GBM Drug Bank

Drugs for Glioblastoma

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Compound Mode of Action (target)


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CompoundPubChem CIDReported EffectMoAPMIDClinical PMIDClinical Trials
Ceritinib57379345NCT02605746
8-Bromo-cyclic AMP32014proliferation24649161, 9484714
Ardipusilloside I197641proliferation24984215
Gedatolisib44516953viabilityPI3K, mTOR24658109
3-Deazaneplanocin73087viabilityHDAC24905315
Pyrazolanthrone8515viabilityJNK23210245
GDC-008457384863orthotopic mouse modelPI3K, mTOR27638506NCT01547546
LB-100 45101433mouse xenograft model, radiosenitisationPP2A25939762NCT03027388
Honokiol72303mouse xenograft model, viability25106108, 25763821, 27064011
Methotrexate126941proliferationDHFR2316540915735920NCT00082797, NCT00463008
BMS-77760724794418mouse xenograft modelAXL26848524
Vincristine5978orthotopic mouse model, proliferationmicrotubule23165409, 24433351, 2838662120855843, 225004NCT00052455, NCT01837862
Pazopanib10113978tyrosine kinase20200024, 23363814NCT00350727, NCT00459381, NCT01392352, NCT01931098, NCT02331498, NCT03275558
Dabrafenib44462760BRAF26680369, 29039591, 29295876NCT02684058
Dorsomorphin11524144viability24419061
Genistein5280961viability19894226
Irinotecan60838migration, viabilitytopoisomerase 124433351, 2683009129245310NCT00003301, NCT00003463, NCT00003484, NCT00005951, NCT00006025, NCT00010036, NCT00027612, NCT00039468, NCT00099125, NCT00132158, NCT00345163, NCT00352521, NCT00412542, NCT00433381, NCT00463073, NCT00562419, NCT00597402, NCT00611728, NCT00612638, NCT00616005, NCT00671801, NCT00734682, NCT00762255, NCT00817284, NCT00967330, NCT00979017, NCT00984438, NCT01017653, NCT01022918, NCT01308632, NCT01837862, NCT01999270, NCT02369367, NCT03119064
Indatraline126280mobilitymonoamine transporter24333442
Silmitasertib24748573mouse xenograft modelCK224036851
Fingolimod107969invasion, migration25070489
Flavopiridol5287969mouse model, radiosenitisationCDK23943501, 27461656, 28111642
Karenitecin148202radiosenitisationtopoisomerase28111642NCT00014521
Afatinib10184653mouse xenograft modeltyrosine kinase25444177NCT00977431, NCT02423525
Oxamate3017661radiosenitisationlactate dehydrogenase28756228
BMS-53692411353973mouse modelIGF-1R, IR25897243
Podofilox10607proliferation23165409
Pargyline4688proliferation23248157
Clioquinol2788viability26725099
Digitoxigenin4369270viability27029345
A-96649216666333radiosenitisationPARP28797568
Paclitaxel36314proliferation, viabilitymicrotubule23165409, 28962238NCT00019019, NCT00479765
Enasidenib89683805IDH2
Metformin4091proliferation24965413NCT01430351, NCT02780024, NCT03151772
Anthothecol21596360proliferation23165409
Strophanthidin6185proliferation23165409
carnosol442009proliferation26939786
Tandutinib3038522mouse xenograft model, transgenic mouse modelmultiple kinases22146535, 23638177
Pitavastatin5282452viability24433351
ON12330056649281proliferation24568969
Perilla alcohol10819proliferation25497898
Alisertib24771867mouse xenograft model, viabilityAurora A kinase24627220, 24879067, 25106428, 27797168, 29016820, 29396807
KU006379416736978viabilitymTOR22125077
9-ING-4144582816orthotopic mouse modelGlycogen Synthase Kinase-328672195
Caudatin72948694proliferation25860846
Homidium3624proliferation23165409
Celastrol122724mouse xenograft model18343027, 19909582, 24810052
Cisplatin84691viabilityDNA intercalation24218165, 24953561, 27993939
3-(3,4-dichlorophenyl)-1-(3,4-dimethylphenyl)-1-(5613034mouse xenograft modelmTORC228453552
Lovastatin53232proliferationHMG-CoA reductase25497898
CPI-45578426698viabilityhistone lysine demethylase28432280
Mitomycin5746proliferation23165409
Mibefradil60663rat model, viabilityT-type calcium channels23198803, 2328741228371832NCT01480050, NCT02202993
DB-07497177068345proliferationsurvivin23325792
Bortezomib387447mouse xenograft model, proliferationproteasome23334228, 24093630, 24297065NCT00006773, NCT00544284, NCT00611325, NCT00641706, NCT00998010, NCT01435395
PJ344858viabilityPARP25531448, 25576921
Dimethylaminomicheliolide54589107rat model25658946
MK-8863651377viabilityLipoxygenase 23261452
Lorlatinib71731823mouse modelALK, ROS125733882
Crenolanib10366136viabilityPDGFRalpha25380967NCT02626364
Vinorelbine5311497viability24433351
Bendamustine6562821626071, 28204914NCT00823797
PI-1039884685radiosenitisation, viabilityPI3K, mTOR16697955, 22125077, 24418474
