
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Minocycline54675783C6, mouse xenograft model21079420NCT02770378 PubChem
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Amlodipine2162viabilityYAP, TAZ LN18, LN229, T98G30082911 PubChem
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6-MOMIPP134155701apoptosis, mitotic arrest, proliferationMicrotubulesmurine glioma xenografts, U251MG30426158 Google
Honokiol72303viabilityPI3K, mTORDBTRG05MG, GBM8401, mouse xenograft model, U373MG, U87MG19483651, 25106108, 25763821, 27064011 PubChem
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Semaxanib5329098angiogenesis, apoptosis, proliferationFlk1, KDRGS9L, rat models11733657NCT00004868 PubChem
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Fucoxanthin5281239proliferationmouse xenograft model, U251MG, U87MG27394418 PubChem
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NSC23766409805viabilityRAC1GL15, SF767, U105MG, U251MG, U343MG, U373MG23736154 PubChem
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Phenformin8249HF2587, orthotopic mouse model27486821, 30186163 PubChem
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HU-33111393311apoptosisTopo2U87MG31020489 PubChem
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AZD1390126689157radiosensitizationGL261, mouse xenograft model29938225NCT03423628 PubChem
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Genistein5280961apoptosis, mitochondrial swelling, viabilityDNA synthesisLN18, LN308, LNT229, T98G, U87MG18357397, 19639205, 19894226 PubChem
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Isoquercitrin (Quercetin 3-glucoside)5280804proliferationGBM9519491660 PubChem
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AC1MMYR23246569proliferationLN229, orthotopic mouse model, U87MG23811941
Midazolam4192proliferationA172, U118, U251MG, U87MG27629139 PubChem
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Schizandrin B158103invasion, proliferationU251MG, U87MG27977512 PubChem
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Baicalin64982invasion, migration, proliferation, viabilityCalcium signaling, PI3K, Akt, mTORU251MG, U87MG30323558 PubChem
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SN-50101150673NFkappaB118MGC, U373MG19201384 Google
B4289797957cell invasionuPAU124218355442 PubChem
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GW29746603857invastion, migration, viabilityEGFR, HER2U251MG, U87MG23115024 PubChem
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5,7-dihydroxy-4'-methoxy-6,8-diprenylisoflavone44403741cytotoxicityU87MG30836216 Google
SB2021905169chemosensitivityp38, MAPKT98G, U251MG19435873 PubChem
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Cyclopamine442972apoptosisHedgehog (Hh) signalingCD34+, U251MG19245435, 29313231 PubChem
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TG10120916722832proliferationJAK2primary human glioma cells26283544 PubChem
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SNS-0323025986angiogenesis, proliferation, radiosensitizationVEGF, HIF1AU87MG17534442, 19287962 PubChem
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Lbw24211503417radiosensitizationGli36, LN827, U87MG18677408, 21724651 PubChem
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Thapsigargin446378viabilitySERCAC6, U251MG, U87MG, XO818599610, 19133225, 27993939 PubChem
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KX2-36111545920proliferation, viabilitySrc family kinase, tubulinGL26130238350 PubChem
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Neurostatin71716390mouse xenograft model, U37320801220 Google
AZD201425262792radiosensitizationmTORstemlike cells24311635NCT02619864 PubChem
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Ms-2754261apoptosis, proliferationDR4, DR5D283, Daoy19148581 PubChem
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Mitomycin5746proliferationprimary human glioma cells23165409 PubChem
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Proteasome Inhibitor I24906271apoptosisNFkappaB, Proteasome118MGC, LN229, U251MG, U373MG19190249, 19201384 Google
Citalopram 2771SSRI, beta-arrestin1C621223624 PubChem
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Endothelin-116212950proliferationERKC618975108 Google
Cycloheximide6197proliferationC619808964, 21159181 PubChem
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5-Nonyloxytryptamine1797viabilityU87MG24433351 PubChem
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NSC141562422114invasion, migration, proliferationMIR155HG/miR155 axis28371892 PubChem
Daporinad6914657viabilityNAMPTC622119381, 26601421 PubChem
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Milciclib16718576proliferationSF268, SF539, U251MG, U87MG23347136 PubChem
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SB-4152864210951apoptosisGSK3U87MG18582478 PubChem
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Axitinib6450551VEGFR, PDGFRmouse model, U87MG25213669, 27926485NCT01441388, NCT01508117, NCT01562197, NCT03275558, NCT03291314 PubChem
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Indatraline126280mobilityMonoamine transporterprimary human glioma cells24333442 PubChem
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Amitriptyline11065inhibitors of cellular respiration, viabilityMEK, MAPKC6, IPSB1811595754, 20332444 PubChem
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Manumycin6438330apoptosisSTAT3, Reactive oxygen speciesA172, T98G, U87MG19409983 PubChem
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Olaparib23725625viabilityPARPLN229, primary human glioma cells, U87MG18954712, 19671736, 25531448, 25576921, 26794465NCT01390571, NCT02974621, NCT03212274 PubChem
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Perifosine148177apoptosis, cell cycle arrest, viabilityAkt, PI3KT98G, U251MG, U373MG, U87MG16103096, 19887560, 24065522NCT01051557, NCT02238496 PubChem
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Haloperidol3559PER1, CRY1U87MG27746588 PubChem
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Palbociclib5330286CDK4, CDK6mouse xenograft model20354191, 24098593, 26149830, 26354993, 27370397, 2890342230151703NCT02255461, NCT03158389 PubChem
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Plumbagin10205proliferation, viabilityA172, primary human glioma cells, SHG44, U251MG23165409, 25528634 PubChem
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Lipoxin A45280914anti-inflammatory effects, proliferation1321N119357230 PubChem
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Rosuvastatin446157viabilityHMGCoA reductase, MAPK, ERK1, 2, RAS, PI3K, Akt, JLN405, U138, U87MG21120479 PubChem
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Dehydroeburicoic acid 15250826apoptosis, proliferationCalpain, Calcium signalingU87MG19848398 PubChem
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GF109203X2396proliferationPKCC618778746, 19822193, 19965895 PubChem
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10-Hydroxycamptothecin97226proliferationInhibitor of Topoisomerase 1primary human glioma cells23165409 PubChem
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Vandetanib3081361proliferation, temozolomide enhancerVEGFR, EGFR, RETtyrosine kinaseGBM6, GBM8, U251MG, U87MG15305185, 16061883, 16299247, 19622715, 20371720, 20811710, 21095630, 2379985220137866, 23099652NCT00441142, NCT00613223, NCT00821080, NCT00995007 PubChem
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Apatinib11315474Tyrosine kinase29245310NCT03567135, NCT03660761 PubChem
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Paclitaxel36314apoptosis, proliferation, viabilityMicrotubulesC6, G144, G166, G179, GBM2, GBM7, GliNS2, LN229, primary human glioma cells, U87MG18599610, 18804099, 19285047, 23165409, 28962238, 30219696, 30321641, 30633585NCT00002814, NCT00014573, NCT00019019, NCT00479765, NCT02711137 PubChem
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Tipifarnib159324angiogenesis, radiosensitizationfarnesyl protein transfeRASemice xenografts, U87MG1467613316818651, 16877733, 18417739, 18725460, 20934264, 28988377NCT00005859, NCT00049387, NCT00050986, NCT00058097, NCT00209989, NCT00335764, NCT02227901 PubChem
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Pravastatin54687viabilityHMGCoA reductase, MAPK, ERK1, 2, RAS, PI3K, Akt, JLN405, U138, U87MG21120479 PubChem
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Finasteride 57363proliferationESF1, RIF1U87MG29543748 PubChem
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Aloe emodin10207apoptosis, proliferationERKC6, U87MG15747063, 30218594 PubChem
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Isoprenaline3779papaverine enhancer, proliferationcAMPC66254438 PubChem
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BIIB02116736529cross-resistanceHsp90SF268, U87MG19244114 PubChem
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Cardamonin641785proliferationmouse model, primary human glioma cells, U87MG26150336 PubChem
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PP242135565635migration, proliferationmTORC1, mTORC2LN1825243800, 26719046 PubChem
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Pristimerin159516proliferationprimary human glioma cells23165409 PubChem
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Volasertib10461508radiosensitization, viabilityPLK1primary human glioma cells24204733, 29535822 PubChem
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SAR-02010644203948DNA damageChk1A172, DBTRG, LN405, P0297, P0306, T98G31639020 PubChem
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WP113011222830apoptosisJAK2, STAT3GSC11, SF188, T98G, U251MG, U87MG19899826, 26872380 PubChem
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Vitexin5280441apoptosis, cell cycle arrest, viabilityAkt, mTORLN1829328424 PubChem
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Sunitinib5329102angiogenesis, invasion, proliferationReceptor tyrosine kinases, STAT3, AktDaoy, F98, mouse model, T98G, U251MG, U87MG17622648, 19101989, 19603143, 20179017, 22449730, 25458015, 3047258720053726, 20872043, 21744079, 22832897, 24311637, 24424564NCT00499473, NCT00535379, NCT00606008, NCT00864864, NCT00923117, NCT01100177, NCT01441388, NCT02928575, NCT03025893, NCT03275558 PubChem
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781661-94-711178236apoptosis, migration, proliferationSurvivinA172, LN18, LN229, LNZ308, LNZ428, M059J, M059K, T98G, U373, U87MG22770110, 23325792, 25201484, 27805285 PubChem
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JIB-046519698viabilityHistone lysine demethylaseA172, CAS1, DBTRG, U251MG, U87MG28432280 PubChem
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Strophanthidin6185proliferationprimary human glioma cells23165409 PubChem
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3-Deazaneplanocin73087viabilityHDACC624905315 PubChem
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Ridaforolimus11520894mTOR22037923NCT00087451, NCT01295632 PubChem
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BDBM8669157340709proliferationACAT1U251MG26252415
Arsenic trioxide14888metabolic activity reduction, proliferation and colony formation, viabilityCatB, CatLA172mouse xenograft model, U118, U87MG20302512, 21594580, 29274334 PubChem
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Gamma-aminobutyric acid119neuroinflammationIL6C618679050 PubChem
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1134156-31-225195348proliferationHsp70, Hsp90U87MG26185541 PubChem
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Eckol145937BACE1 beta-secretase 1 (human)U373MG, U87MG21514314 PubChem
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GW6471446738proliferationPPARalphaprimary human glioma cells29312541 PubChem
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Ralimetinib11570805MAPKmouse xenograft model, U87MG24356814NCT02364206 PubChem
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Bombesin25078147proliferationGRPRC6, U373MG, U87MG18473825 Google
Valganciclovir 135413535bevacizumab enhancer26893852NCT00400322, NCT04116411 PubChem
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STX-01194253236proliferationSTAT3mouse model, primary human glioma cells, U87MG23612755, 24820265, 28716484 PubChem
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Tpi-287118797983viabilityMicrotubulesGB30, U1242, U87MG29396807 PubChem
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PQ4019549305IGF1Rmouse xenograft model, U87MG25971682 PubChem
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Camptothecin24360proliferation, viabilityGL15, primary human glioma cells, SF767, U105MG U251MG, U343MG, U373MG, U87MG16356833, 19633536, 23165409, 23736154, 27029345 PubChem
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Caffeine2519angiogenesis, migration, radiosensitizationIP(3)R3, PI3K, HIFs, PI3K, Akt, MAPK, ERK C6, orthotopic mouse model, T98G, U87MG20103602, 20103623, 21229324, 25011614, 27260469, 29424319 PubChem
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PF-0469150225033539PI3K, mTORmouse xenograft model, U87MG21750219 PubChem
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Visudyne5362420proliferation, viabilityYAPLN229, SNB19, U343, U87MG28790340, 30254296, 30423822 PubChem
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Clomipramine68539inhibitors of cellular respirationIPSB1820332444 PubChem
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F0911-76674192636apoptosis, autophagySIRT1, AMPKmTORULKT98G, U87MG29991742 Google
SGX-52324779724cMETorthotopic mouse model20015006 PubChem
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Scriptaid5186apoptosis, viabilityHDAC, JNKBS153, DKMG19583803, 26032687 PubChem