Tetrandrine73078viability27909720
Vatalanib151194orthotopic mouse modelVEGFR15271251NCT00128700, NCT00387933
AZD201425262792radiosenitisationmTOR24311635NCT02619864
Gitoxin91540proliferation23165409
Tricetin5281701invasion, migration26245494
Tipifarnib159324farnesyl protein transferase18725460, 20934264, 28988377NCT00005859, NCT00049387, NCT00050986, NCT00058097, NCT00209989, NCT00335764, NCT02227901
Ascochlorin11258227invasion, migration28569433
Cordycepin6303orthotopic mouse model26597532, 28068557
Sevoflurane5206invasion, migration27840895
Salvianolic acid B6451084viability23842993
Lonafarnib148195orthotopic mouse model, viabilityfarnesyl transferase2124639421735117, 23633392NCT00038493, NCT00083096, NCT00102648
Guggulsterone53394010viability23548480
BI253611364421orthotopic mouse model, viabilityPLK122415968, 23713868, 24204733
Fenofibrate3339proliferationPPARalpha24493576, 25566967
Convallatoxin441852proliferation23165409
CC-22358298316mTORNCT01177397
5-Nonyloxytryptamine1797viability24433351
SSR128129E68853159radiosenitisationFGFR24953334
Simvastatin54454proliferation23165409
Gamma-Secretase Inhibitor IX5311272proliferation, viabilitygamma-secretase23736154, 25063285
Shikonin479503proliferationtopoisomerase23840441, 24303074, 25688715, 25891245
Lenvatinib9823820mouse modelmultiple kinases28901423NCT01433991
2-Amino-3H-phenoxazin-3-one72725viability24008433
Everolimus6442177mTOR2537128923725999, 25526733NCT00085566, NCT00107237, NCT00387400, NCT00515086, NCT00553150, NCT01062399, NCT01434602, NCT01508104
Dasatinib3062316orthotopic mouse modelSrc1909889922407177, 25758746NCT00423735, NCT00609999, NCT00869401, NCT00895960, NCT00948389, NCT02661113
Volasertib10461508radiosenitisation, viabilityPLK124204733, 29535822
Vinpocetine443955proliferationPDE125620587
Sorafenib216239proliferation, radiosenitisationTyrosone protein kinase23324350, 24139873, 24911215, 24965413, 2754227321954442, 23099651, 23898124, 24786603, 28988377NCT00093613, NCT00329719, NCT00335764, NCT00445588, NCT00597493, NCT00734526, NCT00884416, NCT01183663, NCT01434602, NCT01441388, NCT01817751, NCT02599090
KPT25157519758viabilityCRM125366336
Infigratinib53235510FGFRNCT01975701
AC1MMYR23246569orthotopic mouse model, proliferation23811941
Hispolon53395354viability28618133
Piplartine637858migration24967005
MRK00392043122, 15953832orthotopic mouse model, proliferationgamma secretase23630166, 25293440, 25920606, 26613556
AMG-92560202647proliferationFLT3, CDK426585571
NSC141562422114invasion, migration, proliferationMIR155HG/miR-155 axis28371892
PD03259019826528mouse xenograft model, viabilityMEK22573716, 25431423
Oligomycin78358496viability23523615
Indirubin Derivative E8046419764proliferation26386687
LEQ50645100669smoothened
Sonidegib24775005viabilitysmoothened23482671NCT01576666
SF112666577114mouse xenograft modelPI3K25425962
JS-K9572720mouse xenograft model23370169, 28653883
Cryptotanshinone160254mouse xenograft model28492557
GW29746603857invastion, migration, viabilityEGFR, HER223115024
Dihydroartemisinin456410proliferation26722323
Pimozide16362orthotopic mouse modelUSP1 26032834
Sinomenine5459308mouse model28891980
Fingolimod107970mouse xenograft model, viability25070489, 25939952NCT02490930
Cyclophosphamide2907DNA crosslinking15022289, 15735920NCT00047281, NCT00990496, NCT01403285, NCT01903330
Sirolimus5284616mouse xenograft model, viabilitymTOR23261661, 24043497, 25886314NCT00047073, NCT00509431, NCT00672243, NCT00821080
Oxibendazole4622proliferation23165409
NCL-173755256orthotopic mouse model, proliferationKDM1A23248157, 27893719
Docetaxel148124viability24433351NCT00049296
Xanthohumol639665apoptosis22111577
Puromycin439530proliferation23165409
Germacrone6436348proliferation24889088
Tesevatinib10458325NCT02844439
Aurintricarboxylic acid2259invasion, migration28103571
Fucoxanthin5281239mouse xenograft model, proliferation27394418
Mepacrine237viability25490024, 27029345
WP113011222830apoptosis26872380
Chlorpromazine2726mouse xenograft model, orthotopic mouse model, viability23689352, 28455961
beta-Peltatin92122proliferation23165409
Propofol4943apoptosisReactive oxygen species28804952
Wortmannin312145proliferationPI3K23724064
Ponatinib24826799mouse xenograft model, viabilitytyrosine kinase25378936NCT02478164
Denbinobin10423984viability23123054
Trametinib11707110viabilityMEK2543142329295876NCT02684058