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GSK-3 inhibitor IX448949apoptosis, proliferationGSK-3, EGFR, NF-kBU87MG30984989 PubChem
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Bisacodyl 2391viabilityWNK1 kinase, Akt, SGK1, NBCfamily Na+, HCO3primary human glioblastoma cells29930759 PubChem
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Flavopiridol5287969radiosensitizationCDKMO59K, mouse model, T98G, U87MG14712094, 23943501, 27461656, 28111642 PubChem
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Nelfinavir641431919024924194293NCT00694837, NCT00915694, NCT01020292 PubChem
Artesunate65664cell cycle arrest, proliferation, radiosensitizationCDK2, CDK4, cyclin D1, cyclin B1A172, LN229, U251MG, U87MG22560712, 29600654 PubChem
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7-Hydroxystaurosporine72271proliferationPKCmouse xenograft model, primary human glioma cells, U87MG15780200, 24810059 PubChem
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Chloroquine2719radiosensitization, viabilityCed3LN229, LN308, U118, U251MG, U87MG20406898, 25434381, 27644442, 3087855317350410NCT00224978, NCT02378532, NCT02432417, NCT03243461 PubChem
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Clomifene1548953apoptosisIDH1, D2HGC615289732 PubChem
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Digitoxin441207proliferation, viabilityprimary human glioma cells, U87MG21184646, 23165409 PubChem
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Naltrindole hydrochloride (NTI)24840086proliferation inhibitionNonpeptide ?-opioid receptor1028S, U87MG19208828 Google
Tacalcitol5283734migration, proliferation, viabilityT98G29575677 PubChem
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NSC-8787792577proliferationSHP2 PTPaseLN229.EGFRvIII, U87MG.EGFRvIII19427850 PubChem
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Salinomycin3085092apoptosis, proliferationmouse xenograft model, primary human glioma cells, U251MG, U87MG23165409, 28358414, 28498472, 29925966 PubChem
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Archazolid B16757019cholesterol homeostasis, endosomal/lysosomal malfunctionH(+)ATPaseU87MG25218289 Google
AG-14782051proliferationEGFRmice xenografts, U87MG16522318, 19828040 PubChem
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ARP10111292680apoptosis, autophagyMT1MMPU87MG30291676 PubChem
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Glutathione124886prevented apoptosisDAOY19633536 PubChem
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Semustine5198DNA alkylation225004, 24248532, 26852708, 7013978NCT00335075 PubChem
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Boronophenylalanine 150315viabilityF9830474719 PubChem
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Docosahexaenoic acid445580viabilityC620192116, 29192322 PubChem
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ISO-14633677migration, proliferationMIFHs683, LN18, U37319759012, 20038293 PubChem
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Bafilomycin A16436223autophagy, cytotoxicity, radiosensitization, viabilityH(+)ATPaseCD133+, U251MG19431142, 19566920 PubChem
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Astemizole2247viabilityU87MG27029345 PubChem
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FK50624978521apoptosis, proliferation, vincristine enhancerMRP1C6, U87MG30208561 Google
Epigallocathecin72277viabilityT98G, U87MG19894226 PubChem
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Falcarindiol5281148apoptosis, differentiationU37330388862 PubChem
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CC-22358298316mTOR26177599NCT01177397 PubChem
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F9068343proliferationEGFR, ERK1, JNK, p38, BCL2, p53SHG4419024103 PubChem
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Hypericin3663viabilityT98G, U251MG, U87MG2406606021456013 PubChem
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Regorafenib11167602viabilityVEGFR2TIE2GBM12, GBM14, GBM5, GBM62491121530522967, 30820715NCT02926222, NCT03970447, NCT04051606 PubChem
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LB-100 45101433radiosensitizationPP2Amouse xenograft model, U251MG25939762NCT03027388 PubChem
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Gambogic acid5353639apoptosis, proliferationprimary human glioma cells, U251MG21879332, 23165409 PubChem
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Vmy-1-10344626421apoptosisCDKD556, Daoy21885916 PubChem
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Fingolimod107969invasion, migrationU251MG, U87MG25070489 PubChem
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Naphtho[2,3-f]quinoxaline-7,12-dione (NSC745887)12567021apoptosis, prolifiration, viabilityDcR3, ATMU118MG, U87MG29552282 PubChem
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Imatinib5291citotoxicity, invasion, migration, proliferation, viabilityMultiple kinasesGL15, MOGGUVW, mouse model, SF767, T98G, U105MG, U251MG, U343MG, U373MG16274936, 19048625, 19270491, 19417143, 20032406, 23736154NCT00010049, NCT00039364, NCT00154375, NCT00171938, NCT00290771, NCT00354068, NCT00354913, NCT00387933, NCT00401024, NCT00615927 PubChem
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Grisorixin12780142proliferationCOMI, VIPI stem cells29513090 Google
SH-616760283apoptosisAktLNZ308, U251MG17041888, 18802038, 19808964, 19827268 Google
Myricetin 5281672invasion, migration, proliferationPI3K, Akt, JNKU87MG19804834, 29886836 PubChem
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MPEP (6-Methyl-2-(phenylethynyl)pyridine)3025961neuroprotection, proliferation, synaptic modulationmGluR5C619822193 PubChem
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Minoxidil sulfate4202viabilityReactive oxygen species, RhoA, PI3K, PKBA172, C614695207, 19027730, 23973310 Google
DWP0016 71660487viabilityHDACU251MG23297003 Google
PD1843526918454radiosensitivity, viabilityMEKSNB1930647839 PubChem
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Berberine2353apoptosis, cytotoxicityC619424587 PubChem
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Lactacystin6610292viabilityProteasomeC6, F98, mouse xenograft model16609837, 18539596, 19738049, 23569132 PubChem
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MAZ519839842proliferationC6, U251MG25268128 PubChem
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Pseudolaric acid B6393431apoptosisU87MG22778780 Google
Glutamate33032invasion, proliferationAMPAU87MG19997873 PubChem
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S3I-201252682proliferationSTAT3 inhibitorGS622, GS7219658181 PubChem
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Dronabinol (Delta9-THC)16078apoptosis, cannabidiol enhancer, proliferation, viabilityERK, Reactive oxygen speciesSF126, U251MG, U87MG17675107, 18339876, 20053780, 30597288 PubChem