Acalabrutinib71226662tyrosine kinaseNCT02586857
Idarubicin42890viability24433351
Isotretinoin528237925239666NCT00003564, NCT00112502, NCT00555399, NCT01103375
NVP-AEW54111476171mouse xenograft modelIGF-1R21659463
Sanguinarine5154viability26472194
Digitonin6474107proliferation23165409
Iniparib979606826285766NCT00687765
CBL-013744519124orthotopic mouse model27370399
Transcrocetinate sodium10287099rat model18447715
Entrectinib25141092mouse modelTrk, ROS1, ALK28695888
297157-92-72891837mouse xenograft model27993939
Navitoclax24978538viabilityBcl-2, Bcl-xL, BCL-w 24757258, 26474387, 29016820
1616632-77-973777259viability26474387, 28767654NCT02038699, NCT02525692
Indomethacin3715viabilityCOX27988363
Antimycin A14957proliferation23165409
Gossypol3503viability25375271
Binimetinib10288191orthotopic mouse model, radiosenitisationMAP2K28958992
Flubendazole35802viability24433351
ML29853393916invasion, migrationPLD223445448
Camptothecin24360proliferation, viability23165409, 23736154, 27029345
Foretinib42642645mouse modelc-Met, VEGFR224658326
8-Hydroxy-2-methyl-1H-quinazolin-4-one63306radiosenitisationPARP-125182801
Vemurafenib42611257BRAF24725538
Oroxindin3084961viability24970553
Deoxyglucose108223radiosenitisationglycolysis 28756228
Golvatinib16118392c-Met, VEGFR2NCT01433991
Ribociclib44631912CDK4, CDK6NCT02345824, NCT02933736
Theophylline2153viabilityPDE22227470
Thymoquinone10281proliferation24039814
Melatonin896viability28255276
Salinomycin3085092apoptosis, mouse xenograft model, proliferation23165409, 28358414, 28498472
Fenbendazole3334proliferation23165409
GSK46136415983966mouse xenograft model, proliferationPLK123790466, 24204733
NKTR-1027130072725935109
AMG-51159548184mouse xenograft modelPI3K22897589
Dactinomycin457193proliferation, viability23165409, 24433351
Amlexanox2161proliferationIKBKE29048430
Dactolisib11977753orthotopic mouse mode, proliferation, radiosenitisationPI3K, mTOR19671762, 23603977, 24366691, 25431423, 26188279, 27542970, 27553832NCT01508104
Fludarabine657237proliferation23165409NCT00990496
Gefitinib123631proliferation, radiosenitisation, viabilityEGFR14643025, 23724064, 23736154, 24876095, 2536825523182702NCT00014170, NCT00016991, NCT00025675, NCT00027625, NCT00042991, NCT00052208, NCT00085566, NCT00132158, NCT00238797, NCT01310855
Repaglinide65981orthotopic mouse model28476618
Hypericin5281051viability2406606021456013
Digoxigenin15478proliferation, viability23165409, 27029345
GSK332659590241742NCT02783300
Disulfiram3117proliferation23165409NCT01777919, NCT01907165, NCT02678975, NCT02715609, NCT02770378, NCT03151772
Evodiamine442088mouse model28514905
Resveratrol445154mouse xenograft model23651583
Neratinib9915743orthotopic mouse model, viabilityHer2, EGFR26023796NCT02977780
PLX-472024180719orthotopic mouse modelBRAF26023796
2-Hydroxyoleic acid9796304viability23133576, 23471028
PX-8669849735mouse xenograft modelPI3K2015680325605819NCT01259869
Digoxin2724385proliferation, viability21184646, 23165409
Ancitabine25051proliferation23165409
R42846215462proliferationAXL25980499
AMG 23258573469
Dehydroxymethylepoxyquinomicin9881652mouse xenograft modelNFKB21968049
Carvacrol10364proliferation, viability25913706
Abemaciclib46220502mouse xenograft modelCDK4, CDK626149830NCT02977780, NCT02981940
JIB-046519698viabilityhistone lysine demethylase28432280
Gambogic acid5353639proliferation23165409
Marizomib11347535mouse xenograft model, viabilityproteasome26681765, 26804704
Palomid 52911998575orthotopic mouse modelmTOR23436212
Erdafitinib67462786FGFR
Quercetin5280343viability24379902, 24902789
Nobiletin72344proliferation23546290
Harmol68094viability23338618
Colchicine6167proliferation23165409
Thalidomide542625239666, 25427949NCT00006358, NCT00014443, NCT00039468, NCT00047281, NCT00047294, NCT00049296, NCT00079092, NCT00112502, NCT00412542, NCT00521482
602306-29-616747683proliferationCDK1, CKD2, CDK926585571
Bafetinib11387605tyrosine kinase23380277NCT01234740
Albendazole2082proliferation23165409
Erlotinib176870proliferationEGFR2603268722407177, 24470557, 24637230NCT00030498, NCT00039494, NCT00045110, NCT00054496, NCT00086879, NCT00112736, NCT00124657, NCT00187486, NCT00227032, NCT00274833, NCT00301418, NCT00335764, NCT00337883, NCT00387894, NCT00445588, NCT00509431, NCT00525525, NCT00609999, NCT00671970, NCT00672243, NCT00720356, NCT01103375, NCT01110876, NCT01257594
TGX-2219907093proliferationp110-beta29048665
Alexidine102678, 2090viability27029345
Hsp-99046216556, 16226182, 68275964apoptosis, mouse xenograft model, radiosenitisationHsp9023448094, 24500492
Prazosin4893orthotopic mouse model, viabilityPRKCD27138566
NCD-38102222767ortothopic mouse modelKDM1A27893719
Pamiparib71602594NCT03150862
AZD1152-HQPA16007391mouse xenograft model, proliferationAurora B22382783
Ibuprofen3672migration, proliferation26485029
Rucaparib9931954orthotopic mouse modelPARP26438157
Theobromine5429proliferationPDEs24547961
Disufenton sodium11603334rat model23328810
ZM4474399914412proliferationAurora kinase22160182
Tamoxifen2733526viabilityER25554223NCT00002608, NCT00006388, NCT00492687, NCT00541138
Selumetinib10127622mouse xenograft modelsMEK1, MEK220806365, 22573716
717906-29-111598628migration, proliferationFAK 26883759
Vinblastine13342proliferation23165409, 6690037
BDBM8669157340709proliferationACAT126252415
Vismodegib24776445NCT00980343, NCT03158389
Ridaforolimus11520894mTOR22037923NCT00087451, NCT01295632
XL76549867926mouse xenograft modelPI3K, mTOR2131720826019185NCT00704080, NCT01240460
Tocladesine100299apoptosis12449730
SH5-0772550504mouse xenograft model, viabilitySTAT326088127
Digitoxin441207proliferation, viability21184646, 23165409
Riluzole5070proliferation23724064
PF-0684000323063810
Carmustine2578DNA alkylation24958095, 7013978NCT00002545, NCT00003176, NCT00003348, NCT00003417, NCT00003463, NCT00003484, NCT00003788, NCT00003876, NCT00003996, NCT00004028, NCT00004688, NCT00004892, NCT00005081, NCT00005637, NCT00005855, NCT00006386, NCT00006656, NCT00009854, NCT00017147, NCT00027612, NCT00046878, NCT00068952, NCT00076986, NCT00086879, NCT00362921, NCT00548938, NCT00761280, NCT00795665, NCT00984438, NCT01186406, NCT01310868, NCT01656980
Cycloheximide6197proliferation21159181
Emetine10219proliferation23165409
YU238259121473004proliferationHDR26116172
Oroxylin A5320315viability25213258
MLN492416720766orthotopic mouse modelNEDD8-activating enzyme25904638
STX-01194253236mouse model, proliferationSTAT323612755, 24820265, 28716484
Vandetanib3081361mouse xenograft model, proliferationVEGFR, EGFR, RET-tyrosine kinase19622715, 20371720, 21095630, 2379985223099652NCT00441142, NCT00613223, NCT00821080, NCT00995007
Methyl gallate7428viability23562553
Fluvoxamine5324346mouse model26988603
Tpi-287118797983viabilityMicrotubule29396807
Nelfinavir6414324194293NCT00694837, NCT00915694, NCT01020292
PF-42924223661637viabilitySite-1 protease28645614
Vorinostat5311mouse model, radiosenitisation, viabilityhistone deacetylase17289901, 23962875, 25040548, 25275596, 26794465, 2786349019307505NCT00238303, NCT00555399, NCT00641706, NCT00762255, NCT01110876, NCT01266031, NCT01342757, NCT01378481, NCT01738646
LY2940023973proliferationPI3K22086271, 25425962
UNC202573425588orthotopic mouse modelMER, FLT327783662, 28605477
Sertraline68617viability24433351NCT02770378
Embelin3218viability23514760, 23545899
Xyloketal B10980896proliferation, viability25913706
THZ173602827orthotopic mouse modelCDK728504693
Tnp-470369976angiogenesis27542173
Artesunate105031radiosenitisation22560712
Tivozanib9911830invasion, proliferationVEGFR28287096NCT01846871
Isoliquiritigenin638278viabilitytopoisomerase23229626, 26722447
Vindesine40839viability24433351
GK92156682080orthotopic mouse modeltransglutaminase 228754668
7-Ethyl-10-hydroxycamptothecin104842viabilitytopoisomerase28963609
Caffeine2519migration, orthotopic mouse model25011614, 27260469
Dexanabinol107778NCT01654497
CUDC-10124756910proliferationEGFR, HDAC26032687
72926-24-02930014proliferationEg528965307
Epigallocathecin Gallate65064viability19894226
NVX-2079960374proliferation25361208
AEE78810297043proliferationmTOR15657358NCT00107237, NCT00116376
Capmatinib25145656mouse xenograft modelcMET21918175NCT01324479, NCT01870726, NCT02386826
Ouabain439501viability21184646
Arctigenin64981proliferation28356992
Juglone 3806proliferation28388894, 28791366
Monensin441145proliferation, viability23165409, 27029345
OTX-0159936746orthotopic mouse modelBET27388964NCT02296476
BAY 11-70825353431proliferationNFKB26137111
4506-66-578260migration, orthotopic mouse model, proliferationFAK 23243059, 26883759
Fotemustine104799DNA alkylation27165580NCT01474239
RapaLink-1121231411proliferationmTOR28292440
Pseudolaric acid B6393431apoptosis22778780
Cerivastatin446156viability24433351