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Hispidulin5281628apoptosis, proliferationAMPK, mTORprimary human glioma cells20698539 PubChem
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3-methylademine (3-MA)135398661autophagy, viabilityPI3KCD133+, U251MG19431142, 19566920, 19575007 PubChem
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Galunisertib10090485TGFbeta receptor I kinase24868575, 25424852, 25529192, 26902851NCT01220271, NCT01582269 PubChem
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Ribociclib44631912CDK4, CDK628351928NCT02345824, NCT02933736, NCT03355794, NCT03434262, NCT03834740 PubChem
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O(6)-benzylguanine4578apoptosisMGMTU87MG18812520NCT00002971, NCT00003348, NCT00003567, NCT00004892, NCT00005081, NCT00006474, NCT00017147, NCT00046878, NCT00253487, NCT00362921, NCT00436436, NCT00612989, NCT00613093, NCT00669669, NCT01269424 PubChem
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Convallatoxin441852proliferationprimary human glioma cells23165409 PubChem
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Methyl gallate7428viabilityC6, U37323562553 PubChem
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Tandutinib3038522Multiple kinasesmouse xenograft model, transgenic mouse model22146535, 23638177NCT00379080, NCT00667394 PubChem
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1-Methyl-L-tryptophan676159proliferation, suppression of enzyme activityIndoleamine-2,3-dioxygenase (IDO)LN22919199463 PubChem
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Karenitecin148202radiosensitizationTopoisomeRASeMO59K, T98G28111642NCT00014521 PubChem
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Irinotecan60838migration, viabilityTopoisomeRASe 1A172, C6, LN443, U118, U251MG, U87MG18784279, 19557511, 20415520, 24433351, 26830091, 3098943621744079, 29245310NCT00003301, NCT00003463, NCT00003484, NCT00005951, NCT00006025, NCT00010036, NCT00027612, NCT00039468, NCT00099125, NCT00132158, NCT00268359, NCT00345163, NCT00352521, NCT00412542, NCT00433381, NCT00463073, NCT00562419, NCT00597402, NCT00611728, NCT00612638, NCT00616005, NCT00671801, NCT00734682, NCT00762255, NCT00817284, NCT00967330, NCT00979017, NCT00984438, NCT01017653, NCT01022918, NCT01086345, NCT01308632, NCT01837862, NCT01999270, NCT02055196, NCT02192359, NCT03119064, NCT03607643, NCT03678883 PubChem
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AKBA11168203apoptosis, cell cycle arrest, invasion, migration, proliferationp21, FOXM1, cyclin B1, Aurora B kinase, TOP2AU251MG, U87MG29970196 PubChem
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Tolbutamide 5505proliferationCx43C611741589, 15781061, 16718685, 19176641 PubChem
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Lanatoside C3879viabilityU87MG21184646, 27029345 PubChem
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Monensin441145proliferation, viabilityprimary human glioma cells, U87MG23165409, 27029345 PubChem
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Osajin95168cytotoxicityU87MG30836216 PubChem
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SH-516760282radiosensitivityAktU87MG19828040 PubChem
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Dorsomorphin11524144viabilityA172, T98G, U87MG19428322, 24419061 PubChem
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Z-VAD (OMe)-FMK5497174apoptosisNOS, BCL2CGNH-89, CGNH-NM, CRTMG19748528, 24678780 PubChem
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Elemene6918391cell cycle arrestC618346382 PubChem
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Cyclophosphamide2907DNA crosslinking15022289, 15735920NCT00003185, NCT00008008, NCT00014573, NCT00047281, NCT00990496, NCT01174121, NCT01403285, NCT01454596, NCT01903330, NCT02502708, NCT02844062, NCT02937844, NCT03152318, NCT03412877, NCT04049669, NCT04102436 PubChem
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Paxilline105008apoptosisDR5, CHOP, GADD153, cFLIPsU251MG, U251MGN, U343, U87MG21150246 PubChem
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Ginsenoside RG39918693proliferation, viabilityWnt, beta-catenin, MGMTT98G, U11830431207 PubChem
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DPI (Diphenyleneiodonium chloride)2733504migration/invasionNADPHU87MG19804834 PubChem
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172889-27-94878radiosensitizationSrc family kinaseT98G, U251MG26044161 PubChem
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Z-IETD-fmk25108681Casp8, RIPU343MG19432816 Google
Kainic acid10255viabilityAMPK, NFkappaBC618445478 PubChem
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A93957224905400proliferation, proliferation inhibition, viabilitySCD1T98GR, U87MGR29354058 PubChem
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Bosutinib5328940viabilitySrc family kinase, AktLN229, primary human glioma cells, U87MG3021969625290090, 25411098NCT00959946, NCT01331291 PubChem
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DB-07497177068345proliferationSurvivinA172, LN18, LN229, LNZ308, LNZ428, T98G, U37323325792 Google
487020-03-11936439PBKmouse xenograft model, primary human glioma cells26081429 PubChem
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VPC3218344392752viabilityLPA(1), LPA(3) C618481020 Google
Azacitidine9444apoptosis, migration, viabilityCD31, PDGFRbetaprimary glioblastoma cells, U373MG, U87MG18679414, 29427211NCT02223052, NCT02711137, NCT03684811 PubChem
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Carvedilol 2585apoptosis, proliferationBrDULI, cAMPC620198329NCT03861598, NCT03980249 PubChem
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Arginyl-glycyl-aspartic acid104802migrationPKB phosphorylationglioblastoma stem-like cells30280197 PubChem
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ES9364470790resistance, sensitivityNQO1SF268, U87MG19244114 PubChem
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6-HYDROXYQUINOLINE-4-CARBOXYLIC ACID71363454Proteasome4C8, mouse model26645398 Google
AT101 (Gossypol acetate)227456apoptosisBax, BCL2, BclxLLN22929858681 PubChem
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Diclofenac3033migration, proliferationA172, HTZ349, U87MG26485029 PubChem
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Fluvastatin446155proliferationprimary human glioma cells23165409 PubChem
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Ortataxel691841230726533NCT01989884 PubChem
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Isofuranodiene636458apoptosis, cell cycle arrest, cytotoxic effectT98G, U251MG, U87MG30599912
Gramicidin S 73357proliferationGBM6, U87MG29750582 PubChem
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SU66565312137invasionSrc family kinaseU251MG15561776 PubChem