LY3414959819927proliferation23724064
PD1730741401migration, proliferationFGFR19340397, 26883759
Cladribine20279viability24433351NCT00019071
Peruvoside12314120proliferation23165409
Casticin5315263viability23816816
Silibinin31553viability25750273
Abt-73711228183viabilityBcl-222393246
KU559335278396orthotopic mouse model, radiosenitisationATM25017126, 25205037
Valproic Acid3121radiosenitisation, viability23253698, 24348849, 25275596, 27802437, 2896223823523186
Niclosamide4477proliferation, viability23165409, 27029345
Galunisertib10090485TGFBR124868575, 25424852, 25529192, 26902851NCT01220271, NCT01582269
Temozolomide5394mouse model, viabilityalkylating agent23736154, 24647572, 27878252, 2799393915758009, 19506159, 19636006, 20855843, 20934264, 21735117, 22035272, 22291006, 22578793, 23633392, 23725999, 23898124, 24194293, 24637230, 25239666, 26285766NCT00003176, NCT00003464, NCT00004113, NCT00004200, NCT00005637, NCT00005951, NCT00006025, NCT00006353, NCT00006358, NCT00006474, NCT00014105, NCT00021307, NCT00027625, NCT00028795, NCT00038493, NCT00039494, NCT00047294, NCT00049387, NCT00050986, NCT00052455, NCT00068952, NCT00083096, NCT00085254, NCT00086879, NCT00089427, NCT00099125, NCT00102648, NCT00112502, NCT00128700, NCT00187486, NCT00200161, NCT00238277, NCT00253487, NCT00262730, NCT00274833, NCT00275067, NCT00304031, NCT00311857, NCT00335075, NCT00354068, NCT00365222, NCT00376103, NCT00385853, NCT00387400, NCT00390403, NCT00392171, NCT00394628, NCT00402116, NCT00431561, NCT00433381, NCT00436436, NCT00441142, NCT00458601, NCT00471653, NCT00481455, NCT00482677, NCT00486603, NCT00492687, NCT00498927, NCT00501891, NCT00504660, NCT00508456, NCT00516282, NCT00516607, NCT00521482, NCT00525525, NCT00544284, NCT00548938, NCT00553150, NCT00555399, NCT00575887, NCT00590681, NCT00597402, NCT00597493, NCT00610571, NCT00612339, NCT00612651, NCT00612989, NCT00613093, NCT00615186, NCT00616005, NCT00619112, NCT00643825, NCT00650923, NCT00657267, NCT00662506, NCT00686725, NCT00687765, NCT00689221, NCT00704080, NCT00720564, NCT00723827, NCT00725010, NCT00734526, NCT00756106, NCT00761280, NCT00768911, NCT00770471, NCT00813943, NCT00817284, NCT00820963, NCT00841555, NCT00869401, NCT00883298, NCT00904852, NCT00915694, NCT00941460, NCT00943826, NCT00960492, NCT00967330, NCT00977431, NCT00979017, NCT01004874, NCT01019434, NCT01022918, NCT01026493, NCT01044966, NCT01062399, NCT01102595, NCT01110876, NCT01115491, NCT01120639, NCT01149109, NCT01180816, NCT01186406, NCT01209442, NCT01220271, NCT01242566, NCT01285414, NCT01294735, NCT01342757, NCT01345370, NCT01390571, NCT01402063, NCT01430351, NCT01473901, NCT01478321, NCT01480050, NCT01480479, NCT01502241, NCT01517776, NCT01587144, NCT01700569, NCT01752491, NCT01765088, NCT01777919, NCT01790503, NCT01800695, NCT01830101, NCT01837862, NCT01860638, NCT01907165, NCT02029573, NCT02052648, NCT02092038, NCT02177578, NCT02209948, NCT02227901, NCT02315534, NCT02330991, NCT02337426, NCT02343406, NCT02344355, NCT02364206, NCT02378532, NCT02502708, NCT02573324, NCT02590263, NCT02599090, NCT02617589, NCT02655601, NCT02661282, NCT02667587, NCT02715609, NCT02761070, NCT02770378, NCT02781792, NCT02871843, NCT02898012, NCT02928575, NCT02977780, NCT03018288, NCT03119064, NCT03139916, NCT03149575, NCT03174197, NCT03213002, NCT03224104, NCT03243461, NCT03246113, NCT03291990
Buparlisib16654980mouse xenograft model, proliferation, radiosenitisationPI3K22065080, 24500492, 24741074, 24900266, 25431423, 26846842, 27283525, 27363276NCT01339052, NCT01349660, NCT01473901, NCT01576666, NCT01870726, NCT01934361
Visudyne5362420proliferation28790340
NSC23766409805viabilityRAC123736154
Oxaliplatin9887054mouse xenograft model, radiosenitisationDNA17383816, 18329790
Trichostatin444732viabilityHDAC23564772, 24905315
Cathepsin S Inhibitor16760355viabilityCathepsin S24875536
DWP0016 71660487viabilityHDAC23297003
PF838025265312proliferationAutotaxin23300119
Cabozantinib25102847mouse model, proliferationmultiple kinases21926191, 23484006NCT00704288, NCT00960492, NCT01068782, NCT02885324
Daunorubicin30323proliferation23165409
Mitoxantrone4212proliferation, viabilityTopoisomerase21184646, 23165409
Itraconazole55283viability24433351NCT02770378
Midazolam4192proliferation27629139
Dacomitinib11511120viabilityErbB24658109, 25939761NCT01112527, NCT01520870
trans-ACUB16038368proliferationsEH22382785
Imiquimod57469orthotopic mouse modeltoll-like receptor 721389872NCT01403285
Schizandrin B158103invasion, proliferation27977512
Romidepsin5352062proliferationhistone deacetylases15024582, 27685789NCT00085540
Diclofenac3033migration, proliferation26485029
Tetraethylammonium5413proliferation25700359
Axitinib6450551mouse modelVEGFR, PDGFR25213669, 27926485NCT01441388, NCT01508117, NCT01562197, NCT03275558, NCT03291314
781661-94-711178236apoptosis, migration, proliferationSurvivin22770110, 23325792, 25201484, 27805285
Reversan229870626136652
Cabazitaxel9854073viabilityMicrotubule27203678NCT01740570, NCT01866449
Lanatoside C3879viability21184646, 27029345
Pegdinetanib86278317orthotopic mouse modelVEGFR22287570625388940
Lys0170673567viability22566612
Cytarabine6253proliferation23165409NCT01044966
Forskolin47936proliferationadenylate cyclase24649161, 9484714
Crizotinib11626560mouse xenograft model, viability23556031, 26517812NCT00939770, NCT01441388, NCT02270034
Lenalidomide2163262689197518513880NCT00036894, NCT00165477, NCT00671801, NCT01183663, NCT02369367
Dovitinib9886808proliferationmultiple kinases2850078627100354NCT01753713, NCT01972750
1134156-31-225195348proliferationHsp70, Hsp9026185541
USL31156961879NCT02765165
Apatinib11315474tyrosine kinase29245310
LGK97446926973proliferationPORCN26222502
761437-28-99934347radiosenitisation, viabilityFAK 25625667
Altiratinib54576299mouse xenograft modelc-Met, TIE2, VEGFR226965451
Astemizole2247viability27029345
RG283356654642Temozolomide enhancerHDAC1, HDAC327632183
Thapsigargin446378viabilitySERCA27993939
Plumbagin10205proliferation, viability23165409, 25528634
Alvespimycin5288674radiosenitisationHsp9024418474
Cardamonin641785mouse model, proliferation26150336
GDC-094117755052mouse xenograft model, radiosenitisation, viabilityPI3K 23427298, 24757258, 28147244
Perifosine148177viabilityAkt, PI3K16103096, 24065522
Larotrectinib46188928NCT02576431
Terfenadine5405viability27029345
Carboplatin10339178DNA28534153NCT00005976, NCT00010036, NCT00014105, NCT00021307, NCT00352313, NCT00492687, NCT00541138, NCT00635557, NCT00650949, NCT00995007, NCT01317212, NCT01386710, NCT01837862, NCT01934361, NCT03149575
GSK J471729975proliferationJMJD328978140
Milciclib16718576proliferation23347136
Bosutinib5328940Src25290090, 25411098NCT00959946, NCT01331291
Procarbazine491520855843, 225004NCT00003293, NCT00003564, NCT00003788, NCT00004004, NCT00052455, NCT00079092, NCT01737346
Temsirolimus6918289mTOR2674824123099651, 23564811, 24470557NCT00016328, NCT00022724, NCT00112736, NCT00329719, NCT00335764, NCT00784914, NCT00800917, NCT01019434, NCT01183663, NCT03158389
LOXO-195129103609TRK tyrosine kinaseNCT03215511
Ibrutinib24821094mouse xenograft model, proliferationBruton's tyrosine kinase27564106, 28716053
Aldoxorubicin129636048mouse xenograft modelDNA intercalation25379024NCT02014844
ML29956593054invasion, migrationPLD1, PLD223445448
Captopril44093invasion8572589NCT02770378
Naringin442428invasion, migration26474590
Topotecan60700proliferation, radiosenitisation, viabilitytopoisomerase23165409, 24303074, 24433351, 28797568NCT00014443, NCT00541138, NCT00610571, NCT01004874, NCT01931098
Pomolic acid382831migration, viabilityReactive oxygen species28849227
Gartanin5281633proliferation27491646
Olanzapine4585mouse xenograft model, proliferation25338992
Luteolin5280445migration28927111
Pristimerin159516proliferation23165409
Fluvastatin446155proliferation23165409
LLP356935694viability23251006
Regorafenib11167602viability24911215NCT02926222
Ralimetinib11570805, 11539025mouse xenograft modelMAPK24356814
WP106611210478proliferationJAK23612755NCT01904123
Disufenton sodium6440181orthotopic mouse model, rat model23328810, 26248280
TG0216739650orthotopic mouse model, viability29254993NCT02942264, NCT03224104
Cilengitide176873proliferationintegrin19114005, 2258888317470857, 18981465, 20439646, 25163906, 26008604NCT00006093, NCT00085254, NCT00112866, NCT00679354, NCT00689221, NCT00813943, NCT00979862, NCT01044225, NCT01122888, NCT01124240, NCT01517776, NCT01782976
PP24225243800migration, proliferationmTORC1, mTORC226719046
RG711257406853mouse modelMDM2 26482041
10-Hydroxycamptothecin97226proliferation23165409
6-HYDROXYQUINOLINE-4-CARBOXYLIC ACID71363454mouse modelproteasome26645398
MK-220624964624proliferationAkt22057914, 28320338NCT01295632
4egi-15717952proliferationEIF4E26220902