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Forskolin47936proliferationAdenylate cyclase, Hedgehog (Hh) signalingA172, C62B, NB19, U87MG18719351, 20015475, 21472212, 24649161, 6199388, 9484714 PubChem
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LLnL4332apoptosis, cell cycleCOX2, IL-1beta, TNFalpha, IL6, iNOS, p27, TRIAL, NBV2, primary human glioblastoma cells10411338, 15504253, 19748528 PubChem
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Epirubicin41867proliferation, viabilityDNA intercalationA172, LN443, primary human glioma cells, U118, U87MG23165409, 24433351, 28963609 PubChem
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JS-K9572720mouse xenograft model, U87MG23370169, 28653883 PubChem
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2-Hydroxyoleic acid9796304viability1321N1, SF767, U11823133576, 23471028NCT03867123 PubChem
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Nimustine91657apoptosis, rapamycin enhancer, viabilitymTORU251MG17390104, 18614215 PubChem
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Tnp-470369976angiogenesis9L27542173, 8615672 PubChem
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Morphine5288826proteasome-mediated EAAC1 degradationEAAC1C6, U87MG18539596 PubChem
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Crizotinib11626560prolifiration, viabilitycMETA172, LN18, mouse xenograft model, U373, U87MG23556031, 26517812, 29803091, 30201763NCT01441388, NCT02270034 PubChem
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Theobromine5429proliferationPDEsU87MG24547961 PubChem
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Combretastatin A-45351344apoptosisMicrotubulesT98G30268825 PubChem
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S-Adenosyl-L-homocysteine 439155proliferationMMP2, ERK, PI3K, AktBV2, C619770485 PubChem
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Isolinderalactone5318587apoptosis, DNA damage, proliferation, viabilityBCL2, survivin, XIAP, PARP, Casp3, TUNELglioblastoma xenograft mouse model, U87MG30503550 PubChem
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Iripallidal14335632viabilityA172, LN229, T98G, U87MG20576128 PubChem
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Antroquinonol24875259C6, mouse model26517117 PubChem
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Spironolactone5833apoptosis, proliferation, suppress DNA damage repairEGFR-TKImouse xenograft model, patient derived cell lines GS-Y0131614999 PubChem
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Fluvoxamine5324346mouse model26988603 PubChem
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Riluzole5070proliferationMEK, ERK, CREBC6, U87MG16524382, 21295555, 23724064, 30591460 PubChem
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Reversan229870626136652 PubChem
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Patulin4696proliferationprimary human glioma cells23165409 PubChem
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Pitavastatin5282452radiosensitization, viabilityNFkappaBA172, LN443, U118, U87MG19046042, 24433351 PubChem
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Omacetaxine3628viabilityLN443, U118, U87MG24433351 PubChem
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Evofosfamide11984561DNA crosslinking29415215NCT02342379 PubChem
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Sanguinarine5154viabilityU118MG, U87MG26472194 PubChem
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MRK00315953832proliferationGamma secretaseHSRGBM1, JHH520, orthotopic mouse model, primary human glima cells, U251MG, U87MG23630166, 25293440, 25920606, 26613556 PubChem
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Linifanib11485656apoptosisVEGFR2, PDGFRbeta, Receptor tyrosine kinasemurine glioma models, orthotopic rat model16648571, 22080168 PubChem
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PI-54011669062proliferationmTORU87MG19584227 PubChem
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Carmustine2578viabilityDNA alkylation9L, rat models, U87MG19408974, 30605703, 3060651719770758, 24958095, 7013978NCT00002545, NCT00003176, NCT00003348, NCT00003417, NCT00003463, NCT00003484, NCT00003567, NCT00003788, NCT00003876, NCT00003996, NCT00004028, NCT00004688, NCT00004892, NCT00005081, NCT00005637, NCT00005855, NCT00006386, NCT00006656, NCT00009854, NCT00014573, NCT00017147, NCT00027612, NCT00046878, NCT00068952, NCT00076986, NCT00086879, NCT00362921, NCT00548938, NCT00574964, NCT00669669, NCT00761280, NCT00795665, NCT00814593, NCT00984438, NCT01186406, NCT01310868, NCT01656980, NCT02348255, NCT03722355 PubChem
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A-44365410172943apoptosis, proliferation inhibitionAkt1028S, U87MG19208828 PubChem
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Gadodiamide (Omniscan)24847884co-convection, cytotoxicity, efficacy, lack of toxicity, positive tissue pharmacokineticsU87MG rat xenograft model19466380 PubChem
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Clofazimine2794viabilityA172, LN443, U118, U87MG24433351 PubChem
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Isoflurane3763apoptosis, proliferationEAAT3, PKC, PI3KC614639147 PubChem
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Tivozanib9911830invasion, proliferationVEGFRA172, T98G, U87MG28287096NCT01846871 PubChem
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Cucurbitacin B5281316invasion, proliferationCIP2A, PP2A, Akt, JNK, JUNDBTRG05MG, LN229, T98G, U118MG, U251MG, U87MG18561312, 29393542 PubChem
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BT#9 (N-Carbamimidoyl-4-[(E)-(3-ethyl-2,4,4-trimethylcyclohex-2-en-1-ylidene)methyl]benzamide)137630099apoptosis, invasion, migration, proliferation, respirationMagmas D54MG, GL261 xenografts, U118MG, U251MG, U87MG30414099
Rottlerin5281847proliferationSNB19, U251MG18778746, 19965895, 27626499 PubChem
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Triptolide107985viabilityA172, LN443, U118, U87MG24433351 PubChem
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Capsaicin1548943apoptosisDR5 SNU444, T98G, U251MG, U251MGN, U343, U87MG19939880 PubChem
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Tigecycline54686904apoptosis, proliferationHES1, PI3K, AktU87MG26823491 PubChem
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Dasatinib3062316proliferationSrc family kinase, BcrAbl, cKITLN229, orthotopic mouse model, primary human glioblastoma cells, U87MG19098899, 19190119, 19318569, 19690143, 20226597, 3021969622407177, 25758746NCT00423735, NCT00609999, NCT00869401, NCT00892177, NCT00895960, NCT00948389 PubChem
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Isobutylmethylxanthine3758proliferation, viabilityPDEA172, U87MG22227470, 9484714 PubChem
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AEE78810297043apoptosis, proliferationmTOR, EGFR/HER2D5MG, LN1815657358, 19033391, 19199503NCT00107237, NCT00116376 PubChem