Panobinostat6918837HDAC21984064, 25572329, 26821711NCT00848523, NCT01115036
Demethoxycurcumin5469424mouse xenograft model27757851
3-BrOP11513992viability23132831
Isobutylmethylxanthine3758proliferation, viabilityPDE22227470, 9484714
Doxorubicin31703proliferationDNA intercalation23165409, 24433351, 27029345, 27993939, 28612256NCT00002608, NCT00944801, NCT02758366
Lactacystin6610292mouse xenograft model, viabilityproteasome23569132
Gambogenic Acid10794070apoptosis21879332
GANT61421610viabilityGLI27894350
Etoposide36462proliferation23165409, 24953561NCT00003996, NCT00047281, NCT00612430, NCT00613028, NCT00613223
Triptolide107985viability24433351
Nisoldipine4499viability24433351
GW3965447905mouse xenograft model, proliferationLXR22059152
AZD148016659841orthotopic mouse model, proliferationJAK1, JAK222027691
Talampanel16450919636006, 20143438NCT00062504, NCT00064363, NCT00267592
Satraplatin6918220DNA
Eflornithine3009proliferationornithine decarboxylase25935110
VAL-08315942827mouse xenograft model, proliferation28216618NCT01478178, NCT02717962, NCT03050736, NCT03149575
Otx-00811953346viabilitygalectin-123978989
Fluorouracil3385viabilityNucleic Acid Synthesis24391839, 6690037NCT01183663
Ixazomib25183872proteasomeNCT02630030
Omacetaxine3628viability24433351
Birinapant49836020viabilityIAP26657652
Imatinib5291mouse model, viabilitymultiple kinases16274936, 23736154NCT00010049, NCT00039364, NCT00154375, NCT00171938, NCT00290771, NCT00354068, NCT00354913, NCT00387933, NCT00401024, NCT00615927
Tanespimycin6505803viabilityHsp9026185541, 28542269
NBQX3272524proliferationAMPA23724064
Clorgiline4380proliferationMAO A26871599
Glasdegib25166913smoothened
Enzastaurin176167proliferationPKCbeta1991340820124186, 22291006NCT00295815, NCT00402116, NCT00509821, NCT00516607, NCT00586508
Hydroxyurea3657RNR19904263NCT00019058, NCT00154375, NCT00290771, NCT00354913, NCT00387933, NCT00613054, NCT00613132, NCT00615927
AZD-745125115967
Lapatinib208908proliferationEGFR, HER22491121523363814NCT00095940, NCT00099060, NCT00107003, NCT00350727
UMI-77992586viabilityMcl-128337703
GSK1904529A25124816mouse modelIGF-1R26035416
AT1338711955716mouse xenograft model, zebrafish xenograft modelHsp9028679777
Palbociclib5330286mouse xenograft modelCDK4, CDK6624098593, 26149830, 26354993, 27370397, 28903422NCT02255461, NCT03158389
PCI-2478111749858proliferationHDAC25505847
PF-0469150225033539mouse xenograft modelPI3K, mTOR21750219
Trifluoperazine5566orthotopic mouse model, proliferation23165409, 28870216
AXL171772435mouse xenograft model, proliferationIGF-1R20150364, 23165409NCT01721577
T56-LIMKi9438169viabilityLIM kinase25593987
Bufalin 9547215viability28787697
JQ149871817proliferation, rat xenograft modelBET25056450, 27388964
Olaparib23725625viabilityPARP25531448, 25576921, 26794465NCT01390571
Atorvastatin60823proliferation, viabilityHMG-CoA reductase23165409, 28181188NCT02029573
CC-11558298318NCT01353625, NCT02977780
Scriptaid5186viabilityHDAC26032687
Sulfasalazine5359476proliferation, radiosenitisation25798841, 25937318, 28929335
Rolipram5092mouse xenograft model, proliferationPDE412432276, 17234775, 28202289
TG10120916722832proliferationJAK226283544
Telomestatin443590viabilityG-quadruplexes26845351
Oleuropein5281544invasion, proliferation27498673
Antroquinonol24875259mouse model26517117
Clofazimine2794viability24433351
487020-03-11936439mouse xenograft modelPBK26081429
Evofosfamide11984561DNA crosslinking29415215NCT02342379
Pregnenolone8955viability25013479
Patulin4696proliferation23165409
Ruxolitinib25126798JAK
Andrographolide5318517proliferation22634579
ZSTK47411647372mouse spontanious GBM model, mouse xenograft model, proliferationPI3K24297065, 27553832
Gitoxigenin348482proliferation23165409
Veliparib11960529orthotopic mouse model, radiosenitisationPARP23510353, 28314386NCT00770471, NCT01026493
Anisomycin253602viability21184646, 22684030, 23165409
Dinaciclib46926350proliferationCDK1, CDK2, CDK5, CDK926585571
Chloroquine2719radiosenitisation, viability25434381, 2764444217350410NCT00224978, NCT02378532, NCT02432417, NCT03243461
Cediranib9933475mouse xenograft model, viabilityVEGFR21095630, 25490024, 25676691, 2664539820458050, 23940216, 26008604NCT00305656, NCT00503204, NCT00662506, NCT00777153, NCT00979862, NCT01131234, NCT01310855
109511-58-23006531proliferationMEK1, MEK226748241
SKI II753704radiosenitisationSphK25255218, 28494176