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Temsirolimus6918289mTORT98G, U251MG2674824115998902, 16012795, 23099651, 23564811, 24470557NCT00016328, NCT00022724, NCT00112736, NCT00316849, NCT00329719, NCT00335764, NCT00784914, NCT00800917, NCT01019434, NCT01051557, NCT01183663, NCT02238496, NCT03158389 PubChem
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Evodiamine442088mouse model, U87MG28514905 PubChem
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AZD1152-HQPA16007391proliferationAurora B kinasemouse xenograft model, T98G, U118, U251MG, U37322382783 PubChem
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Huperzine A854026viabilityNFkappaB, iNOS, COX2, NOC617257593 PubChem
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Glycyrrhizin14982Toll like receptor 2 (TLR2) GL26, GL26119143470 PubChem
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Erlotinib176870apoptosis, proliferationEGFRBS153, C6, DKMG, LN229, primary human glioma cells, SF188, U87MG17804702, 18955445, 19301967, 19737945, 20456371, 26032687, 27546621, 30219696, 3098943619562254, 19770758, 20615922, 20716591, 22407177, 24470557, 24637230NCT00030498, NCT00039494, NCT00045110, NCT00054496, NCT00086879, NCT00112736, NCT00124657, NCT00227032, NCT00274833, NCT00301418, NCT00335764, NCT00337883, NCT00387894, NCT00445588, NCT00509431, NCT00609999, NCT00671970, NCT00672243, NCT00720356, NCT01103375, NCT01110876, NCT01257594 PubChem
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Diazepinomicin9868980RAS22048878NCT00730262 PubChem
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Vemurafenib42611257BRAF24725538 PubChem
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ZSTK47411647372proliferationPI3Kmouse spontanious GBM model, mouse xenograft model, U118, U87MG24297065, 27553832 PubChem
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Diclofenac sodium5018304proliferation15PGDH, cyclin D1, p21T98G, U118, U37318757412 PubChem
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Telomestatin443590viabilityGquadruplexesGBM146, GBM15726845351 PubChem
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bVAD-fmk25108682apoptosisPancaspase inhibitorU343MG19432816 Google
Flubendazole35802viabilityU87MG24433351 PubChem
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NMS-P71544556162radiosensitizationmouse xenograft model, U251MG25722303 PubChem
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Atorvastatin60823proliferation, viabilityHMGCoA reductaseA172, LN229, primary human glioma cells, T98G, U138, U373, U87MG20009104, 23165409, 28181188NCT02029573 PubChem
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Naringenin 932invasion, migration, proliferation, viabilityMMP2, MMP9, ERKGBM8401, GBM890130431227 PubChem
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Veliparib11960529radiosensitization, temozolomide enhancerPARPLN18, orthotopic mouse model, primary human glioma cells, T98G, U251MG, U87MG19174557, 23510353, 28314386NCT00770471, NCT01026493, NCT01514201, NCT02152982, NCT03581292 PubChem
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Moxifloxacin 152946apoptosis, proliferation, viabilityGSH, DNA intercalation, Casp3, Casp7U87MG30086267 PubChem
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Actinonin443600angiogenesisN, CD13U87MG19264392 PubChem
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Panobinostat6918837proliferationHDACprimary human glioma cells, stemlike cells18445700, 30348136, 3051526221984064, 25572329, 26821711NCT00848523, NCT01115036 PubChem
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Gitoxigenin348482proliferationprimary human glioma cells23165409 PubChem
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Ciprofloxacin2764apoptosis, proliferation, viabilityGSH, DNA intercalation, Casp3, Casp7U87MG30086267 PubChem
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6-Bromo-5-nitroquinoline280563apoptosis, proliferationC630431695 PubChem
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Carnosol442009proliferationT98G, U343MG, U87MG26939786 PubChem
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ZM4474399914412proliferationAurora kinaseprimary human glioma cells, U251MG, U34322160182 PubChem
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NBQX3272524proliferationAMPAU87MG23724064 PubChem
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Disulfiram3117proliferationprimary human glioma cells23165409NCT01777919, NCT01907165, NCT02678975, NCT02715609, NCT02770378, NCT03151772, NCT03363659 PubChem
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Disufenton11603334angiogenesis, apoptosis, proliferation, temozolomide enhancer, viabilityTGF-beta1, IDO1, SUMO2, PFN1F98, human G55 GBM orthotopic xenograft model, IC3752GBM, orthotopic mouse model, rat model, U87MG23328810, 26248280, 30468988 PubChem
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Chaetocin11657687viabilityHistone lysine methyltransfeRASesC624905315 PubChem
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Salirasib5469318apoptosis, invasion, migration, proliferationRASLN229, U1242MG, U251MG, U373MG, U87MG16239932, 16985068, 17178866 PubChem
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NVX-2079960374proliferationLN229, U251MG, U343MG25361208 PubChem
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297157-92-72891837mouse xenograft model, XO827993939 PubChem
Neratinib9915743viabilityHER2, EGFRDBTRG05MG, orthotopic mouse model, SF268, SKMG318765999, 26023796NCT02977780 PubChem
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Pomolic acid382831migration, viabilityReactive oxygen species28849227 PubChem
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Bortezomib387447proliferation, temozolomide enhancerProteasomeD54MG, mouse xenograft model, primary human glioma cells, T98G, U118, U251MG, U87MG17201170, 17545549, 18445700, 18625341, 18771084, 19190249, 19213072, 20192117, 23334228, 24093630, 24297065, 29750582, 3087568819084346, 19770758NCT00006773, NCT00544284, NCT00611325, NCT00641706, NCT00998010, NCT01435395, NCT03607643, NCT03643549 PubChem
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Cantharidine5944proliferationGBM6, U87MG29750582 PubChem
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2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid115288apoptosis, proliferationLAT1A1207, C6, nude mice xenografts, U178MG, U87MG18382329, 18520037 PubChem
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Dactinomycin457193proliferation, viabilityA172, LN443, primary human glioma cells, U118, U87MG23165409, 24433351 PubChem
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Sonidegib24775005viabilitySmoothened, Gli1, Gli2, Patched1, Patched2primary human glioma cells23482671, 30251117NCT01576666, NCT03434262 PubChem
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1616632-77-973777259viabilityGBM152, GBM18, GBM67R, GBM8, T98G26474387, 28767654NCT02038699, NCT02525692 PubChem
Ivermectin 6321424apoptosisAkt, mTORT98G, U87MG, xenograft mouse models27771251 PubChem
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Peruvoside12314120proliferationprimary human glioma cells23165409 PubChem
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Mangostin5281650autophagy, viabilityAMPKDBTRG05MG, GBM840121314123 PubChem
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Idoxuridine5905proliferation, radiosensitizationC6, rat glioma model30170108 PubChem
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NU744111327430radiosensitivityDNA-PK inhibitor, NHEJU87MG19770758 PubChem
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SSR128129E68853159radiosensitizationFGFRSF763, U87MG24953334 PubChem
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Rotenone6758apoptosisMitochondrial respiratory chain complex I DAOY19633536 PubChem
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OTX-0159936746BETorthotopic mouse model, U87MG27388964, 29764852, 30515262NCT02296476 PubChem
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KT5720454202mRNA synthesis inhibitionPKA, H1RU373, U87MG18498711, 20015475 PubChem
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BMS-536924135440466IGF1R, IRM059K, mouse model25897243 PubChem
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Fotemustine104799DNA alkylation27165580NCT01474239 PubChem
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NHI 1779302apoptosis, cell cycle arrest, proliferation, viabilityLDHAU87MG26494310 Google
4506-66-578260migration, proliferationFAK DBTRG, orthotopic mouse model, T98G, U118MG, U87MG23243059, 23387973, 26883759 PubChem
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CX6146451148viabilityAMPARU87MG29277782 PubChem
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Erdafitinib67462786FGFR26324363 PubChem
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Hispolon53395354, 10082188apoptosis, cell cycle arrest, viabilityCDK, p21, p53U87MG28618133 PubChem
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ML00253764 9842665proliferationMelanocortin receptor428791594 PubChem
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Juglone 3806proliferationU251MG18697955, 28388894, 28791366 PubChem
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Ritonavir392622proliferationHu197, U87MG28319810NCT01095094, NCT02770378 PubChem
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Carnosine 439224proliferationLDHAprimary human glioma cells, T98G19909581 PubChem
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Imipramine 3696apoptosis, autophagyPI3K, Akt, mTORT98G, U87MG21889492, 26412325, 28500556 PubChem
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Nicardipine4474apoptosisABCG2CD133+19340456 PubChem
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Radicicol6323491migrationACLY, Hsp90LN229, SF268, U87MG19244114, 19795461 PubChem
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Carbenoxolone636403GAPC619360884 PubChem
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KP210537176apoptosis, proliferationPI3K, AktU251MG, U87MG16546978 Google
Dovitinib135398510proliferationMultiple kinasesprimary human glioma cells2850078627100354NCT01753713, NCT01972750 PubChem
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Aclidinium bromide11519741apoptosis, invasion, migration, proliferationLong-acting muscarinic antagonist (LAMA)U251, U8729940755 PubChem
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Dermaseptin-PS116130489apoptosis, proliferationBax, BCL2, LDHU251MG30461197 Google
Bimiralisib58507717proliferationPI3K, mTORxenograft model in nude rats and mice28829592, 31618458NCT02850744 PubChem
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Idebenone3686apoptosis, cell cycle arrest, migration, proliferation, temozolomide and oxaliplatin enhancer, viabilityp21, Casp3U373 MG, U87MG30602587 PubChem
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Alendronate2088proliferation, viabilityFDPSprimary human glioma cells28646347, 30333528 PubChem
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STA-21363709proliferationSTAT3 inhibitorGS622, GS7219658181 PubChem
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Buparlisib16654980proliferation, radiosensitizationPI3KLN18, LN229, LNZ308, mouse xenograft model, primary human glioma cells, T98G, U1242, U251MG, U373MG, U87MG22065080, 24500492, 24741074, 24900266, 25431423, 26846842, 27283525, 27363276, 3001838730715997NCT01339052, NCT01349660, NCT01473901, NCT01576666, NCT01870726, NCT01934361 PubChem
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Birinapant49836020viabilityIAPprimary human glioma cells26657652 PubChem
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Asiatic acid119034apoptosis, necrosisCalcium signalingU87MG16897440 PubChem
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Selinexor71481097proliferation, viabilityCRM1, XPO1 AGBM1, BT145, BT159, BT172, LN229, orthotopic mouse model, primary human glioma cells, T98G, U87MG25366336, 30337641NCT01607905, NCT01986348, NCT02323880 PubChem
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Selenium6326970apoptosis, viabilityDBTRG30796690 PubChem
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Clioquinol2788viabilityU87MG26725099 PubChem
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Mycophenolic acid446541cell cycle arrestGFAP, guanine nucleotide biosynthesisC6, U251MG3304619 PubChem
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Lopinavir 92727ritonavir enhancer20683757NCT01095094 PubChem
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Arctigenin64981proliferationT98G, U87MG28356992 PubChem
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GM6001132519migration, survivalMMP, ADAMLN229, U373, U87MG19220854, 19690139 PubChem
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Capmatinib25145656cMETmouse xenograft model, U87MG21918175NCT01324479, NCT01870726, NCT02386826 PubChem
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Triacsin c9576787apoptosisACS (AcylCoA synthetase) inhibitorSF268, U251MG19459852 Google
8-Hydroxy-2-methyl-1H-quinazolin-4-one135398517radiosensitizationPARP1D54, U251MG25182801 PubChem
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STF-62247704473apoptosismTORC1MZ5430250198 PubChem
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Carvacrol10364proliferation, viabilityU251MG25913706 PubChem
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Thalidomide542625239666, 25427949NCT00006358, NCT00014443, NCT00039468, NCT00047281, NCT00047294, NCT00049296, NCT00079092, NCT00112502, NCT00412542, NCT00521482 PubChem