Mebendazole4030orthotopic mouse model, proliferation23165409, 28386621NCT01729260, NCT01837862, NCT02644291
Glaucocalyxin A10471963proliferation24041957
Bibu 136146861539apoptosisEGFR22753156
SH-4-5472188643orthotopic mouse model, proliferationSTAT324900612
Curcumin969516proliferation26046466
Nilotinib644241
172889-27-94878radiosenitisationSrc26044161
Linifanib11485656orthotopic rat modelreceptor tyrosine kinase22080168
PQ4019549305mouse xenograft modelIGF-1R25971682
PIK-7510275789apoptosisPI3K22802621
Nintedanib9809715VEGFR, FGFR, PDGFR23184145, 25338318NCT01251484
GSK1838705A25182616mouse xenograft modelIGF-1R26238593
AG-12089699486, 71657455viabilityIDH1 29670690
Pexidartinib25151352NCT01349036, NCT01790503
SGX-52324779724orthotopic mouse modelc-Met20015006
Acetazolamide1986proliferationcarbonic anhydrase27702686
MAZ519839842proliferation25268128
Epigallocathecin72277viability19894226
Daporinad6914657viabilityNAMPT22119381, 26601421
Sunitinib5329102mouse model, prolifrationReceptor tyrosine kinases22449730, 2545801522832897, 24311637, 24424564NCT00499473, NCT00535379, NCT00606008, NCT00864864, NCT00923117, NCT01100177, NCT01441388, NCT02928575, NCT03025893, NCT03275558
Farnesylthiosalicylic acid329799768invasion, migration, proliferationRas16985068, 17178866
Roscovitine160355proliferationCDK26151768
7-Hydroxystaurosporine72271mouse xenograft model24810059
Phenformin8249orthotopic mouse model27486821
Caffeic acid phenethyl ester5281787apoptosis, proliferation14637186, 23165409, 24997497
Amsacrine2179proliferation23165409
Diazepinomicin9868980Ras22048878NCT00730262
D6094234241proliferation28802717
Proscillaridin A222154orthotopic mouse model, proliferation25400117, 27029345
Chaetocin11657687viabilityHistone lysine methyltransferases24905315
Semustine5198DNA alkylation225004, 7013978NCT00335075
Ritonavir392622proliferation28319810NCT01095094, NCT02770378
Dibutyryl cAMP9687proliferation9484714
Rottlerin5281847proliferation27626499
Teniposide452548proliferation23165409
AZD805525262965mouse xenograft modelmTOR25316808NCT01316809
Bimiralisib58507717PI3K, mTORNCT02850744
Fasudil3547viabilityROCK26725099
Punicalagin44584733viability24077634
Tozasertib5494449mouse xenograft model, radiosenitisation, viabilityAurora kinase23636005, 25522764
Terameprocol476861proliferation2329939022323663NCT00404248
MG-132462382mouse xenograft model, proliferationproteasome22367315, 27993939
Adavosertib24856436mouse xenograft model, viabilityWEE121992793, 25609063
RO492909749867930mouse xenograft modelGamma secretase25486598NCT01122901, NCT01131234, NCT01189240, NCT01269411
KPT27671496742orthotopic mouse model, viabilityCRM125366336
Epirubicin41867proliferation, viabilityDNA intercalation23165409, 24433351, 28963609
Pyrvinium5281035mouse xenograft model, proliferation, viability23165409, 26152745, 27029345
UNII-2AW48LAZ4I72941968orthotopic mouse modeltelomerase26183089
Sulindac sulfide5352624proliferation23280445
Doxazosin3157proliferation27123999
JNJ-101984099797370viabilityPLK124204733
BIX-0129425150857viabilityhistone methyltransferase24905315, 27748874, 27934912
Adenosine dialdehyde99920proliferation23353701
Celecoxib2662viability21847707, 2328044525239666NCT00047281, NCT00047294, NCT00112502, NCT00504660, NCT02770378
Letrozole3902orthotopic mouse model, proliferationAromatase25695958
Alantolactone72724viability22837216
Selinexor71481097orthotopic mouse model, viabilityCRM125366336NCT01607905, NCT01986348
Cucurbitacin I5281321mouse xenograft model, proliferation24599950, 25482928
NMS-P71544556162mouse xenograft model, radiosenitisation25722303
Savolitinib68289010, 68287718mouse xenograft modelc-Met25148209
Lomustine3950orthotopic mouse modelalkylating agent27474153, 2867219520124186, 20855843, 23940216, 24958095NCT00003788, NCT00052455, NCT00068952, NCT00295815, NCT00503204, NCT00504660, NCT00761280, NCT00777153, NCT00948389, NCT01067469, NCT01149109, NCT01562197, NCT01582269, NCT01737346, NCT01860638, NCT01934361, NCT02343406, NCT02765165, NCT02926222, NCT03025893, NCT03149575
Deguelin107935proliferation23165409
ML00253764 9842665proliferationmelanocortin receptor-428791594
Apigenin5280443viability19894226
Capecitabine60953Nucleic Acid Synthesis25290090NCT00504660, NCT00717197, NCT00959946, NCT02669173, NCT03213002
KU6001915953870orthotopic mouse model, radiosenitisationATM23620409, 24443327, 25091220