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LGK97446926973proliferation, temozolomide enhancerporcupine, ALDH3A1GBM1, GBM10, JHH520, LN229, SF18826222502, 29854309 PubChem
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Daunorubicin30323proliferationprimary human glioma cells23165409 PubChem
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CKD 602123773277apoptosis, proliferation, viabilityTopoisomeRASeLN229, U251MG, U343MG, U87MG19424618 Google
Calphostin C 2533viabilityPKCU251MG, U87MG19502590, 19724676, 19965895 PubChem
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CA074 methyl ester6610318apoptosis, proliferationCatB, Clik148BV2, U87MG19748528, 20302512 PubChem
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Fenofibrate3339proliferationPPARalphaT98G, U251MG, U343, U87MG18546270, 24493576, 25566967 PubChem
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MK-220624964624proliferationAktLN229, U87MG19828040, 22057914, 28320338, 29354058NCT01295632 PubChem
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Silmitasertib24748573CK2, IRF342MGBA, E98, GBM8, GL261, mouse xenograft model, T98G, U251MG, U3013MG, U3017MG, U3024MG, U3031MG, U3054MG, U3084MG, U3086MG, U3117MG, U87MG24036851, 28208677, 28683323 PubChem
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Theophylline2153viabilityPDEA172, U87MG22227470 PubChem
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Palomid 52911998575mTORorthotopic mouse model, U87MG23436212 PubChem
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Phospho-valproic acid (MDC-1112)129866270proliferationSTAT3intracranial xenograft model, LN18, LN229, subcutaneous GBM xenografts in mice, U118, U87MG30994173 Google
?/??Thujone91456angiogenesis, apoptosis, proliferation, viabilityVEGF, Ang-4, CD31C6, U87MG26900077 PubChem
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Navitoclax24978538proliferation, viabilityBCL2, BclxL, BCLw, BH3mimeticKNS42, LN229, SF188, T98G, U87MG24757258, 26474387, 29016820, 30337641 PubChem
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Terameprocol476861angiogenesis, apoptosis, cell cycle arrest, proliferationSP1, cyclindependent kinase 1, survivin, VEGFprimary human glioma cells, SF188, T98G, U251MG, U34318311658, 2329939022323663NCT00404248 PubChem
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Chloramphenicol5959proliferationALDHU87MG15777731, 19500061 PubChem
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XL76549867926PI3K, mTORmouse xenograft model2131720826019185NCT00704080, NCT01240460 PubChem
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Lovastatin53232proliferationHMGCoA reductaseU343, U87MG18566746, 25497898 PubChem
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Phenethyl Isothiocyanate 16741apoptosis, proliferationMCL1, XIAPGBM 8401, xenograft model of glioblastoma in nude mice25582659, 30201893 PubChem
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GSK1904529A25124816IGF1Rmouse model, U87MG26035416 PubChem
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Oroxindin3084961viabilityA172, SHG44, U251MG, U87MG24970553 PubChem
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Gedatolisib44516953viabilityPI3K, mTORLN229, mouse xenograft model, U251MG, U373, U87MG21325073, 24658109 PubChem
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Akt Inhibitor IV5719375proliferation inhibitionAkt1028S, U87MG19208828 Google
Pregnenolone8955viabilityC6, LN18, U87MG25013479 PubChem
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Silibinin31553apoptosis, autophagy, proliferation, viabilityCa2+, ROS, MAPK, mTOR, YAP.A172, LN229, U87MG19263218, 21501525, 25750273, 29780826 PubChem
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Proguanil6178111viabilityCLIC1GBM1, GBM2, GBM3, GBM4, GBM5, GBM6, GBM730186163 PubChem
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Isoliquiritigenin638278viabilityTopoisomeRASeU87MG23229626, 26722447 PubChem
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Cabazitaxel9854073viabilityMicrotubulesT98G, U87MG27203678, 29369439NCT01740570, NCT01866449 PubChem
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Zafirlukast5717invasion, migrationCysLT (cysteinyl leukotriene receptor)A172, U37328600709 PubChem
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Ponatinib24826799viabilitySrc family kinase, Abl, VEGFR2, FGFR1LN229, mouse xenograft model, U87MG25378936, 30219696, 30705592NCT02478164 PubChem
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Prochlorperazine4917viabilityU87MG29441946 PubChem
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L-NAME39836migrationNitric oxide synthases (NOS)T98G, U87MG19629394 PubChem
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Dinaciclib46926350proliferationCDK1, CDK2, CDK5, CDK9A172, LN18, LNZ308, T98G, U373, U87MG26585571 PubChem
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Ascochlorin11258227invasion, migrationA172, U373MG28569433 PubChem
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Sildenafil135398744proliferation, viabilityPDE5 rat brain tumor models18674521NCT01817751 PubChem
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3-BrOP11513992viabilityprimaru human glioma cells23132831 PubChem
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UNC202573425588MER, FLT3A172, orthotopic mouse model, SF188, U251MG27783662, 28605477 PubChem
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Iniparib979606826285766NCT00687765 PubChem
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Thymoquinone10281proliferationT98G, U87MG24039814, 29651429, 30197342 PubChem
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Fluphenazine3372apoptosis, proliferation, viabilityCasp3C6, glioblastoma stem-like cells14997012, 26196249 PubChem
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YZ129137628683apoptosis, cell cycle arrest, migration, proliferationHsp90, PI3K, AKT, mTORU87MG3063926130639261 Google
Prazosin4893viabilityPRKCDorthotopic mouse model, primary human glioma cells27138566 PubChem
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Ciglitazone2750viabilityPPARgammaC6, U251MG14699130 PubChem
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GSK1838705A25182616IGF1Rmouse xenograft model, U87MG26238593 PubChem
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Cidofovir60613angiogenesis, survivalCytomegalovirus (CMV)MCMV+ mice30855281 PubChem
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Lithium3028194apoptosis, migration, viabilityGSK3, PIMTprimary human glioma cells, U251MG, U373, U87MG18582478, 18715951, 28359080 PubChem
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Ellagic Acid5281855apoptosis, Bevacizumab enhancerMGMTC631518741 PubChem
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Graphene oxide124202900apoptosis, proliferation, viabilitySTAT inhibitor, Wnt and Notch signalingU118, U87MG25708684, 25759581, 30544611, 30602369 Google